Purified mouse CYP27B1 can hydroxylate 20,23-dihydroxyvitamin D3, producing 1alpha,20,23-trihydroxyvitamin D3, which has altered biological activity (Q34127897)

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English	Purified mouse CYP27B1 can hydroxylate 20,23-dihydroxyvitamin D3, producing 1alpha,20,23-trihydroxyvitamin D3, which has altered biological activity	scientific article

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5 February 2020

Purified mouse CYP27B1 can hydroxylate 20,23-dihydroxyvitamin D3, producing 1alpha,20,23-trihydroxyvitamin D3, which has altered biological activity (English)

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5 February 2020

Andrzej Slominski

6

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5 February 2020

Robert C Tuckey

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5 February 2020

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Wei Li

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5 February 2020

author name string

Edith K Y Tang

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5 February 2020

Zorica Janjetovic

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5 February 2020

Minh N Nguyen

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5 February 2020

Zhao Wang

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5 February 2020

publication date

16 June 2010

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5 February 2020

Drug Metabolism and Disposition

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5 February 2020

38

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5 February 2020

9

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5 February 2020

1553-1559

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5 February 2020

Products of vitamin D3 or 7-dehydrocholesterol metabolism by cytochrome P450scc show anti-leukemia effects, having low or absent calcemic activity.

1 reference

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5 July 2018

20,23-dihydroxyvitamin D3, novel P450scc product, stimulates differentiation and inhibits proliferation and NF-kappaB activity in human keratinocytes

1 reference

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5 July 2018

Expression of 25-hydroxyvitamin D-1alpha-hydroxylase (1alphaOHase, CYP27B1) splice variants in HaCaT keratinocytes and other skin cells: modulation by culture conditions and UV-B treatment in vitro

1 reference

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5 July 2018

20-Hydroxycholecalciferol, product of vitamin D3 hydroxylation by P450scc, decreases NF-kappaB activity by increasing IkappaB alpha levels in human keratinocytes

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5 July 2018

Gemini vitamin D analogues inhibit estrogen receptor-positive and estrogen receptor-negative mammary tumorigenesis without hypercalcemic toxicity

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5 July 2018

Metabolism of vitamin d2 to 17,20,24-trihydroxyvitamin d2 by cytochrome p450scc (CYP11A1).

1 reference

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5 July 2018

Metabolism of 1alpha-hydroxyvitamin D3 by cytochrome P450scc to biologically active 1alpha,20-dihydroxyvitamin D3.

1 reference

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5 July 2018

Nonclassic actions of vitamin D

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5 July 2018

Pathways and products for the metabolism of vitamin D3 by cytochrome P450scc

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5 July 2018

20-Hydroxyvitamin D3, a product of vitamin D3 hydroxylation by cytochrome P450scc, stimulates keratinocyte differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939470

5 July 2018

Vitamin D deficiency

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5 July 2018

Vitamin D receptor agonists: opportunities and challenges in drug discovery

1 reference

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5 July 2018

An alternative pathway of vitamin D metabolism. Cytochrome P450scc (CYP11A1)-mediated conversion to 20-hydroxyvitamin D2 and 17,20-dihydroxyvitamin D2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939470

5 July 2018

Promise of vitamin D analogues in the treatment of hyperproliferative conditions

1 reference

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5 July 2018

The cytochrome P450scc system opens an alternate pathway of vitamin D3 metabolism.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939470

5 July 2018

Progesterone synthesis by the human placenta

1 reference

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5 July 2018

Enzymes involved in the activation and inactivation of vitamin D.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2939470

5 July 2018

A pathway for the metabolism of vitamin D3: unique hydroxylated metabolites formed during catalysis with cytochrome P450scc (CYP11A1).

1 reference

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5 July 2018

Expression of catalytically active human cytochrome p450scc in Escherichia coli and mutagenesis of isoleucine-462.

1 reference

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5 July 2018

Purification and characterization of 25-hydroxyvitamin D3 1alpha-hydroxylase from rat kidney mitochondria

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5 July 2018

1,25-Dihydroxyvitamin D3 production by human keratinocytes. Kinetics and regulation

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5 July 2018

Metabolism of substrates incorporated into phospholipid vesicles by mouse 25-hydroxyvitamin D3 1alpha-hydroxylase (CYP27B1).

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28 October 2018

Kinetics of vitamin D3 metabolism by cytochrome P450scc (CYP11A1) in phospholipid vesicles and cyclodextrin.

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28 October 2018

Purification and characterization of mouse CYP27B1 overproduced by an Escherichia coli system coexpressing molecular chaperonins GroEL/ES.

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28 October 2018

The F-G loop region of cytochrome P450scc (CYP11A1) interacts with the phospholipid membrane

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28 October 2018

Vitamin D and cancer

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12 December 2020

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Co-expression of CYP27B1 enzyme with the 1.5kb CYP27B1 promoter-luciferase transgene in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/20554701

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytochrome P-450scc-substrate interactions. Studies of binding and catalytic activity using hydroxycholesterols

1 reference

https://pubmed.ncbi.nlm.nih.gov/20554701

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enzymatic properties of mouse 25-hydroxyvitamin D3 1 alpha-hydroxylase expressed in Escherichia coli

1 reference

https://pubmed.ncbi.nlm.nih.gov/20554701

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The concentration of adrenodoxin reductase limits cytochrome p450scc activity in the human placenta

1 reference

https://pubmed.ncbi.nlm.nih.gov/20554701

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1124/DMD.110.034389

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5 February 2020

1 reference

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5 February 2020

1 reference

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5 February 2020

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