Antifungal drug development: challenges, unmet clinical needs, and new approaches. (Q37717926)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789878%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

title

Antifungal drug development: challenges, unmet clinical needs, and new approaches (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789878%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789878%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

author name string

Terry Roemer

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789878%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

publication date

1 May 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789878%20AND%20SRC:MED&resulttype=core&format=json

Cold Spring Harbor Perspectives in Medicine

17 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789878%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

volume

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789878%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789878%20AND%20SRC:MED&resulttype=core&format=json

A high-throughput screening assay for fungicidal compounds against Cryptococcus neoformans

17 March 2020

cites work

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23 August 2017

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23 August 2017

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23 August 2017

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Approaches to antifungal therapies and their effectiveness among patients with cryptococcosis

23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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23 August 2017

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Genetic Susceptibility to Fungal Infections in Humans

23 August 2017

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Antifungal drug discovery: something old and something new

23 August 2017

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The antidepressant sertraline provides a promising therapeutic option for neurotropic cryptococcal infections

23 August 2017

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Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles

23 August 2017

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Amphotericin primarily kills yeast by simply binding ergosterol

23 August 2017

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Discovery of a novel class of orally active antifungal beta-1,3-D-glucan synthase inhibitors

23 August 2017

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Efficacy of oral E1210, a new broad-spectrum antifungal with a novel mechanism of action, in murine models of candidiasis, aspergillosis, and fusariosis

23 August 2017

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Cross-species discovery of syncretic drug combinations that potentiate the antifungal fluconazole

23 August 2017

1 reference

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Regulatory circuitry governing fungal development, drug resistance, and disease.

23 August 2017

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Novel high-throughput screen against Candida albicans identifies antifungal potentiators and agents effective against biofilms

23 August 2017

1 reference

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The challenge of managing fusariosis

23 August 2017

1 reference

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The genetic landscape of a cell

23 August 2017

1 reference

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Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin

23 August 2017

1 reference

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Independent association between rate of clearance of infection and clinical outcome of HIV-associated cryptococcal meningitis: analysis of a combined cohort of 262 patients

23 August 2017

1 reference

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Effect of beta-1,6-glucan inhibitors on the invasion process of Candida albicans: potential mechanism of their in vivo efficacy

23 August 2017

1 reference

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Treatment of cryptococcal meningitis in resource limited settings

23 August 2017

1 reference

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Overview of the changing epidemiology of candidemia

23 August 2017

1 reference

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Crystal structures of the human and fungal cytosolic Leucyl-tRNA synthetase editing domains: A structural basis for the rational design of antifungal benzoxaboroles

23 August 2017

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Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease

23 August 2017

1 reference

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Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS

23 August 2017

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Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America

23 August 2017

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Discovery of a small-molecule inhibitor of {beta}-1,6-glucan synthesis

23 August 2017

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A simple and reproducible 96-well plate-based method for the formation of fungal biofilms and its application to antifungal susceptibility testing.

23 August 2017

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Genome-wide fitness test and mechanism-of-action studies of inhibitory compounds in Candida albicans

23 August 2017

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An antifungal agent inhibits an aminoacyl-tRNA synthetase by trapping tRNA in the editing site

23 August 2017

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Differential fungicidal activities of amphotericin B and voriconazole against Aspergillus species determined by microbroth methodology

23 August 2017

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Drugs for bad bugs: confronting the challenges of antibacterial discovery

23 August 2017

1 reference

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Combination treatment of invasive fungal infections

23 August 2017

1 reference

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Chemogenomic profiling: identifying the functional interactions of small molecules in yeast

23 August 2017

1 reference

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Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis

23 August 2017

1 reference

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Functional profiling of the Saccharomyces cerevisiae genome

23 August 2017

1 reference

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Discovery of novel antifungal (1,3)-beta-D-glucan synthase inhibitors

23 August 2017

1 reference

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Evaluation of a novel colorimetric broth microdilution method for antifungal susceptibility testing of yeast isolates

23 August 2017

1 reference

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Prospects for new antibiotics: a molecule-centered perspective

23 August 2017

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Amphotericin B formulations: a comparative review of efficacy and toxicity

6 September 2017

1 reference

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Inhibiting GPI anchor biosynthesis in fungi stresses the endoplasmic reticulum and enhances immunogenicity

6 September 2017

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Mucormycosis in organ and stem cell transplant recipients

6 September 2017

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Echinocandins: are they all the same?

6 September 2017

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Bugs, drugs and chemical genomics

6 September 2017

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Triazole antifungal agents in invasive fungal infections: a comparative review

6 September 2017

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Confronting the challenges of natural product-based antifungal discovery

6 September 2017

1 reference

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An insight into the antifungal pipeline: selected new molecules and beyond.

6 September 2017

1 reference

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Analysis of beta-1,3-glucan assembly in Saccharomyces cerevisiae using a synthetic interaction network and altered sensitivity to caspofungin

6 September 2017

1 reference

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Quantitative phenotypic analysis of yeast deletion mutants using a highly parallel molecular bar-coding strategy

6 September 2017

1 reference

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The antifungal echinocandin caspofungin acetate kills growing cells of Aspergillus fumigatus in vitro

6 September 2017

1 reference

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Serologic evidence for Cryptococcus neoformans infection in early childhood

14 September 2017

1 reference

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Murgocil is a highly bioactive staphylococcal-specific inhibitor of the peptidoglycan glycosyltransferase enzyme MurG.

14 September 2017

1 reference

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Combinatory effect of fluconazole and FDA-approved drugs against Candida albicans

23 June 2018

1 reference

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Combination antifungal therapy for cryptococcal meningitis

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996373

In vitro activity of a new oral glucan synthase inhibitor (MK-3118) tested against Aspergillus spp. by CLSI and EUCAST broth microdilution methods

23 June 2018

1 reference

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Discovery of the parnafungins, antifungal metabolites that inhibit mRNA polyadenylation, from the Fusarium larvarum complex and other Hypocrealean fungi.

23 June 2018

1 reference

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Genomic profiling of drug sensitivities via induced haploinsufficiency.

23 June 2018

1 reference

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Clinical epidemiology of 960 patients with invasive aspergillosis from the PATH Alliance registry

23 June 2018

1 reference

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Synthesis and biological evaluation of antifungal derivatives of enfumafungin as orally bioavailable inhibitors of β-1,3-glucan synthase.

1 September 2018

1 reference

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A new approach to drug discovery: high-throughput screening of microbial natural extracts against Aspergillus fumigatus using resazurin.

1 September 2018

1 reference

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Isolation, structure, and biological activities of Fellutamides C and D from an undescribed Metulocladosporiella (Chaetothyriales) using the genome-wide Candida albicans fitness test.

1 September 2018

1 reference

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A high-throughput assay of yeast cell lysis for drug discovery and genetic analysis.

1 September 2018

1 reference

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PAP inhibitor with in vivo efficacy identified by Candida albicans genetic profiling of natural products.

1 September 2018

1 reference

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Medicinal genetics approach towards identifying the molecular target of a novel inhibitor of fungal cell wall assembly

1 September 2018

1 reference

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Tackling Human Fungal Infections

1 September 2018

1 reference

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Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy

3 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996373

Need for Alternative Trial Designs and Evaluation Strategies for Therapeutic Studies of Invasive Mycoses

3 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3996373

Activity of MK-3118, a new oral glucan synthase inhibitor, tested against Candida spp. by two international methods (CLSI and EUCAST)

3 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24789878

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1101/CSHPERSPECT.A019703

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789878%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24789878%20AND%20SRC:MED&resulttype=core&format=json

17 March 2020

1 reference