Discovery of a novel class of orally active antifungal beta-1,3-D-glucan synthase inhibitors (Q35363744)

7 August 2017

title

Discovery of a novel class of orally active antifungal beta-1,3-D-glucan synthase inhibitors (English)

1 reference

7 August 2017

Scott S Walker

1

1 reference

7 August 2017

Yiming Xu

2

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7 August 2017

Ilias Triantafyllou

3

1 reference

7 August 2017

Michelle F Waldman

4

1 reference

7 August 2017

Cara Mendrick

5

1 reference

7 August 2017

Nathaniel Brown

6

1 reference

7 August 2017

Paul Mann

7

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7 August 2017

Andrew Chau

8

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7 August 2017

Reena Patel

9

1 reference

7 August 2017

Nicholas Bauman

10

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7 August 2017

Christine Norris

11

1 reference

7 August 2017

Barry Antonacci

12

1 reference

7 August 2017

Maya Gurnani

13

1 reference

7 August 2017

Anthony Cacciapuoti

14

1 reference

7 August 2017

Paul M McNicholas

15

1 reference

7 August 2017

Samuel Wainhaus

16

1 reference

7 August 2017

R Jason Herr

17

1 reference

7 August 2017

Rongze Kuang

18

1 reference

7 August 2017

Robert G Aslanian

19

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7 August 2017

Pauline C Ting

20

1 reference

7 August 2017

Todd A Black

21

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7 August 2017

language of work or name

English

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publication date

15 August 2011

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Antimicrobial Agents and Chemotherapy

7 August 2017

published in

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7 August 2017

volume

55

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7 August 2017

issue

11

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7 August 2017

page(s)

5099-5106

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SAR studies of pyridazinone derivatives as novel glucan synthase inhibitors

7 August 2017

cites work

1 reference

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A global protein kinase and phosphatase interaction network in yeast.

12 July 2018

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Fluconazole transport into Candida albicans secretory vesicles by the membrane proteins Cdr1p, Cdr2p, and Mdr1p

12 July 2018

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Multiple functional domains of the yeast l,3-beta-glucan synthase subunit Fks1p revealed by quantitative phenotypic analysis of temperature-sensitive mutants

12 July 2018

1 reference

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Correlating echinocandin MIC and kinetic inhibition of fks1 mutant glucan synthases for Candida albicans: implications for interpretive breakpoints

12 July 2018

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A Ser678Pro substitution in Fks1p confers resistance to echinocandin drugs in Aspergillus fumigatus

12 July 2018

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Resistance to echinocandin-class antifungal drugs

12 July 2018

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Toward a comprehensive atlas of the physical interactome of Saccharomyces cerevisiae

12 July 2018

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Proteome survey reveals modularity of the yeast cell machinery

12 July 2018

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Piperazine propanol derivative as a novel antifungal targeting 1,3-beta-D-glucan synthase

12 July 2018

1 reference

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Characterization of Aspergillus fumigatus mutants with reduced susceptibility to caspofungin

12 July 2018

1 reference

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Specific substitutions in the echinocandin target Fks1p account for reduced susceptibility of rare laboratory and clinical Candida sp. isolates

12 July 2018

1 reference

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Analysis of beta-1,3-glucan assembly in Saccharomyces cerevisiae using a synthetic interaction network and altered sensitivity to caspofungin

12 July 2018

1 reference

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Movement of yeast 1,3-beta-glucan synthase is essential for uniform cell wall synthesis.

12 July 2018

1 reference

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Fungal ß(1,3)-D-glucan synthesis

12 July 2018

1 reference

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Discovery of novel antifungal (1,3)-beta-D-glucan synthase inhibitors

12 July 2018

1 reference

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Photoaffinity analog of the semisynthetic echinocandin LY303366: identification of echinocandin targets in Candida albicans

12 July 2018

1 reference

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Comparison of a 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-5-[(phenylamino)carbonyl]-2H-t etrazolium hydroxide (XTT) colorimetric method with the standardized National Committee for Clinical Laboratory Standards method of testing clinical yeast [...]

12 July 2018

1 reference

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Identification of yeast Rho1p GTPase as a regulatory subunit of 1,3-beta-glucan synthase.

12 July 2018

1 reference

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Rho1p, a yeast protein at the interface between cell polarization and morphogenesis

12 July 2018

1 reference

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A GTP-binding protein regulates the activity of (1-->3)-beta-glucan synthase, an enzyme directly involved in yeast cell wall morphogenesis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195001

Morphological effects of lipopeptides against Aspergillus fumigatus correlate with activities against (1,3)-beta-D-glucan synthase

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195001

The Saccharomyces cerevisiae FKS1 (ETG1) gene encodes an integral membrane protein which is a subunit of 1,3-beta-D-glucan synthase

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195001

A GAL10-CYC1 hybrid yeast promoter identifies the GAL4 regulatory region as an upstream site

12 July 2018

1 reference

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A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae

12 July 2018

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Heterologous gene expression in continuous cultures of budding yeast.

12 July 2018

1 reference

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Papulacandin B: an Inhibitor of Glucan Synthesis in Yeast Spheroplasts

12 July 2018

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On the mode of action of a new antifungal antibiotic, aculeacin A: Inhibition of cell wall synthesis in Saccharomyces cerevisiae

12 July 2018

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Pharmacological characterization of a novel α2C-adrenoceptor agonist N-[3,4-dihydro-4-(1H-imidazol-4-ylmethyl)-2H-1, 4-benzoxazin-6-yl]-N-ethyl-N'-methylurea (compound A).

12 July 2018

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Geographic variation in the frequency of isolation and fluconazole and voriconazole susceptibilities of Candida glabrata: an assessment from the ARTEMIS DISK Global Antifungal Surveillance Program

26 September 2018

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Fungal echinocandin resistance.

26 September 2018

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Neurospora crassa FKS Protein Binds to the (1,3)?-Glucan Synthase Substrate, UDP-Glucose

26 September 2018

1 reference

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Yeast cell permeabilization by osmotic shock allows determination of enzymatic activities in situ

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195001

A recyclable Candida albicans URA3 cassette for PCR product-directed gene disruptions.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195001

Plasmid construction by homologous recombination in yeast.

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3195001

A high throughput in vitro assay for fungal (1,3)beta-glucan synthase inhibitors

26 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21844320

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The synthesis and structure-activity relationship of pyridazinones as glucan synthase inhibitors

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21844320

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/AAC.00432-11

1 reference

7 August 2017

1 reference

7 August 2017

1 reference