Minimizing repolarization-related proarrhythmic risk in drug development and clinical practice. (Q37717622)

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28 January 2020

review article

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title

Minimizing repolarization-related proarrhythmic risk in drug development and clinical practice (English)

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28 January 2020

2

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28 January 2020

author name string

Attila S Farkas

series ordinal

1

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publication date

1 March 2010

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28 January 2020

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28 January 2020

volume

70

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28 January 2020

issue

5

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28 January 2020

page(s)

573-603

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https://scigraph.springernature.com/pub.10.2165/11535230-000000000-00000

28 January 2020

exact match

0 references

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A patient with "atrial torsades de pointes"

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12 December 2020

In vitro and in vivo models for testing arrhythmogenesis in drugs

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12 December 2020

Torsades de pointes liability inter-model comparisons: the experience of the QT PRODACT initiative

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12 December 2020

Adrenaline reveals the torsadogenic effect of combined blockade of potassium channels in anaesthetized guinea pigs

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12 December 2020

End-diastolic myofiber stress and ejection strain increase with ventricular volume overload--Serial in-vivo analyses in dogs with complete atrioventricular block.

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12 December 2020

The hERG potassium channel as a therapeutic target

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12 December 2020

Enhanced susceptibility for acquired torsade de pointes arrhythmias in the dog with chronic, complete AV block is related to cardiac hypertrophy and electrical remodeling

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12 December 2020

Effects of calcium and sodium concentrations on atrioventricular conduction: Experimental study in rabbit hearts with clinical implications on heart block and slow calcium channel blocking agent usage

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12 December 2020

Activation of human ether-a-go-go-related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643).

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12 December 2020

QT dispersion in adult hypertensives

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12 December 2020

The fentanyl/etomidate-anaesthetised beagle (FEAB) dog: a versatile in vivo model in cardiovascular safety research

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12 December 2020

Risk factors and predictors of Torsade de pointes ventricular tachycardia in patients with left ventricular systolic dysfunction receiving Dofetilide

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12 December 2020

Neural Control of Heart Rate Is an Arrhythmia Risk Modifier in Long QT Syndrome

1 reference

12 December 2020

"Torsade de pointes" in a patient with variant angina.

1 reference

12 December 2020

New cell models and assays in cardiac safety profiling

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12 December 2020

Sudden death associated with short-QT syndrome linked to mutations in HERG.

1 reference

12 December 2020

Safety of non-antiarrhythmic drugs that prolong the QT interval or induce torsade de pointes: an overview

1 reference

12 December 2020

Tpeak-Tend interval and Tpeak-Tend/QT ratio as markers of ventricular tachycardia inducibility in subjects with Brugada ECG phenotype

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12 December 2020

Rhythm anomalies related to delayed repolarization in vivo: influence of sarcolemmal Ca++ entry and intracellular Ca++ overload

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12 December 2020

The QT interval: too long, too short or just right

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12 December 2020

Preclinical strategies to assess QT liability and torsadogenic potential of new drugs: the role of experimental models

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12 December 2020

Torsade de pointes due to quinidine: observations in 31 patients

1 reference

12 December 2020

Grapefruit and tonic: a deadly combination in a patient with the long QT syndrome

1 reference

12 December 2020

Preclinical assessment of drug-induced proarrhythmias: role of the arterially perfused rabbit left ventricular wedge preparation

1 reference

12 December 2020

Alpha 1-adrenoceptors in myocardium: functional aspects and transmembrane signaling mechanisms

1 reference

12 December 2020

QTc interval in the assessment of cardiac risk

1 reference

12 December 2020

Exaggerated QT prolongation after cardioversion of atrial fibrillation

1 reference

12 December 2020

Moving towards better predictors of drug-induced torsades de pointes

1 reference

12 December 2020

Beat-to-beat QT interval variability is primarily affected by the autonomic nervous system.

1 reference

12 December 2020

Torsade de pointes due to consumption of Sauropus androgynus as a weight-reducing vegetable

1 reference

12 December 2020

Assessing the proarrhythmic potential of drugs: current status of models and surrogate parameters of torsades de pointes arrhythmias.

1 reference

12 December 2020

Pharmacologically induced long QT type 2 can be rescued by activation of IKs with benzodiazepine R-L3 in isolated guinea pig cardiomyocytes

1 reference

12 December 2020

Drug-induced QT interval shortening: potential harbinger of proarrhythmia and regulatory perspectives

1 reference

12 December 2020

In vivo mechanisms precipitating torsades de pointes in a canine model of drug-induced long-QT1 syndrome

1 reference

12 December 2020

Preliminary report: effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction

1 reference

12 December 2020

1 reference

12 December 2020

Preclinical Torsades-de-Pointes screens: advantages and limitations of surrogate and direct approaches in evaluating proarrhythmic risk

1 reference

12 December 2020

The influence of gender on arrhythmias

1 reference

12 December 2020

Observations on the onset of torsade de pointes arrhythmias in the acquired long QT syndrome

1 reference

12 December 2020

Characteristics and distribution of M cells in arterially perfused canine left ventricular wedge preparations

1 reference

12 December 2020

Risk stratification for sudden cardiac death: is there a clinical role for T wave alternans?

1 reference

12 December 2020

Repolarisation and vulnerability to re-entry in the human heart with short QT syndrome arising from KCNQ1 mutation--a simulation study

1 reference

12 December 2020

Teasing out circadian variability in heart rate turbulence: A new approach to detecting biorhythms underlying cardiac function

1 reference

12 December 2020

Role of subendocardial Purkinje network in triggering torsade de pointes arrhythmia in experimental long QT syndrome

1 reference

12 December 2020

Potentiation of E-4031-induced torsade de pointes by HMR1556 or ATX-II is not predicted by action potential short-term variability or triangulation

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12 December 2020

Molecular aspects of arrhythmias associated with cardiomyopathies

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12 December 2020

Models of torsades de pointes: effects of FPL64176, DPI201106, dofetilide, and chromanol 293B in isolated rabbit and guinea pig hearts.

1 reference

12 December 2020

The utility of hERG and repolarization assays in evaluating delayed cardiac repolarization: influence of multi-channel block

1 reference

12 December 2020

The hERG potassium channel and hERG screening for drug-induced torsades de pointes

1 reference

12 December 2020

Blinded test in isolated female rabbit heart reliably identifies action potential duration prolongation and proarrhythmic drugs: importance of triangulation, reverse use dependence, and instability

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12 December 2020

Basic Mechanisms of Cardiac Impulse Propagation and Associated Arrhythmias

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12 December 2020

Downregulation of delayed rectifier K(+) currents in dogs with chronic complete atrioventricular block and acquired torsades de pointes

1 reference

12 December 2020

Importance of vagally mediated bradycardia for the induction of torsade de pointes in an in vivo model.

1 reference

12 December 2020

Electrophysiologic features of torsades de pointes: insights from a new isolated rabbit heart model

1 reference

12 December 2020

A transient outward potassium current activator recapitulates the electrocardiographic manifestations of Brugada syndrome.

1 reference

12 December 2020

If a drug deemed 'safe' in nonclinical tests subsequently prolongs QT in phase 1 studies, how can its sponsor convince regulators to allow development to proceed?

1 reference

12 December 2020

Comparison of the antiarrhythmic and the proarrhythmic effect of almokalant in anaesthetised rabbits.

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12 December 2020

Inhibition of cytochrome P450 3A: relevant drug interactions in gastroenterology

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12 December 2020

Challenges of characterizing proarrhythmic risk due to QTc prolongation induced by nonadjuvant anticancer agents

1 reference

12 December 2020

Cardiac alternans: diverse mechanisms and clinical manifestations

1 reference

12 December 2020

Assessment of the ion channel-blocking profile of the novel combined ion channel blocker AZD1305 and its proarrhythmic potential versus dofetilide in the methoxamine-sensitized rabbit in vivo

1 reference

12 December 2020

Transseptal dispersion of repolarization and its role in the development of Torsade de Pointes arrhythmias

1 reference

12 December 2020

Ionic, molecular, and cellular bases of QT-interval prolongation and torsade de pointes.

1 reference

12 December 2020

Clinical implications of present physiological understanding of HRV components.

1 reference

12 December 2020

Torsade de pointes tachycardia as a rare manifestation of acute enteroviral myocarditis

1 reference

12 December 2020

Pharmacological response of quinidine induced early afterdepolarisations in canine cardiac Purkinje fibres: insights into underlying ionic mechanisms.

1 reference

12 December 2020

Temporal repolarization lability differences among genotyped patients with the long QT syndrome

1 reference

12 December 2020

Estimation of potency of HERG channel blockers: impact of voltage protocol and temperature

1 reference

12 December 2020

Alpha 1-adrenoceptors reduce background K+ current in rabbit ventricular myocytes

1 reference

12 December 2020

Liquid protein diets and torsade de pointes

1 reference

12 December 2020

QT corrected for heart rate: a new approach and its application.

1 reference

12 December 2020

Primary hyperparathyroidism presenting as torsades de pointes

1 reference

12 December 2020

Ventricular tachycardia with 2 variable opposing foci

1 reference

12 December 2020

Prolongation of the QT interval during therapeutic starvation: a substrate for malignant arrhythmias

1 reference

12 December 2020

Electrophysiological mechanism of the characteristic electrocardiographic morphology of torsade de pointes tachyarrhythmias in the long-QT syndrome: detailed analysis of ventricular tridimensional activation patterns

1 reference

12 December 2020

Cellular basis for the electrocardiographic and arrhythmic manifestations of Timothy syndrome: effects of ranolazine

1 reference

12 December 2020

Benchmarking safety pharmacology regulatory packages and best practice

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12 December 2020

Drug-induced torsades de pointes and implications for drug development.

1 reference

12 December 2020

Instability and triangulation of the action potential predict serious proarrhythmia, but action potential duration prolongation is antiarrhythmic

1 reference

12 December 2020

The calcium/calmodulin/kinase system and arrhythmogenic afterdepolarizations in bradycardia-related acquired long-QT syndrome

1 reference

12 December 2020

State dependent dissociation of HERG channel inhibitors

1 reference

12 December 2020

1 reference

12 December 2020

Novel potent human ether-a-go-go-related gene (hERG) potassium channel enhancers and their in vitro antiarrhythmic activity

1 reference

12 December 2020

Overlap syndrome of cardiac sodium channel disease in mice carrying the equivalent mutation of human SCN5A-1795insD

1 reference

12 December 2020

Unrecognized bulimia nervosa: a potential cause of perioperative cardiac dysrhythmias.

1 reference

12 December 2020

A phenomenon of heart-rate turbulence, its evaluation, and prognostic value.

1 reference

12 December 2020

Ionic remodeling of cardiac Purkinje cells by congestive heart failure

1 reference

12 December 2020

Drug-induced QT interval prolongation--regulatory guidance and perspectives on hERG channel studies.

1 reference

12 December 2020

International Conference on Harmonisation; guidance on S7B Nonclinical Evaluation of the Potential for Delayed Ventricular Repolarization (QT Interval Prolongation) by Human Pharmaceuticals; availability. Notice.

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12 December 2020

Beat-to-beat variability of QT intervals is increased in patients with drug-induced long-QT syndrome: a case control pilot study

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12 December 2020

Inadequate ischaemia-selectivity limits the antiarrhythmic efficacy of mibefradil during regional ischaemia and reperfusion in the rat isolated perfused heart.

1 reference

12 December 2020

Potassium channel down-regulation in heart failure.

1 reference

12 December 2020

Use of the rabbit with a failing heart to test for torsadogenicity

1 reference

12 December 2020

Cellular basis of biventricular hypertrophy and arrhythmogenesis in dogs with chronic complete atrioventricular block and acquired torsade de pointes

1 reference

12 December 2020

QT PRODACT: in vivo QT assay in the conscious dog for assessing the potential for QT interval prolongation by human pharmaceuticals

1 reference

12 December 2020

Heart rate variability in patients with congenital long QT syndrome

1 reference

12 December 2020

Inhibition of cardiac potassium currents by pentobarbital

1 reference

12 December 2020

Discovery of a small molecule activator of the human ether-a-go-go-related gene (HERG) cardiac K+ channel

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12 December 2020

Restitution properties and occurrence of ventricular arrhythmia in LQT2 type of long QT syndrome

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12 December 2020

Low penetrance, subclinical congenital LQTS: concealed LQTS or silent LQTS?

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12 December 2020

Torsade de pointes associated with encephalitis.

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12 December 2020

Quinidine-induced ventricular flutter and fibrillation without digitalis therapy

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12 December 2020

Cardiovascular monkey telemetry: sensitivity to detect QT interval prolongation.

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12 December 2020

Effects of pink grapefruit juice on QT variability in patients with dilated or hypertensive cardiomyopathy and in healthy subjects.

1 reference

12 December 2020

Systemic administration of calmodulin antagonist W-7 or protein kinase A inhibitor H-8 prevents torsade de pointes in rabbits

1 reference

12 December 2020

hERG1 channel activators: a new anti-arrhythmic principle

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12 December 2020

Direct electrophysiological actions of pentobarbital at concentrations achieved during general anesthesia

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12 December 2020

Torsade de pointes: the long-short initiating sequence and other clinical features: observations in 32 patients

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12 December 2020

The effect of alterations to action potential duration on beta-adrenoceptor-mediated aftercontractions in human and guinea-pig ventricular myocytes

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12 December 2020

A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel

1 reference

12 December 2020

In-vitro experimental models for the risk assessment of antibiotic-induced QT prolongation

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12 December 2020

Ionic mechanisms of acquired QT prolongation and torsades de pointes in rabbits with chronic complete atrioventricular block

1 reference

12 December 2020

Use of arterially perfused rabbit ventricular wedge in predicting arrhythmogenic potentials of drugs

1 reference

12 December 2020

Amplified transmural dispersion of repolarization as the basis for arrhythmogenesis in a canine ventricular-wedge model of short-QT syndrome

1 reference

12 December 2020

QT PRODACT: in vivo QT assay with a conscious monkey for assessment of the potential for drug-induced QT interval prolongation

1 reference

12 December 2020

[T-wave alternans and Torsade de Pointes ventricular tachycardia in a patient with intracerebral hemorrhage]

1 reference

12 December 2020

Rb+ flux through hERG channels affects the potency of channel blocking drugs: correlation with data obtained using a high-throughput Rb+ efflux assay

1 reference

12 December 2020

Use of a failing rabbit heart as a model to predict torsadogenicity

1 reference

12 December 2020

RARE CARDIAC ARRHYTHMIAS OF THE PEDIATRIC AGE. I. REPETITIVE PAROXYSMAL TACHYCARDIA

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12 December 2020

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12 December 2020

Cardiac glycosides as novel inhibitors of human ether-a-go-go-related gene channel trafficking

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12 December 2020

Drug-induced torsades de pointes: a review of the Swedish pharmacovigilance database

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12 December 2020

"Atrial torsades de pointes" in the long QT syndrome

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12 December 2020

Cellular basis for arrhythmogenesis in an experimental model of the SQT1 form of the short QT syndrome

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12 December 2020

Molecular mechanisms for drug interactions with hERG that cause long QT syndrome.

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12 December 2020

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12 December 2020

Classification and mechanism of Torsade de Pointes initiation in patients with congenital long QT syndrome

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12 December 2020

Takotsubo cardiomyopathy and QT interval prolongation: who are the patients at risk for torsades de pointes?

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12 December 2020

Drug-induced atrioventricular block: prognosis after discontinuation of the culprit drug.

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12 December 2020

Amiodarone-associated "torsade de pointes". Relevance of concomitant cardiovascular medication in a patient with atrial fibrillation and structural heart disease

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12 December 2020

Assessing risk of a prolonged QT interval-a survey of emergency physicians

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12 December 2020

Alpha-1 adrenergic stimulation of 1,4,5-inositol trisphosphate formation in ventricular myocytes.

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12 December 2020

Images in cardiovascular medicine. T-wave alternans preceding torsade de pointes ventricular tachycardia

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12 December 2020

Drug-induced torsades de pointes in patients aged 80 years or more

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12 December 2020

Use and abuse of QT and TRIaD in cardiac safety research: importance of study design and conduct

1 reference

12 December 2020

Cisapride-induced transmural dispersion of repolarization and torsade de pointes in the canine left ventricular wedge preparation during epicardial stimulation

1 reference

12 December 2020

Ranolazine: ion-channel-blocking actions and in vivo electrophysiological effects

1 reference

12 December 2020

Idiopathic short QT interval: a new clinical syndrome?

1 reference

12 December 2020

Drugs that prolong QT interval as an unwanted effect: assessing their likelihood of inducing hazardous cardiac dysrhythmias

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12 December 2020

Molecular determinants of hERG channel block by terfenadine and cisapride

1 reference

12 December 2020

Torsade de Pointes associated with thyrotoxicosis

1 reference

12 December 2020

Sensitive and reliable proarrhythmia in vivo animal models for predicting drug-induced torsades de pointes in patients with remodelled hearts

1 reference

12 December 2020

Evaluation of baroreceptor reflex by blood pressure monitoring in unanesthetized cats

1 reference

12 December 2020

Mutation in the KCNQ1 gene leading to the short QT-interval syndrome

1 reference

12 December 2020

Biophysical characterization of the new human ether-a-go-go-related gene channel opener NS3623 [N-(4-bromo-2-(1H-tetrazol-5-yl)-phenyl)-N'-(3'-trifluoromethylphenyl)urea].

1 reference

12 December 2020

Variability in the measurement of hERG potassium channel inhibition: effects of temperature and stimulus pattern

1 reference

12 December 2020

Risk of torsades de pointes with non-cardiac drugs. Grapefruit juice is source of potentially life threatening adverse drug reactions

1 reference

12 December 2020

Importance of QT interval determination and renal function assessment during antiarrhythmic drug therapy

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12 December 2020

1 reference

12 December 2020

Factors Affecting Drug Concentrations and QT Interval During Thioridazine Therapy

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12 December 2020

Asynchronous development of electrical remodeling and cardiac hypertrophy in the complete AV block dog.

1 reference

12 December 2020

Correlation between time-domain measures of heart rate variability and scatterplots in postinfarction patients

1 reference

12 December 2020

Drug-induced proarrhythmia and use of QTc-prolonging agents: clues for clinicians

1 reference

12 December 2020

Development of a surgical approach for telemetering guinea pigs as a model for screening QT interval effects.

1 reference

12 December 2020

Current challenges in the evaluation of cardiac safety during drug development: translational medicine meets the Critical Path Initiative

1 reference

12 December 2020

In silico assessment of Y1795C and Y1795H SCN5A mutations: implication for inherited arrhythmogenic syndromes

1 reference

12 December 2020

Taking the "idio" out of "idiosyncratic": predicting torsades de pointes

1 reference

12 December 2020

Potassium channel subunit remodeling in rabbits exposed to long-term bradycardia or tachycardia: discrete arrhythmogenic consequences related to differential delayed-rectifier changes

1 reference

12 December 2020

Loss-of-function mutations in the cardiac calcium channel underlie a new clinical entity characterized by ST-segment elevation, short QT intervals, and sudden cardiac death

1 reference

12 December 2020

T wave alternans in idiopathic long QT syndrome

1 reference

12 December 2020

Detection of proarrhythmia in the female rabbit heart: blinded validation

1 reference

12 December 2020

Relative contributions of TRIaD and QT to proarrhythmia

1 reference

12 December 2020

Refining detection of drug-induced proarrhythmia: QT interval and TRIaD.

1 reference

12 December 2020

In vitro models of proarrhythmia

1 reference

12 December 2020

Cardiac alpha 1-adrenoceptors: an overview

1 reference

12 December 2020

Validation of a guinea pig Langendorff heart model for assessing potential cardiovascular liability of drug candidates

1 reference

12 December 2020

"Torsade de pointes" during amiodarone infusion in a cirrhotic woman with a prolonged QT interval

1 reference

12 December 2020

Torsades de pointes in 3 patients with leukemia treated with arsenic trioxide.

1 reference

12 December 2020

Drug-induced spatial dispersion of repolarization

1 reference

12 December 2020

QTc: how long is too long?

1 reference

12 December 2020

The role of the Na+/Ca2+ exchanger, I(Na) and I(CaL) in the genesis of dofetilide-induced torsades de pointes in isolated, AV-blocked rabbit hearts

1 reference

12 December 2020

Contractile adaptations preserving cardiac output predispose the hypertrophied canine heart to delayed afterdepolarization-dependent ventricular arrhythmias

1 reference

12 December 2020

Electrocardiographic and clinical predictors of torsades de pointes induced by almokalant infusion in patients with chronic atrial fibrillation or flutter: a prospective study.

1 reference

12 December 2020

Model systems for the discovery and development of antiarrhythmic drugs.

1 reference

12 December 2020

Heart rate turbulence slope reduction in imminent ventricular tachyarrhythmia and its implications.

1 reference

12 December 2020

Variability of action potential duration in pharmacologically induced long QT syndrome type 1

1 reference

12 December 2020

Response to intravenous ajmaline: a retrospective analysis of 677 ajmaline challenges.

1 reference

12 December 2020

Cardiac sodium channel overlap syndromes: different faces of SCN5A mutations

1 reference

12 December 2020

Reduction of repolarization reserve unmasks the proarrhythmic role of endogenous late Na(+) current in the heart

1 reference

12 December 2020

Relevance of in vitro SCREENIT results for drug-induced QT interval prolongation in vivo: a database review and analysis

1 reference

12 December 2020

The beta-adrenergic blocker carvedilol restores L-type calcium current in a myocardial infarction model of rabbit

1 reference

12 December 2020

An in vitro model for assessment of drug-induced torsade de pointes arrhythmia : effects of haloperidol and dofetilide on potential duration, repolarization inhomogeneities, and torsade de pointes arrhythmia

1 reference

12 December 2020

Cellular and ionic basis for T-wave alternans under long-QT conditions

1 reference

12 December 2020

Torsades de pointes associated with nonantiarrhythmic drugs and observations on gender and QTc

1 reference

12 December 2020

Proarrhythmia as a class effect of quinolones: increased dispersion of repolarization and triangulation of action potential predict torsades de pointes

1 reference

12 December 2020

Repolarization heterogeneity in the right ventricular outflow tract: correlation with ventricular arrhythmias in Brugada patients and in an in vitro canine Brugada model

1 reference

12 December 2020

Antiarrhythmic agents and proarrhythmia

1 reference

12 December 2020

A novel form of short QT syndrome (SQT3) is caused by a mutation in the KCNJ2 gene

1 reference

12 December 2020

Polymorphic ventricular tachycardia and repolarization abnormalities accompanying intracerebral hemorrhage

1 reference

12 December 2020

Importance of extracardiac alpha1-adrenoceptor stimulation in assisting dofetilide to induce torsade de pointes in rabbit hearts

1 reference

12 December 2020

International Life Sciences Institute (Health and Environmental Sciences Institute, HESI) initiative on moving towards better predictors of drug-induced torsades de pointes

1 reference

12 December 2020

Clinical trial design to evaluate the effects of drugs on cardiac repolarization: current state of the art.

1 reference

12 December 2020

Anorexia nervosa and sudden death

1 reference

12 December 2020

Circadian rhythm of the corrected QT interval: impact of different heart rate correction models

1 reference

12 December 2020

Assessment of microvolt T-wave alternans in high-risk patients with the congenital long-QT syndrome.

1 reference

12 December 2020

Drug-induced Brugada syndrome.

1 reference

12 December 2020

Role of late sodium current in modulating the proarrhythmic and antiarrhythmic effects of quinidine

1 reference

12 December 2020

Risk stratification in the long-QT syndrome.

1 reference

12 December 2020

Role of the cytosolic chaperones Hsp70 and Hsp90 in maturation of the cardiac potassium channel HERG.

1 reference

12 December 2020

Prolonged Atrial Action Potential Durations and Polymorphic Atrial Tachyarrhythmias in Patients with Long QT Syndrome

1 reference

12 December 2020

Electrophysiologic parameters and predisposing factors in the generation of drug-induced Torsade de Pointes arrhythmias

1 reference

12 December 2020

Assessing QT prolongation in conscious dogs: validation of a beat-to-beat method

1 reference

12 December 2020

Congenital deaf-mutism, functional heart disease with prolongation of the Q-T interval and sudden death

1 reference

12 December 2020

There is no transmural heterogeneity in an index of action potential duration in the canine left ventricle

1 reference

12 December 2020

Differential effects of beta-adrenergic agonists and antagonists in LQT1, LQT2 and LQT3 models of the long QT syndrome.

1 reference

12 December 2020

Effects of flecainide and quinidine on arrhythmogenic properties of Scn5a+/- murine hearts modelling the Brugada syndrome

1 reference

12 December 2020

Long QT syndromes and torsade de pointes

1 reference

12 December 2020

QT prolongation with torsade de pointes in pheochromocytoma

1 reference

12 December 2020

Effect of d-sotalol on mortality in patients with left ventricular dysfunction after recent and remote myocardial infarction. The SWORD Investigators. Survival With Oral d-Sotalol.

1 reference

12 December 2020

T wave peak-to-end interval and QT dispersion in acquired long QT syndrome: a new index for arrhythmogenicity

1 reference

12 December 2020

"Torsade de pointes" in patients with structural heart disease and atrial fibrillation treated with amiodarone, beta-blockers, and digitalis

1 reference

12 December 2020

QT interval variables from 24 hour electrocardiography and the two year risk of sudden death

1 reference

12 December 2020

Electrocardiographic interventricular dispersion of repolarization during autonomic adaptation in LQT1 subtype of long QT syndrome.

1 reference

12 December 2020

Abnormal heart rate turbulence predicts the initiation of ventricular arrhythmias

1 reference

12 December 2020

Modulation of cardiac inward rectifier K(+)current by halothane and isoflurane

1 reference

12 December 2020

Drug block of I(kr): model systems and relevance to human arrhythmias

1 reference

12 December 2020

I(NaCa) contributes to electrical heterogeneity within the canine ventricle

1 reference

12 December 2020

HERG-Lite: a novel comprehensive high-throughput screen for drug-induced hERG risk

1 reference

12 December 2020

Effects of a K(+) channel opener to reduce transmural dispersion of repolarization and prevent torsade de pointes in LQT1, LQT2, and LQT3 models of the long-QT syndrome

1 reference

12 December 2020

The mechanism of pause-induced torsade de pointes in long QT syndrome

1 reference

12 December 2020

Sodium calcium exchange as a target for antiarrhythmic therapy

1 reference

12 December 2020

Heart disease and stroke statistics--2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee

1 reference

12 December 2020

Mechanism of arrhythmogenicity of the short-long cardiac sequence that precedes ventricular tachyarrhythmias in the long QT syndrome

1 reference

12 December 2020

Long QTc and torsades de pointes in human immunodeficiency virus disease

1 reference

12 December 2020

Calculation of QT shift in non clinical safety pharmacology studies

1 reference

12 December 2020

The potential for QT prolongation and pro-arrhythmia by non-anti-arrhythmic drugs: clinical and regulatory implications. Report on a Policy Conference of the European Society of Cardiology.

1 reference

12 December 2020

Autonomic aspects of arrhythmogenesis: the enduring and the new.

1 reference

12 December 2020

Pharmacological approach to the treatment of long and short QT syndromes

1 reference

12 December 2020

Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties

1 reference

12 December 2020

Do existing measures of Poincaré plot geometry reflect nonlinear features of heart rate variability?

1 reference

12 December 2020

Assessing predictors of drug-induced torsade de pointes.

1 reference

12 December 2020

Adrenal adenoma presenting with torsade de pointes--a case report

1 reference

12 December 2020

Clinical characteristics of patients with drug-induced QT interval prolongation and torsade de pointes: identification of risk factors.

1 reference

12 December 2020

Clomipramine block of the hERG K+ channel: accessibility to F656 and Y652.

1 reference

12 December 2020

A NEW FAMILIAL CARDIAC SYNDROME IN CHILDREN

1 reference

12 December 2020

A new homogeneous high-throughput screening assay for profiling compound activity on the human ether-a-go-go-related gene channel

1 reference

12 December 2020

How to measure electrocardiographic QT interval in the anaesthetized rabbit.

1 reference

12 December 2020

Abnormal nocturnal heart rate variability and QT dynamics in patients with Brugada syndrome

1 reference

12 December 2020

Relevance of anaesthesia for dofetilide-induced torsades de pointes in alpha1-adrenoceptor-stimulated rabbits

1 reference

12 December 2020

Electropharmacologic characteristics of ventricular proarrhythmia induced by ibutilide

1 reference

12 December 2020

Prevalence of early-onset atrial fibrillation in congenital long QT syndrome

1 reference

12 December 2020

T-wave alternans in LQTS: repolarization-rate dynamics from digital 12-lead Holter data

1 reference

12 December 2020

Detailed analysis of 24 hour ambulatory electrocardiographic recordings during ventricular fibrillation or torsade de pointes

1 reference

12 December 2020

Verapamil prevents torsade de pointes by reduction of transmural dispersion of repolarization and suppression of early afterdepolarizations in an intact heart model of LQT3.

1 reference

12 December 2020

Repolarization dynamics in patients with long QT syndrome

1 reference

12 December 2020

QT PRODACT: evaluation of the potential of compounds to cause QT interval prolongation by action potential assays using guinea-pig papillary muscles

1 reference

12 December 2020

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development

1 reference

12 December 2020

Prolonged QT interval and methadone: implications for palliative care

1 reference

12 December 2020

Beta blockers normalize QT hysteresis in long QT syndrome

1 reference

12 December 2020

Theoretical investigation of action potential duration dependence on extracellular Ca2+ in human cardiomyocytes

1 reference

12 December 2020

Prognostic significance of heart rate turbulence following ventricular premature beats in patients with idiopathic dilated cardiomyopathy

1 reference

12 December 2020

Cardiac repolarisation and drug regulation: assessing cardiac safety 10 years after the CPMP guidance

1 reference

12 December 2020

Cellular basis of drug-induced torsades de pointes

1 reference

12 December 2020

ACC/AHA/ESC 2006 Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: a report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiolo

1 reference

12 December 2020

QTU-prolongation and torsades de pointes induced by putative class III antiarrhythmic agents in the rabbit: etiology and interventions.

1 reference

12 December 2020

Antitorsadogenic effects of ({+/-})-N-(2,6-dimethyl-phenyl)-(4[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazine (ranolazine) in anesthetized rabbits

1 reference

12 December 2020

Assessment of QT liabilities in drug development

1 reference

12 December 2020

Enhanced Ca(2+) release and Na/Ca exchange activity in hypertrophied canine ventricular myocytes: potential link between contractile adaptation and arrhythmogenesis

1 reference

12 December 2020

Combined pharmacological block of I(Kr) and I(Ks) increases short-term QT interval variability and provokes torsades de pointes.

1 reference

12 December 2020

The effect of changes in core body temperature on the QT interval in beagle dogs: a previously ignored phenomenon, with a method for correction

1 reference

12 December 2020

Amiodarone-associated macroscopic T-wave alternans and torsade de pointes unmasking the inherited long QT syndrome

1 reference

12 December 2020

Limited induction of torsade de pointes by terikalant and erythromycin in an in vivo model

1 reference

12 December 2020

International Conference on Harmonisation; guidance on E14 Clinical Evaluation of QT/QTc Interval Prolongation and Proarrhythmic Potential for Non-Antiarrhythmic Drugs; availability. Notice.

1 reference

12 December 2020

Electrophysiological mechanism of enhanced susceptibility of hypertrophied heart to acquired torsade de pointes arrhythmias: tridimensional mapping of activation and recovery patterns

1 reference

12 December 2020

Evaluation of the rubidium efflux assay for preclinical identification of HERG blockade.

1 reference

12 December 2020

Fatal torsade de pointes following jaundice in a patient treated with disopyramide

1 reference

12 December 2020

Predictive in silico modeling for hERG channel blockers

1 reference

12 December 2020

Amplification of spatial dispersion of repolarization underlies sudden cardiac death associated with catecholaminergic polymorphic VT, long QT, short QT and Brugada syndromes

1 reference

12 December 2020

A new method to calculate the beat-to-beat instability of QT duration in drug-induced long QT in anesthetized dogs

1 reference

12 December 2020

Nonselective I(Kr)-blockers do not induce torsades de pointes in the anesthetized rabbit during alpha1-adrenoceptor stimulation.

1 reference

12 December 2020

QT PRODACT: a multi-site study of in vitro action potential assays on 21 compounds in isolated guinea-pig papillary muscles

1 reference

12 December 2020

Pharmacological activation of normal and arrhythmia-associated mutant KCNQ1 potassium channels

1 reference

12 December 2020

Perception of validity of clinical and preclinical methods for assessment of torsades de pointes liability

1 reference

12 December 2020

ECG repolarization waves: their genesis and clinical implications.

1 reference

12 December 2020

Evaluation of drug-induced QT interval prolongation: implications for drug approval and labelling

1 reference

12 December 2020

Preclinical testing of drug-induced proarrhythmia: value of transgenic models.

1 reference

12 December 2020

Latent genetic backgrounds and molecular pathogenesis in drug-induced long-QT syndrome.

1 reference

12 December 2020

Terfenadine-ketoconazole interaction. Pharmacokinetic and electrocardiographic consequences

1 reference

12 December 2020

Dispersion of repolarization in canine ventricle and the electrocardiographic T wave: Tp-e interval does not reflect transmural dispersion

1 reference

12 December 2020

Are electrophysiologically distinct M-cells a characteristic of the wedge preparation?

1 reference

12 December 2020

Predicting drug-induced changes in QT interval and arrhythmias: QT-shortening drugs point to gaps in the ICHS7B Guidelines

1 reference

12 December 2020

A pharmacokinetic-pharmacodynamic model for the quantitative prediction of dofetilide clinical QT prolongation from human ether-a-go-go-related gene current inhibition data

1 reference

12 December 2020

Risks of non-prescription medication. Clobutinol cough syrup as a recent example

1 reference

12 December 2020

Inhibition of the Na+/Ca2+ exchanger suppresses torsades de pointes in an intact heart model of long QT syndrome-2 and long QT syndrome-3.

1 reference

12 December 2020

Increased short-term variability of repolarization predicts d-sotalol-induced torsades de pointes in dogs

1 reference

12 December 2020

Evidence for gender differences in electrophysiological properties of canine Purkinje fibres.

1 reference

12 December 2020

Clofilium in the isolated perfused rabbit heart: a new model to study proarrhythmia induced by class III antiarrhythmic drugs

1 reference

12 December 2020

In-vitro experimental models for the risk assessment of antibiotic-induced QT prolongation

1 reference

12 December 2020

Proarrhythmic effects of intravenous quinidine, amiodarone, D-sotalol, and almokalant in the anesthetized rabbit model of torsade de pointes

1 reference

12 December 2020

Relation of increased short-term variability of QT interval to congenital long-QT syndrome

1 reference

12 December 2020

A highly sensitive canine telemetry model for detection of QT interval prolongation: studies with moxifloxacin, haloperidol and MK-499

1 reference

12 December 2020

The long QT syndromes: a critical review, new clinical observations and a unifying hypothesis

1 reference

12 December 2020

ECG changes in alcoholic intoxication

1 reference

12 December 2020

Electrical alternation of the T-wave: Clinical and experimental evidence of its relationship with the sympathetic nervous system and with the long Q-T syndrome

1 reference

12 December 2020

The effects of plasma proteins on delayed repolarization in vitro with cisapride, risperidone, and D, L-sotalol.

1 reference

12 December 2020

Prevention of clofilium-induced torsade de pointes by prostaglandin E2 does not involve ATP-dependent K+ channels

1 reference

12 December 2020

Drug-induced long-QT syndrome associated with a subclinical SCN5A mutation

1 reference

12 December 2020

Review of the predictive value of the Langendorff heart model (Screenit system) in assessing the proarrhythmic potential of drugs

1 reference

12 December 2020

Blinded validation of the isolated arterially perfused rabbit ventricular wedge in preclinical assessment of drug-induced proarrhythmias.

1 reference

12 December 2020

The canine model with chronic, complete atrio-ventricular block

1 reference

12 December 2020

The anaesthetised methoxamine-sensitised rabbit model of torsades de pointes

1 reference

12 December 2020

Transmural dispersion of repolarization as a key factor of arrhythmogenicity in a novel intact heart model of LQT3

1 reference

12 December 2020

ILSI-HESI cardiovascular safety subcommittee initiative: evaluation of three non-clinical models of QT prolongation.

1 reference

12 December 2020

Catecholamine-induced T-wave lability in congenital long QT syndrome: a novel phenomenon associated with syncope and cardiac arrest

1 reference

12 December 2020

A rabbit Langendorff heart proarrhythmia model: predictive value for clinical identification of Torsades de Pointes

1 reference

12 December 2020

10.2165/11535230-000000000-00000

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20329805%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

28 January 2020

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