The effects of cytochrome P450 induction by xenobiotics on endobiotic metabolism in pre-clinical safety studies (Q37706625)

22 August 2017

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title

The effects of cytochrome P450 induction by xenobiotics on endobiotic metabolism in pre-clinical safety studies (English)

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22 August 2017

David E Amacher

1

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PubMed ID

20218941

22 August 2017

language of work or name

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1 May 2010

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Toxicology Mechanisms and Methods

22 August 2017

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22 August 2017

20

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22 August 2017

4

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22 August 2017

159-166

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3-methylcholanthrene and benzo(a)pyrene modulate cardiac cytochrome P450 gene expression and arachidonic acid metabolism in male Sprague Dawley rats

22 August 2017

1 reference

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CYP4F3B is induced by PGA1 in human liver cells: a regulation of the 20-HETE synthesis

21 January 2018

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Nuclear receptor structure: implications for function

21 January 2018

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Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions

21 January 2018

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Updates on cytochrome P450-mediated cardiovascular drug interactions

21 January 2018

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Pharmacogenomics: translating functional genomics into rational therapeutics

21 January 2018

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A gene expression biomarker provides early prediction and mechanistic assessment of hepatic tumor induction by nongenotoxic chemicals

21 January 2018

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Cytochrome P450 and the biological clock in mammals

21 January 2018

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Regulation of CYP3A4 by the bile acid receptor FXR: evidence for functional binding sites in the CYP3A4 gene

21 January 2018

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LXR deficiency and cholesterol feeding affect the expression and phenobarbital-mediated induction of cytochromes P450 in mouse liver

21 January 2018

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The PAS superfamily: sensors of environmental and developmental signals

21 January 2018

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Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity

21 January 2018

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Induction of drug metabolism: the role of nuclear receptors.

21 January 2018

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21 January 2018

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Cytochrome P450 omega hydroxylase (CYP4) function in fatty acid metabolism and metabolic diseases

21 January 2018

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Cross-talk between transcription factors AhR and Nrf2: lessons for cancer chemoprevention from dioxin.

21 January 2018

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Induction of hepatic cytochrome P450 enzymes: methods, mechanisms, recommendations, and in vitro-in vivo correlations

21 January 2018

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Comparison of the effects of the synthetic pyrethroid Metofluthrin and phenobarbital on CYP2B form induction and replicative DNA synthesis in cultured rat and human hepatocytes

21 January 2018

1 reference

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Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes.

21 January 2018

1 reference

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The effect of fenbuconazole on cell proliferation and enzyme induction in the liver of female CD1 mice.

21 January 2018

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New insights on the xenobiotic-sensing nuclear receptors in liver diseases--CAR and PXR--.

21 January 2018

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Predictive assay for rodent carcinogenicity using in vivo biochemical parameters: operational characteristics and complementarity

21 January 2018

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Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes

21 January 2018

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The roles of nuclear receptors CAR and PXR in hepatic energy metabolism

21 January 2018

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Comparative cytochrome P450 proteomics in the livers of immunodeficient mice using 18O stable isotope labeling

21 January 2018

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Interplay of pregnane X receptor with other nuclear receptors on gene regulation

21 January 2018

1 reference

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Species-specific and age-dependent bile acid composition: aspects on CYP8B and CYP4A subfamilies in bile acid biosynthesis

21 January 2018

1 reference

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Cytochrome P450 and gene activation--from pharmacology to cholesterol elimination and regression of atherosclerosis

21 January 2018

1 reference

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Metabolism of melatonin by human cytochromes p450.

21 January 2018

1 reference

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Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction

21 January 2018

1 reference

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The aryl hydrocarbon receptor activator benzo[a]pyrene enhances vitamin D3 catabolism in macrophages

21 January 2018

1 reference

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The significance of hepatic microsomal enzyme induction and altered thyroid function in rats: implications for thyroid gland neoplasia

21 January 2018

1 reference

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Hepatic OATP1B transporters and nuclear receptors PXR and CAR: interplay, regulation of drug disposition genes, and single nucleotide polymorphisms.

21 January 2018

1 reference

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Endocrine disruptors induce cytochrome P450 by affecting transcriptional regulation via pregnane X receptor

21 January 2018

1 reference

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Characterization of substrate specificity of dog CYP1A2 using CYP1A2-deficient and wild-type dog liver microsomes

21 January 2018

1 reference

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Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants

21 January 2018

1 reference

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A mode of action for induction of liver tumors by Pyrethrins in the rat.

21 January 2018

1 reference

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Regulatory cross-talk between drug metabolism and lipid homeostasis: constitutive androstane receptor and pregnane X receptor increase Insig-1 expression

21 January 2018

1 reference

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Sterol regulatory element binding protein 1 interacts with pregnane X receptor and constitutive androstane receptor and represses their target genes

21 January 2018

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A comparison of the roles of peroxisome proliferator-activated receptor and retinoic acid receptor on CYP26 regulation

21 January 2018

1 reference

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Cytochrome P450 mono-oxygenase gene expression and protein activity in cultures of adult cardiomyocytes of the rat.

21 January 2018

1 reference

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Nuclear receptors and the regulation of drug-metabolizing enzymes and drug transporters: implications for interindividual variability in response to drugs

21 January 2018

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Subchronic toxicity study with ethylene-bis-(oxyethylene)-bis-(3-tert-butyl-4-hydroxy-5-methylhydro cin namate) in the cynomolgus monkey: lack of stimulation of the pituitary-thyroid-liver axis.

21 January 2018

1 reference

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Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development

21 January 2018

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Proteomic analysis of cytochromes P450: a mass spectrometry approach

21 January 2018

1 reference

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P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR.

21 January 2018

1 reference

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Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios

21 January 2018

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Preclinical development of new drugs that enhance thyroid hormone metabolism and clearance: inadequacy of using rats as an animal model for predicting human risks in an IND and NDA.

21 January 2018

1 reference

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Steroid hormone biotransformation and xenobiotic induction of hepatic steroid metabolizing enzymes

21 January 2018

1 reference

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Modulation of cytochrome P450 gene expression and arachidonic acid metabolism during isoproterenol-induced cardiac hypertrophy in rats.

21 January 2018

1 reference

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Acute doxorubicin cardiotoxicity alters cardiac cytochrome P450 expression and arachidonic acid metabolism in rats

21 January 2018

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Induction of several cytochrome P450 genes by doxorubicin in H9c2 cells.

21 January 2018

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Role of NF-kappaB in the regulation of cytochrome P450 enzymes.

21 January 2018

1 reference

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10.3109/15376511003690307

21 January 2018

Identifiers

DOI

1 reference

22 August 2017

1 reference

PubMed ID

20218941