Recently patented and promising ORL-1 ligands: where have we been and where are we going? (Q37697788)

22 August 2017

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title

Recently patented and promising ORL-1 ligands: where have we been and where are we going? (English)

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22 August 2017

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Tally M Largent-Milnes

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1

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author name string

Todd W Vanderah

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2

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PubMed ID

20180617

22 August 2017

language of work or name

English

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publication date

1 March 2010

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Expert Opinion on Therapeutic Patents

22 August 2017

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22 August 2017

20

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22 August 2017

3

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22 August 2017

291-305

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ORL1, a novel member of the opioid receptor family. Cloning, functional expression and localization

22 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

The orphanin FQ/nociceptin (OFQ/N) system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Nociceptin/orphanin FQ and the opioid receptor-like ORL1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Orphanin FQ: a neuropeptide that activates an opioidlike G protein-coupled receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

International Union of Pharmacology. XLVI. G protein-coupled receptor list.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Recognition and activation of the opioid receptor-like ORL 1 receptor by nociceptin, nociceptin analogs and opioids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Functional coupling of the nociceptin/orphanin FQ receptor with the G-protein-activated K+ (GIRK) channel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Increase by the ORL1 receptor (opioid receptor-like1) ligand, nociceptin, of inwardly rectifying K conductance in dorsal raphe nucleus neurones.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Activation of mitogen-activated protein kinase by the nociceptin receptor expressed in Chinese hamster ovary cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Structure, tissue distribution, and chromosomal localization of the prepronociceptin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Primary structure and tissue distribution of the orphanin FQ precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

cDNA cloning of an orphan opiate receptor gene family member and its splice variant

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Nociceptin/orphanin FQ receptor ligands.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Selective and high affinity labeling of neuronal and recombinant nociceptin receptors with the hexapeptide radioprobe [(3)H]Ac-RYYRIK-ol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Pharmacology of nociceptin and its receptor: a novel therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

The mouse vas deferens: a pharmacological preparation sensitive to nociceptin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Highly potent nociceptin analog containing the Arg-Lys triple repeat

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

In vitro and in vivo studies on UFP-112, a novel potent and long lasting agonist selective for the nociceptin/orphanin FQ receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

The opioid-receptor-like 1 (ORL-1) as a potential target for new analgesics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

A new selective antagonist of the nociceptin receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Address and message sequences for the nociceptin receptor: a structure-activity study of nociceptin-(1-13)-peptide amide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Antagonistic effects of [Nphe1]nociceptin(1-13)NH2 on nociceptin receptor mediated inhibition of cAMP formation in Chinese hamster ovary cells stably expressing the recombinant human nociceptin receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

[Nphe1,Arg14,Lys15]nociceptin-NH2, a novel potent and selective antagonist of the nociceptin/orphanin FQ receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

The ORL-1 receptor system: are there opportunities for antagonists in pain therapy?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Structure-activity studies on different modifications of nociceptin/orphanin FQ: identification of highly potent agonists and antagonists of its receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

High-affinity, non-peptide agonists for the ORL1 (orphanin FQ/nociceptin) receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

A synthetic agonist at the orphanin FQ/nociceptin receptor ORL1: anxiolytic profile in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Synthesis of (1S,3aS)-8-(2,3,3a,4,5, 6-hexahydro-1H-phenalen-1-yl)-1-phenyl-1,3,8-triaza-spiro[4. 5]decan-4-one, a potent and selective orphanin FQ (OFQ) receptor agonist with anxiolytic-like properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

The pharmacology of Ro 64-6198, a systemically active, nonpeptide NOP receptor (opiate receptor-like 1, ORL-1) agonist with diverse preclinical therapeutic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Discovery of the first potent and selective small molecule opioid receptor-like (ORL1) antagonist: 1-[(3R,4R)-1-cyclooctylmethyl-3- hydroxymethyl-4-piperidyl]-3-ethyl-1, 3-dihydro-2H-benzimidazol-2-one (J-113397)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Nociceptin/orphanin FQ peptide receptors: pharmacology and clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Identification of an orally active opioid receptor-like 1 (ORL1) receptor antagonist 4-{3-[(2R)-2,3-dihydroxypropyl]-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl}-1-[(1S,3S,4R)-spiro[bicyclo[2.2.1]heptane-2,1'-cyclopropan]-3-ylmethyl]piperidine as clinica

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Identification of a novel spiropiperidine opioid receptor-like 1 antagonist class by a focused library approach featuring 3D-pharmacophore similarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Pharmacological characterization of the nociceptin/orphanin FQ receptor non peptide antagonist Compound 24.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

1-Benzyl-N-[3-[spiroisobenzofuran-1(3H),4'-piperidin-1-yl]propyl]pyrrolidine-2-carboxamide (Compound 24) antagonizes NOP receptor-mediated potassium channel activation in rat periaqueductal gray slices.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

The nociceptin/orphanin FQ receptor: a target with broad therapeutic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

4-Aminoquinolines: novel nociceptin antagonists with analgesic activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Pharmacological profiles of a novel opioid receptor-like1 (ORL(1)) receptor antagonist, JTC-801

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Peptide and nonpeptide ligands for the nociceptin/orphanin FQ receptor ORL1: research tools and potential therapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Modification of Nociception and Morphine Tolerance by the Selective Opiate Receptor-Like Orphan Receptor Antagonist (–)-cis-1-Methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol (SB-612111)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Pharmacological characterization of the nociceptin/orphanin FQ receptor antagonist SB-612111 [(-)-cis-1-methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol]: in vitro studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Identification of an achiral analogue of J-113397 as potent nociceptin/orphanin FQ receptor antagonist.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

The novel nociceptin/orphanin FQ receptor antagonist Trap-101 alleviates experimental parkinsonism through inhibition of the nigro-thalamic pathway: positive interaction with L-DOPA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Stimulating the development of mechanism-based, individualized pain therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

SR 16435 [1-(1-(bicyclo[3.3.1]nonan-9-yl)piperidin-4-yl)indolin-2-one], a novel mixed nociceptin/orphanin FQ/mu-opioid receptor partial agonist: analgesic and rewarding properties in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Relationship between binding affinity and functional activity of nociceptin/orphanin FQ.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Characterization of opiates, neuroleptics, and synthetic analogs at ORL1 and opioid receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Activities of mixed NOP and mu-opioid receptor ligands.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Buprenorphine reduces alcohol drinking through activation of the nociceptin/orphanin FQ-NOP receptor system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Nociceptin-induced apparent hyperalgesia in mice as a result of the prevention of opioid autoanalgesic mechanisms triggered by the stress of an intracerebroventricular injection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

A cellular mechanism for the bidirectional pain-modulating actions of orphanin FQ/nociceptin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Characterization of the nociceptin receptor (ORL-1) agonist, Ro64-6198, in tests of anxiety across multiple species

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Pharmacological characterization of nociceptin/orphanin FQ receptors, a novel opioid receptor family, in the midbrain periaqueductal gray.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Ro 64-6198 [(1S,3aS)-8-(2,3,3a,4,5,6-Hexahydro-1H-phenalen-1-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one] acts differently from nociceptin/orphanin FQ in rat periaqueductal gray slices

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Orphanin FQ inhibits capsaicin-induced thermal nociception in monkeys by activation of peripheral ORL1 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Effects of intrathecally administered nociceptin/orphanin FQ in monkeys: behavioral and mass spectrometric studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Antinociceptive effects of nociceptin/orphanin FQ administered intrathecally in monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Behavioral effects of a synthetic agonist selective for nociceptin/orphanin FQ peptide receptors in monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Long-lasting antinociceptive spinal effects in primates of the novel nociceptin/orphanin FQ receptor agonist UFP-112.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Identification of nociceptin in human cerebrospinal fluid: comparison of levels in pain and non-pain states

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Nociceptin levels in the cerebrospinal fluid of chronic pain patients with or without intrathecal administration of morphine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Levels of neuropeptides nocistatin, nociceptin/orphanin FQ and their precursor protein in a rat neuropathic pain model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Involvement of the Nociceptin/Orphanin FQ-NOP receptor system in the ventrolateral periaqueductal gray following mechanical allodynia in chronic pain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Involvement of endogenous opioid systems in nociceptin-induced spinal antinociception in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Activity of new NOP receptor ligands in a rat peripheral mononeuropathy model: potentiation of morphine anti-allodynic activity by NOP receptor antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Involvement of nociceptin/orphanin FQ and its receptor in electroacupuncture-produced anti-hyperalgesia in rats with peripheral inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Anti-allodynic and anti-hyperalgesic effects of nociceptin receptor antagonist, JTC-801, in rats after spinal nerve injury and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Nociceptin/orphanin FQ receptor activation attenuates antinociception induced by mixed nociceptin/orphanin FQ/mu-opioid receptor agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

The novel neuropeptide orphanin FQ fails to produce conditioned place preference or aversion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Intracerebroventricular orphanin FQ/nociceptin suppresses dopamine release in the nucleus accumbens of anaesthetized rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Orphanin FQ/nociceptin blocks acquisition of morphine place preference.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Orphanin FQ/nociceptin inhibits morphine withdrawal

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543771003602004

Nociceptin/orphanin FQ and drugs of abuse

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543771003602004

Endogenous orphanin FQ/nociceptin is involved in the development of morphine tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Nociceptin/orphanin FQ prevents the antinociceptive action of paracetamol on the rat hot plate test.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Activation of the nociceptin/orphanin FQ receptor reduces bronchoconstriction and microvascular leakage in a rabbit model of gastroesophageal reflux

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Anxiety disorders and comorbid medical illness

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Interpreting the clinical importance of treatment outcomes in chronic pain clinical trials: IMMPACT recommendations

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Activation of nociceptin opioid peptide (NOP) receptor impairs contextual fear learning in mice through glutamatergic mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Orphanin-FQ/nociceptin: lack of anti nociceptive, hyperalgesic or allodynic effects in acute thermal or mechanical tests following intracerebroventricular or intrathecal administration to mice or rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Simultaneous targeting of multiple opioid receptors: a strategy to improve side-effect profile

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Synthesis and biological activity of nociceptin/orphanin FQ analogues substituted in position 7 or 11 with Calpha,alpha-dialkylated amino acids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

The ORL1 receptor: molecular pharmacology and signalling mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Pertussis Toxin-Insensitive Signaling of the ORL1 Receptor: Coupling to Gz and G16 Proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Structure–activity studies on nociceptin/orphanin FQ: from full agonist, to partial agonist, to pure antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

Endogenous nociceptin/orphanin FQ signalling produces opposite spinal antinociceptive and supraspinal pronociceptive effects in the mouse formalin test: Pharmacological and genetic evidences

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

UFP-101 antagonizes the spinal antinociceptive effects of nociceptin/orphanin FQ: Behavioral and electrophysiological studies in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543771003602004

10.1517/13543771003602004

21 January 2018

Identifiers

DOI

1 reference

22 August 2017

1 reference

PubMed ID

20180617