Themis sets the signal threshold for positive and negative selection in T-cell development (Q37687058)

22 August 2017

Themis sets the signal threshold for positive and negative selection in T-cell development (English)

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22 August 2017

10

Hilde Cheroutre

1 reference

22 August 2017

Nicholas R J Gascoigne

12

object named as

Nicholas R J Gascoigne

1 reference

22 August 2017

6

Joanna Brzostek

1 reference

22 August 2017

5

Florence Lambolez

1 reference

22 August 2017

Guo Fu

1

1 reference

22 August 2017

Javier Casas

2

1 reference

22 August 2017

Stephanie Rigaud

3

1 reference

22 August 2017

Vasily Rybakin

4

1 reference

22 August 2017

John A H Hoerter

7

1 reference

22 August 2017

Wolfgang Paster

8

1 reference

22 August 2017

Oreste Acuto

9

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22 August 2017

Karsten Sauer

11

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22 August 2017

language of work or name

English

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publication date

13 November 2013

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22 August 2017

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22 August 2017

504

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22 August 2017

441-445

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22 August 2017

7480

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describes a project that uses

22 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3977001/fullTextXML

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/nature12718

0 references

cites work

Shp1 regulates T cell homeostasis by limiting IL-4 signals

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3977001

GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3977001

Negative selection assay based on stimulation of T cell receptor transgenic thymocytes with peptide-MHC tetramers

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3977001

Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3977001

Protein kinase C η is required for T cell activation and homeostatic proliferation

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3977001

Selection of self-reactive T cells in the thymus

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3977001

Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3977001

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3977001

T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3977001

Multiple common variants for celiac disease influencing immune gene expression

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3977001

Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3977001

A novel gene essential for the development of single positive thymocytes

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3977001

Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3977001

Themis, a T cell-specific protein important for late thymocyte development

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3977001

Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3977001

SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levels

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3977001

Activation of Cdk2 stimulates proteasome-dependent truncation of tyrosine phosphatase SHP-1 in human proliferating intestinal epithelial cells

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3977001

The thymus chapter in the life of gut-specific intra epithelial lymphocytes

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3977001

Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3977001

A requirement for sustained ERK signaling during thymocyte positive selection in vivo

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3977001

BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3977001

The tyrosine phosphatase SHP-1 influences thymocyte selection by setting TCR signaling thresholds.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3977001

T cell receptor antagonist peptides induce positive selection

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3977001

How the TCR balances sensitivity and specificity for the recognition of self and pathogens.

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3977001

Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3977001

A novel SHP-1/Grb2-dependent mechanism of negative regulation of cytokine-receptor signaling: contribution of SHP-1 C-terminal tyrosines in cytokine signaling

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3977001

T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3977001

Multiplexed labeling of samples with cell tracking dyes facilitates rapid and accurate internally controlled calcium flux measurement by flow cytometry

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3977001

Identification of pre- and postselection TCRalphabeta+ intraepithelial lymphocyte precursors in the thymus

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3977001

The role of erk1 and erk2 in multiple stages of T cell development.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3977001

TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3977001

Involvement of the SHP-1 tyrosine phosphatase in regulation of T cell selection

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3977001

Rare, structurally homologous self-peptides promote thymocyte positive selection

2 October 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12718

The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12718

T-cell-receptor affinity and thymocyte positive selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12718

Qualitative and quantitative differences in T cell receptor binding of agonist and antagonist ligands.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12718

Peptide-MHC heterodimers show that thymic positive selection requires a more restricted set of self-peptides than negative selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12718

Duration and Strength of Extracellular Signal-Regulated Kinase Signals Are Altered During Positive Versus Negative Thymocyte Selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12718

Cutting edge: the tyrosine phosphatase SHP-1 regulates thymocyte positive selection

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24226767

12 December 2020

inferred from PubMed ID database lookup

Positive regulation of Itk PH domain function by soluble IP4

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24226767

12 December 2020

inferred from PubMed ID database lookup

CD1d-Restricted NKT Cells: An Interstrain Comparison

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24226767

12 December 2020

inferred from PubMed ID database lookup

Strong agonist ligands for the T cell receptor do not mediate positive selection of functional CD8+ T cells

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12718

7 January 2021

inferred from DOI database lookup

Identification of a naturally occurring ligand for thymic positive selection

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12718

7 January 2021

inferred from DOI database lookup

The impact of duration versus extent of TCR occupancy on T cell activation: a revision of the kinetic proofreading model

1 reference

https://api.crossref.org/works/10.1038%2FNATURE12718

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NATURE12718

1 reference

Dimensions Publication ID

22 August 2017

0 references

1 reference

22 August 2017

1 reference