Efficacy and safety of ticagrelor: a reversible P2Y12 receptor antagonist (Q37685847)

22 August 2017

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title

Efficacy and safety of ticagrelor: a reversible P2Y12 receptor antagonist (English)

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22 August 2017

Shawn D Anderson

1

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22 August 2017

Niren K Shah

series ordinal

2

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22 August 2017

Juwon Yim

series ordinal

3

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22 August 2017

Benjamin J Epstein

series ordinal

4

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22 August 2017

language of work or name

English

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publication date

2 February 2010

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Annals of Pharmacotherapy

22 August 2017

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22 August 2017

44

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22 August 2017

3

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22 August 2017

524-537

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Role of platelets in atherothrombosis

22 August 2017

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2007 focused update of the ACC/AHA 2004 guidelines for the management of patients with ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines

21 January 2018

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ACC/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial Infarction

21 January 2018

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Heart disease and stroke statistics--2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee

21 January 2018

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Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study

21 January 2018

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Addition of clopidogrel to aspirin in 45,852 patients with acute myocardial infarction: randomised placebo-controlled trial

21 January 2018

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Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events

21 January 2018

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Variability in responsiveness to oral antiplatelet therapy

21 January 2018

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Antiplatelet drug resistance and drug-drug interactions: Role of cytochrome P450 3A4

21 January 2018

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Antiplatelet therapy: anti-ischemic benefits versus bleeding risk

21 January 2018

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Assessment, mechanisms, and clinical implication of variability in platelet response to aspirin and clopidogrel therapy

21 January 2018

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Risk of adverse outcomes associated with concomitant use of clopidogrel and proton pump inhibitors following acute coronary syndrome

21 January 2018

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Monitoring oral antiplatelet therapy: is it justified?

21 January 2018

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Specific impairment of human platelet P2Y(AC) ADP receptor-mediated signaling by the antiplatelet drug clopidogrel

21 January 2018

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ADP receptor P2Y12 is expressed in vascular smooth muscle cells and stimulates contraction in human blood vessels

21 January 2018

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Ticagrelor binds to human P2Y(12) independently from ADP but antagonizes ADP-induced receptor signaling and platelet aggregation.

21 January 2018

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Preclinical and clinical studies with selective reversible direct P2Y12 antagonists

21 January 2018

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Inhibition of platelet aggregation by AZD6140, a reversible oral P2Y12 receptor antagonist, compared with clopidogrel in patients with acute coronary syndromes

21 January 2018

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Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y12 antagonist AZD6140 with aspirin in patients with atherosclerosis: a double-blind comparison to clopidogrel with aspirin

21 January 2018

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Ticagrelor: the first reversibly binding oral P2Y12 receptor antagonist

21 January 2018

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Safety, tolerability, and initial efficacy of AZD6140, the first reversible oral adenosine diphosphate receptor antagonist, compared with clopidogrel, in patients with non-ST-segment elevation acute coronary syndrome: primary results of the DISPERSE

21 January 2018

1 reference

Comparison of ticagrelor, the first reversible oral P2Y(12) receptor antagonist, with clopidogrel in patients with acute coronary syndromes: Rationale, design, and baseline characteristics of the PLATelet inhibition and patient Outcomes (PLATO) tria

21 January 2018

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Ticagrelor versus clopidogrel in patients with acute coronary syndromes

21 January 2018

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Randomized trial of high loading dose of clopidogrel for reduction of periprocedural myocardial infarction in patients undergoing coronary intervention: results from the ARMYDA-2 (Antiplatelet therapy for Reduction of MYocardial Damage during Angiop

21 January 2018

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Intensifying platelet inhibition--navigating between Scylla and Charybdis

21 January 2018

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Dyspnoea after antiplatelet agents: the AZD6140 controversy

21 January 2018

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Adenosine induces a cholinergic tracheal reflex contraction in guinea pigs in vivo via an adenosine A1 receptor-dependent mechanism

21 January 2018

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Adenosine receptors as therapeutic targets

21 January 2018

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Ticlopidine hydrochloride: Relationship between dose, kinetics, plasma concentration and effect on platelet function

21 January 2018

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Interactions of two major metabolites of prasugrel, a thienopyridine antiplatelet agent, with the cytochromes P450.

21 January 2018

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Cytochrome p-450 polymorphisms and response to clopidogrel

21 January 2018

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Genetic determinants of response to clopidogrel and cardiovascular events

21 January 2018

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Cytochrome P450 genetic polymorphisms and the response to prasugrel: relationship to pharmacokinetic, pharmacodynamic, and clinical outcomes

21 January 2018

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The perioperative management of antithrombotic therapy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition).

21 January 2018

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Prasugrel versus clopidogrel in patients with acute coronary syndromes

21 January 2018

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Comparison of ticagrelor and thienopyridine P2Y(12) binding characteristics and antithrombotic and bleeding effects in rat and dog models of thrombosis/hemostasis

21 January 2018

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Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation

21 January 2018

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Adenosine and adenosine receptors in the cardiovascular system: biochemistry, physiology, and pharmacology

21 January 2018

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Adenosine: trigger and mediator of cardioprotection

21 January 2018

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21 January 2018

Identifiers

DOI

10.1345/APH.1M548

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22 August 2017

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