Antiplatelet drug resistance and drug-drug interactions: Role of cytochrome P450 3A4 (Q28201011)

Rapid and simple platelet function assay to assess glycoprotein IIb/IIIa receptor blockade.

Europe PubMed Central

title

Antiplatelet drug resistance and drug-drug interactions: Role of cytochrome P450 3A4 (English)

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Wei C Lau

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Paul A Gurbel

series ordinal

2

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language of work or name

English

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publication date

December 2006

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published in

Pharmaceutical Research

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volume

23

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issue

12

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page(s)

2691-708

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cites work

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Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic events in patients with acute myocardial infarction

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Platelet factor 4 induces human natural killer cells to synthesize and release interleukin-8.

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The relation of dosing to clopidogrel responsiveness and the incidence of high post-treatment platelet aggregation in patients undergoing coronary stenting

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Stereoselective inhibition of human platelet aggregation by R-138727, the active metabolite of CS-747 (prasugrel, LY640315), a novel P2Y12 receptor inhibitor.

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Preliminary Data from a Field Trial of the PFA-100™ System

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Benefit of clopidogrel in patients with acute coronary syndromes without ST-segment elevation in various risk groups

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Role of platelets in coronary thrombosis and reperfusion of ischemic myocardium

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Comparison of modified Thrombelastograph and Plateletworks whole blood assays to optical platelet aggregation for monitoring reversal of clopidogrel inhibition in elective surgery patients.

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Durability of platelet inhibition by clopidogrel

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Aspirin non-responder status in patients with recurrent cerebral ischemic attacks

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Resistance to antiplatelet resistance is it justified?

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Scientific and therapeutic insights into the role of the platelet P2Y12 receptor in thrombosis

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12 December 2020

Clopidogrel effect on platelet reactivity in patients with stent thrombosis: results of the CREST Study

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12 December 2020

Clinical utility of available methods for determining platelet function

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12 December 2020

Oral bioavailability of hyperforin from hypericum extracts in rats and human volunteers

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12 December 2020

Contribution of hepatic cytochrome P450 3A4 metabolic activity to the phenomenon of clopidogrel resistance

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12 December 2020

Risk of cardiovascular events associated with selective COX-2 inhibitors

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The difference between clopidogrel responsiveness and posttreatment platelet reactivity

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A new method of representing drug-induced platelet inhibition: better description of time course, response variability, non-response, and heightened activity

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12 December 2020

Possible mechanisms of aspirin resistance

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12 December 2020

St John's Wort: effect on CYP3A4 activity

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12 December 2020

Oxidant stress and aspirin-insensitive thromboxane biosynthesis in severe unstable angina

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12 December 2020

Clopidogrel resistance: a new chapter in a fast-moving story

1 reference

12 December 2020

The in vivo pharmacological profile of CS-747, a novel antiplatelet agent with platelet ADP receptor antagonist properties

1 reference

12 December 2020

The antiaggregating activity of clopidogrel is due to a metabolic activation by the hepatic cytochrome P450-1A

1 reference

12 December 2020

Compliance as a critical consideration in patients who appear to be resistant to aspirin after healing of myocardial infarction

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12 December 2020

Absorption, metabolization, and antiplatelet effects of 300-, 600-, and 900-mg loading doses of clopidogrel: results of the ISAR-CHOICE (Intracoronary Stenting and Antithrombotic Regimen: Choose Between 3 High Oral Doses for Immediate Clopidogrel Ef

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A meta‐analysis of studies on the association of the platelet PlA polymorphism of glycoprotein IIIa and risk of coronary heart disease

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12 December 2020

Platelet GP IIIa Pl(A) polymorphisms display different sensitivities to agonists

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12 December 2020

Comparison of clinical benefits of clopidogrel therapy in patients with acute coronary syndromes taking atorvastatin versus other statin therapies

1 reference

12 December 2020

Randomized comparison of prasugrel (CS-747, LY640315), a novel thienopyridine P2Y12 antagonist, with clopidogrel in percutaneous coronary intervention: results of the Joint Utilization of Medications to Block Platelets Optimally (JUMBO)-TIMI 26 trial

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12 December 2020

2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin

1 reference

12 December 2020

Lack of association between the P2Y12 receptor gene polymorphism and platelet response to clopidogrel in patients with coronary artery disease

1 reference

12 December 2020

HMG-CoA reductase inhibitors and P-glycoprotein modulation

1 reference

12 December 2020

Assessment of platelet function assays

1 reference

12 December 2020

Platelet activation in myocardial ischemic syndromes

1 reference

12 December 2020

A Gi-dependent pathway is required for activation of the small GTPase Rap1B in human platelets

1 reference

12 December 2020

Activation of the GP IIb-IIIa complex induced by platelet adhesion to collagen is mediated by both alpha2beta1 integrin and GP VI

1 reference

12 December 2020

Aspirin non-responsiveness as measured by PFA-100 in patients with coronary artery disease

1 reference

12 December 2020

Overestimation of platelet aspirin resistance detection by thrombelastograph platelet mapping and validation by conventional aggregometry using arachidonic acid stimulation

1 reference

12 December 2020

Cyclooxygenase-2 expression and inhibition in atherothrombosis

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12 December 2020

Central role of the P2Y12 receptor in platelet activation

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12 December 2020