Hepatic OATP and OCT uptake transporters: their role for drug-drug interactions and pharmacogenetic aspects (Q37680968)

21 August 2017

1 reference

title

Hepatic OATP and OCT uptake transporters: their role for drug-drug interactions and pharmacogenetic aspects (English)

1 reference

21 August 2017

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Christina Fahrmayr

1

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21 August 2017

Martin F Fromm

series ordinal

2

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21 August 2017

Jörg König

series ordinal

3

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21 August 2017

language of work or name

English

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publication date

1 August 2010

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21 August 2017

Drug Metabolism Reviews

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21 August 2017

42

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21 August 2017

380-401

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21 August 2017

3

1 reference

Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1

21 August 2017

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Biochemical, cellular, and pharmacological aspects of the multidrug transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Organic anion transporter family: current knowledge.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Impact of regulatory polymorphisms in organic anion transporter genes in the human liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Interaction of oral antidiabetic drugs with hepatic uptake transporters: focus on organic anion transporting polypeptides and organic cation transporter 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Gemfibrozil greatly increases plasma concentrations of cerivastatin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Drug metabolizing enzymes related to laboratory medicine: cytochromes P-450 and UDP-glucuronosyltransferases.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Excretion of foetal bilirubin by the rat placenta-maternal liver tandem.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Role of organic anion-transporting polypeptides, OATP-A, OATP-C and OATP-8, in the human placenta-maternal liver tandem excretory pathway for foetal bilirubin.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Effect of OATP1B1 (SLCO1B1) variant alleles on the pharmacokinetics of pitavastatin in healthy volunteers.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Influence of OATP1B1 genotype on the pharmacokinetics of rosuvastatin in Koreans.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Association between a frequent allele of the gene encoding OATP1B1 and enhanced LDL-lowering response to fluvastatin therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

The effect of SLCO1B1*15 on the disposition of pravastatin and pitavastatin is substrate dependent: the contribution of transporting activity changes by SLCO1B1*15.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

1199G>A and 2677G>T/A polymorphisms of ABCB1 independently affect tacrolimus concentration in hepatic tissue after liver transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Effects of herbal extracts on the function of human organic anion-transporting polypeptide OATP-B.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Influence of the SLCO1B1*1b and *5 haplotypes on pravastatin's cholesterol lowering capabilities and basal sterol serum levels.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Cloning and characterization of two human polyspecific organic cation transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Organic anion transporting polypeptide 2B1 is a high-affinity transporter for atorvastatin and is expressed in the human heart

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

The superfamily of organic anion transporting polypeptides

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Organic anion transporting polypeptides of the OATP/ SLC21 family: phylogenetic classification as OATP/ SLCO superfamily, new nomenclature and molecular/functional properties

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Influence of the organic anion-transporting polypeptide 1B1 (OATP1B1) polymorphisms on irinotecan-pharmacokinetics and clinical outcome of patients with advanced non-small cell lung cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteinsIntroduction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Pharmacokinetics and response to pravastatin in paediatric patients with familial hypercholesterolaemia and in paediatric cardiac transplant recipients in relation to polymorphisms of the SLCO1B1 and ABCB1 genes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Interaction of imatinib with human organic ion carriers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

SLCO1B1 (OATP1B1, an uptake transporter) and ABCG2 (BCRP, an efflux transporter) variant alleles and pharmacokinetics of pitavastatin in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Genetic polymorphisms of uptake (OATP1B1, 1B3) and efflux (MRP2, BCRP) transporters: implications for inter-individual differences in the pharmacokinetics and pharmacodynamics of statins and other clinically relevant drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Catalog of 258 single-nucleotide polymorphisms (SNPs) in genes encoding three organic anion transporters, three organic anion-transporting polypeptides, and three NADH:ubiquinone oxidoreductase flavoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Predominant contribution of OATP1B3 to the hepatic uptake of telmisartan, an angiotensin II receptor antagonist, in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Prediction of the in vivo interaction between midazolam and macrolides based on in vitro studies using human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Functional analysis of single nucleotide polymorphisms of hepatic organic anion transporter OATP1B1 (OATP-C).

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Comparative pharmacokinetic interaction profiles of pravastatin, simvastatin, and atorvastatin when coadministered with cytochrome P450 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Genome-wide association meta-analysis for total serum bilirubin levels

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Relevance of the organic cation transporters 1 and 2 for antiretroviral drug therapy in human immunodeficiency virus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Effects of the SLCO1B1*1B haplotype on the pharmacokinetics and pharmacodynamics of repaglinide and nateglinide

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Different effects of SLCO1B1 polymorphism on the pharmacokinetics and pharmacodynamics of repaglinide and nateglinide

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

The effect of SLCO1B1 polymorphism on repaglinide pharmacokinetics persists over a wide dose range

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Functional characterization of SLCO1B1 (OATP-C) variants, SLCO1B1*5, SLCO1B1*15 and SLCO1B1*15+C1007G, by using transient expression systems of HeLa and HEK293 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Organic anion transporting polypeptide 1B1 activity classified by SLCO1B1 genotype influences atrasentan pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Localization, substrate specificity, and drug resistance conferred by conjugate export pumps of the MRP family.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Clinical relevance of a pharmacogenetic approach using multiple candidate genes to predict response and resistance to imatinib therapy in chronic myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Association of genetic polymorphisms in SLCO1B3 and ABCC2 with docetaxel-induced leukopenia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

The SLC22 drug transporter family

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Pharmacogenomics of human OATP transporters

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Human hepatobiliary transport of organic anions analyzed by quadruple-transfected cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

The MRP family of drug efflux pumps

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Role of transporters in the tissue-selective distribution and elimination of drugs: transporters in the liver, small intestine, brain and kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Gemfibrozil increases plasma pravastatin concentrations and reduces pravastatin renal clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Rosuvastatin pharmacokinetics and pharmacogenetics in white and Asian subjects residing in the same environment

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Mutations in the SLCO1B3 gene affecting the substrate specificity of the hepatocellular uptake transporter OATP1B3 (OATP8).

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

SLCO1B1 variants and statin-induced myopathy--a genomewide study

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Uptake of ursodeoxycholate and its conjugates by human hepatocytes: role of Na(+)-taurocholate cotransporting polypeptide (NTCP), organic anion transporting polypeptide (OATP) 1B1 (OATP-C), and oatp1B3 (OATP8).

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Involvement of multiple efflux transporters in hepatic disposition of fexofenadine

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporter

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Influence of SLCO1B1, 1B3, 2B1 and ABCC2 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

A novel variant allele of OATP-C (SLCO1B1) found in a Japanese patient with pravastatin-induced myopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Absorption of montelukast is transporter mediated: a common variant of OATP2B1 is associated with reduced plasma concentrations and poor response

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Evidence for inverse effects of OATP-C (SLC21A6) 5 and 1b haplotypes on pravastatin kinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

OATP1B1, OATP1B3, and mrp2 are involved in hepatobiliary transport of olmesartan, a novel angiotensin II blocker

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Pharmacokinetic comparison of the potential over-the-counter statins simvastatin, lovastatin, fluvastatin and pravastatin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Simvastatin but not pravastatin is very susceptible to interaction with the CYP3A4 inhibitor itraconazole.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Drug interactions with lipid-lowering drugs: mechanisms and clinical relevance

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Polymorphic organic anion transporting polypeptide 1B1 is a major determinant of repaglinide pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Fexofenadine pharmacokinetics are associated with a polymorphism of the SLCO1B1 gene (encoding OATP1B1)

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Acute effects of pravastatin on cholesterol synthesis are associated with SLCO1B1 (encoding OATP1B1) haplotype *17.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1)

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Functional Characterization of pH-Sensitive Organic Anion Transporting Polypeptide OATP-B in Human

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Role of organic anion transporter OATP1B1 (OATP-C) in hepatic uptake of irinotecan and its active metabolite, 7-ethyl-10-hydroxycamptothecin: in vitro evidence and effect of single nucleotide polymorphisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Involvement of organic anion transporting polypeptides in the transport of troglitazone sulfate: implications for understanding troglitazone hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

The MATE proteins as fundamental transporters of metabolic and xenobiotic organic cations

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Organic anion-transporting polypeptide 1B1 mediates transport of Gimatecan and BNP1350 and can be inhibited by several classic ATP-binding cassette (ABC) B1 and/or ABCG2 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Disposition of ezetimibe is influenced by polymorphisms of the hepatic uptake carrier OATP1B1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Quantitative prediction of macrolide drug-drug interaction potential from in vitro studies using testosterone as the human cytochrome P4503A substrate

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Organic anion transporters of the SLC22 family: biopharmaceutical, physiological, and pathological roles

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Novel single nucleotide polymorphisms of organic cation transporter 1 (SLC22A1) affecting transport functions

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Hepatic uptake of the novel antifungal agent caspofungin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Transcellular transport of organic cations in double-transfected MDCK cells expressing human organic cation transporters hOCT1/hMATE1 and hOCT2/hMATE1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

The effect of gemfibrozil on the pharmacokinetics of rosuvastatin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Drug transport in intestine, liver and kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

The influence of macrolide antibiotics on the uptake of organic anions and drugs mediated by OATP1B1 and OATP1B3.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Identification of multispecific organic anion transporter 2 expressed predominantly in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Contribution of OATP (organic anion-transporting polypeptide) family transporters to the hepatic uptake of fexofenadine in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Novel liver-specific organic anion transporter OAT7 that operates the exchange of sulfate conjugates for short chain fatty acid butyrate

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: analysis of the mechanism of the clinically relevant drug-drug inter

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Effect of genetic variation in the organic cation transporter 1, OCT1, on metformin pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Identification of OATP1B3 as a high-affinity hepatocellular transporter of paclitaxel

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Variants in the SLCO1B3 gene: interethnic distribution and association with paclitaxel pharmacokinetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Dose and concentration dependent effect of ranitidine on procainamide disposition and renal clearance in man

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Characterization of an organic anion-transporting polypeptide (OATP-B) in human placenta

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Isolation of a family of organic anion transporters from human liver and kidney

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Pharmacokinetic interaction between pravastatin and olmesartan in relation to SLCO1B1 polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Transport of drugs across the hepatic sinusoidal membrane: sinusoidal drug influx and efflux in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Effect of genetic polymorphism of OATP-C (SLCO1B1) on lipid-lowering response to HMG-CoA reductase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Polymorphism in human organic cation transporters and metformin action

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Functional characterization of human organic anion transporting polypeptide B (OATP-B) in comparison with liver-specific OATP-C.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Bosentan is a substrate of human OATP1B1 and OATP1B3: inhibition of hepatic uptake as the common mechanism of its interactions with cyclosporin A, rifampicin, and sildenafil

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Characterization of hepatobiliary transport systems of a novel alpha4beta1/alpha4beta7 dual antagonist, TR-14035.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Identification of human metabolites of (-)-N-{2-[(R)-3-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a novel If channel inhibitor, and investigation of the transporter-mediated renal and hepati

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Single- and multiple-dose pharmacokinetics of bosentan and its interaction with ketoconazole

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Interactions of rifamycin SV and rifampicin with organic anion uptake systems of human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

The polymorphisms Asn130Asp and Val174Ala in OATP1B1 and the CYP2C9 allele *3 independently affect torsemide pharmacokinetics and pharmacodynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Gemfibrozil inhibits CYP2C8-mediated cerivastatin metabolism in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Expression of the uptake drug transporter hOCT1 is an important clinical determinant of the response to imatinib in chronic myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Effect of SLCO1B1 polymorphism on the plasma concentrations of bile acids and bile acid synthesis marker in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Involvement of transporters in the hepatic uptake and biliary excretion of valsartan, a selective antagonist of the angiotensin II AT1-receptor, in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Effect of SLCO1B1 genetic polymorphism on the pharmacokinetics of nateglinide

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Mechanism-based inhibition of cytochrome P450 3A4 by therapeutic drugs.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Impact of the SLCO1B1 polymorphism on the pharmacokinetics and lipid-lowering efficacy of multiple-dose pravastatin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

SLCO1B1 polymorphism and sex affect the pharmacokinetics of pravastatin but not fluvastatin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

Different Effects of SLCO1B1 Polymorphism on the Pharmacokinetics of Atorvastatin and Rosuvastatin

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

SLCO1B1 polymorphism markedly affects the pharmacokinetics of simvastatin acid

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F03602530903491683

10.3109/03602530903491683

21 January 2018

Identifiers

DOI

1 reference

21 August 2017

1 reference