Radiation countermeasure agents: an update (Q37658857)

21 August 2017

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title

Radiation countermeasure agents: an update (English)

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21 August 2017

Francis Dumont

1

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21 August 2017

Antoine Le Roux

series ordinal

2

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21 August 2017

Pierre Bischoff

series ordinal

3

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21 August 2017

language of work or name

English

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publication date

1 January 2010

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Expert Opinion on Therapeutic Patents

21 August 2017

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21 August 2017

20

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21 August 2017

1

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21 August 2017

73-101

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Radiosensitising agents for the radiotherapy of cancer: advances in traditional and hypoxia targeted radiosensitisers

21 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Radiosensitising agents for the radiotherapy of cancer: novel molecularly targeted approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Effects of radiation on normal tissue: consequences and mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working Group

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Future strategies for mitigation and treatment of chronic radiation-induced normal tissue injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Bacq and Alexander Award lecture--chemical radioprotection: past, present, and future prospects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Trends in the development of radioprotective agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Pharmacologic approaches to radiation protection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

History and development of radiation-protective agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Amifostine: the first selective-target and broad-spectrum radioprotector

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Priority list of research areas for radiological nuclear threat countermeasures

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Biological chemistry of reactive oxygen and nitrogen and radiation-induced signal transduction mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Protection against ionizing radiation by antioxidant nutrients and phytochemicals

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Antioxidants reduce consequences of radiation exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Inflammation and chronic oxidative stress in radiation-induced late normal tissue injury: therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Alternate delivery route for amifostine as a radio-/chemo-protecting agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Radioprotection and radiosensitization by curcumin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Chemical reactivities and physical effects in comparison between tocopherols and tocotrienols: physiological significance and prospects as antioxidants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Tocotrienols in health and disease: the other half of the natural vitamin E family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Gamma-tocotrienol, a tocol antioxidant as a potent radioprotector

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Induction of cytokines by radioprotective tocopherol analogs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

gamma-Tocotrienol ameliorates intestinal radiation injury and reduces vascular oxidative stress after total-body irradiation by an HMG-CoA reductase-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Simvastatin ameliorates radiation enteropathy development after localized, fractionated irradiation by a protein C-independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

In vitro studies with methylproamine: a potent new radioprotector

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Ethyl pyruvate, a potentially effective mitigator of damage after total-body irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Ethyl pyruvate administration inhibits hepatic tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Vacancy engineered ceria nanostructures for protection from radiation-induced cellular damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Mitochondrial localization of superoxide dismutase is required for decreasing radiation-induced cellular damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Targeted delivery of radioprotective agents to mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

The chemistry and biology of nitroxide compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Structural requirements for optimized delivery, inhibition of oxidative stress, and antiapoptotic activity of targeted nitroxides

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

A mitochondria-targeted nitroxide/hemigramicidin S conjugate protects mouse embryonic cells against gamma irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

A recombinant MnSOD is radioprotective for normal cells and radiosensitizing for tumor cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Catalytic antioxidants: a radical approach to new therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Long-term administration of a small molecular weight catalytic metalloporphyrin antioxidant, AEOL 10150, protects lungs from radiation-induced injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Low molecular weight catalytic metalloporphyrin antioxidant AEOL 10150 protects lungs from fractionated radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Radioprotective effects of manganese-containing superoxide dismutase mimics on ataxia-telangiectasia cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Apoptosis - the p53 network

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Radiation and ceramide-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

The p53 family and programmed cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Dangerous habits of a security guard: the two faces of p53 as a drug target

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Pifithrin-alpha protects against DNA damage-induced apoptosis downstream of mitochondria independent of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Inhibition of p73 function by Pifithrin-alpha as revealed by studies in zebrafish embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

PUMA regulates intestinal progenitor cell radiosensitivity and gastrointestinal syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Checkpoint kinase inhibitors: SAR and radioprotective properties of a series of 2-arylbenzimidazoles

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Enabling death by the Abl tyrosine kinase: mechanisms for nuclear shuttling of c-Abl in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Radiation protection by a new chemical entity, Ex-Rad: efficacy and mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

A radioprotective effect of imatinib (Gleevec) in human squamous carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Lithium and GSK-3: one inhibitor, two inhibitory actions, multiple outcomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Inhibition of glycogen synthase kinase 3 beta attenuates neurocognitive dysfunction resulting from cranial irradiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Principles of bioactive lipid signalling: lessons from sphingolipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Roles of bioactive sphingolipids in cancer biology and therapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Sphingosine-1-phosphate protects proliferating endothelial cells from ceramide-induced apoptosis but not from DNA damage-induced mitotic death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

"Inside-out" signaling of sphingosine-1-phosphate: therapeutic targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Lysophosphatidic acid protects and rescues intestinal epithelial cells from radiation- and chemotherapy-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

The lysophosphatidic acid type 2 receptor is required for protection against radiation-induced intestinal injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Role of cell cycle in mediating sensitivity to radiotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Selective killing of cancer cells by beta -lapachone: direct checkpoint activation as a strategy against cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Synergistic effects of radiation and beta-lapachone in DU-145 human prostate cancer cells in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

The paradox of histone deacetylase inhibitor-mediated modulation of cellular responses to radiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Histone deacetylase inhibitors: signalling towards p21cip1/waf1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Genistein protects against biomarkers of delayed lung sequelae in mice surviving high-dose total body irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Genistein inhibits radiation-induced activation of NF-kappaB in prostate cancer cells promoting apoptosis and G2/M cell cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Effects of genistein administration on cytokine induction in whole-body gamma irradiated mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

NF-kappa B-mediated adaptive resistance to ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Activation of nuclear factor kappaB In vivo selectively protects the murine small intestine against ionizing radiation-induced damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Lipopeptide structure determines TLR2 dependent cell activation level

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Role of cytokines and growth factors in radioprotection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Cytokine-based treatment of accidentally irradiated victims and new approaches

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

IL-12 facilitates both the recovery of endogenous hematopoiesis and the engraftment of stem cells after ionizing radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Multilineage hematopoietic recovery with concomitant antitumor effects using low dose Interleukin-12 in myelosuppressed tumor-bearing mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

The FGF family: biology, pathophysiology and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Palifermin (recombinant keratinocyte growth factor-1): a pleiotropic growth factor with multiple biological activities in preventing chemotherapy- and radiotherapy-induced mucositis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Velafermin (rhFGF-20) reduces the severity and duration of hamster cheek pouch mucositis induced by fractionated radiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Comparison of expression profiles of several fibroblast growth factor receptors in the mouse jejunum: suggestive evidence for a differential radioprotective effect among major FGF family members and the potency of FGF1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

An FGF1:FGF2 chimeric growth factor exhibits universal FGF receptor specificity, enhanced stability and augmented activity useful for epithelial proliferation and radioprotection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Protective effect of esculentoside A on radiation-induced dermatitis and fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Synthetic oligopeptides related to the [beta]-subunit of human chorionic gonadotropin attenuate inflammation and liver damage after (trauma) hemorrhagic shock and resuscitation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Small molecular inhibitor of transforming growth factor-beta protects against development of radiation-induced lung injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Medical countermeasures against nuclear threats: radionuclide decorporation agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Deficiency of microvascular thrombomodulin and up-regulation of protease-activated receptor-1 in irradiated rat intestine: possible link between endothelial dysfunction and chronic radiation fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

The somatostatin analog SOM230 (pasireotide) ameliorates injury of the intestinal mucosa and increases survival after total-body irradiation by inhibiting exocrine pancreatic secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Desferrithiocin analogue uranium decorporation agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

High LET heavy ion radiation induces p53-independent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

The genetic basis of tissue responses to ionizing radiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903490429

10.1517/13543770903490429

21 January 2018

Identifiers

DOI

1 reference

21 August 2017

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