Intracellular Pharmacokinetics of Antiretroviral Drugs in HIV-Infected Patients, and their Correlation with Drug Action (Q37650120)

21 August 2017

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title

Intracellular Pharmacokinetics of Antiretroviral Drugs in HIV-Infected Patients, and their Correlation with Drug Action (English)

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21 August 2017

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anti-retroviral agent

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6

Anne-Marie Taburet

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21 August 2017

5

France Mentré

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21 August 2017

Caroline Bazzoli

1

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21 August 2017

Vincent Jullien

series ordinal

2

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21 August 2017

Clotilde Le Tiec

series ordinal

3

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21 August 2017

Elisabeth Rey

series ordinal

4

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21 August 2017

publication date

1 January 2010

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Clinical Pharmacokinetics

21 August 2017

published in

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21 August 2017

volume

49

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21 August 2017

issue

1

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21 August 2017

page(s)

17-45

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https://scigraph.springernature.com/pub.10.2165/11318110-000000000-00000

21 August 2017

exact match

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cites work

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The durability of virological success of tenofovir and didanosine dosed at either 400 or 250 mg once daily

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Suboptimal CD4 gains in HIV-infected patients receiving didanosine plus tenofovir

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Effect of quercetin on the plasma and intracellular concentrations of saquinavir in healthy adults

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Low levels of deoxynucleotides in peripheral blood lymphocytes: a strategy to inhibit human immunodeficiency virus type 1 replication

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Intracellular and plasma pharmacokinetics of saquinavir-ritonavir, administered at 1,600/100 milligrams once daily in human immunodeficiency virus-infected patients

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Development of an assay method for the detection and quantification of protease and non-nucleoside reverse transcriptase inhibitors in plasma and in peripherical blood mononuclear cells by liquid chromatography coupled with ultraviolet or tandem mas

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The mechanism of insulin resistance caused by HIV protease inhibitor therapy.

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Prediction of neuropsychiatric adverse events associated with long-term efavirenz therapy, using plasma drug level monitoring

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HIV-associated lipodystrophy: a review of underlying mechanisms and therapeutic options

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Liquid chromatography-tandem mass spectrometric quantitative determination of the HIV protease inhibitor atazanavir (BMS-232632) in human peripheral blood mononuclear cells (PBMC): practical approaches to PBMC preparation and PBMC assay design for h

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Evidence and possible consequences of the phosphorylation of nucleoside reverse transcriptase inhibitors in human red blood cells.

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An inhibitor of HIV-1 protease modulates proteasome activity, antigen presentation, and T cell responses

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12 December 2020

Genetic variation in drug transporters in ethnic populations

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12 December 2020

Differential extracellular and intracellular concentrations of zidovudine and lamivudine in semen and plasma of HIV-1-infected men.

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12 December 2020

Pharmacogenetics of anti-HIV drugs

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12 December 2020

Effect of ribavirin on intracellular and plasma pharmacokinetics of nucleoside reverse transcriptase inhibitors in patients with human immunodeficiency virus-hepatitis C virus coinfection: results of a randomized clinical study

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12 December 2020

Integrase inhibitors: a new treatment option for patients with human immunodeficiency virus infection

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12 December 2020

Atazanavir modestly increases plasma levels of raltegravir in healthy subjects

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12 December 2020

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Intracellular indinavir pharmacokinetics in HIV-infected patients: comparison with plasma pharmacokinetics

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12 December 2020

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Tenofovir-associated Fanconi syndrome: review of the FDA adverse event reporting system

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12 December 2020

Intracellular and plasma pharmacokinetics of nelfinavir and M8 in HIV-infected patients: relationship with P-glycoprotein expression

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12 December 2020

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12 December 2020

A review of low-dose ritonavir in protease inhibitor combination therapy

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12 December 2020

Influence of prior exposure to zidovudine on stavudine phosphorylation in vivo and ex vivo

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12 December 2020

Association between ABCC2 gene haplotypes and tenofovir-induced proximal tubulopathy.

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12 December 2020

Incidence of liver injury after beginning antiretroviral therapy with efavirenz or nevirapine

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12 December 2020

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12 December 2020

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12 December 2020

Influence of atazanavir 200 mg on the intracellular and plasma pharmacokinetics of saquinavir and ritonavir 1600/100 mg administered once daily in HIV-infected patients

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12 December 2020

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12 December 2020

Hematologic toxicity of zidovudine in HIV-infected patients

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12 December 2020

Intracellular pharmacokinetics of tenofovir diphosphate, carbovir triphosphate, and lamivudine triphosphate in patients receiving triple-nucleoside regimens

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Low response to pegylated interferon plus ribavirin in HIV-infected patients with chronic hepatitis C treated with abacavir.

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

Pharmacogenetic characteristics of indinavir, zidovudine, and lamivudine therapy in HIV-infected adults: a pilot study

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12 December 2020

Intracellular carbovir triphosphate levels in patients taking abacavir once a day.

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12 December 2020

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12 December 2020

Steady-state pharmacokinetics of abacavir in plasma and intracellular carbovir triphosphate following administration of abacavir at 600 milligrams once daily and 300 milligrams twice daily in human immunodeficiency virus-infected subjects

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12 December 2020

Concentration-controlled compared with conventional antiretroviral therapy for HIV infection

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12 December 2020

An MDR1-3435 variant is associated with higher plasma nelfinavir levels and more rapid virologic response in HIV-1 infected children

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12 December 2020

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12 December 2020

Mechanism of the potentiating effect of ribavirin on the activity of 2',3'-dideoxyinosine against human immunodeficiency virus

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12 December 2020

Once-daily dosing of saquinavir soft-gel capsules and ritonavir combination in HIV-1-infected patients (IMEA015 study).

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12 December 2020

P-glycoprotein and MRP1 expression and reduced ritonavir and saquinavir accumulation in HIV-infected individuals

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12 December 2020

Choroid plexus controls brain availability of anti-HIV nucleoside analogs via pharmacologically inhibitable organic anion transporters

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12 December 2020

Pharmacokinetic and pharmacodynamic characteristics of emtricitabine support its once daily dosing for the treatment of HIV infection

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12 December 2020

Mechanisms of drug transfer across the human placenta-a workshop report

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12 December 2020

Physiological concentrations of purines and pyrimidines

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12 December 2020

Intracellular nucleoside triphosphate concentrations in HIV-infected patients on dual nucleoside reverse transcriptase inhibitor therapy.

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12 December 2020

Development of a direct assay for measuring intracellular AZT triphosphate in humans peripheral blood mononuclear cells

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12 December 2020

HIV-associated lipodystrophy syndrome: description and pathogenesis

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12 December 2020

Pharmacokinetic evaluation of the effects of ribavirin on zidovudine triphosphate formation: ACTG 5092s Study Team

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12 December 2020

Influence of CYP2B6 polymorphism on plasma and intracellular concentrations and toxicity of efavirenz and nevirapine in HIV-infected patients

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Intracellular studies of the nucleoside reverse transcriptase inhibitor active metabolites: a review.

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12 December 2020

Role of pharmacogenetics of ATP-binding cassette transporters in the pharmacokinetics of drugs.

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Metabolic abnormalities in skeletal muscle of patients receiving zidovudine therapy observed by 31P in vivo magnetic resonance spectroscopy

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12 December 2020

Switching effective antiretroviral therapy: a review.

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12 December 2020

Antiretroviral therapy in adults: updated recommendations of the International AIDS Society-USA Panel

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12 December 2020

Modulation of human BCRP (ABCG2) activity by anti-HIV drugs

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12 December 2020

Intracellular metabolism of zidovudine and stavudine in combination

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12 December 2020

Abacavir and mycophenolic acid, an inhibitor of inosine monophosphate dehydrogenase, have profound and synergistic anti-HIV activity

1 reference

12 December 2020

Measurement of intracellular didanosine and tenofovir phosphorylated metabolites and possible interaction of the two drugs in human immunodeficiency virus-infected patients

1 reference

12 December 2020

Improved method to quantify intracellular zidovudine mono- and triphosphate in peripheral blood mononuclear cells by liquid chromatography-tandem mass spectrometry

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12 December 2020

The intracellular pharmacology of antiretroviral protease inhibitors

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12 December 2020

Liquid chromatography-tandem mass spectrometric determination of tenofovir-diphosphate in human peripheral blood mononuclear cells

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Activity, safety, and immunological effects of hydroxyurea added to didanosine in antiretroviral-naive and experienced HIV type 1-infected subjects: a randomized, placebo-controlled trial, ACTG 307.

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Early virologic nonresponse to tenofovir, abacavir, and lamivudine in HIV-infected antiretroviral-naive subjects

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12 December 2020

Monitoring of didanosine and stavudine intracellular trisphosphorylated anabolite concentrations in HIV-infected patients

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12 December 2020

Virological, intracellular and plasma pharmacological parameters predicting response to lopinavir/ritonavir (KALEPHAR study).

1 reference

12 December 2020

Intracellular accumulation of human immunodeficiency virus protease inhibitors

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12 December 2020

Dyslipidaemia associated with antiretroviral therapy in HIV-infected patients

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12 December 2020

Intracellular and plasma pharmacokinetics of nevirapine in human immunodeficiency virus-infected individuals

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12 December 2020

Fatal lactic acidosis and acute renal failure after addition of tenofovir to an antiretroviral regimen containing didanosine

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Intracellular and plasma pharmacokinetics of efavirenz in HIV-infected individuals

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12 December 2020

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12 December 2020

Effect of hydroxyurea and dideoxyinosine on intracellular 3'-deoxyadenosine-5'-triphosphate concentrations in HIV-infected patients

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Pharmacokinetics, pharmacodynamics and drug interaction potential of enfuvirtide

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Intracellular and plasma efavirenz concentrations in HIV-infected patients switching from successful protease inhibitor-based highly active antiretroviral therapy (HAART) to efavirenz-based HAART (SUSTIPHAR Study)

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12 December 2020

Simultaneous quantitation of the 5'-triphosphate metabolites of zidovudine, lamivudine, and stavudine in peripheral mononuclear blood cells of HIV infected patients by high-performance liquid chromatography tandem mass spectrometry

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12 December 2020

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Ribavirin antagonizes the effect of azidothymidine on HIV replication

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12 December 2020

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12 December 2020

Specificity enhancement with LC-positive ESI-MS/MS for the measurement of nucleotides: application to the quantitative determination of carbovir triphosphate, lamivudine triphosphate and tenofovir diphosphate in human peripheral blood mononuclear ce

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Peripheral blood mononuclear cell counting using a DNA-detection-based method.

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Systemic pharmacokinetics and cellular pharmacology of zidovudine in human immunodeficiency virus type 1-infected women and newborn infants

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Predictors of HIV drug-resistance mutations in a large antiretroviral-naive cohort initiating triple antiretroviral therapy

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12 December 2020

Effect of Lamivudine on the plasma and intracellular pharmacokinetics of apricitabine, a novel nucleoside reverse transcriptase inhibitor, in healthy volunteers

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12 December 2020

Ten years of highly active antiretroviral therapy for HIV infection

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12 December 2020

Influence of development, HIV infection, and antiretroviral therapies on the gene expression profiles of ABC transporters in human lymphocytes

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12 December 2020

Intracellular pharmacokinetics of once versus twice daily zidovudine and lamivudine in adolescents.

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Thymidine and 3'-azido-3'-deoxythymidine metabolism in human peripheral blood lymphocytes and monocyte-derived macrophages. A study of both anabolic and catabolic pathways

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12 December 2020

Explaining variability in the relationship between antiretroviral adherence and HIV mutation accumulation

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12 December 2020

Expression of adenosine triphosphate-binding cassette (ABC) drug transporters in peripheral blood cells: relevance for physiology and pharmacotherapy

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12 December 2020

Drug interactions with new and investigational antiretrovirals

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12 December 2020

The impact of sex and contraceptive therapy on the plasma and intracellular pharmacokinetics of zidovudine

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12 December 2020

Clinical pharmacokinetics of zidovudine: inter and intraindividual variability and relationship to long term efficacy and toxicity.

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12 December 2020

Intracellular concentration of protease inhibitors in HIV-1-infected patients: correlation with MDR-1 gene expression and low dose of ritonavir

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12 December 2020

Pharmacokinetics of antiretroviral regimens containing tenofovir disoproxil fumarate and atazanavir-ritonavir in adolescents and young adults with human immunodeficiency virus infection

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12 December 2020

Expression and functionality of anti-human immunodeficiency virus and anticancer drug uptake transporters in immune cells

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12 December 2020

Clinical and genetic determinants of intracellular tenofovir diphosphate concentrations in HIV-infected patients

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12 December 2020

Population pharmacokinetics and effects of efavirenz in patients with human immunodeficiency virus infection

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12 December 2020

Prototype trial design for rapid dose selection of antiretroviral drugs: an example using emtricitabine (Coviracil).

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12 December 2020

Effect of mycophenolate mofetil on the pharmacokinetics of antiretroviral drugs and on intracellular nucleoside triphosphate pools

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12 December 2020

Systematic and comprehensive strategy for reducing matrix effects in LC/MS/MS analyses

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12 December 2020

An enzyme immunoassay for the quantification of plasma and intracellular lopinavir in HIV-infected patients

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12 December 2020

Correlates of zidovudine phosphorylation with markers of HIV disease progression and drug toxicity

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12 December 2020

Risk factors for symptomatic mitochondrial toxicity in HIV/hepatitis C virus-coinfected patients during interferon plus ribavirin-based therapy

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12 December 2020

In vivo antagonism with zidovudine plus stavudine combination therapy

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12 December 2020

The transport of anti-HIV drugs across blood-CNS interfaces: summary of current knowledge and recommendations for further research.

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12 December 2020

The role of efavirenz compared with protease inhibitors in the body fat changes associated with highly active antiretroviral therapy

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12 December 2020

High virological failure rate in HIV patients after switching to a regimen with two nucleoside reverse transcriptase inhibitors plus tenofovir.

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12 December 2020

The effect of ABCB1 polymorphism on the pharmacokinetics of saquinavir alone and in combination with ritonavir.

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12 December 2020

Antiviral dynamics and sex differences of zidovudine and lamivudine triphosphate concentrations in HIV-infected individuals

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12 December 2020

Zidovudine phosphorylation and mitochondrial toxicity in vitro

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12 December 2020

10.2165/11318110-000000000-00000

Identifiers

DOI

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21 August 2017

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