Toxicity of antiretroviral nucleoside and nucleotide analogues: is mitochondrial toxicity the only mechanism? (Q34122406)

31 July 2017

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title

Toxicity of antiretroviral nucleoside and nucleotide analogues: is mitochondrial toxicity the only mechanism? (English)

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31 July 2017

anti-retroviral agent

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toxicity

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author name string

G Moyle

series ordinal

1

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31 July 2017

1 December 2000

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31 July 2017

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31 July 2017

23

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31 July 2017

6

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31 July 2017

467-481

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https://scigraph.springernature.com/pub.10.2165/00002018-200023060-00001

31 July 2017

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cites work

Hepatic failure and lactic acidosis due to fialuridine (FIAU), an investigational nucleoside analogue for chronic hepatitis B.

1 reference

12 December 2020

AZT-induced hypermethylation of human thymidine kinase gene in the absence of total DNA hypermethylation

1 reference

12 December 2020

Zidovudine-induced experimental myopathy: dual mechanism of mitochondrial damage

1 reference

12 December 2020

Effects of antiviral nucleoside analogs on human DNA polymerases and mitochondrial DNA synthesis

1 reference

12 December 2020

Fialuridine is phosphorylated and inhibits DNA synthesis in isolated rat hepatic mitochondria

1 reference

12 December 2020

Inhibition of HIV reverse transcriptase by 2',3'-dideoxynucleoside triphosphates

1 reference

12 December 2020

Molecular mechanism of the short-term cardiotoxicity caused by 2',3'-dideoxycytidine (ddC): modulation of reactive oxygen species levels and ADP-ribosylation reactions

1 reference

12 December 2020

Neuropathology and pathogenesis of mitochondrial diseases

1 reference

12 December 2020

Clinical mitochondrial genetics

1 reference

12 December 2020

Involvement of oxygen-derived free radicals in L-arginine-induced acute pancreatitis

1 reference

12 December 2020

Ultrastructural characteristics and DNA immunocytochemistry in human immunodeficiency virus and zidovudine-associated myopathies

1 reference

12 December 2020

Nerve growth factor binding in aged rat central nervous system: effect of acetyl-L-carnitine

1 reference

12 December 2020

Disorders of the mitochondria

1 reference

12 December 2020

Myopathies associated with human immunodeficiency virus and zidovudine: can their effects be distinguished?

1 reference

12 December 2020

Zidovudine (AZT) causes an oxidation of mitochondrial DNA in mouse liver

1 reference

12 December 2020

Lack of mitochondrial toxicity in CEM cells treated with carbovir

1 reference

12 December 2020

Cytotoxicity of 3'-azido-3'-deoxythymidine correlates with 3'-azidothymidine-5'-monophosphate (AZTMP) levels, whereas anti-human immunodeficiency virus (HIV) activity correlates with 3'-azidothymidine-5'-triphosphate (AZTTP) levels in cultured CEM T

1 reference

12 December 2020

Comparison of the DNA incorporation in human MOLT-4 cells of two 2'-beta-fluoronucleosides, 2'-beta-fluoro-2',3'-dideoxyadenosine and fialuridine

1 reference

12 December 2020

Effect of oral probenecid coadministration on the chronic toxicity and pharmacokinetics of intravenous cidofovir in cynomolgus monkeys.

1 reference

12 December 2020

Metabolism and DNA interaction of 2',3'-didehydro-2',3'-dideoxythymidine in human bone marrow cells

1 reference

12 December 2020

Depletion of muscle mitochondrial DNA in AIDS patients with zidovudine-induced myopathy

1 reference

12 December 2020

Unique intracellular activation of the potent anti-human immunodeficiency virus agent 1592U89

1 reference

12 December 2020

Mitochondrial sensitivity to AZT.

1 reference

12 December 2020

Mitochondrial respiratory chain disorders and the liver

1 reference

12 December 2020

Effect of anti-human immunodeficiency virus nucleoside analogs on mitochondrial DNA and its implication for delayed toxicity

1 reference

12 December 2020

AZT causes tissue-specific inhibition of mitochondrial bioenergetic function.

1 reference

12 December 2020

Cellular and molecular events leading to mitochondrial toxicity of 1-(2-deoxy-2-fluoro-1-beta-D-arabinofuranosyl)-5-iodouracil in human liver cells

1 reference

12 December 2020

Free radicals generated by xanthine oxidase mediate pancreatitis-associated organ failure

1 reference

12 December 2020

The bottleneck in AZT activation

1 reference

12 December 2020

The antiviral nucleotide analogs cidofovir and adefovir are novel substrates for human and rat renal organic anion transporter 1.

1 reference

12 December 2020

Catabolism of 3'-azido-3'-deoxythymidine in hepatocytes and liver microsomes, with evidence of formation of 3'-amino-3'-deoxythymidine, a highly toxic catabolite for human bone marrow cells

1 reference

12 December 2020

Mitochondrial encephalomyopathies

1 reference

12 December 2020

Fialuridine and its metabolites inhibit DNA polymerase gamma at sites of multiple adjacent analog incorporation, decrease mtDNA abundance, and cause mitochondrial structural defects in cultured hepatoblasts

1 reference

12 December 2020

The role of carnitine in intracellular metabolism

1 reference

12 December 2020

Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators

1 reference

12 December 2020

Early features of zidovudine-associated myopathy: histopathological findings and clinical correlations

1 reference

12 December 2020

Stavudine selectively induces apoptosis in HIV type 1-infected cells

1 reference

12 December 2020

Genotoxicity and mitochondrial damage in human lymphocytic cells chronically exposed to 3'-azido-2',3'-dideoxythymidine

1 reference

12 December 2020

Interference with cell cycle progression and induction of apoptosis by dideoxynucleoside analogs

1 reference

12 December 2020

Persistent mitochondrial dysfunction and perinatal exposure to antiretroviral nucleoside analogues

1 reference

12 December 2020

Metabolism of 14C-2',3'-dideoxyinosine by the in situ perfused rat liver preparation

1 reference

12 December 2020

Severe transient neonatal lactic acidosis during prophylactic zidovudine treatment

1 reference

12 December 2020

Recovery of replication-competent HIV despite prolonged suppression of plasma viremia

1 reference

12 December 2020

Irreversible telomere shortening by 3'-azido-2',3'-dideoxythymidine (AZT) treatment

1 reference

12 December 2020

Rat multispecific organic anion transporter 1 (rOAT1) transports zidovudine, acyclovir, and other antiviral nucleoside analogs

1 reference

12 December 2020

Expression of human mitochondrial thymidine kinase in Escherichia coli: correlation between the enzymatic activity of pyrimidine nucleoside analogues and their inhibitory effect on bacterial growth

1 reference

12 December 2020

Diverging substrate specificity of pure human thymidine kinases 1 and 2 against antiviral dideoxynucleosides

1 reference

12 December 2020

Preferential incorporation of 3'-azido-2',3'-dideoxythymidine into telomeric DNA and Z-DNA-containing regions of Chinese hamster ovary cells

1 reference

12 December 2020

Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines

1 reference

12 December 2020

Incorporation of nucleoside analogs into nuclear or mitochondrial DNA is determined by the intracellular phosphorylation site

1 reference

12 December 2020

Hepatocellular mitochondrial alterations in patients with chronic hepatitis C: ultrastructural and biochemical findings

1 reference

12 December 2020

Inhibitory effects of zidovudine in erythroid progenitor cells. Reversal with a combination of erythropoietin and interleukin-3.

1 reference

12 December 2020

Mitochondrial abnormalities in human immunodeficiency virus-associated myopathy

1 reference

12 December 2020

Oxidative phosphorylation at the fin de siècle

1 reference

12 December 2020

Differential effects of antiretroviral nucleoside analogs on mitochondrial function in HepG2 cells

1 reference

12 December 2020

Divergent anti-human immunodeficiency virus activity and anabolic phosphorylation of 2',3'-dideoxynucleoside analogs in resting and activated human cells.

1 reference

12 December 2020

Effect of nucleoside analogs on neurite regeneration and mitochondrial DNA synthesis in PC-12 cells

1 reference

12 December 2020

Incorporation of zidovudine into leukocyte DNA from HIV-1-positive adults and pregnant women, and cord blood from infants exposed in utero

1 reference

12 December 2020

Comparative effects of 3'-azido-3'-deoxythymidine and its metabolite 3'-amino-3'-deoxythymidine on hemoglobin synthesis in K-562 human leukemia cells

1 reference

12 December 2020

Cellular and mitochondrial toxicity of zidovudine (AZT), didanosine (ddI) and zalcitabine (ddC) on cultured human muscle cells

1 reference

12 December 2020

Comparison of mitochondrial morphology, mitochondrial DNA content, and cell viability in cultured cells treated with three anti-human immunodeficiency virus dideoxynucleosides

1 reference

12 December 2020

Antiviral activity and toxicity of fialuridine in the woodchuck model of hepatitis B virus infection

1 reference

12 December 2020

Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy

1 reference

12 December 2020

Cellular pharmacology of 3'-azido-3'-deoxythymidine with evidence of incorporation into DNA of human bone marrow cells

1 reference

12 December 2020

The pc12 cell as a model for studies of the mechanism of induction of peripheral neuropathy by anti-HIV-1 dideoxynucleoside analogs

1 reference

12 December 2020

Massive conversion of guanosine to 8-hydroxy-guanosine in mouse liver mitochondrial DNA by administration of azidothymidine

1 reference

12 December 2020

Mitochondrial toxicity of nucleoside analogue reverse transcriptase inhibitors: a looming obstacle for long-term antiretroviral therapy?

1 reference

12 December 2020

MRP4: A previously unidentified factor in resistance to nucleoside-based antiviral drugs

1 reference

12 December 2020

In vivo and in vitro effects of the azidothymidine analog dideoxyinosine on the exocrine pancreas of the rat

1 reference

12 December 2020

Fludarabine- and gemcitabine-induced apoptosis: incorporation of analogs into DNA is a critical event

1 reference

12 December 2020

Mammalian DNA polymerases alpha, beta, gamma, delta, and epsilon incorporate fialuridine (FIAU) monophosphate into DNA and are inhibited competitively by FIAU Triphosphate

1 reference

12 December 2020

Selective assays for thymidine kinase 1 and 2 and deoxycytidine kinase and their activities in extracts from human cells and tissues.

1 reference

12 December 2020

Zidovudine-induced fatal lactic acidosis and hepatic failure in patients with acquired immunodeficiency syndrome: report of two patients and review of the literature

1 reference

12 December 2020

Oxidative damage and mutation to mitochondrial DNA and age-dependent decline of mitochondrial respiratory function

1 reference

12 December 2020

Acetyl-carnitine deficiency in AIDS patients with neurotoxicity on treatment with antiretroviral nucleoside analogues

1 reference

12 December 2020

Mechanisms of toxicity of 3'-azido-3'-deoxythymidine. Its interaction with adenylate kinase.

1 reference

12 December 2020

Mitochondrial DNA polymerase gamma deficiency and mtDNA depletion in a child with Alpers' syndrome.

1 reference

12 December 2020

Genotoxicity of 3'-azido-3'-deoxythymidine in the human lymphoblastoid cell line, TK6: relationships between DNA incorporation, mutant frequency, and spectrum of deletion mutations in HPRT

1 reference

12 December 2020

Thymidine and 3'-azido-3'-deoxythymidine metabolism in human peripheral blood lymphocytes and monocyte-derived macrophages. A study of both anabolic and catabolic pathways

1 reference

12 December 2020

Neonatal Fanconi syndrome due to deficiency of complex III of the respiratory chain

1 reference

12 December 2020

Impaired mitochondrial function in microvesicular steatosis. Effects of drugs, ethanol, hormones and cytokines

1 reference

12 December 2020

A risk-benefit assessment of HIV protease inhibitors

1 reference

12 December 2020

Fialuridine accumulates in DNA of dogs, monkeys, and rats following long-term oral administration

1 reference

12 December 2020

Cytotoxicity of antiviral nucleotides adefovir and cidofovir is induced by the expression of human renal organic anion transporter 1.

1 reference

12 December 2020

Massive hepatic steatosis and lactic acidosis in a patient with AIDS who was receiving zidovudine

1 reference

12 December 2020

Phosphorylation of the anti-hepatitis B nucleoside analog 1-(2'-deoxy-2'-fluoro-1-beta-D-arabinofuranosyl)-5-iodouracil (FIAU) by human cytosolic and mitochondrial thymidine kinase and implications for cytotoxicity

1 reference

12 December 2020

Adverse effects of reverse transcriptase inhibitors: mitochondrial toxicity as common pathway

1 reference

12 December 2020

Mitochondrial toxicity of antiviral drugs

1 reference

12 December 2020

Human DNA polymerases alpha and beta are able to incorporate anti-HIV deoxynucleotides into DNA

1 reference

12 December 2020

Treatment of mitochondrial disease

1 reference

12 December 2020

Anti-HIV antiviral activity of stavudine in a thymidine kinase-deficient cellular line

1 reference

12 December 2020

Biochemical pharmacology of (+)- and (-)-2',3'-dideoxy-3'-thiacytidine as anti-hepatitis B virus agents

1 reference

12 December 2020

10.2165/00002018-200023060-00001

Identifiers

DOI

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PubMed ID

11144657

Dimensions Publication ID

31 July 2017

0 references

1 reference

PubMed ID

11144657