Hypothalamic inflammation and energy homeostasis: resolving the paradox (Q37613162)

21 August 2017

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title

Hypothalamic inflammation and energy homeostasis: resolving the paradox (English)

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21 August 2017

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Joshua P Thaler

1

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21 August 2017

Sun Ju Choi

series ordinal

2

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21 August 2017

Michael W Schwartz

series ordinal

3

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21 August 2017

Brent E Wisse

series ordinal

4

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21 August 2017

12 October 2009

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Frontiers in Neuroendocrinology

21 August 2017

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21 August 2017

31

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21 August 2017

79-84

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21 August 2017

1

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Melanocortin-4 receptor is required for acute homeostatic responses to increased dietary fat.

21 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Glucose regulates AMP-activated protein kinase activity and gene expression in clonal, hypothalamic neurons expressing proopiomelanocortin: additive effects of leptin or insulin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Metabolic endotoxemia initiates obesity and insulin resistance

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

alpha-MSH in systemic inflammation. Central and peripheral actions.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Toll-like receptor 4 on nonhematopoietic cells sustains CNS inflammation during endotoxemia, independent of systemic cytokines.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Role of glucocorticoids in the response of the hypothalamo-corticotrope, immune and adipose systems to repeated endotoxin administration.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Diet-induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

A functional anatomical analysis of central pathways subserving the effects of interleukin-1 on stress-related neuroendocrine neurons.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Interleukin-6 (IL-6)--a molecule with both beneficial and destructive potentials

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Mature-Onset Obesity in Interleukin-1 Receptor I Knockout Mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Lipopolysaccharide (LPS)- and muramyl dipeptide (MDP)-induced anorexia during refeeding following acute fasting: characterization of brain cytokine and neuropeptide systems mRNAs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Basal and IL-1beta-stimulated cytokine and neuropeptide mRNA expression in brain regions of young and old Long-Evans rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Neuroprotective role of the innate immune system by microglia

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

MyD88 signaling in brain endothelial cells is essential for the neuronal activity and glucocorticoid release during systemic inflammation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Adrenalectomy enhances pro-inflammatory cytokines gene expression, in the spleen, pituitary and brain of mice in response to lipopolysaccharide.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Differential role of melanocortins in mediating leptin's central effects on feeding and reproduction

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Inflammation and metabolic disorders

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Interleukin-1beta system (ligand, receptor type I, receptor accessory protein and receptor antagonist), TNF-alpha, TGF-beta1 and neuropeptide Y mRNAs in specific brain regions during bacterial LPS-induced anorexia.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Cytokines and sickness behavior: implications from knockout animal models

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Ciliary neurotrophic factor and leptin induce distinct patterns of immediate early gene expression in the brain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Vascular inflammation, insulin resistance, and reduced nitric oxide production precede the onset of peripheral insulin resistance.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Activation of IKKbeta by glucose is necessary and sufficient to impair insulin signaling and nitric oxide production in endothelial cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Monocyte chemoattractant protein deficiency fails to restrain macrophage infiltration into adipose tissue [corrected].

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Cytokine-induced sickness behaviour: mechanisms and implications

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Effects of systemic immunogenic insults and circulating proinflammatory cytokines on the transcription of the inhibitory factor kappaB alpha within specific cellular populations of the rat brain.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Toll-like receptor 4: the missing link of the cerebral innate immune response triggered by circulating gram-negative bacterial cell wall components

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Peripheral administration of lipopolysaccharide induces the expression of cytokine transcripts in the brain and pituitary of mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Endogenous brain IL-1 mediates LPS-induced anorexia and hypothalamic cytokine expression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Invited review: cytokine regulation of fever: studies using gene knockout mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Role of leptin in immunology

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Leptin actions on food intake and body temperature are mediated by IL-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Effect of high fat diets on energy balance and thermogenesis in brown adipose tissue of lean and genetically obese ob/ob mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Endoplasmic reticulum stress plays a central role in development of leptin resistance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Immunoregulators in the nervous system

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Central nervous system mechanisms contributing to the cachexia-anorexia syndrome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Induction of pro-inflammatory cytokine mRNAs in the brain after peripheral injection of subseptic doses of lipopolysaccharide in the rat.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

GM-CSF action in the CNS decreases food intake and body weight

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Effect of LPS administration on the expression of POMC, NPY, galanin, CART and MCH mRNAs in the rat hypothalamus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Interleukin-6-deficient mice develop mature-onset obesity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Obesity is associated with macrophage accumulation in adipose tissue

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Leptin and OB-R: body weight regulation by a cytokine receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Physiological regulation of hypothalamic IL-1beta gene expression by leptin and glucocorticoids: implications for energy homeostasis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Evidence that lipopolysaccharide-induced anorexia depends upon central, rather than peripheral, inflammatory signals.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Central interleukin-1 (IL1) signaling is required for pharmacological, but not physiological, effects of leptin on energy balance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Role of hypothalamic interleukin-1beta (IL-1beta) in regulation of energy homeostasis by melanocortins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

Cytokine-induced sickness behavior: mechanisms and implications

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YFRNE.2009.10.002

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/J.YFRNE.2009.10.002

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release_mzp3l6g2mvd65lukpdgu2m2zca

21 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/mzp3l6g2mvd65lukpdgu2m2zca

mapped directly with Wikidata item

24 November 2022

based on heuristic

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