Interleukin 27: a double-edged sword for offense and defense (Q37607910)

21 August 2017

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title

Interleukin 27: a double-edged sword for offense and defense (English)

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21 August 2017

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Hiroki Yoshida

1

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21 August 2017

Mako Nakaya

series ordinal

2

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21 August 2017

Yoshiyuki Miyazaki

series ordinal

3

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21 August 2017

2 October 2009

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Journal of Leukocyte Biology

21 August 2017

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21 August 2017

86

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21 August 2017

6

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21 August 2017

1295-1303

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The expanding universe of T-cell subsets: Th1, Th2 and more.

21 August 2017

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Interleukin-12 and the regulation of innate resistance and adaptive immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Understanding the pro- and anti-inflammatory properties of IL-27.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

The regulation of immunity to Leishmania major

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

The inhibitory cytokine IL-35 contributes to regulatory T-cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Two-sided roles of IL-27: induction of Th1 differentiation on naive CD4+ T cells versus suppression of proinflammatory cytokine production including IL-23-induced IL-17 on activated CD4+ T cells partially through STAT3-dependent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

EBV-induced gene 3 transcription is induced by TLR signaling in primary dendritic cells via NF-kappa B activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Regulation of IL-27 p28 gene expression in macrophages through MyD88- and interferon-gamma-mediated pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

IFN-alpha regulates Toll-like receptor-mediated IL-27 gene expression in human macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Commensal Gram-negative bacteria prime human dendritic cells for enhanced IL-23 and IL-27 expression and enhanced Th1 development

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Expression of IL-27 in human Th1-associated granulomatous diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

IL-27 subunits and its receptor (WSX-1) mRNAs are markedly up-regulated in inflammatory cells in the CNS during experimental autoimmune encephalomyelitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

How microorganisms tip the balance between interleukin-12 family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Advances in understanding the anti-inflammatory properties of IL-27.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Positive and negative regulation of the IL-27 receptor during lymphoid cell activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Augmentation of antigen-presenting and Th1-promoting functions of dendritic cells by WSX-1(IL-27R) deficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Development of Th1-type immune responses requires the type I cytokine receptor TCCR

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Cutting Edge: Role of IL-27/WSX-1 Signaling for Induction of T-Bet Through Activation of STAT1 During Initial Th1 Commitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine production

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Interleukin-12 and interleukin-27 regulate macrophage control of Mycobacterium tuberculosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Hyperproduction of proinflammatory cytokines by WSX-1-deficient NKT cells in concanavalin A-induced hepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Cutting edge: early IL-4 production governs the requirement for IL-27-WSX-1 signaling in the development of protective Th1 cytokine responses following Leishmania major infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

IL-27 limits IL-2 production during Th1 differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Th17: an effector CD4 T cell lineage with regulatory T cell ties

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Interleukin-10-secreting type 1 regulatory T cells in rodents and humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Cutting edge: IL-27 induces the transcription factor c-Maf, cytokine IL-21, and the costimulatory receptor ICOS that coordinately act together to promote differentiation of IL-10-producing Tr1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

IL-27 abrogates receptor activator of NF-kappa B ligand-mediated osteoclastogenesis of human granulocyte-macrophage colony-forming unit cells through STAT1-dependent inhibition of c-Fos.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Potent antitumor activity of interleukin-27.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Augmentation of effector CD8+ T cell generation with enhanced granzyme B expression by IL-27.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Differential effects of IL-27 on human B cell subsets

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Induction of IgG2a class switching in B cells by IL-27.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Expression of IL-27 in murine carcinoma cells produces antitumor effects and induces protective immunity in inoculated host animals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Interleukin-23 and interleukin-27 exert quite different antitumor and vaccine effects on poorly immunogenic melanoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Cutting edge: a key pathogenic role of IL-27 in T cell- mediated hepatitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Regulation of the class II and class I MHC pathways in human THP-1 monocytic cells by interleukin-27.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Tumor-specific cytotoxic T cell generation and dendritic cell function are differentially regulated by interleukin 27 during development of anti-tumor immunity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Adjuvant activities of novel cytokines, interleukin-23 (IL-23) and IL-27, for induction of hepatitis C virus-specific cytotoxic T lymphocytes in HLA-A*0201 transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Interleukin 27 attenuates collagen-induced arthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Amelioration of delayed-type hypersensitivity responses by IL-27 administration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Expression of Epstein-Barr virus-induced gene 3 and other interleukin-12-related molecules by human intestinal epithelium

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Expression of interleukin-12-related cytokine transcripts in inflammatory bowel disease: elevated interleukin-23p19 and interleukin-27p28 in Crohn's disease but not in ulcerative colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

High levels of proinflammatory cytokines, but not markers of tissue injury, in unaffected intestinal areas from patients with IBD

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Disruption of T helper 2-immune responses in Epstein-Barr virus-induced gene 3-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

T helper 1-inducing property of IL-27/WSX-1 signaling is required for the induction of experimental colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

IL-27 regulates homeostasis of the intestinal CD4+ effector T cell pool and limits intestinal inflammation in a murine model of colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Deficiency in EBV-induced gene 3 (EBI3) in MRL/lpr mice results in pathological alteration of autoimmune glomerulonephritis and sialadenitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Amelioration of human lupus-like phenotypes in MRL/lpr mice by overexpression of interleukin 27 receptor alpha (WSX-1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

IL-27 and IFN-αSignal via Stat1 and Stat3 and Induce T-Bet and IL-12Rβ2 in Naive T Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Interleukin-12 family members and type I interferons in Th17-mediated inflammatory disorders.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Type I interferon as a link between innate and adaptive immunity through dendritic cell stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Interferons as pathogenic effectors in autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Interferon-beta1b in multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Distinct and Nonredundant In Vivo Functions of IFNAR on Myeloid Cells Limit Autoimmunity in the Central Nervous System

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Treatment with recombinant interferon-beta reduces inflammation and slows cartilage destruction in the collagen-induced arthritis model of rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

IFN-beta modulates the response to TLR stimulation in human DC: involvement of IFN regulatory factor-1 (IRF-1) in IL-27 gene expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

A new modality for immunosuppression: targeting the JAK/STAT pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Is JAK3 a new drug target for immunomodulation-based therapies?

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

Prevention of Organ Allograft Rejection by a Specific Janus Kinase 3 Inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

IL-27 is expressed in chronic human eczematous skin lesions and stimulates human keratinocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

IL-27 inhibits the development of regulatory T cells via STAT3

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609445

21 January 2018

Identifiers

DOI

10.1189/JLB.0609445

1 reference

release_bsn5ycqze5cstghfeok7rlwoj4

21 August 2017

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Fatcat

https://api.fatcat.wiki/v0/release/bsn5ycqze5cstghfeok7rlwoj4

mapped directly with Wikidata item

24 November 2022

based on heuristic

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