Apoptosis and autophagy: Targeting autophagy signalling in cancer cells -'trick or treats'? (Q37605154)

21 August 2017

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title

Apoptosis and autophagy: Targeting autophagy signalling in cancer cells -'trick or treats'? (English)

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21 August 2017

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Elisabeth A Corcelle

1

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21 August 2017

Pietri Puustinen

series ordinal

2

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21 August 2017

Marja Jäättelä

series ordinal

3

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21 August 2017

language of work or name

English

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publication date

29 September 2009

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21 August 2017

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21 August 2017

276

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21 August 2017

6084-6096

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21 August 2017

21

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Autophagy fights disease through cellular self-digestion

21 August 2017

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Autophagy in the Pathogenesis of Disease

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Autophagy and multivesicular bodies: two closely related partners

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

New insights into the mechanisms of macroautophagy in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Toward unraveling membrane biogenesis in mammalian autophagy

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

TOR signaling in growth and metabolism

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

The mTOR pathway and its role in human genetic diseases

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Peptide combinatorial libraries identify TSC2 as a death-associated protein kinase (DAPK) death domain-binding protein and reveal a stimulatory role for DAPK in mTORC1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

AMP-activated Protein Kinase and the Regulation of Autophagic Proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

AMPK phosphorylation of raptor mediates a metabolic checkpoint

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Phosphatidic acid signaling to mTOR: signals for the survival of human cancer cells

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Localization of Rheb to the endomembrane is critical for its signaling function

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Development by self-digestion: molecular mechanisms and biological functions of autophagy

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Autophagy mediates the mitotic senescence transition

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Hierarchy of Atg proteins in pre-autophagosomal structure organization

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

E2F1 inhibits c-Myc-driven apoptosis via PIK3CA/Akt/mTOR and COX-2 in a mouse model of human liver cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Activated eIF4E-binding Protein Slows G1 Progression and Blocks Transformation by c-myc without Inhibiting Cell Growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Mammalian target of rapamycin and S6 kinase 1 positively regulate 6-thioguanine-induced autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Generation of high curvature membranes mediated by direct endophilin bilayer interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Bif-1/endophilin B1: a candidate for crescent driving force in autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

The regulation and function of Class III PI3Ks: novel roles for Vps34.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

FoxO3 controls autophagy in skeletal muscle in vivo

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

E2F1 regulates autophagy and the transcription of autophagy genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

A novel cell type-specific role of p38α in the control of autophagy and cell death in colorectal cancer cells

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Lysosomes and autophagy in cell death control

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Abl kinases regulate autophagy by promoting the trafficking and function of lysosomal components

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Disruption of autophagy at the maturation step by the carcinogen lindane is associated with the sustained mitogen-activated protein kinase/extracellular signal-regulated kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Sensitization to the lysosomal cell death pathway by oncogene-induced down-regulation of lysosome-associated membrane proteins 1 and 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Control of the autophagy maturation step by the MAPK ERK and p38: lessons from environmental carcinogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62.

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

DAP-kinase is a mediator of endoplasmic reticulum stress-induced caspase activation and autophagic cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Tap42-associated protein phosphatase type 2A negatively regulates induction of autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Myotubularin phosphatases: policing 3-phosphoinositides

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

A scaffold makes the switch

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Control of autophagy by oncogenes and tumor suppressor genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress: implications for Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Autophagy: an emerging target for cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Role of autophagy in cancer

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Autophagy as a cell death and tumor suppressor mechanism

21 January 2018

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Induction of autophagy and inhibition of tumorigenesis by beclin 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Tissue-specific Autophagy Alterations and Increased Tumorigenesis in Mice Deficient in Atg4C/Autophagin-3

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

21 January 2018

Surfing the p53 network

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https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated autophagic cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Autophagy and signaling: their role in cell survival and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Autophagy delays apoptotic death in breast cancer cells following DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

BNIP3 as a Progression Marker in Primary Human Breast Cancer; Opposing Functions inIn situVersus Invasive Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Opposing roles of mitogenic and stress signaling pathways in the induction of cancer dormancy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

The molecular programme of tumour reversion: the steps beyond malignant transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Distinct roles for cysteine cathepsin genes in multistage tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Involvement of protective autophagy in TRAIL resistance of apoptosis-defective tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Inhibition of autophagy at a late stage enhances imatinib-induced cytotoxicity in human malignant glioma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Anti-cancer agent siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Rapamycin: something old, something new, sometimes borrowed and now renewed

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Curcumin disrupts the Mammalian target of rapamycin-raptor complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Take your PIK: phosphatidylinositol 3-kinase inhibitors race through the clinic and toward cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

Potentiation of radiation sensitivity in breast tumor cells by the vitamin D3 analogue, EB 1089, through promotion of autophagy and interference with proliferative recovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1742-4658.2009.07332.X

10.1111/J.1742-4658.2009.07332.X

21 January 2018

Identifiers

DOI

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21 August 2017

1 reference