APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase (Q37577458)

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28 February 2020

title

APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase (English)

1 reference

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28 February 2020

3

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28 February 2020

Galina Selivanova

5

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28 February 2020

Elias Arnér

7

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28 February 2020

Klas Wiman

8

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28 February 2020

author name string

X Peng

1

1 reference

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28 February 2020

M-Q-Z Zhang

2

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28 February 2020

G Hosny

4

1 reference

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28 February 2020

V J N Bykov

6

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28 February 2020

publication date

24 October 2013

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28 February 2020

published in

Cell Death and Disease

1 reference

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28 February 2020

volume

4

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28 February 2020

page(s)

e881

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APR-246/PRIMA-1(MET) rescues epidermal differentiation in skin keratinocytes derived from EEC syndrome patients with p63 mutations

28 February 2020

cites work

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Thioredoxin reductase inhibition elicits Nrf2-mediated responses in Clara cells: implications for oxidant-induced lung injury

23 August 2017

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23 August 2017

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Focus on mammalian thioredoxin reductases--important selenoproteins with versatile functions

23 August 2017

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23 August 2017

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23 August 2017

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Cell death by SecTRAPs: thioredoxin reductase as a prooxidant killer of cells

23 August 2017

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23 August 2017

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Effects of thioredoxin reductase-1 deletion on embryogenesis and transcriptome

23 August 2017

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23 August 2017

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Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database

23 August 2017

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Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

23 August 2017

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Restoration of p53 function leads to tumour regression in vivo

23 August 2017

1 reference

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Modeling the therapeutic efficacy of p53 restoration in tumors

23 August 2017

1 reference

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The antioxidant function of the p53 tumor suppressor

23 August 2017

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Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity

23 August 2017

1 reference

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The thioredoxin reductase/thioredoxin system: novel redox targets for cancer therapy

23 August 2017

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Rapid induction of cell death by selenium-compromised thioredoxin reductase 1 but not by the fully active enzyme containing selenocysteine

23 August 2017

1 reference

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Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

23 August 2017

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p53 mutation spectrum and load: the generation of hypotheses linking the exposure of endogenous or exogenous carcinogens to human cancer

23 August 2017

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A model for p53-induced apoptosis

23 August 2017

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Reactive oxygen species are downstream mediators of p53-dependent apoptosis

23 August 2017

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Loss of thioredoxin reductase 1 renders tumors highly susceptible to pharmacologic glutathione deprivation

23 August 2017

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PRIMA-1(MET)/APR-246 targets mutant forms of p53 family members p63 and p73.

14 September 2017

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p53-dependent inhibition of TrxR1 contributes to the tumor-specific induction of apoptosis by RITA.

14 September 2017

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High levels of thioredoxin reductase 1 modulate drug-specific cytotoxic efficacy

14 September 2017

1 reference

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PRIMA-1 reactivates mutant p53 by covalent binding to the core domain

14 September 2017

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Inhibition of Mammalian thioredoxin reductase by some flavonoids: implications for myricetin and quercetin anticancer activity

14 September 2017

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WT p53, but not tumor-derived mutants, bind to Bcl2 via the DNA binding domain and induce mitochondrial permeabilization.

14 September 2017

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Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs.

14 September 2017

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Electrophilic prostaglandins and lipid aldehydes repress redox-sensitive transcription factors p53 and hypoxia-inducible factor by impairing the selenoprotein thioredoxin reductase

14 September 2017

1 reference

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Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling

14 September 2017

1 reference

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Possible involvement of thioredoxin reductase as well as thioredoxin in cellular sensitivity to cis-diamminedichloroplatinum (II).

28 September 2017

1 reference

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Mutant p53 targeting by the low molecular weight compound STIMA-1

28 September 2017

1 reference

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Wild-type p53 induces apoptosis in a Burkitt lymphoma (BL) line that carries mutant p53.

25 June 2018

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Pyrroloquinoline quinone modulates the kinetic parameters of the mammalian selenoprotein thioredoxin reductase 1 and is an inhibitor of glutathione reductase.

25 June 2018

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PRIMA-1MET inhibits growth of mouse tumors carrying mutant p53.

1 September 2018

1 reference

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Inhibition of thioredoxin reductase but not of glutathione reductase by the major classes of alkylating and platinum-containing anticancer compounds.

1 September 2018

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PRIMA-1(MET) synergizes with cisplatin to induce tumor cell apoptosis.

1 September 2018

1 reference

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The thioredoxin-thioredoxin reductase system: over-expression in human cancer.

1 September 2018

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Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known anticancer drugs: a statistical analysis of information in the National Cancer Institute database.

1 September 2018

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Targeting p53 in vivo: a first-in-human study with p53-targeting compound APR-246 in refractory hematologic malignancies and prostate cancer

1 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24157875

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Pharmacological rescue of mutant p53 conformation and function

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24157875

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Mutant p53 gain of function: differential effects of different p53 mutants on resistance of cultured cells to chemotherapy

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24157875

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/CDDIS.2013.417

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24157875%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24157875%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24157875%20AND%20SRC:MED&resulttype=core&format=json