p53 mutation spectrum and load: the generation of hypotheses linking the exposure of endogenous or exogenous carcinogens to human cancer (Q33750337)

29 July 2017

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title

p53 mutation spectrum and load: the generation of hypotheses linking the exposure of endogenous or exogenous carcinogens to human cancer (English)

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29 July 2017

hypothesis generation

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Hussain SP

1

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PubMed ID

10517975

29 July 2017

Harris CC

series ordinal

2

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PubMed ID

10517975

29 July 2017

language of work or name

English

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publication date

1 July 1999

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29 July 2017

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29 July 2017

428

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29 July 2017

23-32

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29 July 2017

1-2

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p53 mutations in human cancers

29 July 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

The p53 tumour suppressor gene

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Geographic variation of p53 mutational profile in nonmalignant human liver

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Aflatoxin B1 induces the transversion of G-->T in codon 249 of the p53 tumor suppressor gene in human hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Reactions between nitric oxide, superoxide, and peroxynitrite: footprints of peroxynitrite in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

DNA deaminating ability and genotoxicity of nitric oxide and its progenitors

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

DNA damage and mutation in human cells exposed to nitric oxide in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Nitric oxide induces oxidative damage in addition to deamination in macrophage DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Mutagenesis associated with nitric oxide production in transgenic SJL mice

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Nitric oxide induces upregulation of Fas and apoptosis in vascular smooth muscle.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

S-nitrosylation regulates apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Peroxynitrite-mediated nitration of tyrosine residues in Escherichia coli glutamine synthetase mimics adenylylation: relevance to signal transduction

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Nitric oxide protects cultured rat hepatocytes from tumor necrosis factor-alpha-induced apoptosis by inducing heat shock protein 70 expression

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Suppression of apoptosis by nitric oxide via inhibition of interleukin-1beta-converting enzyme (ICE)-like and cysteine protease protein (CPP)-32-like proteases

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

p53 and vascular endothelial growth factor regulate tumor growth of NOS2-expressing human carcinoma cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Diffusion of nitric oxide in the aorta wall monitored in situ by porphyrinic microsensors.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Nitric oxide synthases: roles, tolls, and controls

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharide

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Transcriptional regulation of human inducible nitric oxide synthase (NOS2) gene by cytokines: initial analysis of the human NOS2 promoter

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Inhibition of cytokine‐induced nitric oxide production by transforming growth factor‐beta 1 in human smooth muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes?

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

WAF1, a potential mediator of p53 tumor suppression

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

p53 is required for radiation-induced apoptosis in mouse thymocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Induction of cytochrome P-450 isozymes by mirex and chlordecone.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

p53 expression in nitric oxide-induced apoptosis

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https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Nitric oxide-induced apoptosis: p53-dependent and p53-independent signalling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Regulation of the human hsp70 promoter by p53

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https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Up-regulation of inducible nitric oxide synthase expression in cancer-prone p53 knockout mice.

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https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

T antigen is bound to a host protein in SY40-transformed cells

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse

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https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Participation of p53 cellular tumour antigen in transformation of normal embryonic cells

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Cellular immortalization by a cDNA clone encoding the transformation-associated phosphoprotein p53

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https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Reconstitution of p53 expression in a nonproducer Ab-MuLV-transformed cell line by transfection of a functional p53 gene.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Wild-type p53 can inhibit oncogene-mediated focus formation

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

The p53 proto-oncogene can act as a suppressor of transformation

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https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Suppression of human colorectal carcinoma cell growth by wild-type p53

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

p53 functions as a cell cycle control protein in osteosarcomas

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Genetic mechanisms of tumor suppression by the human p53 gene

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https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Somatic point mutations in the p53 gene of human tumors and cell lines: updated compilation

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

IARC Database of p53 gene mutations in human tumors and cell lines: updated compilation, revised formats and new visualisation tools

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Detection of DNA adducts by high-performance liquid chromatography with electrochemical detection

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

p53: at the crossroads of molecular carcinogenesis and risk assessment

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Multifactorial analysis of p53 alteration in human cancer: a review

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

The p53 activation domain binds the TATA box-binding polypeptide in Holo-TFIID, and a neighboring p53 domain inhibits transcription

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https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

p53 function and dysfunction

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https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60

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https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Human TAFII31 protein is a transcriptional coactivator of the p53 protein

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Presence of a potent transcription activating sequence in the p53 protein

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Wild-type p53 binds to the TATA-binding protein and represses transcription

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Specific repression of TATA-mediated but not initiator-mediated transcription by wild-type p53.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

High-resolution structure of the oligomerization domain of p53 by multidimensional NMR

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Crystal structure of the tetramerization domain of the p53 tumor suppressor at 1.7 angstroms

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https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Allosteric activation of latent p53 tetramers

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https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Solution structure of the tetrameric minimum transforming domain of p53

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Activation of p53 sequence-specific DNA binding by short single strands of DNA requires the p53 C-terminus

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Two domains of p53 interact with the TATA-binding protein, and the adenovirus 13S E1A protein disrupts the association, relieving p53-mediated transcriptional repression

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Mammalian p53 can function as a transcription factor in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

UV-induced mutagenesis of human p53 in a vector replicated in Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Radon and lung carcinogenesis: mutability of p53 codons 249 and 250 to 238Pu alpha-particles in human bronchial epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Mutational hot spot in the p53 gene in human hepatocellular carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Aberrations of p53 gene in human hepatocellular carcinoma from China.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

The 1995 Walter Hubert Lecture--molecular epidemiology of human cancer: insights from the mutational analysis of the p53 tumour-suppressor gene

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Hepatocellular carcinoma: from gene to public health.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Aflatoxin B1-induced DNA adduct formation and p53 mutations in CYP450-expressing human liver cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

p53-mediated cellular response to DNA damage in cells with replicative hepatitis B virus

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Comparison of ultraviolet irradiation-induced mutagenesis of the lacI gene in Escherichia coli and in human 293 cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Restricted ultraviolet mutational spectrum in a shuttle vector propagated in xeroderma pigmentosum cells

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

UV mutagenic photoproducts in Escherichia coli and human cells: a molecular genetics perspective on human skin cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

UV and skin cancer: specific p53 gene mutation in normal skin as a biologically relevant exposure measurement

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Sunburn and p53 in the onset of skin cancer

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

A specific spectrum of p53 mutations in lung cancer from smokers: review of mutations compiled in the IARC p53 database

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

p53 mutations in lung cancers from non-smoking atomic-bomb survivors

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53.

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

A tobacco-specific N-nitrosamine or cigarette smoke condensate causes neoplastic transformation of xenotransplanted human bronchial epithelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS1383-5742%2899%2900028-9

7 January 2021

10.1016/S1383-5742(99)00028-9

Identifiers

DOI

1 reference

29 July 2017

1 reference

PubMed ID

10517975