Stressing the ubiquitin-proteasome system (Q37562694)

21 August 2017

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title

Stressing the ubiquitin-proteasome system (English)

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ubiquitin-proteasome system

21 August 2017

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Nico P Dantuma

1

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author name string

Kristina Lindsten

series ordinal

2

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21 August 2017

25 July 2009

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21 August 2017

Cardiovascular Research

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21 August 2017

85

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21 August 2017

2

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21 August 2017

263-271

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Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

21 August 2017

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

21 January 2018

Conformational disease

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

A missense mutation in the alphaB-crystallin chaperone gene causes a desmin-related myopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Rapid degradation of a large fraction of newly synthesized proteins by proteasomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Making sense of mass destruction: quantitating MHC class I antigen presentation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Characterization of rapidly degraded polypeptides in mammalian cells reveals a novel layer of nascent protein quality control.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Heat shock and oxygen radicals stimulate ubiquitin-dependent degradation mainly of newly synthesized proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Molecular chaperones in the cytosol: from nascent chain to folded protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

The 26S proteasome: a molecular machine designed for controlled proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

A gated channel into the proteasome core particle

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

The proteasome: paradigm of a self-compartmentalizing protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Mechanisms underlying ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Lysine 63-linked polyubiquitin chain may serve as a targeting signal for the 26S proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Ubiquitin-binding domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

A genomic and functional inventory of deubiquitinating enzymes

21 January 2018

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https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

A cryptic protease couples deubiquitination and degradation by the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Proteins are unfolded on the surface of the ATPase ring before transport into the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

One step at a time: endoplasmic reticulum-associated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Quality control in the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Quality control in the endoplasmic reticulum protein factory

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

The ER-resident ubiquitin-specific protease 19 participates in the UPR and rescues ERAD substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Ubiquitin-dependent and -independent mitochondrial protein quality controls: implications in ageing and neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

To be, or not to be--molecular chaperones in protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

The triage of damaged proteins: degradation by the ubiquitin-proteasome pathway or repair by molecular chaperones.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

CHIP suppresses polyglutamine aggregation and toxicity in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Co-chaperone CHIP associates with expanded polyglutamine protein and promotes their degradation by proteasomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Molecular chaperone targeting and regulation by BAG family proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Misfolded proteins partition between two distinct quality control compartments

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Autophagy fights disease through cellular self-digestion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Aggregate formation inhibits proteasomal degradation of polyglutamine proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Degradation-mediated protein quality control in the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Proteasome-independent functions of ubiquitin in endocytosis and signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

How the ubiquitin-proteasome system controls transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Principles of ubiquitin and SUMO modifications in DNA repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

A dynamic ubiquitin equilibrium couples proteasomal activity to chromatin remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Selective arrangement of ubiquitinated and D1 protein-containing nucleosomes within the drosophila genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Polycomb silencers control cell fate, development and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Selective accumulation of aggregation-prone proteasome substrates in response to proteotoxic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Regulation of ubiquitin-proteasome system mediated degradation by cytosolic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Ubiquitin mRNA is a major stress-induced transcript in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Ubiquitin chains are remodeled at the proteasome by opposing ubiquitin ligase and deubiquitinating activities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

An inhibitor of a deubiquitinating enzyme regulates ubiquitin homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Loss of Usp14 results in reduced levels of ubiquitin in ataxia mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Transgenic rescue of ataxia mice with neuronal-specific expression of ubiquitin-specific protease 14

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Mutant ubiquitin UBB+1 is accumulated in sporadic inclusion-body myositis muscle fibers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Coexpression and accumulation of ubiquitin +1 and ZZ proteins in livers of children with alpha(1)-antitrypsin deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Inhibition of the ubiquitin-proteasome system in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Dose-dependent inhibition of proteasome activity by a mutant ubiquitin associated with neurodegenerative disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Endoplasmic reticulum stress compromises the ubiquitin-proteasome system

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Disease-specific accumulation of mutant ubiquitin as a marker for proteasomal dysfunction in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Minimal length requirement for proteasomal degradation of ubiquitin-dependent substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Concurrent translocation of multiple polypeptide chains through the proteasomal degradation channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

An unstructured initiation site is required for efficient proteasome-mediated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Proteasome substrate degradation requires association plus extended peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Taking a bite: proteasomal protein processing

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Impairment of the ubiquitin-proteasome system by protein aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Disease-associated prion protein oligomers inhibit the 26S proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

The ubiquitin-proteasome reporter GFPu does not accumulate in neurons of the R6/2 transgenic mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

17-DMAG ameliorates polyglutamine-mediated motor neuron degeneration through well-preserved proteasome function in an SBMA model mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Progressively impaired proteasomal capacity during terminal plasma cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

RPN4 is a ligand, substrate, and transcriptional regulator of the 26S proteasome: a negative feedback circuit

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Rpn4p acts as a transcription factor by binding to PACE, a nonamer box found upstream of 26S proteasomal and other genes in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Identification and characterization of a Drosophila proteasome regulatory network

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Molecular sequelae of proteasome inhibition in human multiple myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Inhibition of proteasome activity induces concerted expression of proteasome genes and de novo formation of Mammalian proteasomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

A giant protease with potential to substitute for some functions of the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

c-myc overexpression activates alternative pathways for intracellular proteolysis in lymphoma cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Tumors acquire inhibitor of apoptosis protein (IAP)-mediated apoptosis resistance through altered specificity of cytosolic proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Antioxidants Enhance Mammalian Proteasome Expression through the Keap1-Nrf2 Signaling Pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Stress-specific activation and repression of heat shock factors 1 and 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Ubx2 links the Cdc48 complex to ER-associated protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Membrane-bound Ubx2 recruits Cdc48 to ubiquitin ligases and their substrates to ensure efficient ER-associated protein degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Involvement of valosin-containing protein, an ATPase Co-purified with IkappaBalpha and 26 S proteasome, in ubiquitin-proteasome-mediated degradation of IkappaBalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

The ubiquitin-selective chaperone CDC-48/p97 links myosin assembly to human myopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Monitoring the ubiquitin/proteasome system in conformational diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

The development of proteasome inhibitors as anticancer drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Altered proteasomal function due to the expression of polyglutamine-expanded truncated N-terminal huntingtin induces apoptosis by caspase activation through mitochondrial cytochrome c release

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Polarised asymmetric inheritance of accumulated protein damage in higher eukaryotes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Prion-induced amyloid heart disease with high blood infectivity in transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Missense mutations in desmin associated with familial cardiac and skeletal myopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Desmin myopathy, a skeletal myopathy with cardiomyopathy caused by mutations in the desmin gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Functional alterations of the ubiquitin-proteasome system in motor neurons of a mouse model of familial amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Human alpha B-crystallin mutation causes oxido-reductive stress and protein aggregation cardiomyopathy in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Endoplasmic reticulum stress in the heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

The role of the unfolded protein response in the heart.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

PUMA is critical for neonatal cardiomyocyte apoptosis induced by endoplasmic reticulum stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Oxidized and ubiquitinated proteins may predict recovery of postischemic cardiac function: essential role of the proteasome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Proteasome inhibitors disrupt the unfolded protein response in myeloma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Acute severe cardiac failure in a myeloma patient due to proteasome inhibitor bortezomib

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Overexpression of endoplasmic reticulum-resident chaperone attenuates cardiomyocyte death induced by proteasome inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Inhibition of the ubiquitin-proteasome pathway induces differential heat-shock protein response in cardiomyocytes and renders early cardiac protection

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

The ubiquitin-proteasome system in myocardial ischaemia and preconditioning

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

The ubiquitin-proteasome system in cardiac proteinopathy: a quality control perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Success in translational research: lessons from the development of bortezomib

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

The major substrates for TAP in vivo are derived from newly synthesized proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

A proteolytic system that compensates for loss of proteasome function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCVR%2FCVP255

21 January 2018

Identifiers

DOI

10.1093/CVR/CVP255

1 reference

release_7dzfbmee5nc73msguqbipjdrdy

21 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/7dzfbmee5nc73msguqbipjdrdy

mapped directly with Wikidata item

24 November 2022

based on heuristic

PubMed ID

19633314

1 reference

PubMed ID

19633314