Recent insights into the structure of Toll-like receptors and post-translational modifications of their associated signalling proteins. (Q37559669)

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3 February 2020

review article

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title

Recent insights into the structure of Toll-like receptors and post-translational modifications of their associated signalling proteins (English)

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3 February 2020

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2

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3 February 2020

author name string

Susan Carpenter

series ordinal

1

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language of work or name

English

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publication date

29 July 2009

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3 February 2020

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3 February 2020

volume

422

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3 February 2020

page(s)

1-10

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issue

1

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The immune system evolved to discriminate infectious nonself from noninfectious self

3 February 2020

cites work

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A family of human receptors structurally related to Drosophila Toll

21 January 2018

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A structural basis of the interactions between leucine-rich repeats and protein ligands

21 January 2018

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A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

21 January 2018

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Structural basis for signal transduction by the Toll/interleukin-1 receptor domains

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The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling.

21 January 2018

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The TLR3 signaling complex forms by cooperative receptor dimerization

21 January 2018

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Structural Basis of Toll-Like Receptor 3 Signaling with Double-Stranded RNA

21 January 2018

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Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide

21 January 2018

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The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex

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Structural diversity of the hagfish variable lymphocyte receptors

21 January 2018

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The crystal structure of the human toll-like receptor 10 cytoplasmic domain reveals a putative signaling dimer

21 January 2018

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The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens.

21 January 2018

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Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88.

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Structural and functional evidence for the role of the TLR2 DD loop in TLR1/TLR2 heterodimerization and signaling

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The molecular structure of the Toll-like receptor 3 ligand-binding domain.

21 January 2018

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Crystal structure of human toll-like receptor 3 (TLR3) ectodomain

21 January 2018

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Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran

21 January 2018

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MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4

21 January 2018

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Structure and function of lipopolysaccharides.

21 January 2018

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Inhibition of endotoxin response by e5564, a novel Toll-like receptor 4-directed endotoxin antagonist

21 January 2018

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Regulatory roles for MD-2 and TLR4 in ligand-induced receptor clustering

21 January 2018

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Elucidation of the MD-2/TLR4 interface required for signaling by lipid IVa.

21 January 2018

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Structures of the toll-like receptor family and its ligand complexes

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Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway

21 January 2018

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Double-stranded RNA signaling by Toll-like receptor 3 requires specific tyrosine residues in its cytoplasmic domain

21 January 2018

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Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling

21 January 2018

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A phosphorylation site in the Toll-like receptor 5 TIR domain is required for inflammatory signalling in response to flagellin

21 January 2018

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Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling

21 January 2018

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MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction

21 January 2018

1 reference

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Tyrosine phosphorylation of MyD88 adapter-like (Mal) is critical for signal transduction and blocked in endotoxin tolerance

21 January 2018

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Signalling adaptors used by Toll-like receptors: an update.

21 January 2018

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TAG, a splice variant of the adaptor TRAM, negatively regulates the adaptor MyD88-independent TLR4 pathway

21 January 2018

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The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction

21 January 2018

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21 January 2018

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Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction

21 January 2018

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The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling

21 January 2018

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Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4

21 January 2018

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Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol

21 January 2018

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Pyogenic bacterial infections in humans with IRAK-4 deficiency

21 January 2018

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IRAK-M is a negative regulator of Toll-like receptor signaling

21 January 2018

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Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2.

21 January 2018

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Ubiquitin-binding domains

21 January 2018

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Ubiquitylation and cell signaling

21 January 2018

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Histone H2A monoubiquitination represses transcription by inhibiting RNA polymerase II transcriptional elongation

21 January 2018

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Regulation of ubiquitin-binding proteins by monoubiquitination

21 January 2018

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A ubiquitin ligase complex assembles linear polyubiquitin chains

21 January 2018

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Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation

21 January 2018

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Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation

21 January 2018

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Structural Basis for Recognition of Diubiquitins by NEMO

21 January 2018

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Ubiquitin signalling in the NF-kappaB pathway

21 January 2018

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Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination

21 January 2018

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Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway

21 January 2018

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TIFA activates IkappaB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6.

21 January 2018

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IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination

21 January 2018

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Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors

21 January 2018

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Pellino Proteins Contain a Cryptic FHA Domain that Mediates Interaction with Phosphorylated IRAK1

21 January 2018

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Pellino3 is a novel upstream regulator of p38 MAPK and activates CREB in a p38-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20090616

Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family: direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases

21 January 2018

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https://api.crossref.org/works/10.1042%2FBJ20090616

The Pellino family: IRAK E3 ligases with emerging roles in innate immune signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20090616

Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20090616

Characterization of Pellino2, a substrate of IRAK1 and IRAK4

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20090616

Pellino 3b negatively regulates interleukin-1-induced TAK1-dependent NF kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20090616

The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20090616

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20090616

Targeting the ubiquitin system in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20090616

21 January 2018

Identifiers

DOI

10.1042/BJ20090616

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19627256%20AND%20SRC:MED&resulttype=core&format=json

3 February 2020

1 reference