Kv1.3 potassium channels as a therapeutic target in multiple sclerosis (Q37523986)

20 August 2017

1 reference

title

Kv1.3 potassium channels as a therapeutic target in multiple sclerosis (English)

1 reference

20 August 2017

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Srikant Rangaraju

1

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20 August 2017

Victor Chi

series ordinal

2

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20 August 2017

Michael W Pennington

series ordinal

3

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20 August 2017

K George Chandy

series ordinal

4

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20 August 2017

language of work or name

English

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publication date

1 August 2009

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Expert Opinion on Therapeutic Targets

20 August 2017

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20 August 2017

13

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20 August 2017

8

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20 August 2017

909-924

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Comparison of subcutaneous interferon beta-1a with glatiramer acetate in patients with relapsing multiple sclerosis (the REbif vs Glatiramer Acetate in Relapsing MS Disease [REGARD] study): a multicentre, randomised, parallel, open-label trial

20 August 2017

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Assessment: the use of natalizumab (Tysabri) for the treatment of multiple sclerosis (an evidence-based review): report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Disease-modifying therapy in multiple sclerosis: update and clinical implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Disease-modifying agents for multiple sclerosis: recent advances and future prospects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Identification and development of new therapeutics for multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Expression of CCR7 in multiple sclerosis: implications for CNS immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

CD83-positive dendritic cells are present in occasional perivascular cuffs in multiple sclerosis lesions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Dendritic cells are abundant in non-lesional gray matter in multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Dendritic cells in a mature age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

The role of B cells in multiple sclerosis: rationale for B-cell-targeted therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Recapitulation of B cell differentiation in the central nervous system of patients with multiple sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Short-lived plasma blasts are the main B cell effector subset during the course of multiple sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Immunological memory: contribution of memory B cells expressing costimulatory molecules in the resting state.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Voltage-gated K+ channels in human T lymphocytes: a role in mitogenesis?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

K channels in T lymphocytes: a patch clamp study using monoclonal antibody adhesion

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

K+ channels as targets for specific immunomodulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Kv1.3 channels are a therapeutic target for T cell-mediated autoimmune diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Extracellular K(+) and opening of voltage-gated potassium channels activate T cell integrin function: physical and functional association between Kv1.3 channels and beta1 integrins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Human homologue of the Drosophila discs large tumor suppressor binds to p56lck tyrosine kinase and Shaker type Kv1.3 potassium channel in T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Pharmacokinetics, toxicity, and functional studies of the selective Kv1.3 channel blocker 5-(4-phenoxybutoxy)psoralen in rhesus macaques

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Targeting effector memory T cells with a selective peptide inhibitor of Kv1.3 channels for therapy of autoimmune diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Subset-specific expression of potassium channels in developing murine T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Design of PAP-1, a selective small molecule Kv1.3 blocker, for the suppression of effector memory T cells in autoimmune diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Calcium-activated potassium channels in resting and activated human T lymphocytes. Expression levels, calcium dependence, ion selectivity, and pharmacology

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

A human intermediate conductance calcium-activated potassium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

hSK4, a member of a novel subfamily of calcium-activated potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

A novel gene, hKCa4, encodes the calcium-activated potassium channel in human T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Calmodulin mediates calcium-dependent activation of the intermediate conductance KCa channel, IKCa1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Up-regulation of the IKCa1 potassium channel during T-cell activation. Molecular mechanism and functional consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Two types of potassium channels in murine T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Altered K+ channel expression in abnormal T lymphocytes from mice with the lpr gene mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Ca(2+)-activated K+ channels in human leukemic T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Identification of Kv1.1 expression by murine CD4-CD8- thymocytes. A role for voltage-dependent K+ channels in murine thymocyte development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Modulation of Kv channel expression and function by TCR and costimulatory signals during peripheral CD4(+) lymphocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

SK2 encodes the apamin-sensitive Ca(2+)-activated K(+) channels in the human leukemic T cell line, Jurkat

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Differential Ca2+ influx, KCa channel activity, and Ca2+ clearance distinguish Th1 and Th2 lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

TRESK-like potassium channels in leukemic T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Diverse K+ channels in primary human T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

TASK-3, a new member of the tandem pore K(+) channel family

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Anandamide, an endogenous cannabinoid, inhibits Shaker-related voltage-gated K+ channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Molecular clustering of STIM1 with Orai1/CRACM1 at the plasma membrane depends dynamically on depletion of Ca2+ stores and on electrostatic interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Molecular properties and physiological roles of ion channels in the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Calcium signaling in lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Calcium signaling in immune cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

STIM1, an essential and conserved component of store-operated Ca2+ channel function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Orai1 is an essential pore subunit of the CRAC channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

The elementary unit of store-operated Ca2+ entry: local activation of CRAC channels by STIM1 at ER-plasma membrane junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Amplification of CRAC current by STIM1 and CRACM1 (Orai1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

CRACM1 multimers form the ion-selective pore of the CRAC channel.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Heterogeneity of lymphocyte calcium metabolism is caused by T cell-specific calcium-sensitive potassium channel and sensitivity of the calcium ATPase pump to membrane potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Selective blockers of voltage-gated K+ channels depolarize human T lymphocytes: mechanism of the antiproliferative effect of charybdotoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Voltage-gated and Ca(2+)-activated K+ channels in intact human T lymphocytes. Noninvasive measurements of membrane currents, membrane potential, and intracellular calcium

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Study of membrane potential in T lymphocytes subpopulations using flow cytometry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Colocalization and nonrandom distribution of Kv1.3 potassium channels and CD3 molecules in the plasma membrane of human T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Kv1.3 potassium channels are localized in the immunological synapse formed between cytotoxic and target cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

The Ca(2+)-activated K(+) channel KCa3.1 compartmentalizes in the immunological synapse of human T lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

The voltage-gated Kv1.3 K(+) channel in effector memory T cells as new target for MS

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Potassium channels Kv1.3 and Kv1.5 are expressed on blood-derived dendritic cells in the central nervous system.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Association of Kv1.5 and Kv1.3 contributes to the major voltage-dependent K+ channel in macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Kv1.5 association modifies Kv1.3 traffic and membrane localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Ion channels modulating mouse dendritic cell functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Microglia Kv1.3 channels contribute to their ability to kill neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

The potassium channels Kv1.5 and Kv1.3 modulate distinct functions of microglia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Charybdotoxin blocks voltage-gated K+ channels in human and murine T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Charybdotoxin inhibits proliferation and interleukin 2 production in human peripheral blood lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Selective blockade of T lymphocyte K(+) channels ameliorates experimental autoimmune encephalomyelitis, a model for multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Topology of the pore-region of a K+ channel revealed by the NMR-derived structures of scorpion toxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

The signature sequence of voltage-gated potassium channels projects into the external vestibule

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Structural conservation of the pores of calcium-activated and voltage-gated potassium channels determined by a sea anemone toxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Structural conservation in prokaryotic and eukaryotic potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Crystal structure of a mammalian voltage-dependent Shaker family K+ channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Characterization of a potassium channel toxin from the Caribbean Sea anemone Stichodactyla helianthus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

A potassium-channel toxin from the sea anemone Bunodosoma granulifera, an inhibitor for Kv1 channels. Revision of the amino acid sequence, disulfide-bridge assignment, chemical synthesis, and biological activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Mapping the functional anatomy of BgK on Kv1.1, Kv1.2, and Kv1.3. Clues to design analogs with enhanced selectivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

ShK-Dap22, a potent Kv1.3-specific immunosuppressive polypeptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

A novel fluorescent toxin to detect and investigate Kv1.3 channel up-regulation in chronically activated T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Engineering a stable and selective peptide blocker of the Kv1.3 channel in T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

WIN 17317-3, a new high-affinity probe for voltage-gated sodium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Correolide and derivatives are novel immunosuppressants blocking the lymphocyte Kv1.3 potassium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Kv1.3-blocking 5-phenylalkoxypsoralens: a new class of immunomodulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Clofazimine inhibits human Kv1.3 potassium channel by perturbing calcium oscillation in T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Voltage-gated potassium channels regulate calcium-dependent pathways involved in human T lymphocyte activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Imaging of effector memory T cells during a delayed-type hypersensitivity reaction and suppression by Kv1.3 channel block

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Characterization of the functional properties of the voltage-gated potassium channel Kv1.3 in human CD4+ T lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Double-blind, randomized, controlled clinical trial of clofazimine compared with chloroquine in patients with systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Successful treatment of generalized pustular psoriasis with clofazimine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Treatment of pustular psoriasis with clofazimine

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Targeting effector memory T cells with the small molecule Kv1.3 blocker PAP-1 suppresses allergic contact dermatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Selective blockade of voltage-gated potassium channels reduces inflammatory bone resorption in experimental periodontal disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Immune response: the key to bone resorption in periodontal disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Molecular characterization of a voltage-gated potassium channel expressed in rat testis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

The voltage-gated potassium channel Kv1.3 regulates energy homeostasis and body weight

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Clofazimine enteropathy in a pediatric bone marrow transplant recipient

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Splenic infarction and tissue accumulation of crystals associated with the use of clofazimine (Lamprene; B663) in the treatment of pyoderma gangrenosum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

CD4+CD28- costimulation-independent T cells in multiple sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Treatment of chronic plaque psoriasis by selective targeting of memory effector T lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Alefacept (anti-CD2) causes a selective reduction in circulating effector memory T cells (Tem) and relative preservation of central memory T cells (Tcm) in psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

CD4-positive effector memory T cells participate in disease expression in ANCA-associated vasculitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

CD28- T cells display features of effector memory T cells in Wegener's granulomatosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Persistent expansion of CD4+ effector memory T cells in Wegener's granulomatosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Expansion of circulating NKG2D+ effector memory T-cells and expression of NKG2D-ligand MIC in granulomaous lesions in Wegener's granulomatosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Clonal CD8+ TCR-Vbeta expanded populations with effector memory phenotype in Churg Strauss syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Oligoclonal expansion of circulating and tissue-infiltrating CD8+ T cells with killer/effector phenotypes in juvenile dermatomyositis syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Chemokine receptor CCR7 is expressed in muscle fibers in juvenile dermatomyositis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Characterisation of the immune response to type I collagen in scleroderma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Fibrosing alveolitis in systemic sclerosis: increase in memory T-cells in lung interstitium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Desmoglein-1-specific T lymphocytes from patients with endemic pemphigus foliaceus (fogo selvagem).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Potassium channel-blockers as therapeutic agents to interfere with bone resorption of periodontal disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

Severe chronic graft-versus-host disease is characterized by a preponderance of CD4(+) effector memory cells relative to central memory cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728220903018957

10.1517/14728220903018957

21 January 2018

Identifiers

DOI

1 reference

20 August 2017

1 reference