Targeting effector memory T cells with the small molecule Kv1.3 blocker PAP-1 suppresses allergic contact dermatitis (Q24685784)

2

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Daniel Homerick

3

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Stephen Griffey

4

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Heike Wulff

Journal of Investigative Dermatology

5

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language of work or name

English

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publication date

June 2007

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published in

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volume

127

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issue

6

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page(s)

1419-29

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cites work

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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

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Blockade of the voltage-gated potassium channel Kv1.3 inhibits immune responses in vivo

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28 September 2017

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Alefacept therapy reduces the effector T-cell population in lesional psoriatic epidermis

28 September 2017

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Chemical allergy: considerations for the practical application of cytokine profiling

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28 September 2017

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GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetes

28 September 2017

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Safety and efficacy of pimecrolimus (ASM 981) cream 1% in the treatment of mild and moderate atopic dermatitis in children and adolescents

28 September 2017

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Molecular properties and physiological roles of ion channels in the immune system

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Selective blocking of voltage-gated K+ channels improves experimental autoimmune encephalomyelitis and inhibits T cell activation

28 September 2017

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Sensitization versus elicitation in allergic contact dermatitis: potential differences at cellular and molecular levels

28 September 2017

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Mast cells control neutrophil recruitment during T cell-mediated delayed-type hypersensitivity reactions through tumor necrosis factor and macrophage inflammatory protein 2.

28 September 2017

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Role of cytokines in epidermal Langerhans cell migration

28 September 2017

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Expression of IL-17 in human memory CD45RO+ T lymphocytes and its regulation by protein kinase A pathway

28 September 2017

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Pimecrolimus inhibits the elicitation phase but does not suppress the sensitization phase in murine contact hypersensitivity, in contrast to tacrolimus and cyclosporine A.

28 September 2017

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Alefacept treatment in psoriatic arthritis: reduction of the effector T cell population in peripheral blood and synovial tissue is associated with improvement of clinical signs of arthritis

30 May 2018

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Extracellular K(+) and opening of voltage-gated potassium channels activate T cell integrin function: physical and functional association between Kv1.3 channels and beta1 integrins

30 May 2018

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30 May 2018

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CD8+ T cells are effector cells of contact dermatitis to common skin allergens in mice.

30 May 2018

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Dissociation between sex differences in the immunological, behavioral, and physiological effects of kappa- and delta-opioids in Fischer rats

28 November 2018

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Relationship of CD86 surface marker expression and cytotoxicity on dendritic cells exposed to chemical allergen

28 November 2018

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Qualitative and quantitative evaluation of a local lymph node assay based on ex vivo interleukin-2 production.

28 November 2018

1 reference

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CD28nullCD4+ T cells--characterization of an effector memory T-cell population in patients with rheumatoid arthritis

28 November 2018

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Memory effector (CD45RO+) and cytotoxic (CD8+) T cells appear early in the margin zone of spreading psoriatic lesions in contrast to cells expressing natural killer receptors, which appear late.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1929164

Differential voltage-dependent K+ channel responses during proliferation and activation in macrophages.

28 November 2018

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Pimecrolimus identifies a common genomic anti-inflammatory profile, is clinically highly effective in psoriasis and is well tolerated

28 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1929164

Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses

28 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1929164

Local lymph node assay with non-radioisotope alternative endpoints

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1929164

Treatment of chronic plaque psoriasis by selective targeting of memory effector T lymphocytes.

28 November 2018

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New insights into endotoxin-induced activation of macrophages: involvement of a K+ channel in transmembrane signaling.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1929164

Enhancement of the contact hypersensitivity reaction by acute morphine administration at the elicitation phase.

28 November 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1929164

Complex subunit assembly of neuronal voltage-gated K+ channels. Basis for high-affinity toxin interactions and pharmacology.

28 November 2018

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Identification of Kv1.1 expression by murine CD4-CD8- thymocytes. A role for voltage-dependent K+ channels in murine thymocyte development.

28 November 2018

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A randomized, double-blind, placebo-controlled phase III study evaluating efficacy and tolerability of 2 courses of alefacept in patients with chronic plaque psoriasis

28 November 2018

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12 December 2020

Kv1.3 potassium channels in human alveolar macrophages

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12 December 2020

Allergic contact dermatitis

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12 December 2020

Comparative evaluation of arachidonic acid (AA)- and tetradecanoylphorbol acetate (TPA)-induced dermal inflammation

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12 December 2020

Voltage-activated proton currents in human THP-1 monocytes

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12 December 2020

A novel anti-inflammatory drug, SDZ ASM 981, for the topical and oral treatment of skin diseases: in vivo pharmacology

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12 December 2020

Immunoregulatory mechanisms involved in elicitation of allergic contact hypersensitivity

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12 December 2020

Contact dermatitis I. Pathophysiology of contact sensitivity

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12 December 2020

Development of a non-radioactive endpoint in a modified local lymph node assay

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12 December 2020

Identifiers

DOI

10.1038/SJ.JID.5700717

1 reference

Dimensions Publication ID

3175112

1042752121

0 references

3175112

1 reference

1 reference

1 reference