2'-O-methyl-modified phosphorothioate antisense oligonucleotides have reduced non-specific effects in vitro (Q37521252)

20 August 2017

2'-O-methyl-modified phosphorothioate antisense oligonucleotides have reduced non-specific effects in vitro (English)

1 reference

20 August 2017

3

Alexey Bochkarev

1 reference

20 August 2017

Byong Hoon Yoo

1

1 reference

20 August 2017

Elena Bochkareva

series ordinal

2

1 reference

20 August 2017

Tung-Chung Mou

series ordinal

4

1 reference

20 August 2017

Donald M Gray

series ordinal

5

1 reference

20 August 2017

language of work or name

English

0 references

publication date

2 April 2004

1 reference

20 August 2017

Nucleic Acids Research

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20 August 2017

32

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20 August 2017

6

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20 August 2017

2008-2016

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describes a project that uses

20 August 2017

ImageQuant

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC390367/fullTextXML

inferred from PubMed Central ID database lookup

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Independent and coordinated functions of replication protein A tandem high affinity single-stranded DNA binding domains

23 August 2017

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Antisense inhibition of gene expression in cells by oligonucleotides incorporating locked nucleic acids: effect of mRNA target sequence and chimera design

23 August 2017

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Potential roles of antisense oligonucleotides in cancer therapy. The example of Bcl-2 antisense oligonucleotides

23 August 2017

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Novel antisense and peptide nucleic acid strategies for controlling gene expression

23 August 2017

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The experimental use of antisense oligonucleotides: a guide for the perplexed

23 August 2017

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Antisense oligonucleotides: promise and reality.

23 August 2017

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The biochemistry of apoptosis

23 August 2017

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Mechanisms and applications of immune stimulatory CpG oligodeoxynucleotides

23 August 2017

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Detection of proteins binding to short RNA.DNA hybrids or short antisense oligonucleotides in Xenopus laevis oocytes and human macrophage cell extracts by photoaffinity radiolabeling

23 August 2017

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BCL-2 family: regulators of cell death

23 August 2017

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The RPA32 subunit of human replication protein A contains a single-stranded DNA-binding domain

23 August 2017

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Replication protein A: a heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism

23 August 2017

1 reference

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Solution structure of an RNA.2'-O-methylated RNA hybrid duplex containing an RNA.DNA hybrid segment at the center

23 August 2017

1 reference

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Structure of the single-stranded-DNA-binding domain of replication protein A bound to DNA

23 August 2017

1 reference

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Evidence from CD spectra that d(purine).r(pyrimidine) and r(purine).d(pyrimidine) hybrids are in different structural classes

23 August 2017

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CpG motifs in bacterial DNA trigger direct B-cell activation

23 August 2017

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Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

23 August 2017

1 reference

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Evaluation of C-5 propynyl pyrimidine-containing oligonucleotides in vitro and in vivo

23 August 2017

1 reference

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The high binding affinity of phosphorothioate-modified oligomers for Ff gene 5 protein is moderated by the addition of C-5 propyne or 2'-O-methyl modifications

6 September 2017

1 reference

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Inhibition of DNA replication and induction of S phase cell cycle arrest by G-rich oligonucleotides

6 September 2017

1 reference

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Antiproliferative activity of G-rich oligonucleotides correlates with protein binding

6 September 2017

1 reference

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Phosphorothioate oligonucleotides bind in a non sequence-specific manner to the nucleolar protein C23/nucleolin

6 September 2017

1 reference

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Design of antisense oligonucleotides stabilized by locked nucleic acids

6 September 2017

1 reference

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CD, absorption and thermodynamic analysis of repeating dinucleotide DNA, RNA and hybrid duplexes [d/r(AC)]12.[d/r(GT/U)]12 and the influence of phosphorothioate substitution

14 September 2017

1 reference

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G3139 (oblimersen) may inhibit prostate cancer cell growth in a partially bis-CpG-dependent non-antisense manner

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=390367

Comparison of different antisense strategies in mammalian cells using locked nucleic acids, 2'-O-methyl RNA, phosphorothioates and small interfering RNA.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=390367

Importance of poly(ADP-ribose) polymerase and its cleavage in apoptosis. Lesson from an uncleavable mutant

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=390367

Phosphorothioate antisense oligodeoxynucleotides: questions of specificity

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=390367

Nuclease resistance and antisense activity of modified oligonucleotides targeted to Ha-ras

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=390367

Induction of apoptosis in small-cell lung cancer cells by an antisense oligodeoxynucleotide targeting the Bcl-2 coding sequence

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=390367

Antisense ferritin oligonucleotides inhibit growth and induce apoptosis in human breast carcinoma cells

25 June 2018

1 reference

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Inhibition of potentially anti-apoptotic proteins by antisense protein kinase C-alpha (Isis 3521) and antisense bcl-2 (G3139) phosphorothioate oligodeoxynucleotides: relationship to the decreased viability of T24 bladder and PC3 prostate cancer cell

2 September 2018

1 reference

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Heating greatly speeds Coomassie blue staining and destaining.

2 September 2018

1 reference

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Characterization of a potent and specific class of antisense oligonucleotide inhibitor of human protein kinase C-alpha expression

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=390367

Evaluation of 2'-modified oligonucleotides containing 2'-deoxy gaps as antisense inhibitors of gene expression.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=390367

Absorption and circular dichroism spectroscopy of nucleic acid duplexes and triplexes

2 September 2018

1 reference

12 December 2020

c-myc antisense oligodeoxyribonucleotides inhibit proliferation of non-small cell lung cancer

1 reference

12 December 2020

Hybrid oligomer duplexes formed with phosphorothioate DNAs: CD spectra and melting temperatures of S-DNA.RNA hybrids are sequence-dependent but consistent with similar heteronomous conformations

1 reference

12 December 2020

Antisense and sensibility

1 reference

12 December 2020

Identifiers

DOI

10.1093/NAR/GKH516

1 reference

20 August 2017

1 reference

20 August 2017

1 reference