Gating mechanisms in Cys-loop receptors (Q37464841)

20 August 2017

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title

Gating mechanisms in Cys-loop receptors (English)

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20 August 2017

Trevor M Lewis

3

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Peter R Schofield

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Peter R Schofield

series ordinal

2

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author name string

Jennie M E Cederholm

series ordinal

1

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20 August 2017

29 April 2009

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European Biophysics Journal

20 August 2017

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20 August 2017

39

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20 August 2017

1

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20 August 2017

37-49

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https://scigraph.springernature.com/pub.10.1007/s00249-009-0452-y

20 August 2017

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cites work

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Transducing agonist binding to channel gating involves different interactions in 5-HT3 and GABAC receptors

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Nicotinic receptor interloop proline anchors beta1-beta2 and Cys loops in coupling agonist binding to channel gating

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Coupling of agonist binding to channel gating in the GABA(A) receptor

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The pre-M1 segment of the alpha1 subunit is a transduction element in the activation of the GABAA receptor

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Agonist-driven conformational changes in the inner beta-sheet of alpha7 nicotinic receptors

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Analysis of GLRA1 in hereditary and sporadic hyperekplexia: a novel mutation in a family cosegregating for hyperekplexia and spastic paraparesis

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Agonist binding site of Torpedo electric tissue nicotinic acetylcholine receptor. A negatively charged region of the delta subunit within 0.9 nm of the alpha subunit binding site disulfide

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Channel opening motion of alpha7 nicotinic acetylcholine receptor as suggested by normal mode analysis

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12 December 2020

Establishing an ion pair interaction in the homomeric rho1 gamma-aminobutyric acid type A receptor that contributes to the gating pathway.

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12 December 2020

Gating dynamics of the acetylcholine receptor extracellular domain.

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Modular design of Cys-loop ligand-gated ion channels: functional 5-HT3 and GABA rho1 receptors lacking the large cytoplasmic M3M4 loop

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Cis-trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel.

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12 December 2020

Charged residues in the alpha1 and beta2 pre-M1 regions involved in GABAA receptor activation.

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12 December 2020

Activation of the nicotinic acetylcholine receptor involves a switch in conformation of the alpha subunits.

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Mutations in the alpha 1 subunit of the inhibitory glycine receptor cause the dominant neurologic disorder, hyperekplexia

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Single-channel study of the spasmodic mutation alpha1A52S in recombinant rat glycine receptors

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12 December 2020

Normal-mode analysis of the glycine alpha1 receptor by three separate methods

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12 December 2020

Startle disease mutations reduce the agonist sensitivity of the human inhibitory glycine receptor

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12 December 2020

Structure and gating mechanism of the acetylcholine receptor pore

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12 December 2020

Gating of alpha3beta4 neuronal nicotinic receptor can be controlled by the loop M2-M3 of both alpha3 and beta4 subunits.

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12 December 2020

Dynamic modification of a mutant cytoplasmic cysteine residue modulates the conductance of the human 5-HT3A receptor

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12 December 2020

The extracellular linker of muscle acetylcholine receptor channels is a gating control element

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12 December 2020

Nanosecond-timescale conformational dynamics of the human alpha7 nicotinic acetylcholine receptor

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12 December 2020

Coarse-grained normal mode analysis in structural biology

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The role of tyrosine residues in the extracellular domain of the 5-hydroxytryptamine3 receptor.

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Identification of critical residues in loop E in the 5-HT3ASR binding site

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12 December 2020

Principal pathway coupling agonist binding to channel gating in nicotinic receptors

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12 December 2020

A cytoplasmic region determines single-channel conductance in 5-HT3 receptors

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12 December 2020

A unified view of the role of electrostatic interactions in modulating the gating of Cys loop receptors

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12 December 2020

A single residue in the M2-M3 loop is a major determinant of coupling between binding and gating in neuronal nicotinic receptors.

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12 December 2020

Mechanics of channel gating of the nicotinic acetylcholine receptor

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Properties of human glycine receptors containing the hyperekplexia mutation alpha1(K276E), expressed in Xenopus oocytes.

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Evaluation of a proposed mechanism of ligand-gated ion channel activation in the GABAA and glycine receptors

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Normal mode analysis suggests a quaternary twist model for the nicotinic receptor gating mechanism

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Mapping the conformational wave of acetylcholine receptor channel gating

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Characterization of the effects of charged residues in the intracellular loop on ion permeation in alpha1 glycine receptor channels.

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Role of charged residues in coupling ligand binding and channel activation in the extracellular domain of the glycine receptor.

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Mutations affecting the glycine receptor agonist transduction mechanism convert the competitive antagonist, picrotoxin, into an allosteric potentiator.

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Mutational analysis of familial and sporadic hyperekplexia

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Cys-loop receptors: new twists and turns

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A missense mutation in the gene encoding the alpha 1 subunit of the inhibitory glycine receptor in the spasmodic mouse

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12 December 2020

Acetylcholine receptor gating: movement in the alpha-subunit extracellular domain

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12 December 2020

A stepwise mechanism for acetylcholine receptor channel gating

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12 December 2020

A highly conserved aspartic acid residue in the signature disulfide loop of the alpha 1 subunit is a determinant of gating in the glycine receptor

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12 December 2020

Refined structure of the nicotinic acetylcholine receptor at 4A resolution

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12 December 2020

A conserved salt bridge critical for GABA(A) receptor function and loop C dynamics

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12 December 2020

Mutation of an arginine residue in the human glycine receptor transforms beta-alanine and taurine from agonists into competitive antagonists

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12 December 2020

An intersubunit hydrogen bond in the nicotinic acetylcholine receptor that contributes to channel gating.

1 reference

12 December 2020

Tyrosine residues that control binding and gating in the 5-hydroxytryptamine3 receptor revealed by unnatural amino acid mutagenesis.

1 reference

12 December 2020

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

1 reference

12 December 2020

Identification of domains influencing assembly and ion channel properties in alpha 7 nicotinic receptor and 5-HT3 receptor subunit chimaeras.

1 reference

12 December 2020

Initial coupling of binding to gating mediated by conserved residues in the muscle nicotinic receptor

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12 December 2020

Acetylcholine receptor gating at extracellular transmembrane domain interface: the cys-loop and M2-M3 linker

1 reference

12 December 2020

Improved gating of a chimeric alpha7-5HT3A receptor upon mutations at the M2-M3 extracellular loop

1 reference

12 December 2020

Common determinants of single channel conductance within the large cytoplasmic loop of 5-hydroxytryptamine type 3 and alpha4beta2 nicotinic acetylcholine receptors.

1 reference

12 December 2020

GABA(A) receptor M2-M3 loop secondary structure and changes in accessibility during channel gating.

1 reference

12 December 2020

A novel hyperekplexia-causing mutation in the pre-transmembrane segment 1 of the human glycine receptor alpha1 subunit reduces membrane expression and impairs gating by agonists.

1 reference

12 December 2020

X-ray structure of a prokaryotic pentameric ligand-gated ion channel

1 reference

12 December 2020

Arginine 222 in the pre-transmembrane domain 1 of 5-HT3A receptors links agonist binding to channel gating

1 reference

12 December 2020

Charged Residues in the β2 Subunit Involved in GABAA Receptor Activation

1 reference

12 December 2020

Identification of intracellular and extracellular domains mediating signal transduction in the inhibitory glycine receptor chloride channel

1 reference

12 December 2020

Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel

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12 December 2020

Inhibition mechanism of the acetylcholine receptor by alpha-neurotoxins as revealed by normal-mode dynamics

1 reference

12 December 2020

Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors

1 reference

12 December 2020

Roles for loop 2 residues of alpha1 glycine receptors in agonist activation.

1 reference

12 December 2020

10.1007/S00249-009-0452-Y

Identifiers

DOI

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20 August 2017

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PubMed ID

19404635