Tumour hypoxia causes DNA hypermethylation by reducing TET activity (Q37463942)

20 August 2017

Tumour hypoxia causes DNA hypermethylation by reducing TET activity (English)

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Flora D'Anna

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Massimiliano Mazzone

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Massimiliano Mazzone

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Mathew L Coleman

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Mathew Coleman

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Diether Lambrechts

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Diether Lambrechts

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Vessela N Kristensen

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Peter Carmeliet

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Frederic Amant

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Luc Schoonjans

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Anna Kuchnio

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Bram Boeckx

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Laurien Van Dyck

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Jessica Steinbacher

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Hui Zhao

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Athanasios Ploumakis

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Bart Ghesquière

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Els Hermans

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language of work or name

English

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publication date

17 August 2016

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describes a project that uses

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ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5133388/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/nature19081

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Tet-assisted bisulfite sequencing of 5-hydroxymethylcytosine.

23 August 2017

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Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

23 August 2017

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Quantitative sequencing of 5-methylcytosine and 5-hydroxymethylcytosine at single-base resolution

23 August 2017

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Methylome analysis using MeDIP-seq with low DNA concentrations

23 August 2017

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Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation

23 August 2017

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23 August 2017

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23 August 2017

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Boronate oxidation as a bioorthogonal reaction approach for studying the chemistry of hydrogen peroxide in living systems

23 August 2017

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Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA

23 August 2017

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Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine

23 August 2017

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23 August 2017

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TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity

23 August 2017

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Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

23 August 2017

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Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

23 August 2017

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Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis

23 August 2017

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Hypoxia-inducible factors and the response to hypoxic stress

23 August 2017

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Evolution in health and medicine Sackler colloquium: Stochastic epigenetic variation as a driving force of development, evolutionary adaptation, and disease

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Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

23 August 2017

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Hypoxia induces protection against etoposide-induced apoptosis: molecular profiling of changes in gene expression and transcription factor activity

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Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes

23 August 2017

1 reference

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The Cancer Cell Oxygen Sensor PHD2 Promotes Metastasis via Activation of Cancer-Associated Fibroblasts

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1 reference

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1 reference

Crossref

https://api.crossref.org/works/10.1038%2FNATURE19081

21 January 2018

Identifiers

DOI

10.1038/NATURE19081

1 reference

20 August 2017

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20 August 2017

PubMed publication ID

27533040

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