Pigment epithelium-derived factor maintains retinal pigment epithelium function by inhibiting vascular endothelial growth factor-R2 signaling through gamma-secretase (Q37431688)

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scientific article published on September 2009

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English	Pigment epithelium-derived factor maintains retinal pigment epithelium function by inhibiting vascular endothelial growth factor-R2 signaling through gamma-secretase	scientific article published on September 2009

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6 February 2020

Pigment epithelium-derived factor maintains retinal pigment epithelium function by inhibiting vascular endothelial growth factor-R2 signaling through gamma-secretase (English)

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6 February 2020

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Kumar Sambamurti

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6 February 2020

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Zsolt Ablonczy

1

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6 February 2020

Annamalai Prakasam

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6 February 2020

James Fant

3

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6 February 2020

Abdul Fauq

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6 February 2020

Craig Crosson

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1 September 2009

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6 February 2020

Journal of Biological Chemistry

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6 February 2020

284

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6 February 2020

30177-30186

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6 February 2020

Oxidative stress renders retinal pigment epithelial cells susceptible to complement-mediated injury.

1 reference

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VEGF-A stimulates ADAM17-dependent shedding of VEGFR2 and crosstalk between VEGFR2 and ERK signaling.

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Geranylgeranyl pyrophosphate stimulates gamma-secretase to increase the generation of Abeta and APP-CTFgamma.

1 reference

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Identification of a lipase-linked cell membrane receptor for pigment epithelium-derived factor

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Pigment epithelium-derived factor downregulates vascular endothelial growth factor (VEGF) expression and inhibits VEGF-VEGF receptor 2 binding in diabetic retinopathy

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Confluent monolayers of cultured human fetal retinal pigment epithelium exhibit morphology and physiology of native tissue.

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Vascular endothelial growth factor expression in the retinal pigment epithelium is essential for choriocapillaris development and visual function

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Is gamma-secretase a multienzyme complex for membrane protein degradation? Models and speculations

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Regulators of vascular permeability: potential sites for intervention in the treatment of macular edema

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PEDF: a pigment epithelium-derived factor with potent neuronal differentiative activity

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VEGF modulation of retinal pigment epithelium resistance

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Stimulation of apical and basolateral VEGF-A and VEGF-C secretion by oxidative stress in polarized retinal pigment epithelial cells.

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IGF-1-induced VEGF and IGFBP-3 secretion correlates with increased HIF-1 alpha expression and activity in retinal pigment epithelial cell line D407.

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based on heuristic

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Triple therapy for choroidal neovascularization due to age-related macular degeneration: verteporfin PDT, bevacizumab, and dexamethasone

1 reference

https://pubmed.ncbi.nlm.nih.gov/19723623

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M109.032391

1 reference

Europe PubMed Central

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6 February 2020

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Europe PubMed Central

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6 February 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19723623%20AND%20SRC:MED&resulttype=core&format=json

6 February 2020

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