Effects of tacrolimus (FK506) on human insulin gene expression, insulin mRNA levels, and insulin secretion in HIT-T15 cells (Q37362163)

19 August 2017

Effects of tacrolimus (FK506) on human insulin gene expression, insulin mRNA levels, and insulin secretion in HIT-T15 cells (English)

1 reference

19 August 2017

1 reference

J B Redmon

1

1 reference

19 August 2017

L K Olson

2

1 reference

19 August 2017

M B Armstrong

3

1 reference

19 August 2017

M J Greene

4

1 reference

19 August 2017

R P Robertson

5

1 reference

19 August 2017

language of work or name

English

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publication date

1 December 1996

1 reference

Journal of Clinical Investigation

19 August 2017

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19 August 2017

98

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19 August 2017

12

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19 August 2017

2786-2793

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Chronic exposure of HIT cells to high glucose concentrations paradoxically decreases insulin gene transcription and alters binding of insulin gene regulatory protein.

19 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507744

Posttransplant diabetes mellitus in African Americans after renal transplantation under FK 506 immunosuppression

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507744

Reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expression

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507744

Insulin synthesis in a clonal cell line of simian virus 40-transformed hamster pancreatic beta cells

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507744

Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507744

Structure and pancreatic expression of the insulin and glucagon genes

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507744

Metabolic control of insulin gene expression and biosynthesis

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507744

New onset of diabetes in FK 506 vs cyclosporine-treated kidney transplant recipients

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507744

Adverse effects associated with the use of FK 506

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507744

Kidney transplantation under FK 506 immunosuppression

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507744

Effect of the immunosuppressant FK506 on glucose-induced insulin secretion from adult rat islets of Langerhans

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507744

Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507744

Clinical trial of FK 506 immunosuppression in adult cardiac transplantation

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507744

Transcription of the insulin gene: towards defining the glucose-sensitive cis-element and trans-acting factors

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507744

FK506 and cyclosporin, molecular probes for studying intracellular signal transduction

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507744

Transcriptional inhibition of insulin by FK506 and possible involvement of FK506 binding protein-12 in pancreatic beta-cell.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507744

The reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to high glucose concentration is associated with the loss of RIPE3b1 and STF-1 transcription factor expression

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507744

Somatostatin inhibits insulin-gene expression through a posttranscriptional mechanism in a hamster islet cell line

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507744

Variable regulation by insulin of insulin gene expression in HIT-T15 cells

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507744

Regulation of human insulin gene transcription by glucose, epinephrine, and somatostatin.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507744

Inhibition of cAMP-responsive element-mediated gene transcription by cyclosporin A and FK506 after membrane depolarization

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507744

Insulin biosynthesis. I. On the mechanism of glucose stimulation.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507744

Regulation of insulin gene expression by dexamethasone, Ca2+ and a phorbol ester

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507744

Regulation of insulin gene expression by glucose and calcium in transfected primary islet cultures

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507744

Identification of the calmodulin-regulated protein phosphatase, calcineurin, in rat pancreatic islets

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507744

Effect of FK 506 on glucose metabolism and insulin secretion in normal rats

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507744

Glucose induces insulin gene transcription in a murine pancreatic beta-cell line

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507744

Somatostatin and Epinephrine Decrease Insulin Messenger Ribonucleic Acid in HIT Cells through a Pertussis Toxin-Sensitive Mechanism*

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507744

Specific disruption of renal function and gene transcription by cyclosporin A.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507744

G-proteins and hormonal inhibition of insulin secretion from HIT-T15 cells and isolated rat islets

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507744

FK-506- and CsA-sensitive activation of the interleukin-2 promoter by calcineurin

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507744

Galanin inhibits proinsulin gene expression stimulated by the insulinotropic hormone glucagon-like peptide-I(7-37) in mouse insulinoma beta TC-1 cells

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507744

Control of insulin gene expression by glucose

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=507744

Direct effect of glucose on the preproinsulin mRNA level in isolated pancreatic islets

26 June 2018

1 reference

12 December 2020

Control of insulin gene expression in pancreatic beta-cells and in an insulin-producing cell line, RIN-5F cells. I. Effects of glucose and cyclic AMP on the transcription of insulin mRNA

1 reference

12 December 2020

Control of insulin gene expression in pancreatic beta-cells and in an insulin-producing cell line, RIN-5F cells. II. Regulation of insulin mRNA stability

1 reference

12 December 2020

Novel immunosuppressive agent, FK506. In vitro effects on the cloned T cell activation

1 reference

12 December 2020

Sequences within the 5'-flanking region of the S14 gene confer responsiveness to glucose in primary hepatocytes

1 reference

12 December 2020

Inhibition of insulin release by FK 506 and its prevention by rioprostil, a stable prostaglandin E1 analogue

1 reference

12 December 2020

Effect of FK506 on insulin secretion in normal dogs

1 reference

12 December 2020

Morphological and functional changes of islets of Langerhans in FK506-treated rats

1 reference

12 December 2020

Metabolic effects of cyclosporin A and FK 506 in liver transplant recipients

1 reference

12 December 2020

Roles of calmodulin-dependent protein kinases and phosphatase in calcium-dependent transcription of immediate early genes

1 reference

12 December 2020

Inhibition of glucose-stimulated insulin release from beta TC3 cells and rodent islets by an analog of FK506

1 reference

12 December 2020

Calmodulin can modulate protein phosphorylation in rat liver cells nuclei

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI119105

1 reference

19 August 2017

1 reference

19 August 2017

1 reference