Human multiple myeloma cells are sensitized to topoisomerase II inhibitors by CRM1 inhibition (Q37347745)

19 August 2017

Human multiple myeloma cells are sensitized to topoisomerase II inhibitors by CRM1 inhibition (English)

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19 August 2017

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Joel G Turner

1

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19 August 2017

Douglas C Marchion

2

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19 August 2017

Jana L Dawson

3

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19 August 2017

Michael F Emmons

4

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19 August 2017

Lori A Hazlehurst

5

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19 August 2017

Peter Washausen

6

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19 August 2017

Daniel M Sullivan

7

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19 August 2017

language of work or name

English

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publication date

18 August 2009

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19 August 2017

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19 August 2017

69

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19 August 2017

17

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19 August 2017

6899-6905

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describes a project that uses

19 August 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2744372/fullTextXML

inferred from PubMed Central ID database lookup

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CRM1-mediated nuclear export of proteins and drug resistance in cancer

6 September 2017

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Controlling protein compartmentalization to overcome disease

6 September 2017

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Mechanisms of resistance to topoisomerase I-targeting drugs

6 September 2017

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The topoisomerase IIbeta circular clamp arrests transcription and signals a 26S proteasome pathway

6 September 2017

1 reference

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Regulation of tumor suppressors by nuclear-cytoplasmic shuttling

6 September 2017

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A masked NES in INI1/hSNF5 mediates hCRM1-dependent nuclear export: implications for tumorigenesis

6 September 2017

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Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN.

6 September 2017

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Localization of G-protein-coupled receptors in health and disease

6 September 2017

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6 September 2017

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The comet moment as a measure of DNA damage in the comet assay

6 September 2017

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Leptomycins A and B, new antifungal antibiotics. II. Structure elucidation

6 September 2017

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Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML.

6 September 2017

1 reference

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The FA/BRCA pathway is involved in melphalan-induced DNA interstrand cross-link repair and accounts for melphalan resistance in multiple myeloma cells

14 September 2017

1 reference

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Human topoisomerase IIalpha nuclear export is mediated by two CRM-1-dependent nuclear export signals

14 September 2017

1 reference

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Nuclear export of phosphorylated galectin-3 regulates its antiapoptotic activity in response to chemotherapeutic drugs.

14 September 2017

1 reference

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The cytoplasmic trafficking of DNA topoisomerase IIalpha correlates with etoposide resistance in human myeloma cells

14 September 2017

1 reference

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Bcr‐Abl upregulates cytosolic p21WAF‐1/CIP‐1 by a phosphoinositide‐3‐kinase (PI3K)‐independent pathway

14 September 2017

1 reference

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Multi parameter in vitro testing of ratjadone using flow cytometry

14 September 2017

1 reference

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Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis

14 September 2017

1 reference

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The dopamine D3 receptor interacts with itself and the truncated D3 splice variant d3nf: D3-D3nf interaction causes mislocalization of D3 receptors

14 September 2017

1 reference

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Drug resistance to DNA topoisomerase I and II inhibitors in human leukemia, lymphoma, and multiple myeloma

28 September 2017

1 reference

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Cell adhesion to fibronectin (CAM-DR) influences acquired mitoxantrone resistance in U937 cells

26 June 2018

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Ratjadone and leptomycin B block CRM1-dependent nuclear export by identical mechanisms.

2 September 2018

1 reference

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Ratjadones inhibit nuclear export by blocking CRM1/exportin 1.

2 September 2018

1 reference

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Reduction in drug-induced DNA double-strand breaks associated with beta1 integrin-mediated adhesion correlates with drug resistance in U937 cells

2 September 2018

1 reference

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Changes in subcellular distribution of topoisomerase IIalpha correlate with etoposide resistance in multicell spheroids and xenograft tumors.

2 September 2018

1 reference

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Purification and characterization of an altered topoisomerase II from a drug-resistant Chinese hamster ovary cell line.

2 September 2018

1 reference

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Cell density-dependent VP-16 sensitivity of leukaemic cells is accompanied by the translocation of topoisomerase IIalpha from the nucleus to the cytoplasm

2 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19690141

12 December 2020

inferred from PubMed ID database lookup

The chemistry and biology of ratjadone

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19690141

12 December 2020

inferred from PubMed ID database lookup

Cytoplasmic mislocalization of p27Kip1 protein is associated with constitutive phosphorylation of Akt or protein kinase B and poor prognosis in acute myelogenous leukemia

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19690141

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1158/0008-5472.CAN-09-0484

1 reference

release_662jtlehu5btbnd5empp54bryq

19 August 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/662jtlehu5btbnd5empp54bryq

24 November 2022

mapped directly with Wikidata item

1 reference

19 August 2017

PubMed publication ID

19690141

1 reference