Regulation of tumor suppressors by nuclear-cytoplasmic shuttling (Q35047240)

6 August 2017

title

Regulation of tumor suppressors by nuclear-cytoplasmic shuttling (English)

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6 August 2017

Megan Fabbro

1

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6 August 2017

Beric R Henderson

series ordinal

2

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6 August 2017

publication date

1 January 2003

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Experimental Cell Research

6 August 2017

language of work or name

English

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published in

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6 August 2017

volume

282

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6 August 2017

issue

2

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6 August 2017

page(s)

59-69

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publication type of scholarly work

6 August 2017

review article

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Nucleocytoplasmic transport: signals, mechanisms and regulation

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Transport into and out of the cell nucleus

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Nuclear import and export: transport factors, mechanisms and regulation

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Nuclear targeting signal recognition: a key control point in nuclear transport?

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Antioncogenes and human cancer

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The multistep nature of cancer

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Regulation of p53 function

7 January 2021

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Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion

7 January 2021

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Aberrant subcellular localization of BRCA1 in breast cancer

7 January 2021

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An important role for BRCA1 in breast cancer progression is indicated by its loss in a large proportion of non-familial breast cancers

7 January 2021

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Nuclear accumulation of p53 protein is mediated by several nuclear localization signals and plays a role in tumorigenesis

7 January 2021

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A short amino acid sequence able to specify nuclear location

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Nuclear targeting sequences — a consensus?

7 January 2021

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A bipartite nuclear localization signal is required for p53 nuclear import regulated by a carboxyl-terminal domain

7 January 2021

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Transport routes through the nuclear pore complex

7 January 2021

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The GTP-binding protein Ran/TC4 is required for protein import into the nucleus

7 January 2021

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Phosphorylation near nuclear localization signal regulates nuclear import of adenomatous polyposis coli protein

7 January 2021

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The nuclear localization sequences of the BRCA1 protein interact with the importin-alpha subunit of the nuclear transport signal receptor

7 January 2021

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Localization of BRCA1 and a splice variant identifies the nuclear localization signal

7 January 2021

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Nuclear import and export signals in control of the p53-related protein p73.

7 January 2021

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Nuclear/cytoplasmic localization of the von Hippel-Lindau tumor suppressor gene product is determined by cell density

7 January 2021

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Transforming growth factor beta-independent shuttling of Smad4 between the cytoplasm and nucleus.

7 January 2021

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ARM domain-dependent nuclear import of adenomatous polyposis coli protein is stimulated by the B56 alpha subunit of protein phosphatase 2A.

7 January 2021

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A repeating amino acid motif shared by proteins with diverse cellular roles

7 January 2021

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Nuclear localization signal-independent and importin/karyopherin-independent nuclear import of beta-catenin

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

BARD1 induces BRCA1 intranuclear foci formation by increasing RING-dependent BRCA1 nuclear import and inhibiting BRCA1 nuclear export

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

Identification of a RING protein that can interact in vivo with the BRCA1 gene product

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

Structure of a BRCA1-BARD1 heterodimeric RING-RING complex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

Protein sequence requirements for function of the human T-cell leukemia virus type 1 Rex nuclear export signal delineated by a novel in vivo randomization-selection assay

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

A comparison of the activity, sequence specificity, and CRM1-dependence of different nuclear export signals

7 January 2021

1 reference

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CRM1 is an export receptor for leucine-rich nuclear export signals

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

Evidence for a role of CRM1 in signal-mediated nuclear protein export

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

Exportin 1 (Crm1p) is an essential nuclear export factor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

CRM1 is responsible for intracellular transport mediated by the nuclear export signal

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNA

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

The K nuclear shuttling domain: a novel signal for nuclear import and nuclear export in the hnRNP K protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

HNS, a nuclear-cytoplasmic shuttling sequence in HuR

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

Calreticulin Is a receptor for nuclear export

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

Ran-mediated nuclear export of the von Hippel-Lindau tumor suppressor protein occurs independently of its assembly with cullin-2

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

NF-AT activation requires suppression of Crm1-dependent export by calcineurin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

The subcellular localization of PBX1 and EXD proteins depends on nuclear import and export signals and is modulated by association with PREP1 and HTH

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

Cytoplasmic dynein and dynactin in cell division and intracellular transport

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

WAF1, a potential mediator of p53 tumor suppression

7 January 2021

1 reference

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The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases

7 January 2021

1 reference

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Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

mdm2 expression is induced by wild type p53 activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

In search of the tumour-suppressor functions of BRCA1 and BRCA2

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

Functional communication between endogenous BRCA1 and its partner, BARD1, during Xenopus laevis development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

A masked NES in INI1/hSNF5 mediates hCRM1-dependent nuclear export: implications for tumorigenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

An intact HDM2 RING-finger domain is required for nuclear exclusion of p53.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

The MDM2 RING-finger domain is required to promote p53 nuclear export

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

Identification of p53 Sequence Elements That Are Required for MDM2-Mediated Nuclear Export

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

C-terminal ubiquitination of p53 contributes to nuclear export

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

Functional analysis and intracellular localization of p53 modified by SUMO-1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

ADP-ribosylation of p53 tumor suppressor protein: mutant but not wild-type p53 is modified

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

ADP-ribosylation of wild-type p53 in vitro: binding of p53 protein to specific p53 consensus sequence prevents its modification

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

Post-translational modifications and activation of p53 by genotoxic stresses

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

Nuclear and cytoplasmic localizations of the adenomatous polyposis coli protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

Nuclear-cytoplasmic shuttling of APC regulates beta-catenin subcellular localization and turnover

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

APC-mediated downregulation of beta-catenin activity involves nuclear sequestration and nuclear export

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

The APC tumour suppressor has a nuclear export function

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

Cell Density and Phosphorylation Control the Subcellular Localization of Adenomatous Polyposis Coli Protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

Adenomatous polyposis coli (APC) protein moves along microtubules and concentrates at their growing ends in epithelial cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

Negative cross-talk between p53 and the glucocorticoid receptor and its role in neuroblastoma cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

Identification of a Novel Cytoplasmic Protein That Specifically Binds to Nuclear Localization Signal Motifs

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

Cooperation of a Single Lysine Mutation and a C-terminal Domain in the Cytoplasmic Sequestration of the p53 Protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

The nuclear import of p53 is determined by the presence of a basic domain and its relative position to the nuclear localization signal

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

p76(MDM2) inhibits the ability of p90(MDM2) to destabilize p53.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

c-Abl regulates p53 levels under normal and stress conditions by preventing its nuclear export and ubiquitination

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

Nucleolar Arf sequesters Mdm2 and activates p53

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

RB regulates the stability and the apoptotic function of p53 via MDM2

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

Tumor suppressor protein VHL is induced at high cell density and mediates contact inhibition of cell growth

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

APC, signal transduction and genetic instability in colorectal cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by a breast cancer-derived mutation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

Autoubiquitination of the BRCA1*BARD1 RING ubiquitin ligase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

Identification of a functional nuclear export sequence in BRCA1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

Regulation of intracellular dynamics of Smad4 by its leucine-rich nuclear export signal

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

A transforming p53 mutant, which binds DNA, transactivates and induces apoptosis reveals a nuclear:cytoplasmic shuttling defect

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-4827%2802%2900019-8

10.1016/S0014-4827(02)00019-8

7 January 2021

Identifiers

DOI

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6 August 2017

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