Linking epithelial polarity and carcinogenesis by multitasking Helicobacter pylori virulence factor CagA. (Q37333631)

19 August 2017

1 reference

title

Linking epithelial polarity and carcinogenesis by multitasking Helicobacter pylori virulence factor CagA. (English)

1 reference

Helicobacter pylori infectious disease

19 August 2017

0 references

1 reference

1 reference

M Hatakeyama

1

1 reference

PubMed ID

19029944

19 August 2017

language of work or name

English

0 references

publication date

1 November 2008

1 reference

19 August 2017

1 reference

19 August 2017

27

1 reference

19 August 2017

7047-7054

1 reference

19 August 2017

55

1 reference

https://scigraph.springernature.com/pub.10.1038/onc.2008.353

19 August 2017

0 references

cites work

Analyses of the cag pathogenicity island of Helicobacter pylori

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Mouse model of Noonan syndrome reveals cell type- and gene dosage-dependent effects of Ptpn11 mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Helicobacter pylori CagA protein can be tyrosine phosphorylated in gastric epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Translocation of the Helicobacter pylori CagA protein in gastric epithelial cells by a type IV secretion apparatus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Helicobacter pylori CagA induces a transition from polarized to invasive phenotypes in MDCK cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

The signals and pathways activating cellular senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Stops along the RAS pathway in human genetic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Activating mutations of the noonan syndrome-associated SHP2/PTPN11 gene in human solid tumors and adult acute myelogenous leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Dare to be different: asymmetric cell division in Drosophila, C. elegans and vertebrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Differential expression of the human homologue of drosophila discs large oncosuppressor in histologic samples from human papillomavirus-associated lesions as a marker for progression to malignancy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Activation of beta-catenin by carcinogenic Helicobacter pylori

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Oncogenic human papillomavirus E6 proteins target the discs large tumour suppressor for proteasome-mediated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

E-cadherin germline mutations in familial gastric cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Oncogenic mechanisms of the Helicobacter pylori CagA protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

SagA of CagA in Helicobacter pylori pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

A serine/threonine kinase gene defective in Peutz-Jeghers syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Helicobacter pylori CagA induces Ras-independent morphogenetic response through SHP-2 recruitment and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

EPIYA motif is a membrane-targeting signal of Helicobacter pylori virulence factor CagA in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Atypical PKC phosphorylates PAR-1 kinases to regulate localization and activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Helicobacter pylori and atrophic gastritis: importance of the cagA status

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Expression of Dickkopf genes is strongly reduced in malignant melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Deregulation of beta-catenin signal by Helicobacter pylori CagA requires the CagA-multimerization sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Helicobacter exploits integrin for type IV secretion and kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Parsing the polarity code

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

The role of Shp2 (PTPN11) in cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Helicobacter pylori CagA interacts with E-cadherin and deregulates the beta-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Protein kinase Ciota is required for Ras transformation and colon carcinogenesis in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Influence of EPIYA-repeat polymorphism on the phosphorylation-dependent biological activity of Helicobacter pylori CagA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Human scribble (Vartul) is targeted for ubiquitin-mediated degradation by the high-risk papillomavirus E6 proteins and the E6AP ubiquitin-protein ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Analysis of the expression and localisation of a LAP protein, human scribble, in the normal and neoplastic epithelium of uterine cervix

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

A Genetic Screen in Drosophila for Metastatic Behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Structure of the catalytic and ubiquitin-associated domains of the protein kinase MARK/Par-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Cancer burden in the year 2000. The global picture

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Helicobacter pylori infection and the risk of gastric carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Helicobacter pylori and gastrointestinal tract adenocarcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Phosphorylation of Helicobacter pylori CagA by c-Abl leads to cell motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Cellular senescence in vivo: a barrier to tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Atypical protein kinase C iota is an oncogene in human non-small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Helicobacter pylori cag-type IV secretion system facilitates corpus colonization to induce precancerous conditions in Mongolian gerbils

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Helicobacter pylori CagA targets PAR1/MARK kinase to disrupt epithelial cell polarity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Altered states: involvement of phosphorylated CagA in the induction of host cellular growth changes by Helicobacter pylori

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Colorectal cancer and genetic alterations in the Wnt pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Src is the kinase of the Helicobacter pylori CagA protein in vitro and in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

c-Src/Lyn kinases activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Tyrosine phosphorylation of the Helicobacter pylori CagA antigen after cag-driven host cell translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

The PAR-aPKC system: lessons in polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Tax oncoprotein of HTLV-1 binds to the human homologue of Drosophila discs large tumor suppressor protein, hDLG, and perturbs its function in cell growth control

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Activation of Abl by Helicobacter pylori: a novel kinase for CagA and crucial mediator of host cell scattering

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Epithelial cell polarity and cell junctions in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Focal adhesion kinase is a substrate and downstream effector of SHP-2 complexed with Helicobacter pylori CagA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Helicobacter pylori infection and the development of gastric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Analysis of detergent-resistant membranes of Helicobacter pylori infected gastric adenocarcinoma cells reveals a role for MARK2/Par1b in CagA-mediated disruption of cellular polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Identification of genes required for cytoplasmic localization in early C. elegans embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Expression of Hugl-1 is strongly reduced in malignant melanoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Helicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

Structural basis and functional consequence of Helicobacter pylori CagA multimerization in cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2008.353

31 March 2020

Identifiers

DOI

10.1038/ONC.2008.353

1 reference

19 August 2017

1 reference

PubMed ID

19029944