Accelerated ageing: from mechanism to therapy through animal models (Q37328057)

19 August 2017

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title

Accelerated ageing: from mechanism to therapy through animal models (English)

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19 August 2017

3

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19 August 2017

Alvaro J Obaya

2

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author name string

Fernando G Osorio

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1

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PubMed ID

19015945

19 August 2017

José M P Freije

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4

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PubMed ID

19015945

19 August 2017

language of work or name

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18 November 2008

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19 August 2017

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19 August 2017

18

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19 August 2017

1

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19 August 2017

7-15

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https://scigraph.springernature.com/pub.10.1007/s11248-008-9226-z

19 August 2017

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cites work

From immature lamin to premature aging: molecular pathways and therapeutic opportunities.

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https://api.crossref.org/works/10.1007%2FS11248-008-9226-Z

Microcephalia with mandibular and dental dysplasia in adult Zmpste24-deficient mice.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11248-008-9226-Z

Hutchinson-Gilford progeria syndrome: review of the phenotype.

21 January 2018

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Identification of a human cDNA encoding a novel protein structurally related to the yeast membrane-associated metalloprotease, Ste24p

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11248-008-9226-Z

Autophagy and aging: new lessons from progeroid mice

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11248-008-9226-Z

Treatment with a farnesyltransferase inhibitor improves survival in mice with a Hutchinson-Gilford progeria syndrome mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11248-008-9226-Z

DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A.

21 January 2018

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12 December 2020

Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development

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12 December 2020

Lamin a truncation in Hutchinson-Gilford progeria.

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12 December 2020

Identification, functional expression and enzymic analysis of two distinct CaaX proteases from Caenorhabditis elegans.

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12 December 2020

Puzzles, promises and a cure for ageing

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Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

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Loss of ZMPSTE24 (FACE-1) causes autosomal recessive restrictive dermopathy and accumulation of Lamin A precursors.

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12 December 2020

Human progeroid syndromes, aging and cancer: new genetic and epigenetic insights into old questions

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12 December 2020

Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.

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12 December 2020

Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome

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12 December 2020

Phenotype and course of Hutchinson-Gilford progeria syndrome

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12 December 2020

A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation.

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12 December 2020

Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome

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12 December 2020

Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome

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12 December 2020

A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria.

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12 December 2020

Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated.

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12 December 2020

Genomic instability in laminopathy-based premature aging

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12 December 2020

Stem cells, ageing and the quest for immortality.

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Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging.

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12 December 2020

Incomplete processing of mutant lamin A in Hutchinson-Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition

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12 December 2020

From old organisms to new molecules: integrative biology and therapeutic targets in accelerated human ageing.

1 reference

12 December 2020

Inhibiting farnesylation reverses the nuclear morphology defect in a HeLa cell model for Hutchinson-Gilford progeria syndrome

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12 December 2020

Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes

1 reference

12 December 2020

Lamin A/C is a risk biomarker in colorectal cancer

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12 December 2020

Positional cloning of the Werner's syndrome gene

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12 December 2020

Prelamin A and lamin A appear to be dispensable in the nuclear lamina

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12 December 2020

Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing

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12 December 2020

Essential role of limiting telomeres in the pathogenesis of Werner syndrome

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Progressive vascular smooth muscle cell defects in a mouse model of Hutchinson-Gilford progeria syndrome

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12 December 2020

Premature aging in mice activates a systemic metabolic response involving autophagy induction.

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12 December 2020

Mutations in the WRN gene in mice accelerate mortality in a p53-null background

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12 December 2020

A newly identified splice site mutation in ZMPSTE24 causes restrictive dermopathy in the Middle East

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12 December 2020

Compound heterozygous ZMPSTE24 mutations reduce prelamin A processing and result in a severe progeroid phenotype

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12 December 2020

Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice.

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12 December 2020

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12 December 2020

Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice

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12 December 2020

Epidermal expression of the truncated prelamin A causing Hutchinson-Gilford progeria syndrome: effects on keratinocytes, hair and skin

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12 December 2020

Understanding the odd science of aging

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12 December 2020

Nuclear envelope defects cause stem cell dysfunction in premature-aging mice

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12 December 2020

Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation.

1 reference

12 December 2020

Targeted transgenic expression of the mutation causing Hutchinson-Gilford progeria syndrome leads to proliferative and degenerative epidermal disease

1 reference

12 December 2020

Prelamin A farnesylation and progeroid syndromes

1 reference

12 December 2020

Lamin A-dependent nuclear defects in human aging

1 reference

12 December 2020

Dual roles for Ste24p in yeast a-factor maturation: NH2-terminal proteolysis and COOH-terminal CAAX processing

1 reference

12 December 2020

K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

1 reference

12 December 2020

Increasing the length of progerin's isoprenyl anchor does not worsen bone disease or survival in mice with Hutchinson-Gilford progeria syndrome

1 reference

12 December 2020

Reversible phenotype in a mouse model of Hutchinson-Gilford progeria syndrome

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12 December 2020

WRN at telomeres: implications for aging and cancer

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12 December 2020

Identification and chromosomal location of two human genes encoding enzymes potentially involved in proteolytic maturation of farnesylated proteins

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12 December 2020

Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect.

1 reference

12 December 2020

Zinc metalloproteinase, ZMPSTE24, is mutated in mandibuloacral dysplasia

1 reference

12 December 2020

10.1007/S11248-008-9226-Z

Identifiers

DOI

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19 August 2017

1 reference

PubMed ID

19015945