The immunopathology of thymic GVHD. (Q37313942)

19 August 2017

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title

The immunopathology of thymic GVHD. (English)

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19 August 2017

Werner Krenger

1

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19 August 2017

Georg A Holländer

series ordinal

2

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19 August 2017

language of work or name

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31 October 2008

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Seminars in Immunopathology

19 August 2017

published in

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19 August 2017

volume

30

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19 August 2017

issue

4

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19 August 2017

page(s)

439-456

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https://scigraph.springernature.com/pub.10.1007/s00281-008-0131-6

19 August 2017

exact match

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cites work

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A central role for central tolerance

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Absence of regulatory T-cell control of TH1 and TH17 cells is responsible for the autoimmune-mediated pathology in chronic graft-versus-host disease

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Distinct contributions of CD4(+) and CD8(+) naive and memory T-cell subsets to overall T-cell-receptor repertoire complexity following transplantation of T-cell-depleted CD34-selected hematopoietic progenitor cells from unrelated donors.

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Polarized type 2 alloreactive CD4+ and CD8+ donor T cells fail to induce experimental acute graft-versus-host disease

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Evidence for thymic function in the elderly

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Management of acute graft-versus-host disease

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Regulation of thymic epithelium by keratinocyte growth factor

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Graft-versus-host disease and the Th1/Th2 paradigm

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Circulating T cell repertoire complexity in normal individuals and bone marrow recipients analyzed by CDR3 size spectratyping. Correlation with immune status.

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Review of 54 patients with complete DiGeorge anomaly enrolled in protocols for thymus transplantation: outcome of 44 consecutive transplants

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12 December 2020

Graft-versus-host-disease-associated thymic damage results in the appearance of T cell clones with anti-host reactivity

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Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation

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Thymic selection and thymic major histocompatibility complex class II expression are abnormal in mice undergoing graft-versus-host reactions

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Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration

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Abnormal CD4:CD8 ratios and delayed germinal center reconstitution in lymph nodes of human graft recipients with graft-versus-host disease (GVHD): an immunohistological study

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Current status of haploidentical stem cell transplantation

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12 December 2020

Self-reactive T cells selected on thymic cortical epithelium are polyclonal and are pathogenic in vivo.

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12 December 2020

The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments

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12 December 2020

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12 December 2020

Cell expansion and growth arrest phases during the transition from precursor (CD4-8-) to immature (CD4+8+) thymocytes in normal and genetically modified mice

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12 December 2020

Cellular and molecular events during early thymus development

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12 December 2020

IL-12 stimulates the development of acute graft-versus-host disease in mice that normally would develop chronic, autoimmune graft-versus-host disease

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12 December 2020

Patterns of T-cell reconstitution by assessment of T-cell receptor excision circle and T-cell receptor clonal repertoire after allogeneic hematopoietic stem cell transplantation in leukemia patients--a study in Chinese patients

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12 December 2020

Rapid immune reconstitution after a reduced-intensity conditioning regimen and a CD3-depleted haploidentical stem cell graft for paediatric refractory haematological malignancies

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12 December 2020

Graft-versus-host reactions: clues to the etiopathology of a spectrum of immunological diseases

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12 December 2020

Evaluation of thymopoiesis using T cell receptor excision circles (TRECs): differential correlation between adult and pediatric TRECs and naïve phenotypes

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12 December 2020

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12 December 2020

Stimulation of mature unprimed CD8+ T cells by semiprofessional antigen-presenting cells in vivo

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12 December 2020

T cell subsets in the thymus of graft-versus-host immunosuppressed mice. Sensitivity of the L3T4+Lyt-2- subset to cortisone.

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12 December 2020

Positive selection of T lymphocytes on fibroblasts

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12 December 2020

T cell receptor diversity in severe combined immunodeficiency following HLA-haploidentical bone marrow transplantation.

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

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12 December 2020

Androgen receptors in thymic epithelium modulate thymus size and thymocyte development

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12 December 2020

Keratinocyte growth factor augments immune reconstitution after autologous hematopoietic progenitor cell transplantation in rhesus macaques

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12 December 2020

Factors influencing T-lymphopoiesis after allogeneic hematopoietic cell transplantation

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12 December 2020

A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3.

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12 December 2020

T cell repertoire development in humans with SCID after nonablative allogeneic marrow transplantation

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12 December 2020

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12 December 2020

Crosstalk in the mouse thymus

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12 December 2020

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12 December 2020

Recipient CD4+ T cells that survive irradiation regulate chronic graft-versus-host disease

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12 December 2020

Emergent autoimmunity in graft-versus-host disease

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12 December 2020

Role of cytotoxic T lymphocytes in the prevention of lupus-like disease occurring in a murine model of graft-vs-host disease

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12 December 2020

Reentry of T cells to the adult thymus is restricted to activated T cells

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12 December 2020

Prognostic value of pretransplantation host thymic function in HLA-identical sibling hematopoietic stem cell transplantation

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12 December 2020

Palifermin (Kepivance) for the treatment of oral mucositis in patients with hematologic malignancies requiring hematopoietic stem cell support

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12 December 2020

Effect of HIV on thymic function before and after antiretroviral therapy in children

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12 December 2020

Complete sequential regeneration of graft-vs.-host-induced severely dysplastic thymuses. Implications for the pathogenesis of chronic graft-vs.-host disease

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12 December 2020

Thymic T cell export is not influenced by the peripheral T cell pool.

1 reference

12 December 2020

Apoptosis of thymocytes during acute graft-versus-host disease is independent of glucocorticoids

1 reference

12 December 2020

Differential cytokine production associated with distinct phases of murine graft-versus-host reaction

1 reference

12 December 2020

The development of mouse APECED models provides new insight into the role of AIRE in immune regulation

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12 December 2020

The contribution of the thymus to immune reconstitution after hematopoietic stem-cell transplantation

1 reference

12 December 2020

Thymocyte-thymocyte interaction for efficient positive selection and maturation of CD4 T cells.

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12 December 2020

Prediction of T-cell reconstitution by assessment of T-cell receptor excision circle before allogeneic hematopoietic stem cell transplantation in pediatric patients.

1 reference

12 December 2020

Thymic microenvironments, 3-D versus 2-D?

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12 December 2020

Both activated and nonactivated leukocytes from the periphery continuously enter the thymic medulla of adult rats: phenotypes, sources and magnitude of traffic

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12 December 2020

Development of the thymus requires signaling through the fibroblast growth factor receptor R2-IIIb

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12 December 2020

CD4+ T cells generated de novo from donor hemopoietic stem cells mediate the evolution from acute to chronic graft-versus-host disease

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12 December 2020

Efficient T cell repertoire selection in tetraparental chimeric mice independent of thymic epithelial MHC

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12 December 2020

The effect of thymic function on immunocompetence following bone marrow transplantation.

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12 December 2020

Critical role of interleukin-2 in the development of acute graft-versus-host disease.

1 reference

12 December 2020

Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells

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12 December 2020

Thymic involution in murine graft-versus-host reaction. Epithelial injury mimicking human thymic dysplasia

1 reference

12 December 2020

Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex

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12 December 2020

T-Cell immune reconstitution in pediatric leukemia patients after allogeneic bone marrow transplantation with T-cell-depleted or unmanipulated grafts: evaluation of overall and antigen-specific T-cell repertoires

1 reference

12 December 2020

Defective thymic education of L3T4+ T helper cell function in graft-vs-host mice

1 reference

12 December 2020

A Unique Thymic Fibroblast Population Revealed by the Monoclonal Antibody MTS-15

1 reference

12 December 2020

Early reconstitution of the T-cell repertoire after non-myeloablative peripheral blood stem cell transplantation is from post-thymic T-cell expansion and is unaffected by graft-versus-host disease or mixed chimaerism

1 reference

12 December 2020

Effective donor lymphohematopoietic reconstitution after haploidentical CD34+-selected hematopoietic stem cell transplantation in children with refractory severe aplastic anemia

1 reference

12 December 2020

The role of endogenous glucocorticoids on host T cell populations in the peripheral lymphoid organs of mice with graft-versus-host disease

1 reference

12 December 2020

T-cell regeneration: all repertoires are not created equal

1 reference

12 December 2020

Evidence for adequate thymic function but impaired naive T-cell survival following allogeneic hematopoietic stem cell transplantation in the absence of chronic graft-versus-host disease

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12 December 2020

Immunological reconstitution after hematopoietic cell transplantation - its relation to the contents of the graft

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12 December 2020

Nonmyeloablative allogeneic hematopoietic stem cell transplant using mismatched/haploidentical donors: a review

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12 December 2020

Immune restoration following hematopoietic stem cell transplantation: an evolving target

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12 December 2020

Effects of castration on thymocyte development in two different models of thymic involution

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12 December 2020

National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and staging working group report

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12 December 2020

The cellular mechanism of Aire control of T cell tolerance.

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12 December 2020

T cell contact with Ia antigens on nonhemopoietic cells in vivo can lead to immunity rather than tolerance

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12 December 2020

Insights into thymic aging and regeneration

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12 December 2020

Reconstitution of the T-cell compartment after bone marrow transplantation: restoration of the repertoire by thymic emigrants.

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12 December 2020

Interferon-gamma suppresses T-cell proliferation to mitogen via the nitric oxide pathway during experimental acute graft-versus-host disease

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12 December 2020

Age-dependent incidence, time course, and consequences of thymic renewal in adults

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12 December 2020

Immunological lessons learnt from patients transplanted with fully mismatched stem cells

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12 December 2020

Pathways of T-cell regeneration in mice and humans: implications for bone marrow transplantation and immunotherapy

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12 December 2020

Repopulation of the mouse thymus after sublethal fission neutron irradiation. I. Sequential appearance of thymocyte subpopulations

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12 December 2020

Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire

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12 December 2020

Bone marrow transplantation and approaches to avoid graft-versus-host disease (GVHD).

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12 December 2020

Immune reconstitution: from stem cells to lymphocytes

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12 December 2020

Effect of Highly Active Antiretroviral Therapy and Thymic Transplantation on Immunoreconstitution in HIV Infection

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12 December 2020

Longitudinal monitoring of immune reconstitution by CDR3 size spectratyping after T-cell-depleted allogeneic bone marrow transplant and the effect of donor lymphocyte infusions on T-cell repertoire.

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12 December 2020

Thymic emigration: conveyor belts or lucky dips?

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12 December 2020

Phase 1/2 randomized, placebo-control trial of palifermin to prevent graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT).

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12 December 2020

Keratinocyte growth factor is required for hair development but not for wound healing

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12 December 2020

Cytotoxic effects of irradiation and deoxyguanosine on fetal thymus

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12 December 2020

Changes in the human thymus during aging

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12 December 2020

Mechanisms of suppression by suppressor T cells

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12 December 2020

Direct evidence for new T-cell generation by patients after either T-cell-depleted or unmodified allogeneic hematopoietic stem cell transplantations

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12 December 2020

Immune reconstitution after allogeneic marrow transplantation compared with blood stem cell transplantation

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12 December 2020

Hematopoietic growth factors including keratinocyte growth factor in allogeneic and autologous stem cell transplantation

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12 December 2020

Impact of niche aging on thymic regeneration and immune reconstitution.

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12 December 2020

Immunobiology of acute graft-versus-host disease

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12 December 2020

Assessment of thymic output in adults after haematopoietic stem-cell transplantation and prediction of T-cell reconstitution

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12 December 2020

Evolutionary comparison of murine and human delta T-cell receptor deleting elements

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12 December 2020

Thymic involution mimicking thymic dysplasia: a consequence of transfusion-induced graft versus host disease in a premature infant

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12 December 2020

T-cell receptor excision circles: a novel prognostic parameter for the outcome of transplantation in multiple myeloma patients

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12 December 2020

Projection of an immunological self shadow within the thymus by the aire protein

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12 December 2020

Thymus: a direct target tissue in graft-versus-host reaction after allogeneic bone marrow transplantation that results in abrogation of induction of self-tolerance

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12 December 2020

Fibroblast growth factor receptor 2-IIIb acts upstream of Shh and Fgf4 and is required for limb bud maintenance but not for the induction of Fgf8, Fgf10, Msx1, or Bmp4.

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12 December 2020

A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression.

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12 December 2020

Keratinocyte growth factor and androgen blockade work in concert to protect against conditioning regimen-induced thymic epithelial damage and enhance T-cell reconstitution after murine bone marrow transplantation

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12 December 2020

Myasthenia gravis in association with allogeneic bone marrow transplantation: clinical observations, therapeutic implications and review of literature

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12 December 2020

Sustained thymopoiesis and improvement in functional immunity induced by exogenous KGF administration in murine models of aging

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12 December 2020

Essential role of the thymus to reconstitute naive (CD45RA+) T-helper cells after human allogeneic bone marrow transplantation

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12 December 2020

Protection from thymic epithelial cell injury by keratinocyte growth factor: a new approach to improve thymic and peripheral T-cell reconstitution after bone marrow transplantation

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12 December 2020

Immune reconstitution following haematopoietic stem cell transplantation

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12 December 2020

Requirement of residual thymus to restore normal T-cell subsets after human allogeneic bone marrow transplantation

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12 December 2020

Formation of a functional thymus initiated by a postnatal epithelial progenitor cell.

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12 December 2020

Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels

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12 December 2020

Recovery of immune reactivity after T-cell-depleted bone marrow transplantation depends on thymic activity

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12 December 2020

The quantitative assessment of MHC II on thymic epithelium: implications in cortical thymocyte development.

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12 December 2020

Clonal analysis reveals a common progenitor for thymic cortical and medullary epithelium

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12 December 2020

Keratinocyte growth factor preserves normal thymopoiesis and thymic microenvironment during experimental graft-versus-host disease

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12 December 2020

T-cell immunodeficiency following cytotoxic antineoplastic therapy: a review

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12 December 2020

Anti-TGF-beta treatment prevents skin and lung fibrosis in murine sclerodermatous graft-versus-host disease: a model for human scleroderma

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Control of lymphocyte recirculation in man. I. Differential regulation of the peripheral lymph node homing receptor L-selectin on T cells during the virgin to memory cell transition.

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12 December 2020

The clinical spectrum of acute graft-versus-host disease

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12 December 2020

Gene dosage--limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity.

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12 December 2020

Endocrine involvement in minor (non-H-2) graft versus host reaction in mice: dissociated effect on corticosterone and aldosterone plasma levels

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12 December 2020

Novel strategies for the treatment and diagnosis of graft-versus-host-disease

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12 December 2020

Generation of functional thymocytes in the human adult.

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12 December 2020

Successful formation of a chimeric human thymus allograft following transplantation of cultured postnatal human thymus

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12 December 2020

Strategies to enhance T-cell reconstitution in immunocompromised patients

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12 December 2020

T cell functional defect associated with thymid epithelial cell injury induced by a graft-versus-host reaction

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12 December 2020

Thymus medulla consisting of epithelial islets each derived from a single progenitor

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12 December 2020

Thymic atrophy in murine acute graft-versus-host disease is effected by impaired cell cycle progression of host pro-T and pre-T cells.

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12 December 2020

Factors affecting reconstitution of the T cell compartment in allogeneic haematopoietic cell transplant recipients.

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12 December 2020

Molecular characterization of the mouse involuted thymus: aberrations in expression of transcription regulators in thymocyte and epithelial compartments

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12 December 2020

Donor T-cell alloreactivity against host thymic epithelium limits T-cell development after bone marrow transplantation

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12 December 2020

Results of the EBMT activity survey 2005 on haematopoietic stem cell transplantation: focus on increasing use of unrelated donors

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12 December 2020

Thymic output generates a new and diverse TCR repertoire after autologous stem cell transplantation in multiple sclerosis patients.

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12 December 2020

Immunobiology of allogeneic hematopoietic stem cell transplantation

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12 December 2020

Reconstitution of adaptive and innate immunity following allogeneic hematopoietic stem cell transplantation in humans

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12 December 2020

The thymus in patients with allogeneic bone marrow transplants

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12 December 2020

Haploidentical haematopoietic stem cell transplantation for acute leukaemia in adults: experience in Europe and the United States.

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12 December 2020

Comparison of immune reconstitution after unrelated and related T-cell-depleted bone marrow transplantation: effect of patient age and donor leukocyte infusions

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12 December 2020

T-cell receptor excision circle and T-cell dynamics after allogeneic stem cell transplantation are related to clinical events

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12 December 2020

Cytokine cascades in acute graft-versus-host disease

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12 December 2020

The thymus in GVHD pathophysiology

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12 December 2020

Reconstruction of the immune system after unrelated or partially matched T-cell-depleted bone marrow transplantation in children: immunophenotypic analysis and factors affecting the speed of recovery

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12 December 2020

A broad T-cell repertoire diversity and an efficient thymic function indicate a favorable long-term immune reconstitution after cord blood stem cell transplantation

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12 December 2020

Donor-derived thymic-dependent T cells cause chronic graft-versus-host disease

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12 December 2020

The effect of graft-versus-host disease on T cell production and homeostasis

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12 December 2020

Evidence for extrathymic generation of intermediate T cell receptor cells in the liver revealed in thymectomized, irradiated mice subjected to bone marrow transplantation

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12 December 2020

Enhancing T cell reconstitution after hematopoietic stem cell transplantation: a brief update of the latest trends

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12 December 2020

Generating intrathymic microenvironments to establish T-cell tolerance.

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12 December 2020

Thymic epithelial injury in graft-versus-host reactions following adrenalectomy

1 reference

12 December 2020

Exclusion of circulating T cells from the thymus does not apply in the neonatal period

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12 December 2020

Leukocyte migration and graft-versus-host disease

1 reference

12 December 2020

T cell immune reconstitution following lymphodepletion.

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12 December 2020

Autoimmunity following haematopoietic stem-cell transplantation

1 reference

12 December 2020

T-cell regeneration after bone marrow transplantation: differential CD45 isoform expression on thymic-derived versus thymic-independent progeny.

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12 December 2020

Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells.

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12 December 2020

Thymic Involution with Loss of Hassall's Corpuscles Mimicking Thymic Dysplasia in a Child with Transfusion-Associated Graft-Versus-Host Disease

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12 December 2020

Long-term follow-up in patients with severe combined immunodeficiency treated by bone marrow transplantation

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12 December 2020

Loss of normal thymic repertoire selection and persistence of autoreactive T cells in graft vs host disease.

1 reference

12 December 2020

The effect of graded doses of fission neutrons or X rays on the stromal compartment of the thymus in mice

1 reference

12 December 2020

The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection

1 reference

12 December 2020

Late infections after allogeneic bone marrow transplantations: comparison of incidence in related and unrelated donor transplant recipients.

1 reference

12 December 2020

Development of the dendritic cell system during mouse ontogeny

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12 December 2020

Long-term immune reconstitution and outcome after HLA-nonidentical T-cell-depleted bone marrow transplantation for severe combined immunodeficiency: a European retrospective study of 116 patients.

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12 December 2020

T-cell receptor Vbeta repertoire after myeloablative and reduced intensity conditioning allogeneic haematopoietic stem cell transplantation

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12 December 2020

Thymic generation and regeneration

1 reference

12 December 2020

Rare peripheral T cells migrate to and persist in normal mouse thymus

1 reference

12 December 2020

10.1007/S00281-008-0131-6

Identifiers

DOI

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19 August 2017

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