Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells (Q37305230)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24162018%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

title

Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells (English)

1 reference

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28 February 2020

1 reference

2

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28 February 2020

Claudia R Ball

14

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28 February 2020

Michael Boutros

17

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28 February 2020

author name string

Oksana Voloshanenko

1

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28 February 2020

Taronish D Dubash

3

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28 February 2020

Iris Augustin

4

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28 February 2020

Marie Metzig

5

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28 February 2020

Giusi Moffa

6

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28 February 2020

Christian Hundsrucker

7

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28 February 2020

Grainne Kerr

8

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28 February 2020

Thomas Sandmann

9

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28 February 2020

Benedikt Anchang

10

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28 February 2020

Kubilay Demir

11

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28 February 2020

Christina Boehm

12

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28 February 2020

Svenja Leible

13

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28 February 2020

Hanno Glimm

15

1 reference

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28 February 2020

Rainer Spang

16

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28 February 2020

language of work or name

English

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publication date

1 January 2013

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28 February 2020

published in

Nature Communications

1 reference

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28 February 2020

volume

4

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28 February 2020

page(s)

2610

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Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

28 February 2020

copyright license

start time

28 October 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

exact match

https://scigraph.springernature.com/pub.10.1038/ncomms3610

0 references

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6 September 2017

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Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

6 September 2017

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6 September 2017

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6 September 2017

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APC mutations in colorectal tumours from FAP patients are selected for CtBP-mediated oligomerization of truncated APC.

6 September 2017

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Inactivation of promoter 1B of APC causes partial gene silencing: evidence for a significant role of the promoter in regulation and causative of familial adenomatous polyposis.

6 September 2017

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Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells

6 September 2017

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Deconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling

6 September 2017

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The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse

6 September 2017

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Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts

6 September 2017

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Wnt activity defines colon cancer stem cells and is regulated by the microenvironment

6 September 2017

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Lentiviral vectors to probe and manipulate the Wnt signaling pathway

6 September 2017

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Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

6 September 2017

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Colonic crypt organization and tumorigenesis

6 September 2017

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Wnt signalling and its impact on development and cancer

6 September 2017

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The retromer complex influences Wnt secretion by recycling wntless from endosomes to the trans-Golgi network

6 September 2017

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The genomic landscapes of human breast and colorectal cancers

6 September 2017

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Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis

6 September 2017

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Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion

6 September 2017

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Secretion of Wnt ligands requires Evi, a conserved transmembrane protein

6 September 2017

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Wntless, a conserved membrane protein dedicated to the secretion of Wnt proteins from signaling cells

6 September 2017

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A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation

6 September 2017

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Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction

6 September 2017

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Wnt signalling in stem cells and cancer

6 September 2017

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The Wnt signaling pathway in development and disease

6 September 2017

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APC dosage effects in tumorigenesis and stem cell differentiation

6 September 2017

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Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration

6 September 2017

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Epigenetic inactivation of SFRP genes allows constitutive WNT signaling in colorectal cancer

6 September 2017

1 reference

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The Wnt antagonist sFRP1 in colorectal tumorigenesis

6 September 2017

1 reference

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APC, signal transduction and genetic instability in colorectal cancer

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3826636

Disease model: familial adenomatous polyposis

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3826636

Overexpression of beta-catenin induces apoptosis independent of its transactivation function with LEF-1 or the involvement of major G1 cell cycle regulators

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3826636

Apc1638T: a mouse model delineating critical domains of the adenomatous polyposis coli protein involved in tumorigenesis and development

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3826636

Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3826636

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3826636

Contribution of the 15 amino acid repeats of truncated APC to beta-catenin degradation and selection of APC mutations in colorectal tumours from FAP patients

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3826636

APC is essential for targeting phosphorylated beta-catenin to the SCFbeta-TrCP ubiquitin ligase.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3826636

Dickkopf-4 is frequently down-regulated and inhibits growth of colorectal cancer cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3826636

Truncated APC regulates the transcriptional activity of beta-catenin in a cell cycle dependent manner

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3826636

Apc modulates embryonic stem-cell differentiation by controlling the dosage of beta-catenin signaling

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3826636

Regulation of S33/S37 phosphorylated beta-catenin in normal and transformed cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3826636

The APC gene product associates with microtubules in vivo and promotes their assembly in vitro.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3826636

Patterning and nuclear beta-catenin expression in the colonic adenoma-carcinoma sequence. Analogies with embryonic gastrulation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3826636

Loss of beta-catenin regulation by the APC tumor suppressor protein correlates with loss of structure due to common somatic mutations of the gene

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3826636

Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3826636

Redundant sources of Wnt regulate intestinal stem cells and promote formation of Paneth cells.

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3826636

Smed-Evi/Wntless is required for beta-catenin-dependent and -independent processes during planarian regeneration.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3826636

The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3826636

Expression of nuclear beta-catenin and c-myc is correlated with tumor size but not with proliferative activity of colorectal adenomas

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3826636

Distinct types of tumor-initiating cells form human colon cancer tumors and metastases

2 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24162018

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Heterogeneous expression of Wnt/beta-catenin target genes within colorectal cancer

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24162018

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NCOMMS3610

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24162018%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24162018%20AND%20SRC:MED&resulttype=core&format=json

28 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24162018%20AND%20SRC:MED&resulttype=core&format=json