Initial testing of the investigational NEDD8-activating enzyme inhibitor MLN4924 by the pediatric preclinical testing program. (Q37295143)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22012946%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

title

Initial testing of the investigational NEDD8-activating enzyme inhibitor MLN4924 by the pediatric preclinical testing program (English)

1 reference

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14 January 2020

3

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14 January 2020

Richard B Lock

5

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14 January 2020

C P Reynolds

8

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14 January 2020

Min H Kang

9

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14

Peter J Houghton

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14 January 2020

2

John M Maris

1 reference

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14 January 2020

1

Malcolm A Smith

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14 January 2020

4

E Anders Kolb

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14 January 2020

7

Stephen T Keir

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14 January 2020

6

Hernan Carol

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14 January 2020

author name string

Christopher L Morton

10

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14 January 2020

Jianrong Wu

11

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14 January 2020

Peter G Smith

12

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14 January 2020

Jie Yu

13

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14 January 2020

language of work or name

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19 October 2011

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14 January 2020

published in

Pediatric Blood Cancer

1 reference

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14 January 2020

volume

59

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14 January 2020

page(s)

246-253

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14 January 2020

issue

2

1 reference

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NEDD8-targeting drug MLN4924 elicits DNA rereplication by stabilizing Cdt1 in S phase, triggering checkpoint activation, apoptosis, and senescence in cancer cells

14 January 2020

cites work

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Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ

6 September 2017

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Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma

6 September 2017

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TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas

6 September 2017

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An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

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Inhibition of NEDD8-activating enzyme induces rereplication and apoptosis in human tumor cells consistent with deregulating CDT1 turnover

6 September 2017

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Inhibition of NEDD8-activating enzyme: a novel approach for the treatment of acute myeloid leukemia.

14 September 2017

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Constitutive NF-kappaB activity regulates the expression of VEGF and IL-8 and tumor angiogenesis of human glioblastoma.

14 September 2017

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Oncogenic CARD11 mutations in human diffuse large B cell lymphoma

14 September 2017

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Expression of the constitutively activated RelA/NF-kappaB in human astrocytic tumors and the in vitro implication in the regulation of urokinase-type plasminogen activator, migration, and invasion

14 September 2017

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Initial testing (stage 1) of the proteasome inhibitor bortezomib by the pediatric preclinical testing program.

14 September 2017

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A fluorescence microplate cytotoxicity assay with a 4-log dynamic range that identifies synergistic drug combinations

14 September 2017

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Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia.

14 September 2017

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Evaluation of the antitumor efficacy, pharmacokinetics, and pharmacodynamics of the histone deacetylase inhibitor depsipeptide in childhood cancer models in vivo

14 September 2017

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In vivo evaluation of ixabepilone (BMS247550), a novel epothilone B derivative, against pediatric cancer models

14 September 2017

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Characterization of childhood acute lymphoblastic leukemia xenograft models for the preclinical evaluation of new therapies

14 September 2017

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Experimental chemotherapy of human medulloblastoma cell lines and transplantable xenografts with bifunctional alkylating agents

14 September 2017

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MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-{kappa}B-dependent lymphoma

15 July 2018

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Expression of nuclear factor-kappaB in human astrocytomas: relation to pI kappa Ba, vascular endothelial growth factor, Cox-2, microvascular characteristics, and survival.

3 September 2018

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The pediatric preclinical testing program: description of models and early testing results.

3 September 2018

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Analysis of the activation status of Akt, NFkappaB, and Stat3 in human diffuse gliomas

3 September 2018

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Primary mediastinal large B-cell lymphoma with sclerosis in pediatric and adolescent patients: treatment and results from three therapeutic studies of the Berlin-Frankfurt-Münster Group

3 September 2018

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3 September 2018

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Nuclear factor-κB activation and differential expression of survivin and Bcl-2 in human grade 2-4 astrocytomas

3 September 2018

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Crossref

https://api.crossref.org/works/10.1002%2FPBC.23357

Guidelines for accurate EC50/IC50 estimation

21 January 2018

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PubMed

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inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1002/PBC.23357

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22012946%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22012946%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

1 reference