Sirtuins--novel therapeutic targets to treat age-associated diseases (Q37283448)

19 August 2017

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title

Sirtuins--novel therapeutic targets to treat age-associated diseases (English)

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19 August 2017

Siva Lavu

1

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19 August 2017

Olivier Boss

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2

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19 August 2017

Peter J Elliott

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3

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19 August 2017

Philip D Lambert

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4

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19 August 2017

1 October 2008

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Nature Reviews Drug Discovery

19 August 2017

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19 August 2017

7

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19 August 2017

841-853

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19 August 2017

10

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https://scigraph.springernature.com/pub.10.1038/nrd2665

19 August 2017

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cites work

Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae

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Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins

31 March 2020

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Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

31 March 2020

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Glucose tolerance and skeletal muscle gene expression in response to alternate day fasting

31 March 2020

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Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS.

31 March 2020

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Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

31 March 2020

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SIRT1 transgenic mice show phenotypes resembling calorie restriction

31 March 2020

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SirT1 regulates energy metabolism and response to caloric restriction in mice

31 March 2020

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SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}

31 March 2020

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Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1

31 March 2020

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Isoflavones promote mitochondrial biogenesis.

31 March 2020

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Mitochondrial dysfunction in the elderly: possible role in insulin resistance

31 March 2020

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Mitochondrial dysfunction is a common phenotype in aging and cancer

31 March 2020

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Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans

31 March 2020

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Caloric restriction protects mitochondrial function with aging in skeletal and cardiac muscles

31 March 2020

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Long-term caloric restriction ameliorates the decline in diastolic function in humans.

31 March 2020

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Calorie restriction improves cardiovascular risk factors via reduction of mitochondrial reactive oxygen species in type II diabetic rats

31 March 2020

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Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

31 March 2020

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Resveratrol improves health and survival of mice on a high-calorie diet

31 March 2020

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Resveratrol, a polyphenolic phytostilbene, inhibits endothelial monocyte chemotactic protein-1 synthesis and secretion.

31 March 2020

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Resveratrol: preventing properties against vascular alterations and ageing

31 March 2020

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Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

31 March 2020

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Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides.

31 March 2020

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Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

31 March 2020

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SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents

31 March 2020

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Effects of p-nonylphenol and resveratrol on body and organ weight and in vivo fertility of outbred CD-1 mice

31 March 2020

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Resveratrol stimulates AMP kinase activity in neurons

31 March 2020

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Effects of long-term treatment with resveratrol and subcutaneous and oral estradiol administration on pituitary function in rats.

31 March 2020

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Resveratrol acts as a mixed agonist/antagonist for estrogen receptors alpha and beta

31 March 2020

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SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells

31 March 2020

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Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase

31 March 2020

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The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases

31 March 2020

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Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

31 March 2020

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A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family.

31 March 2020

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hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

31 March 2020

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Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose

31 March 2020

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Calorie restriction increases muscle mitochondrial biogenesis in healthy humans

31 March 2020

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Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt

31 March 2020

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The NAD biosynthesis pathway mediated by nicotinamide phosphoribosyltransferase regulates Sir2 activity in mammalian cells

31 March 2020

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Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

31 March 2020

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Negative control of p53 by Sir2alpha promotes cell survival under stress

31 March 2020

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Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase

31 March 2020

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SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation

31 March 2020

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The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase

31 March 2020

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SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction

31 March 2020

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Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases

31 March 2020

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Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2

31 March 2020

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Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase

31 March 2020

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Structure of the histone deacetylase SIRT2

31 March 2020

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Structural basis of inhibition of the human NAD+-dependent deacetylase SIRT5 by suramin

31 March 2020

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Genomic instability and aging-like phenotype in the absence of mammalian SIRT6

31 March 2020

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SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

31 March 2020

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Regulation of SIRT6 protein levels by nutrient availability

31 March 2020

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Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription

31 March 2020

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Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice

31 March 2020

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Sirt1 regulates aging and resistance to oxidative stress in the heart

31 March 2020

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Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

31 March 2020

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SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis

31 March 2020

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Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation

31 March 2020

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The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis

31 March 2020

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Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease

31 March 2020

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Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons.

31 March 2020

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Lack of serotonin1B receptor expression leads to age-related motor dysfunction, early onset of brain molecular aging and reduced longevity

31 March 2020

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Sirtuin functions in health and disease

31 March 2020

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SIRT1 and endocrine signaling

31 March 2020

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SIRT1 deacetylates and positively regulates the nuclear receptor LXR

31 March 2020

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Energy sensing and regulation of gene expression in skeletal muscle

31 March 2020

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Sirt1 protects against high-fat diet-induced metabolic damage

31 March 2020

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Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span

31 March 2020

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Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice.

31 March 2020

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Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells

31 March 2020

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The direct involvement of SirT1 in insulin-induced insulin receptor substrate-2 tyrosine phosphorylation

31 March 2020

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Resveratrol inhibits insulin responses in a SirT1-independent pathway

31 March 2020

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Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes

31 March 2020

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Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2.

31 March 2020

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Anti-inflammatory effect of resveratrol on TNF-alpha-induced MCP-1 expression in adipocytes

31 March 2020

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Resveratrol inhibits expression and binding activity of the monocyte chemotactic protein-1 receptor, CCR2, on THP-1 monocytes.

31 March 2020

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Inflammation, stress, and diabetes

31 March 2020

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Effect of resveratrol, a polyphenolic phytoalexin, on thermal hyperalgesia in a mouse model of diabetic neuropathic pain

31 March 2020

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Intermittent fasting prevents the progression of type I diabetic nephropathy in rats and changes the expression of Sir2 and p53.

31 March 2020

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Fidarestat improves cardiomyocyte contractile function in db/db diabetic obese mice through a histone deacetylase Sir2-dependent mechanism.

31 March 2020

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Deletions of muscle mitochondrial DNA in patients with mitochondrial myopathies

31 March 2020

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Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy

31 March 2020

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Mitochondrial dysfunction and neuromuscular disease

31 March 2020

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Mitochondrial DNA mutations in diseases of energy metabolism

31 March 2020

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A mutation in the tRNA(Leu)(UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies.

31 March 2020

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A point mutation in the mitochondrial tRNA(Leu)(UUR) gene in MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes).

31 March 2020

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Mouse models of mitochondrial disease, oxidative stress, and senescence.

31 March 2020

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How is mitochondrial biogenesis affected in mitochondrial disease?

31 March 2020

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31 March 2020

Mitochondrial myopathies

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Mitochondrial diseases: therapeutic approaches

31 March 2020

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Exercise and training in mitochondrial myopathies

31 March 2020

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Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres

31 March 2020

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Resveratrol in cardioprotection: a therapeutic promise of alternative medicine

31 March 2020

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Vascular dysfunction in aging: potential effects of resveratrol, an anti-inflammatory phytoestrogen

31 March 2020

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SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase

31 March 2020

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Potassium channels-mediated vasorelaxation of rat aorta induced by resveratrol

31 March 2020

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Resveratrol inhibits aggregation of platelets from high-risk cardiac patients with aspirin resistance

31 March 2020

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Resveratrol, a natural ingredient of grape skin: antiarrhythmic efficacy and ionic mechanisms.

31 March 2020

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Silibinin protects against isoproterenol-induced rat cardiac myocyte injury through mitochondrial pathway after up-regulation of SIRT1

31 March 2020

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Inhibition of the activity of human lymphocyte Kv1.3 potassium channels by resveratrol

31 March 2020

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Transcriptional coactivator PGC-1 alpha controls the energy state and contractile function of cardiac muscle.

31 March 2020

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Histone H2A.z is essential for cardiac myocyte hypertrophy but opposed by silent information regulator 2alpha.

31 March 2020

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SIRT1 gene, age-related diseases, and mortality: the Leiden 85-plus study.

31 March 2020

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SIRT1 controls endothelial angiogenic functions during vascular growth

31 March 2020

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Forkhead class O transcription factor 3a activation and Sirtuin1 overexpression in the hypertrophied myocardium of the diabetic Goto-Kakizaki rat.

31 March 2020

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Silent information regulator 2alpha, a longevity factor and class III histone deacetylase, is an essential endogenous apoptosis inhibitor in cardiac myocytes

31 March 2020

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Sir-viving cardiac stress: cardioprotection mediated by a longevity gene

31 March 2020

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Statin and resveratrol in combination induces cardioprotection against myocardial infarction in hypercholesterolemic rat

31 March 2020

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Poly(ADP-ribose) polymerase-1-deficient mice are protected from angiotensin II-induced cardiac hypertrophy

31 March 2020

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Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2alpha deacetylase activity

31 March 2020

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Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease

31 March 2020

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Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man

31 March 2020

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Modulation of sirtuins: new targets for antiageing.

31 March 2020

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Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction

31 March 2020

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SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling

31 March 2020

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Resveratrol protects against neurotoxicity induced by kainic acid

31 March 2020

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Incidence of dementia and Alzheimer disease in 2 communities: Yoruba residing in Ibadan, Nigeria, and African Americans residing in Indianapolis, Indiana

31 March 2020

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Caloric intake and the risk of Alzheimer disease.

31 March 2020

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Gene-diet interactions in brain aging and neurodegenerative disorders

31 March 2020

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Caloric restriction attenuates Abeta-deposition in Alzheimer transgenic models

31 March 2020

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A local mechanism mediates NAD-dependent protection of axon degeneration

31 March 2020

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Comparative analysis of the effects of resveratrol in two apoptotic models: inhibition of complex I and potassium deprivation in cerebellar neurons.

31 March 2020

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Antioxidant compounds protect dopamine neurons from death due to oxidative stress in vitro

31 March 2020

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SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons

31 March 2020

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Peripheral neuropathy is an early complication of type 2 diabetes in adolescence

31 March 2020

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Axon pathology in neurological disease: a neglected therapeutic target

31 March 2020

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Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration

31 March 2020

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Retinal ganglion cell loss induced by acute optic neuritis in a relapsing model of multiple sclerosis

31 March 2020

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SIRT1 activation confers neuroprotection in experimental optic neuritis

31 March 2020

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Interaction of aging-associated signaling cascades: inhibition of NF-kappaB signaling by longevity factors FoxOs and SIRT1.

31 March 2020

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Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor kappaB-mediated transcription

31 March 2020

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Effect of cis-resveratrol on genes involved in nuclear factor kappa B signaling

31 March 2020

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Resveratrol (trans-3,5,4'-trihydroxystilbene) ameliorates experimental allergic encephalomyelitis, primarily via induction of apoptosis in T cells involving activation of aryl hydrocarbon receptor and estrogen receptor

31 March 2020

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SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease.

31 March 2020

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Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophages

31 March 2020

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Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging

31 March 2020

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Inhibition of SIRT1 reactivates silenced cancer genes without loss of promoter DNA hypermethylation

31 March 2020

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The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth

31 March 2020

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Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses

31 March 2020

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Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis

31 March 2020

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SIRT1 interacts with p73 and suppresses p73-dependent transcriptional activity

31 March 2020

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Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle

31 March 2020

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Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene

31 March 2020

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Cytogenetics and Molecular Genetics of Malignant Gliomas and Medulloblastoma

31 March 2020

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Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling

31 March 2020

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SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress

31 March 2020

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SirT1 fails to affect p53-mediated biological functions

31 March 2020

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Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage

31 March 2020

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Function of the SIRT1 protein deacetylase in cancer

31 March 2020

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Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins

31 March 2020

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SIRT1 acts as a nutrient-sensitive growth suppressor and its loss is associated with increased AMPK and telomerase activity

31 March 2020

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Overview of caloric restriction and ageing

31 March 2020

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Unlocking the secrets of longevity genes

31 March 2020

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Increase in activity during calorie restriction requires Sirt1

31 March 2020

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SIRT6 in DNA repair, metabolism and ageing

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRD2665

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19 August 2017

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