Synergistic apoptotic response between valproic acid and fludarabine in chronic lymphocytic leukaemia (CLL) cells involves the lysosomal protease cathepsin B (Q37275725)

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scientific article published on 18 October 2013

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English	Synergistic apoptotic response between valproic acid and fludarabine in chronic lymphocytic leukaemia (CLL) cells involves the lysosomal protease cathepsin B	scientific article published on 18 October 2013

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scholarly article

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28 February 2020

Synergistic apoptotic response between valproic acid and fludarabine in chronic lymphocytic leukaemia (CLL) cells involves the lysosomal protease cathepsin B (English)

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28 February 2020

apoptotic process

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1 reference

based on heuristic

inferred from title

chronic lymphocytic leukemia

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based on heuristic

inferred from title

Spencer B. Gibson

8

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28 February 2020

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J-Y Yoon

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28 February 2020

D Szwajcer

2

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28 February 2020

G Ishdorj

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28 February 2020

P Benjaminson

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28 February 2020

W Xiao

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28 February 2020

R Kumar

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28 February 2020

J B Johnston

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28 February 2020

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18 October 2013

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28 February 2020

Blood Cancer Journal

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28 February 2020

3

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28 February 2020

e153

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28 February 2020

Lysosomes and lysosomal cathepsins in cell death

1 reference

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6 September 2017

TOSO, the Fcmicro receptor, is highly expressed on chronic lymphocytic leukemia B cells, internalizes upon IgM binding, shuttles to the lysosome, and is downregulated in response to TLR activation

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Fc gamma receptor IIb on target B cells promotes rituximab internalization and reduces clinical efficacy.

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6 September 2017

Kinetics of the cell biological changes occurring in the progression of DNA damage-induced senescence

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Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

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6 September 2017

Fludarabine, cyclophosphamide, and rituximab chemoimmunotherapy is highly effective treatment for relapsed patients with CLL.

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Ubiquitin: Same Molecule, Different Degradation Pathways

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Influence of bone marrow stromal microenvironment on forodesine-induced responses in CLL primary cells

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6 September 2017

Direct measurement of cathepsin B activity in the cytosol of apoptotic cells by an activity-based probe

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6 September 2017

Phase II study of the histone deacetylase inhibitor MGCD0103 in patients with previously treated chronic lymphocytic leukaemia

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6 September 2017

Treatment of fludarabine-refractory chronic lymphocytic leukemia

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6 September 2017

Lysosomal membrane permeabilization in cell death

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6 September 2017

Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines

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6 September 2017

Valproic acid sensitizes chronic lymphocytic leukemia cells to apoptosis and restores the balance between pro- and antiapoptotic proteins

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6 September 2017

Analysis of apoptosis by propidium iodide staining and flow cytometry

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6 September 2017

Protein turnover via autophagy: implications for metabolism

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6 September 2017

How I treat refractory CLL.

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6 September 2017

Many cuts to ruin: a comprehensive update of caspase substrates

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6 September 2017

Pharmacological and therapeutic properties of valproate: a summary after 35 years of clinical experience

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6 September 2017

Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

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6 September 2017

Lysosomal cysteine proteases: facts and opportunities

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6 September 2017

Cathepsin B contributes to TNF-alpha-mediated hepatocyte apoptosis by promoting mitochondrial release of cytochrome c

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6 September 2017

National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment

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6 September 2017

Potentiation of apoptosis by histone deacetylase inhibitors and doxorubicin combination: cytoplasmic cathepsin B as a mediator of apoptosis in multiple myeloma

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14 September 2017

Necroptosis, necrosis and secondary necrosis converge on similar cellular disintegration features.

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14 September 2017

Apoptosis induced by histone deacetylase inhibitors in leukemic cells is mediated by Bim and Noxa.

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14 September 2017

PS-341 (bortezomib) induces lysosomal cathepsin B release and a caspase-2-dependent mitochondrial permeabilization and apoptosis in human pancreatic cancer cells

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14 September 2017

Caspase- and mitochondrial dysfunction-dependent mechanisms of lysosomal leakage and cathepsin B activation in DNA damage-induced apoptosis.

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14 September 2017

Tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin B-dependent mechanism.

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14 September 2017

Histone deacetylase inhibitors potentiate TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in lymphoid malignancies.

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14 September 2017

Lysosomal Acid Hydrolases in Isolated Normal and Chronic Lymphocytic Leukemia (CLL) T- and B-Lymphocytes

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Doxorubicin-induced cell death requires cathepsin B in HeLa cells

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Inhibition of histone deacetylase activity by valproic acid blocks adipogenesis

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26 June 2018

Sulforaphane induces cytotoxicity and lysosome- and mitochondria-dependent cell death in colon cancer cells with deleted p53.

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3 September 2018

Stat3 controls lysosomal-mediated cell death in vivo

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3 September 2018

The histone deacetylase inhibitor MGCD0103 induces apoptosis in B-cell chronic lymphocytic leukemia cells through a mitochondria-mediated caspase activation cascade.

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3 September 2018

Antileukemic activity of valproic acid in chronic lymphocytic leukemia B cells defined by microarray analysis

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3 September 2018

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Results of first salvage therapy for patients refractory to a fludarabine regimen in chronic lymphocytic leukemia

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CD40 stimulation sensitizes CLL cells to lysosomal cell death induction by type II anti-CD20 mAb GA101

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12 December 2020

based on heuristic

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Valproic acid induces apoptosis in chronic lymphocytic leukemia cells through activation of the death receptor pathway and potentiates TRAIL response

1 reference

https://pubmed.ncbi.nlm.nih.gov/24141622

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activity and isoenzymes of acid phosphatase in human B-cell lymphomas of low-grade malignancy: a novel aid in the classification of malignant lymphoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/24141622

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oral valproic acid for epilepsy--long-term experience in therapy and side effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/24141622

12 December 2020

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10.1038/BCJ.2013.50

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28 February 2020

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28 February 2020

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28 February 2020

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