Many cuts to ruin: a comprehensive update of caspase substrates (Q35091412)

6 August 2017

2 references

3 October 2022

Many cuts to ruin: a comprehensive update of caspase substrates (English)

1 reference

6 August 2017

Fischer U

1

1 reference

PubMed ID

12655297

6 August 2017

Jänicke RU

series ordinal

2

1 reference

PubMed ID

12655297

6 August 2017

Schulze-Osthoff K

series ordinal

3

1 reference

6 August 2017

1 January 2003

2 references

Cell Death & Differentiation

6 August 2017

3 October 2022

2 references

6 August 2017

3 October 2022

10

1 reference

6 August 2017

76-100

1 reference

6 August 2017

1

1 reference

https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401160

6 August 2017

0 references

cites work

B cell receptor cross-linking prevents Fas-induced cell death by inactivating the IL-1 beta-converting enzyme protease and regulating Bcl-2/Bcl-x expression

1 reference

12 December 2020

Cleavage of the Bloom's syndrome gene product during apoptosis by caspase-3 results in an impaired interaction with topoisomerase IIIalpha

1 reference

12 December 2020

Proteolytic cleavage of ras GTPase-activating protein during apoptosis

1 reference

12 December 2020

Caspase-mediated cleavage of the TIAM1 guanine nucleotide exchange factor during apoptosis

1 reference

12 December 2020

Activation of the Drosophila NF-kappaB factor Relish by rapid endoproteolytic cleavage

1 reference

12 December 2020

Identification of the MDM2 oncoprotein as a substrate for CPP32-like apoptotic proteases

1 reference

12 December 2020

Physiological and pathological caspase cleavage of the neuronal RasGEF GRASP-1 as detected using a cleavage site-specific antibody

1 reference

12 December 2020

Distinct cleavage products of nuclear proteins in apoptosis and necrosis revealed by autoantibody probes

1 reference

12 December 2020

A caspase cleavage fragment of p115 induces fragmentation of the Golgi apparatus and apoptosis

1 reference

12 December 2020

Proteolytic cleavage and activation of protein kinase C [micro] by caspase-3 in the apoptotic response of cells to 1-beta -D-arabinofuranosylcytosine and other genotoxic agents

1 reference

12 December 2020

Caspase-mediated fragmentation of calpain inhibitor protein calpastatin during apoptosis

1 reference

12 December 2020

The 72-kDa component of signal recognition particle is cleaved during apoptosis

1 reference

12 December 2020

The La (SS-B) autoantigen, a key protein in RNA biogenesis, is dephosphorylated and cleaved early during apoptosis

1 reference

12 December 2020

Caspase-dependent activation of cyclin-dependent kinases during Fas-induced apoptosis in Jurkat cells

1 reference

12 December 2020

Caspase activation is required for terminal erythroid differentiation

1 reference

12 December 2020

Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme

1 reference

12 December 2020

Tau cleavage and dephosphorylation in cerebellar granule neurons undergoing apoptosis

1 reference

12 December 2020

Caspase-3 mediated cleavage of BRCA1 during UV-induced apoptosis.

1 reference

12 December 2020

The development-associated cleavage of lens connexin 45.6 by caspase-3-like protease is regulated by casein kinase II-mediated phosphorylation

1 reference

12 December 2020

Identification of NRF2, a member of the NF-E2 family of transcription factors, as a substrate for caspase-3(-like) proteases

1 reference

12 December 2020

p28 Bap31, a Bcl-2/Bcl-XL- and procaspase-8-associated protein in the endoplasmic reticulum

1 reference

12 December 2020

Active caspase-8 translocates into the nucleus of apoptotic cells to inactivate poly(ADP-ribose) polymerase-2

1 reference

12 December 2020

Cleavage of actin by interleukin 1 beta-converting enzyme to reverse DNase I inhibition

1 reference

12 December 2020

Cleavage and shedding of E-cadherin after induction of apoptosis

1 reference

12 December 2020

Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity

1 reference

12 December 2020

Plasma membrane Ca2+ATPase isoform 4b is cleaved and activated by caspase-3 during the early phase of apoptosis.

1 reference

12 December 2020

A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes

1 reference

12 December 2020

The fate of U1 snRNP during anti-Fas induced apoptosis: specific cleavage of the U1 snRNA molecule

1 reference

12 December 2020

Cleavage of CDK inhibitor p21(Cip1/Waf1) by caspases is an early event during DNA damage-induced apoptosis.

1 reference

12 December 2020

Cdc42 is a substrate for caspases and influences Fas-induced apoptosis

1 reference

12 December 2020

Proteolytic cleavage of the mdm2 oncoprotein during apoptosis

1 reference

12 December 2020

Non-erythroid alpha-spectrin breakdown by calpain and interleukin 1 beta-converting-enzyme-like protease(s) in apoptotic cells: contributory roles of both protease families in neuronal apoptosis

1 reference

12 December 2020

Phosphatidylserine externalization during CD95-induced apoptosis of cells and cytoplasts requires ICE/CED-3 protease activity

1 reference

12 December 2020

Baculovirus apoptotic suppressor P49 is a substrate inhibitor of initiator caspases resistant to P35 in vivo

1 reference

12 December 2020

Limited caspase cleavage of human BAP31.

1 reference

12 December 2020

Activation of atypical protein kinase C zeta by caspase processing and degradation by the ubiquitin-proteasome system

1 reference

12 December 2020

Proteolytic activation of PKN by caspase-3 or related protease during apoptosis

1 reference

12 December 2020

Caspase-dependent cleavage of ErbB-2 by geldanamycin and staurosporin

1 reference

12 December 2020

The RET proto-oncogene induces apoptosis: a novel mechanism for Hirschsprung disease

1 reference

12 December 2020

Caspase 7-induced cleavage of kinectin in apoptotic cells

1 reference

12 December 2020

D4-GDI, a substrate of CPP32, is proteolyzed during Fas-induced apoptosis

1 reference

12 December 2020

Phosphorylation of bid by casein kinases I and II regulates its cleavage by caspase 8.

1 reference

12 December 2020

Caspase-dependent proteolysis of integral and peripheral proteins of nuclear membranes and nuclear pore complex proteins during apoptosis

1 reference

12 December 2020

Caspase-mediated cleavage of adenovirus early region 1A proteins

1 reference

12 December 2020

Identification of keratins 18, 19 and heat-shock protein 90 beta as candidate substrates of proteolysis during ionizing radiation-induced apoptosis of estrogen-receptor negative breast tumor cells

1 reference

12 December 2020

Caspase-dependent N-terminal cleavage of influenza virus nucleocapsid protein in infected cells.

1 reference

12 December 2020

Fas-induced arachidonic acid release is mediated by Ca2+-independent phospholipase A2 but not cytosolic phospholipase A2, which undergoes proteolytic inactivation

1 reference

12 December 2020

The regulation of anoikis: MEKK-1 activation requires cleavage by caspases

1 reference

12 December 2020

Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract

1 reference

12 December 2020

Spodoptera frugiperda caspase-1, a novel insect death protease that cleaves the nuclear immunophilin FKBP46, is the target of the baculovirus antiapoptotic protein p35.

1 reference

12 December 2020

Cleavage of the Serum Response Factor during Death Receptor-induced Apoptosis Results in an Inhibition of the c-FOSPromoter Transcriptional Activity

1 reference

12 December 2020

Cleavage of focal adhesion kinase by caspases during apoptosis

1 reference

12 December 2020

The Caenorhabditis elegans sex determination protein FEM-1 is a CED-3 substrate that associates with CED-4 and mediates apoptosis in mammalian cells.

1 reference

12 December 2020

Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing

1 reference

12 December 2020

Caspase-mediated parkin cleavage in apoptotic cell death.

1 reference

12 December 2020

Identification of caspase 3-mediated cleavage and functional alteration of eukaryotic initiation factor 2alpha in apoptosis

1 reference

12 December 2020

Disruption of focal adhesions mediates detachment during neuronal apoptosis

1 reference

12 December 2020

Transcription factor AP-2alpha is preferentially cleaved by caspase 6 and degraded by proteasome during tumor necrosis factor alpha-induced apoptosis in breast cancer cells

1 reference

12 December 2020

Presenilins are processed by caspase-type proteases.

1 reference

12 December 2020

MEK kinase 1, a substrate for DEVD-directed caspases, is involved in genotoxin-induced apoptosis

1 reference

12 December 2020

Nuclear changes in necrotic HL-60 cells.

1 reference

12 December 2020

Caspase-mediated calcineurin activation contributes to IL-2 release during T cell activation.

1 reference

12 December 2020

DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis

1 reference

12 December 2020

Predominant identification of RNA-binding proteins in Fas-induced apoptosis by proteome analysis

1 reference

12 December 2020

The large subunit of the DNA replication complex C (DSEB/RF-C140) cleaved and inactivated by caspase-3 (CPP32/YAMA) during Fas-induced apoptosis

1 reference

12 December 2020

Caspase activation is required for T cell proliferation

1 reference

12 December 2020

Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis

1 reference

12 December 2020

Activation of pro-caspase-7 by serine proteases includes a non-canonical specificity

1 reference

12 December 2020

Apoptotic cleavage of cytoplasmic dynein intermediate chain and p150(Glued) stops dynein-dependent membrane motility.

1 reference

12 December 2020

Identification of AHNAK as a novel autoantigen in systemic lupus erythematosus

1 reference

12 December 2020

Developmentally regulated activation of apoptosis early in Xenopus gastrulation results in cyclin A degradation during interphase of the cell cycle

1 reference

12 December 2020

The gamma subunit of the rod photoreceptor cGMP phosphodiesterase can modulate the proteolysis of two cGMP binding cGMP-specific phosphodiesterases (PDE6 and PDE5) by caspase-3.

1 reference

12 December 2020

Cleavage of polypeptide chain initiation factor eIF4GI during apoptosis in lymphoma cells: characterisation of an internal fragment generated by caspase-3-mediated cleavage

1 reference

12 December 2020

Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I.

1 reference

12 December 2020

Proteolysis of human eukaryotic translation initiation factor eIF4GII, but not eIF4GI, coincides with the shutoff of host protein synthesis after poliovirus infection

1 reference

12 December 2020

The cleavage of Akt/protein kinase B by death receptor signaling is an important event in detachment-induced apoptosis

1 reference

12 December 2020

The cAMP-specific phosphodiesterase PDE4A5 is cleaved downstream of its SH3 interaction domain by caspase-3. Consequences for altered intracellular distribution

1 reference

12 December 2020

Human autoimmune sera as molecular probes for the identification of an autoantigen kinase signaling pathway

1 reference

12 December 2020

Caspase-mediated degradation of T-cell receptor zeta-chain

1 reference

12 December 2020

Caspase-mediated cleavage of focal adhesion kinase pp125FAK and disassembly of focal adhesions in human endothelial cell apoptosis

1 reference

12 December 2020

The fate of the nuclear matrix-associated-region-binding protein SATB1 during apoptosis

1 reference

12 December 2020

Disruption of the interaction of mammalian protein synthesis eukaryotic initiation factor 4B with the poly(A)-binding protein by caspase- and viral protease-mediated cleavages

1 reference

12 December 2020

Selective degradation of the PKC-epsilon isoform during cell death in AKR-2B fibroblasts

1 reference

12 December 2020

Functional characterization of DNase X, a novel endonuclease expressed in muscle cells

1 reference

12 December 2020

Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis

1 reference

12 December 2020

The EMAPII cytokine is released from the mammalian multisynthetase complex after cleavage of its p43/proEMAPII component

1 reference

12 December 2020

Changes in integrity and association of eukaryotic protein synthesis initiation factors during apoptosis

1 reference

12 December 2020

The adenomatous polyposis coli protein and retinoblastoma protein are cleaved early in apoptosis and are potential substrates for caspases.

1 reference

12 December 2020

Molecular cloning of the interleukin-1 beta converting enzyme

1 reference

12 December 2020

Regulation of endothelial monocyte-activating polypeptide II release by apoptosis

1 reference

12 December 2020

Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation

1 reference

12 December 2020

Regulation of protein phosphatase 2A activity by caspase-3 during apoptosis

1 reference

12 December 2020

Pro-B-cell-specific transcription and proapoptotic function of protein kinase Ceta

1 reference

12 December 2020

Caspase cleavage of the transcription factor FLI-1 during preB leukemic cell death.

1 reference

12 December 2020

Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE

1 reference

12 December 2020

Cleavage of rabaptin-5 blocks endosome fusion during apoptosis.

1 reference

12 December 2020

Caspases disrupt the nuclear-cytoplasmic barrier

1 reference

12 December 2020

The fate of desmosomal proteins in apoptotic cells

1 reference

12 December 2020

Caspase-mediated cleavage of the ubiquitin-protein ligase Nedd4 during apoptosis

1 reference

12 December 2020

Caspase-mediated cleavage of APC results in an amino-terminal fragment with an intact armadillo repeat domain

1 reference

12 December 2020

Functional discontinuities in prothymosin alpha caused by caspase cleavage in apoptotic cells

1 reference

12 December 2020

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

1 reference

12 December 2020

Caspases cleave focal adhesion kinase during apoptosis to generate a FRNK-like polypeptide.

1 reference

12 December 2020

Specific cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein is a characteristic biochemical feature of apoptotic cell death

1 reference

12 December 2020

Fas-induced proteolytic activation and intracellular redistribution of the stress-signaling kinase MEKK1

1 reference

12 December 2020

Caspases mediate retinoic acid-induced degradation of the acute promyelocytic leukemia PML/RARalpha fusion protein

1 reference

12 December 2020

Proteome analysis of nuclear matrix proteins during apoptotic chromatin condensation

1 reference

12 December 2020

PITSLRE protein kinase activity is associated with apoptosis

1 reference

12 December 2020

Conversion of Bcl-2 to a Bax-like death effector by caspases

1 reference

12 December 2020

Caspase-dependent cleavage and inactivation of the Vav1 proto-oncogene product during apoptosis prevents IL-2 transcription

1 reference

12 December 2020

Proteolytic activation of protein kinase C delta by an ICE/CED 3-like protease induces characteristics of apoptosis

1 reference

12 December 2020

Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis

1 reference

12 December 2020

Involvement of caspase-1 and caspase-3 in the production and processing of mature human interleukin 18 in monocytic THP.1 cells

1 reference

12 December 2020

Caspase-mediated proteolytic activation of calcineurin in thapsigargin-mediated apoptosis in SH-SY5Y neuroblastoma cells

1 reference

12 December 2020

The neuronal microtubule-associated protein tau is a substrate for caspase-3 and an effector of apoptosis

1 reference

12 December 2020

Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35.

1 reference

12 December 2020

Simultaneous Degradation of αII- and βII-Spectrin by Caspase 3 (CPP32) in Apoptotic Cells

1 reference

12 December 2020

Proteolytic activation of MST/Krs, STE20-related protein kinase, by caspase during apoptosis.

1 reference

12 December 2020

Antiapoptotic herpesvirus Bcl-2 homologs escape caspase-mediated conversion to proapoptotic proteins

1 reference

12 December 2020

The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases

1 reference

12 December 2020

1 reference

12 December 2020

Dynamic changes of NuMA during the cell cycle and possible appearance of a truncated form of NuMA during apoptosis

1 reference

12 December 2020

Cleavage and phosphorylation of XRCC4 protein induced by X-irradiation

1 reference

12 December 2020

Specific proteolysis of the kinase protein kinase C-related kinase 2 by caspase-3 during apoptosis. Identification by a novel, small pool expression cloning strategy

1 reference

12 December 2020

Caspase-3 cleaves Apaf-1 into an approximately 30 kDa fragment that associates with an inappropriately oligomerized and biologically inactive approximately 1.4 MDa apoptosome complex

1 reference

12 December 2020

SPAK, a STE20/SPS1-related kinase that activates the p38 pathway

1 reference

12 December 2020

Caspase cleavage enhances the apoptosis-inducing effects of BAD.

1 reference

12 December 2020

Cleavage of beta-catenin and plakoglobin and shedding of VE-cadherin during endothelial apoptosis: evidence for a role for caspases and metalloproteinases

1 reference

12 December 2020

Limited proteolysis of filamin is catalyzed by caspase-3 in U937 and Jurkat cells

1 reference

12 December 2020

Early activation of caspases during T lymphocyte stimulation results in selective substrate cleavage in nonapoptotic cells

1 reference

12 December 2020

The adapter protein apoptotic protease-activating factor-1 (Apaf-1) is proteolytically processed during apoptosis

1 reference

12 December 2020

DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis

1 reference

12 December 2020

Proteolytic cleavage of HsRad51 during apoptosis

1 reference

12 December 2020

Dentatorubral pallidoluysian atrophy (DRPLA) protein is cleaved by caspase-3 during apoptosis

1 reference

12 December 2020

F1Aalpha, a death receptor-binding protein homologous to the Caenorhabditis elegans sex-determining protein, FEM-1, is a caspase substrate that mediates apoptosis

1 reference

12 December 2020

The RasGAP N-terminal Fragment Generated by Caspase Cleavage Protects Cells in a Ras/PI3K/Akt-dependent Manner That Does Not Rely on NFκB Activation

1 reference

12 December 2020

p41 as a possible marker for cell death is generated by caspase cleavage of p42/SETbeta in irradiated MOLT-4 cells

1 reference

12 December 2020

Targeted proteolysis of the focal adhesion kinase pp125 FAK during c-MYC-induced apoptosis is suppressed by integrin signalling.

1 reference

12 December 2020

Caspase proteolysis of the cohesin component RAD21 promotes apoptosis

1 reference

12 December 2020

Cytochrome c release, mitochondrial membrane depolarization, caspase-3 activation, and Bax-alpha cleavage during IFN-alpha-induced apoptosis in Daudi B lymphoma cells

1 reference

12 December 2020

Caspase-mediated cleavage of TRAF3 in FasL-stimulated Jurkat-T cells

1 reference

12 December 2020

The hepatitis C virus core protein interacts with NS5A and activates its caspase-mediated proteolytic cleavage

1 reference

12 December 2020

Caspase-dependent activation of calpain during drug-induced apoptosis

1 reference

12 December 2020

Myocyte enhancer factor 2A and 2D undergo phosphorylation and caspase-mediated degradation during apoptosis of rat cerebellar granule neurons.

1 reference

12 December 2020

Caspase-induced proteolysis of the cyclin-dependent kinase inhibitor p27Kip1 mediates its anti-apoptotic activity.

1 reference

12 December 2020

Inositol 1,4,5-trisphosphate receptor type 1 is a substrate for caspase-3 and is cleaved during apoptosis in a caspase-3-dependent manner

1 reference

12 December 2020

Caspase 3 cleavage of the Ste20-related kinase SLK releases and activates an apoptosis-inducing kinase domain and an actin-disassembling region

1 reference

12 December 2020

pp60(cSrc) is a caspase-3 substrate and Is essential for the transformed phenotype of A431 cells

1 reference

12 December 2020

Caspases mediate nucleoporin cleavage, but not early redistribution of nuclear transport factors and modulation of nuclear permeability in apoptosis

1 reference

12 December 2020

Death by a thousand cuts: an ever increasing list of caspase substrates

1 reference

12 December 2020

Caspase-mediated activation and induction of apoptosis by the mammalian Ste20-like kinase Mst1

1 reference

12 December 2020

Cleavage and relocation of the tyrosine kinase P59FYN during Fas-mediated apoptosis in T lymphocytes

1 reference

12 December 2020

Rapid cytochrome c release, activation of caspases 3, 6, 7 and 8 followed by Bap31 cleavage in HeLa cells treated with photodynamic therapy

1 reference

12 December 2020

Proteolysis of heat shock transcription factor is associated with apoptosis in rat Nb2 lymphoma cells

1 reference

12 December 2020

Caspase-induced inactivation of the anti-apoptotic TRAF1 during Fas ligand-mediated apoptosis

1 reference

12 December 2020

Filamin (280-kDa Actin-binding Protein) Is a Caspase Substrate and Is Also Cleaved Directly by the Cytotoxic T Lymphocyte Protease Granzyme B during Apoptosis

1 reference

12 December 2020

xIAP induces cell-cycle arrest and activates nuclear factor-kappaB : new survival pathways disabled by caspase-mediated cleavage during apoptosis of human endothelial cells

1 reference

12 December 2020

Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 protein

1 reference

12 December 2020

The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis

1 reference

12 December 2020

Overexpression of Helicard, a CARD-containing helicase cleaved during apoptosis, accelerates DNA degradation

1 reference

12 December 2020

Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis

1 reference

12 December 2020

In acute promyelocytic leukemia NB4 cells, the synthetic retinoid CD437 induces contemporaneously apoptosis, a caspase-3-mediated degradation of PML/RARalpha protein and the PML retargeting on PML-nuclear bodies

1 reference

12 December 2020

Vitamin D(3)-induced apoptosis of murine squamous cell carcinoma cells. Selective induction of caspase-dependent MEK cleavage and up-regulation of MEKK-1.

1 reference

12 December 2020

Selective cleavage of nuclear autoantigens during CD95 (Fas/APO-1)-mediated T cell apoptosis

1 reference

12 December 2020

Specific cleavage of the large subunit of replication factor C in apoptosis is mediated by CPP32-like protease

1 reference

12 December 2020

Antiapoptotic signaling generated by caspase-induced cleavage of RasGAP.

1 reference

12 December 2020

Caspase-mediated inhibition of human cytosolic phospholipase A2 during apoptosis

1 reference

12 December 2020

RNA polymerase II large subunit is cleaved by caspases during DNA damage-induced apoptosis

1 reference

12 December 2020

Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases

1 reference

12 December 2020

The fate of E- and P-cadherin during the early stages of apoptosis

1 reference

12 December 2020

Caspase-mediated cleavage of the stacking protein GRASP65 is required for Golgi fragmentation during apoptosis

1 reference

12 December 2020

The caspase-cleaved DAP5 protein supports internal ribosome entry site-mediated translation of death proteins

1 reference

12 December 2020

Apoptosis of the teratocarcinoma cell line Tera-1 leads to the cleavage of HERV-K10gag proteins by caspases and/or granzyme B.

1 reference

12 December 2020

Activation and caspase-mediated inhibition of PARP: a molecular switch between fibroblast necrosis and apoptosis in death receptor signaling.

1 reference

12 December 2020

Proteolytic processing of the Alzheimer's disease amyloid precursor protein within its cytoplasmic domain by caspase-like proteases.

1 reference

12 December 2020

p21-activated kinase (PAK) is required for Fas-induced JNK activation in Jurkat cells

1 reference

12 December 2020

Contribution to antimitochondrial antibody production: cleavage of pyruvate dehydrogenase complex-E2 by apoptosis-related proteases

1 reference

12 December 2020

Caspase-mediated cleavage and functional changes of hematopoietic progenitor kinase 1 (HPK1)

1 reference

12 December 2020

Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2

1 reference

12 December 2020

Differential requirements for caspase-8 activity in the mechanism of phosphorylation of eIF2alpha, cleavage of eIF4GI and signaling events associated with the inhibition of protein synthesis in apoptotic Jurkat T cells

1 reference

12 December 2020

Caspase cleavage of initiation factor 4E-binding protein 1 yields a dominant inhibitor of cap-dependent translation and reveals a novel regulatory motif

1 reference

12 December 2020

Activation of hPAK65 by caspase cleavage induces some of the morphological and biochemical changes of apoptosis

1 reference

12 December 2020

Specific cleavage of alpha-fodrin during Fas- and tumor necrosis factor-induced apoptosis is mediated by an interleukin-1beta-converting enzyme/Ced-3 protease distinct from the poly(ADP-ribose) polymerase protease

1 reference

12 December 2020

Caspase-dependent cleavage of cadherins and catenins during osteoblast apoptosis

1 reference

12 December 2020

Caspase-mediated cleavage of DNA topoisomerase I at unconventional sites during apoptosis

1 reference

12 December 2020

Caspase-mediated cleavage of eukaryotic translation initiation factor subunit 2alpha

1 reference

12 December 2020

Cleavage of purified neuronal clathrin assembly protein (CALM) by caspase 3 and calpain

1 reference

12 December 2020

Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: role of a caspase cascade

1 reference

12 December 2020

The novel SAR-binding domain of scaffold attachment factor A (SAF-A) is a target in apoptotic nuclear breakdown.

1 reference

12 December 2020

NS1 protein of influenza A virus down-regulates apoptosis

1 reference

12 December 2020

Selective cleavage of BLM, the bloom syndrome protein, during apoptotic cell death

1 reference

12 December 2020

Targeting of the transcription factor Max during apoptosis: phosphorylation-regulated cleavage by caspase-5 at an unusual glutamic acid residue in position P1

1 reference

12 December 2020

Lamin proteolysis facilitates nuclear events during apoptosis

1 reference

12 December 2020

p53 inhibits alpha 6 beta 4 integrin survival signaling by promoting the caspase 3-dependent cleavage of AKT/PKB

1 reference

12 December 2020

c-IAP1 is cleaved by caspases to produce a proapoptotic C-terminal fragment

1 reference

12 December 2020

Identification of a caspase-9 substrate and detection of its cleavage in programmed cell death during mouse development

1 reference

12 December 2020

Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis

1 reference

12 December 2020

Caspase-cleaved TRAF1 negatively regulates the antiapoptotic signals of TRAF2 during TNF-induced cell death

1 reference

12 December 2020

Selective down-regulation of IP(3)receptor subtypes by caspases and calpain during TNF alpha -induced apoptosis of human T-lymphoma cells

1 reference

12 December 2020

Degradation of the type I inositol 1,4,5-trisphosphate receptor by caspase-3 in SH-SY5Y neuroblastoma cells undergoing apoptosis

1 reference

12 December 2020

Caspase-dependent cleavage of carbamoyl phosphate synthetase II during apoptosis

1 reference

12 December 2020

Cleavage of translation initiation factor 4G (eIF4G) during anti-Fas IgM-induced apoptosis does not require signalling through the p38 mitogen-activated protein (MAP) kinase

1 reference

12 December 2020

The Drosophila caspase DRONC cleaves following glutamate or aspartate and is regulated by DIAP1, HID, and GRIM.

1 reference

12 December 2020

Caspase 7 can cleave tumor necrosis factor receptor-I (p60) at a non-consensus motif, in vitro

1 reference

12 December 2020

A novel form of DAP5 protein accumulates in apoptotic cells as a result of caspase cleavage and internal ribosome entry site-mediated translation

1 reference

12 December 2020

Caspase-mediated cleavage of hematopoietic progenitor kinase 1 (HPK1) converts an activator of NFkappaB into an inhibitor of NFkappaB

1 reference

12 December 2020

Caspase-3-Dependent Cleavage of the Glutamate-L-Cysteine Ligase Catalytic Subunit during Apoptotic Cell Death

1 reference

12 December 2020

Apoptosis overrides survival signals through a caspase-mediated dominant-negative NF-kappa B loop

1 reference

12 December 2020

TRAF1 is a substrate of caspases activated during tumor necrosis factor receptor-alpha-induced apoptosis

1 reference

12 December 2020

Dismantling cell-cell contacts during apoptosis is coupled to a caspase-dependent proteolytic cleavage of beta-catenin.

1 reference

12 December 2020

Caspase-3-mediated cleavage of protein kinase C theta in induction of apoptosis

1 reference

12 December 2020

CD95 (Fas)-induced caspase-mediated proteolysis of NF-kappaB

1 reference

12 December 2020

Characterization of the execution phase of apoptosis in vitro using extracts from condemned-phase cells

1 reference

12 December 2020

Autoantigens as substrates for apoptotic proteases: implications for the pathogenesis of systemic autoimmune disease

1 reference

12 December 2020

Linkage of caspase-mediated degradation of paxillin to apoptosis in Ba/F3 murine pro-B lymphocytes

1 reference

12 December 2020

Cleavage of the actin-capping protein alpha -adducin at Asp-Asp-Ser-Asp633-Ala by caspase-3 is preceded by its phosphorylation on serine 726 in cisplatin-induced apoptosis of renal epithelial cells

1 reference

12 December 2020

Caspase-mediated cleavage of the Ca2+/calmodulin-dependent protein kinase-like kinase facilitates neuronal apoptosis

1 reference

12 December 2020

The Fas-induced apoptosis analyzed by high throughput proteome analysis

1 reference

12 December 2020

Human replication protein Cdc6 is selectively cleaved by caspase 3 during apoptosis

1 reference

12 December 2020

p53 expression in K562 cells is associated with caspase-mediated cleavage of c-ABL and BCR-ABL protein kinases

1 reference

12 December 2020

Purification of an interleukin-1 beta converting enzyme-related cysteine protease that cleaves sterol regulatory element-binding proteins between the leucine zipper and transmembrane domains

1 reference

12 December 2020

C/EBPbeta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival

1 reference

12 December 2020

Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.

1 reference

12 December 2020

Platelet formation is the consequence of caspase activation within megakaryocytes

1 reference

12 December 2020

Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1 reference

12 December 2020

Identification of hTAF(II)80 delta links apoptotic signaling pathways to transcription factor TFIID function

1 reference

12 December 2020

Mammalian caspases: structure, activation, substrates, and functions during apoptosis

1 reference

12 December 2020

Caspase-3-generated fragment of gelsolin: effector of morphological change in apoptosis

1 reference

12 December 2020

The role of Asp-462 in regulating Akt activity

1 reference

12 December 2020

Caspase-mediated activation of a 36-kDa myelin basic protein kinase during anticancer drug-induced apoptosis

1 reference

12 December 2020

The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A

1 reference

12 December 2020

Identification of the cytolinker plectin as a major early in vivo substrate for caspase 8 during CD95- and tumor necrosis factor receptor-mediated apoptosis

1 reference

12 December 2020

Activation of actin-cleavable interleukin 1beta-converting enzyme (ICE) family protease CPP-32 during chemotherapeutic agent-induced apoptosis in ovarian carcinoma cells

1 reference

12 December 2020

Proteolytic processing of the adherens junctions components beta-catenin and gamma-catenin/plakoglobin during apoptosis

1 reference

12 December 2020

Caspase activation of mammalian sterile 20-like kinase 3 (Mst3). Nuclear translocation and induction of apoptosis

1 reference

12 December 2020

Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation

1 reference

12 December 2020

Negative regulation of erythropoiesis by caspase-mediated cleavage of GATA-1

1 reference

12 December 2020

Distinct roles of two intracellular phospholipase A2s in fatty acid release in the cell death pathway. Proteolytic fragment of type IVA cytosolic phospholipase A2alpha inhibits stimulus-induced arachidonate release, whereas that of type VI Ca2+-inde

1 reference

12 December 2020

Cleavage of Fyn and Lyn in their N-terminal unique regions during induction of apoptosis: a new mechanism for Src kinase regulation.

1 reference

12 December 2020

Apoptosis-induced cleavage of beta-catenin by caspase-3 results in proteolytic fragments with reduced transactivation potential

1 reference

12 December 2020

A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

1 reference

12 December 2020

Cleavage of hepatitis C virus nonstructural protein 5A by a caspase-like protease(s) in mammalian cells

1 reference

12 December 2020

GAL4 is a substrate for caspases: implications for two-hybrid screening and other GAL4-based assays.

1 reference

12 December 2020

Huntington disease: new insights on the role of huntingtin cleavage

1 reference

12 December 2020

Inhibition of death receptor signals by cellular FLIP

1 reference

12 December 2020

Generation of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavage

1 reference

12 December 2020

The endothelial monocyte-activating polypeptide II (EMAP II) is a substrate for caspase-7.

1 reference

12 December 2020

Cleavage of plasma membrane calcium pumps by caspases: a link between apoptosis and necrosis.

1 reference

12 December 2020

Microfilament reorganization during apoptosis: the role of Gas2, a possible substrate for ICE-like proteases

1 reference

12 December 2020

Modulation of cell death by Bcl-XL through caspase interaction

1 reference

12 December 2020

Staurosporine treatment and serum starvation promote the cleavage of emerin in cultured mouse myoblasts: involvement of a caspase-dependent mechanism

1 reference

12 December 2020

Caspase 3 activity is required for skeletal muscle differentiation

1 reference

12 December 2020

Proteolytic cleavage of phospholipase C-gamma1 during apoptosis in Molt-4 cells.

1 reference

12 December 2020

Cloning of MASK, a novel member of the mammalian germinal center kinase III subfamily, with apoptosis-inducing properties

1 reference

12 December 2020

Phosphorylation of IkappaB-alpha inhibits its cleavage by caspase CPP32 in vitro

1 reference

12 December 2020

Human RNA helicase A is a lupus autoantigen that is cleaved during apoptosis

1 reference

12 December 2020

Caspase-mediated cleavage of p130cas in etoposide-induced apoptotic Rat-1 cells

1 reference

12 December 2020

Dynamic O-glycosylation of nuclear and cytosolic proteins: further characterization of the nucleocytoplasmic beta-N-acetylglucosaminidase, O-GlcNAcase

1 reference

12 December 2020

Actin cleavage by CPP-32/apopain during the development of apoptosis

1 reference

12 December 2020

Cleavage of eukaryotic translation initiation factor 4GII correlates with translation inhibition during apoptosis

1 reference

12 December 2020

Proteolysis of the human DNA polymerase epsilon catalytic subunit by caspase-3 and calpain specifically during apoptosis

1 reference

12 December 2020

Proteolytic cleavage of cyclin E leads to inactivation of associated kinase activity and amplification of apoptosis in hematopoietic cells

1 reference

12 December 2020

The proteolytic cleavage of protein kinase C isotypes, which generates kinase and regulatory fragments, correlates with Fas-mediated and 12-O-tetradecanoyl-phorbol-13-acetate-induced apoptosis

1 reference

12 December 2020

CREB is cleaved by caspases during neural cell apoptosis

1 reference

12 December 2020

The interleukin-1 receptor binds the human interleukin-1 alpha precursor but not the interleukin-1 beta precursor

1 reference

12 December 2020

Proteolytic cleavage of epidermal growth factor receptor by caspases.

1 reference

12 December 2020

Evidence for caspase-mediated cleavage of AMPA receptor subunits in neuronal apoptosis and Alzheimer's disease.

1 reference

12 December 2020

Functional consequences of caspase activation in cardiac myocytes

1 reference

12 December 2020

A cloning method for caspase substrates that uses the yeast two-hybrid system: cloning of the antiapoptotic gene gelsolin

1 reference

12 December 2020

SATB1 cleavage by caspase 6 disrupts PDZ domain-mediated dimerization, causing detachment from chromatin early in T-cell apoptosis

1 reference

12 December 2020

Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

1 reference

12 December 2020

Polypyrimidine tract-binding proteins are cleaved by caspase-3 during apoptosis

1 reference

12 December 2020

DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis

1 reference

12 December 2020

Caspase cleavage of keratin 18 and reorganization of intermediate filaments during epithelial cell apoptosis

1 reference

12 December 2020

Cleavage of PITSLRE kinases by ICE/CASP-1 and CPP32/CASP-3 during apoptosis induced by tumor necrosis factor

1 reference

12 December 2020

Proteolytic activation of protein kinase C delta by an ICE-like protease in apoptotic cells.

1 reference

12 December 2020

Eukaryotic translation initiation factor 4G is targeted for proteolytic cleavage by caspase 3 during inhibition of translation in apoptotic cells

1 reference

12 December 2020

Specific cleavage of the retinoblastoma protein by an ICE-like protease in apoptosis.

1 reference

12 December 2020

Kennedy's disease: caspase cleavage of the androgen receptor is a crucial event in cytotoxicity

1 reference

12 December 2020

Cleavage and inactivation of ATM during apoptosis.

1 reference

12 December 2020

Resistance of actin to cleavage during apoptosis.

1 reference

12 December 2020

Nicotine preconditioning antagonizes activity-dependent caspase proteolysis of a glutamate receptor

1 reference

12 December 2020

CD95/Fas induces cleavage of the GrpL/Gads adaptor and desensitization of antigen receptor signaling

1 reference

12 December 2020

Caspase activation in the terminal differentiation of human epidermal keratinocytes

1 reference

12 December 2020

PARP is important for genomic stability but dispensable in apoptosis

1 reference

12 December 2020

Apoptosis-induced cleavage of keratin 15 and keratin 17 in a human breast epithelial cell line

1 reference

12 December 2020

Inhibition of interleukin-1 beta converting enzyme by the cowpox virus serpin CrmA. An example of cross-class inhibition.

1 reference

12 December 2020

Heteronuclear Ribonucleoproteins C1 and C2, Components of the Spliceosome, Are Specific Targets of Interleukin 1β-converting Enzyme-like Proteases in Apoptosis

1 reference

12 December 2020

The viral nucleocapsid protein of transmissible gastroenteritis coronavirus (TGEV) is cleaved by caspase-6 and -7 during TGEV-induced apoptosis

1 reference

12 December 2020

Caspase-3-mediated processing of poly(ADP-ribose) glycohydrolase during apoptosis

1 reference

12 December 2020

The docking protein HEF1 is an apoptotic mediator at focal adhesion sites

1 reference

12 December 2020

Eukaryotic initiation factor 4GII (eIF4GII), but not eIF4GI, cleavage correlates with inhibition of host cell protein synthesis after human rhinovirus infection

1 reference

12 December 2020

Life and death decisions: regulation of apoptosis by proteolysis of signaling molecules

1 reference

12 December 2020

Bacterial lipopolysaccharide disrupts endothelial monolayer integrity and survival signaling events through caspase cleavage of adherens junction proteins.

1 reference

12 December 2020

The large subunit of replication factor C is a substrate for caspase-3 in vitro and is cleaved by a caspase-3-like protease during Fas-mediated apoptosis

1 reference

12 December 2020

Proteolytic activation of ETK/Bmx tyrosine kinase by caspases

1 reference

12 December 2020

Specific involvement of caspases in the differentiation of monocytes into macrophages

1 reference

12 December 2020

Translation inhibition in apoptosis: caspase-dependent PKR activation and eIF2-alpha phosphorylation

1 reference

12 December 2020

Caspases: more than just killers?

1 reference

12 December 2020

Essential myosin light chain as a target for caspase-3 in failing myocardium

1 reference

12 December 2020

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1 reference

12 December 2020

Cleavage of zetaPKC but not lambda/iotaPKC by caspase-3 during UV-induced apoptosis.

1 reference

12 December 2020

Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production.

1 reference

12 December 2020

LBR, a chromatin and lamin binding protein from the inner nuclear membrane, is proteolyzed at late stages of apoptosis

1 reference

12 December 2020

Proteolysis of the docking protein HEF1 and implications for focal adhesion dynamics

1 reference

12 December 2020

Caspase cleavage of members of the amyloid precursor family of proteins

1 reference

12 December 2020

Caspase-mediated cleavage of the chromosome-binding domain of lamina-associated polypeptide 2 alpha.

1 reference

12 December 2020

A role for caspases in lens fiber differentiation

1 reference

12 December 2020

Apoptotic cleavage of scaffold attachment factor A (SAF-A) by caspase-3 occurs at a noncanonical cleavage site

1 reference

12 December 2020

Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death

1 reference

12 December 2020

Protease Involvement in Fodrin Cleavage and Phosphatidylserine Exposure in Apoptosis

1 reference

12 December 2020

Sequence-specific DNA binding activity of RNA helicase A to the p16INK4a promoter

1 reference

12 December 2020

Differential regulation and ATP requirement for caspase-8 and caspase-3 activation during CD95- and anticancer drug-induced apoptosis

1 reference

12 December 2020

STAT1 is inactivated by a caspase

1 reference

12 December 2020

Direct cleavage by the calcium-activated protease calpain can lead to inactivation of caspases

1 reference

12 December 2020

Inhibition of Akt and its anti-apoptotic activities by tumor necrosis factor-induced protein kinase C-related kinase 2 (PRK2) cleavage

1 reference

12 December 2020

Inactivation of farnesyltransferase and geranylgeranyltransferase I by caspase-3: cleavage of the common alpha subunit during apoptosis

1 reference

12 December 2020

Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line. Cleavage of heterogeneous nuclear ribonucleoprotein A1 by caspase 3.

1 reference

12 December 2020

MDMX stability is regulated by p53-induced caspase cleavage in NIH3T3 mouse fibroblasts

1 reference

12 December 2020

Apoptosis generates stable fragments of human type I keratins

1 reference

12 December 2020

Caspase cleavage of the nuclear autoantigen LEDGF/p75 abrogates its pro-survival function: implications for autoimmunity in atopic disorders

1 reference

12 December 2020

Prothymosin alpha fragmentation in apoptosis.

1 reference

12 December 2020

Caspase-dependent cleavage of signaling proteins during apoptosis. A turn-off mechanism for anti-apoptotic signals

1 reference

12 December 2020

Caspase-dependent cleavage of the hematopoietic specific adaptor protein Gads alters signalling from the T cell receptor

1 reference

12 December 2020

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

1 reference

12 December 2020

Calcium/calmodulin-dependent protein kinase IV is cleaved by caspase-3 and calpain in SH-SY5Y human neuroblastoma cells undergoing apoptosis.

1 reference

12 December 2020

Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease

1 reference

12 December 2020

Tissue transglutaminase is a caspase substrate during apoptosis. Cleavage causes loss of transamidating function and is a biochemical marker of caspase 3 activation.

1 reference

12 December 2020

Cleavage of the calpain inhibitor, calpastatin, during apoptosis

1 reference

12 December 2020

Three mutations in v-Rel render it resistant to cleavage by cell-death protease caspase-3.

1 reference

12 December 2020

Regulation of apoptosis by phosphatidylinositol 4,5-bisphosphate inhibition of caspases, and caspase inactivation of phosphatidylinositol phosphate 5-kinases

1 reference

12 December 2020

The human homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis

1 reference

12 December 2020

Yeast two-hybrid screening using constitutive-active caspase-7 as bait in the identification of PA28gamma as an effector caspase substrate

1 reference

12 December 2020

Processing and activation of pro-interleukin-16 by caspase-3

1 reference

12 December 2020

Caspase-3-induced gelsolin fragmentation contributes to actin cytoskeletal collapse, nucleolysis, and apoptosis of vascular smooth muscle cells exposed to proinflammatory cytokines.

1 reference

12 December 2020

Activation of death-inducing signaling complex (DISC) by pro-apoptotic C-terminal fragment of RIP

1 reference

12 December 2020

Retinoid-induced apoptosis and Sp1 cleavage occur independently of transcription and require caspase activation

1 reference

12 December 2020

Proteolytic cleavage of protein kinase Cmu upon induction of apoptosis in U937 cells

1 reference

12 December 2020

Caspase processing and nuclear export of CTP:phosphocholine cytidylyltransferase alpha during farnesol-induced apoptosis

1 reference

12 December 2020

Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis

1 reference

12 December 2020

Selective proteolysis of the nuclear replication factor MCM3 in apoptosis

1 reference

12 December 2020

Caspase cleavage of vimentin disrupts intermediate filaments and promotes apoptosis

1 reference

12 December 2020

Defective Rho GTPase regulation by IL-1 beta-converting enzyme-mediated cleavage of D4 GDP dissociation inhibitor.

1 reference

12 December 2020

Mitochondria-targeting drugs arsenic trioxide and lonidamine bypass the resistance of TPA-differentiated leukemic cells to apoptosis.

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401160

7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/SJ.CDD.4401160

1 reference

6 August 2017

0 references

1 reference

PubMed ID

12655297