Pharmacogenetics in drug discovery and development: a translational perspective (Q37275470)

19 August 2017

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title

Pharmacogenetics in drug discovery and development: a translational perspective (English)

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19 August 2017

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Allen D Roses

1

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19 August 2017

19 September 2008

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Nature Reviews Drug Discovery

19 August 2017

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19 August 2017

7

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19 August 2017

807-817

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19 August 2017

10

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https://scigraph.springernature.com/pub.10.1038/nrd2593

19 August 2017

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21 January 2018

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Pharmacogenetics and obesity: common gene variants influence weight loss response of the norepinephrine/dopamine transporter inhibitor GW320659 in obese subjects

31 March 2020

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Efficacy of rosiglitazone in a genetically defined population with mild-to-moderate Alzheimer's disease

31 March 2020

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Translation of pharmacogenomics and pharmacogenetics: a regulatory perspective

31 March 2020

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The innovative use of a large-scale industry biomedical consortium to research the genetic basis of drug induced serious adverse events

31 March 2020

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Clinical translation of genotyping and haplotyping data: implementation of in vivo pharmacology experience leading drug prescription to pharmacotyping

31 March 2020

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Database size and power to detect safety signals in pharmacovigilance

31 March 2020

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Evaluation of Serious Adverse Drug Reactions

31 March 2020

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Pharmacogenetics of hypersensitivity to abacavir: from PGx hypothesis to confirmation to clinical utility

31 March 2020

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31 March 2020

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Personalized medicine: elusive dream or imminent reality?

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Genome-based pharmacogenetics and the pharmaceutical industry

31 March 2020

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31 March 2020

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31 March 2020

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The new type 2 diabetes gene TCF7L2

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Genome-wide association studies provide new insights into type 2 diabetes aetiology

31 March 2020

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31 March 2020

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Current status of genome-wide scanning for hypertension

31 March 2020

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New gene associations in osteoarthritis: what do they provide, and where are we going?

31 March 2020

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31 March 2020

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The road to genome-wide association studies

31 March 2020

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New links to the pathogenesis of Crohn disease provided by genome-wide association scans

31 March 2020

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Genetics of type 2 diabetes

31 March 2020

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Genetics of bipolar disorder

31 March 2020

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Genetic susceptibility to age-related macular degeneration: a paradigm for dissecting complex disease traits

31 March 2020

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Genome-wide association scans identify multiple confirmed susceptibility loci for Crohn's disease: lessons for study design

31 March 2020

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The genetics of inflammatory bowel disease

31 March 2020

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Genome-wide association studies of cancer

31 March 2020

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Multiple newly identified loci associated with prostate cancer susceptibility

31 March 2020

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Multiple loci identified in a genome-wide association study of prostate cancer

31 March 2020

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31 March 2020

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Genome-wide association: which do you want first: the good news, the bad news, or the good news?

31 March 2020

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31 March 2020

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High prevalence of major cardiovascular risk factors in first-degree relatives of individuals with familial premature coronary artery disease--the GENECARD project

31 March 2020

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Design of the Genetics of Early Onset Cardiovascular Disease (GENECARD) study

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Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24.

31 March 2020

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Use of pairwise marker combination and recursive partitioning in a pharmacogenetic genome-wide scan

31 March 2020

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Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

31 March 2020

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A genome-wide association study identifies novel risk loci for type 2 diabetes

31 March 2020

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Further Investigation of Linkage Disequilibrium SNPs and their Ability to Identify Associated Susceptibility Loci

31 March 2020

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Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4

31 March 2020

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Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls

31 March 2020

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Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci

31 March 2020

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A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

31 March 2020

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A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer

31 March 2020

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Genome-wide genotyping in amyotrophic lateral sclerosis and neurologically normal controls: first stage analysis and public release of data

31 March 2020

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Association between SORL1 and Alzheimer's disease in a genome-wide study

31 March 2020

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A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease risk

31 March 2020

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31 March 2020

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Genetic Association Studies of Cancer: Where Do We Go from Here?

31 March 2020

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Druggability of human disease genes.

31 March 2020

1 reference

Complex disease-associated pharmacogenetics: drug efficacy, drug safety, and confirmation of a pathogenetic hypothesis (Alzheimer's disease).

31 March 2020

1 reference

Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir

31 March 2020

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Genetic variations in HLA-B region and hypersensitivity reactions to abacavir

31 March 2020

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HLA-B*5701 clinical testing: early experience in the United States

31 March 2020

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Stimulation of cholecystokinin-A receptors with GI181771X does not cause weight loss in overweight or obese patients.

31 March 2020

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Rosiglitazone attenuates learning and memory deficits in Tg2576 Alzheimer mice

31 March 2020

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Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

31 March 2020

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EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

31 March 2020

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Molecular targeted therapy of lung cancer: EGFR mutations and response to EGFR inhibitors

31 March 2020

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Molecular pathogenesis of pancreatic cancer: advances and challenges

31 March 2020

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PIK3CA mutation is predictive of poor survival in patients with colorectal cancer

31 March 2020

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Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer

31 March 2020

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Lapatinib-associated toxicity and practical management recommendations

31 March 2020

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Lapatinib plus capecitabine for HER2-positive advanced breast cancer

31 March 2020

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Thiopurine S-methyltransferase pharmacogenetics: insights, challenges and future directions

31 March 2020

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Preponderance of thiopurine S-methyltransferase deficiency and heterozygosity among patients intolerant to mercaptopurine or azathioprine

31 March 2020

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The thiopurines: an update

31 March 2020

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Individualizing therapy with 6-mercaptopurine and 6-thioguanine related to the thiopurine methyltransferase genetic polymorphism

31 March 2020

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Pharmacodynamic resistance to warfarin associated with a Val66Met substitution in vitamin K epoxide reductase complex subunit 1.

31 March 2020

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Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2

31 March 2020

1 reference

"Personalized medicine: elusive dream or imminent reality?": A commentary.

31 March 2020

1 reference

HLA-B*5701 screening for hypersensitivity to abacavir

31 March 2020

1 reference

Hypersensitivity reactions during therapy with the nucleoside reverse transcriptase inhibitor abacavir

31 March 2020

1 reference

Pharmacogenetics and the potential for the individualization of antiretroviral therapy

31 March 2020

1 reference

Rosiglitazone evaluated for cardiovascular outcomes--an interim analysis

31 March 2020

1 reference

Effect of Rosiglitazone on the Risk of Myocardial Infarction and Death from Cardiovascular Causes

31 March 2020

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Estimating the extent of reporting to FDA: a case study of statin-associated rhabdomyolysis

31 March 2020

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Knowledge creation about ADRs--turning the perspective from the rear mirror to the projector?

31 March 2020

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The US drug safety system: role of the pharmaceutical industry

31 March 2020

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Rosiglitazone--continued uncertainty about safety

31 March 2020

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A second generation human haplotype map of over 3.1 million SNPs

31 March 2020

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The International HapMap Project

31 March 2020

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Drug discovery: a historical perspective

31 March 2020

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A genomewide scan for early-onset coronary artery disease in 438 families: the GENECARD Study

31 March 2020

1 reference

Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants

31 March 2020

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Novel genes identified in a high-density genome wide association study for nicotine dependence

31 March 2020

1 reference

A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

31 March 2020

1 reference

Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study

31 March 2020

1 reference

A 4-Mb high-density single nucleotide polymorphism-based map around human APOE

31 March 2020

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Pharmacogenetics goes genomic

31 March 2020

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Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

31 March 2020

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31 March 2020

1 reference

Lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity

31 March 2020

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Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons

31 March 2020

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A comprehensive review of genetic association studies

31 March 2020

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Comprehensive analysis of APOE and selected proximate markers for late-onset Alzheimer's disease: patterns of linkage disequilibrium and disease/marker association

31 March 2020

1 reference

Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease

31 March 2020

1 reference

Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus.

31 March 2020

1 reference

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

31 March 2020

1 reference

Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution

31 March 2020

1 reference

Disease-specific target selection: a critical first step down the right road

31 March 2020

1 reference

Lapatinib in breast cancer

31 March 2020

1 reference

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7 January 2021

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Identifiers

DOI

10.1038/NRD2593

1 reference

19 August 2017

1 reference

PubMed ID

18806753