The P53 pathway: what questions remain to be explored? (Q36430168)

14 August 2017

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title

The P53 pathway: what questions remain to be explored? (English)

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14 August 2017

A J Levine

1

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PubMed ID

16557269

14 August 2017

W Hu

series ordinal

2

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PubMed ID

16557269

14 August 2017

Z Feng

series ordinal

3

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14 August 2017

1 June 2006

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Cell Death & Differentiation

14 August 2017

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14 August 2017

13

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14 August 2017

6

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14 August 2017

1027-1036

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https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401910

14 August 2017

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P53 is a tumor suppressor gene

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Surfing the p53 network

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7 January 2021

The complexity of p53 modulation: emerging patterns from divergent signals

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7 January 2021

The role of p53 in determining sensitivity to radiotherapy

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7 January 2021

Decision making by p53: life, death and cancer

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7 January 2021

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7 January 2021

The p53 pathway: positive and negative feedback loops

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7 January 2021

The coordinate regulation of the p53 and mTOR pathways in cells

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7 January 2021

AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

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7 January 2021

On the shoulders of giants: p63, p73 and the rise of p53.

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7 January 2021

The p53MH algorithm and its application in detecting p53-responsive genes

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7 January 2021

Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation

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7 January 2021

The ubiquitin ligase COP1 is a critical negative regulator of p53

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7 January 2021

Accelerated MDM2 auto-degradation induced by DNA-damage kinases is required for p53 activation

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7 January 2021

Post-translational modifications and activation of p53 by genotoxic stresses

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7 January 2021

Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity

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7 January 2021

Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation

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7 January 2021

Regulation of p53 responses by post-translational modifications

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7 January 2021

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

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7 January 2021

p53 linear diffusion along DNA requires its C terminus

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Tumor suppression by Ink4a-Arf: progress and puzzles

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Generation of oscillations by the p53-Mdm2 feedback loop: a theoretical and experimental study

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Dynamics of the p53-Mdm2 feedback loop in individual cells

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

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7 January 2021

Amplification of a gene encoding a p53-associated protein in human sarcomas

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7 January 2021

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

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7 January 2021

Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

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7 January 2021

Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

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7 January 2021

An intact HDM2 RING-finger domain is required for nuclear exclusion of p53.

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7 January 2021

A phosphatidylinositol 3-kinase/Akt pathway promotes translocation of Mdm2 from the cytoplasm to the nucleus

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7 January 2021

HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

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7 January 2021

Cyclin G recruits PP2A to dephosphorylate Mdm2

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7 January 2021

Coordination and communication between the p53 and IGF-1-AKT-TOR signal transduction pathways

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7 January 2021

p53 isoforms can regulate p53 transcriptional activity.

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7 January 2021

Loss of function of def selectively up-regulates Delta113p53 expression to arrest expansion growth of digestive organs in zebrafish.

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7 January 2021

Definition of a consensus binding site for p53

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7 January 2021

The transcriptional program following p53 activation

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7 January 2021

Transcription-independent pro-apoptotic functions of p53.

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7 January 2021

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

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7 January 2021

Does p53 affect organismal aging?

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7 January 2021

Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD

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7 January 2021

Induction of the growth inhibitor IGF-binding protein 3 by p53

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7 January 2021

Differential regulation of plasminogen activator and inhibitor gene transcription by the tumor suppressor p53

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7 January 2021

p53 regulates the expression of the tumor suppressor gene maspin

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7 January 2021

Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401910

7 January 2021

TSAP6 facilitates the secretion of translationally controlled tumor protein/histamine-releasing factor via a nonclassical pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401910

7 January 2021

Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

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7 January 2021

Radiation-induced cell cycle arrest compromised by p21 deficiency

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7 January 2021

A p53-dependent checkpoint pathway prevents rereplication

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7 January 2021

Analysis of centrosome abnormalities and angiogenesis in epidermal-targeted p53172H mutant and p53-knockout mice after chemical carcinogenesis: evidence for a gain of function

1 reference

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7 January 2021

The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401910

7 January 2021

The codon 72 polymorphic variants of p53 have markedly different apoptotic potential

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401910

7 January 2021

p53 polymorphisms in Russia and Belarus: correlation of the 2-1-1 haplotype frequency with longitude

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401910

7 January 2021

The R72P P53 mutation is associated with familial breast cancer in Jewish women

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401910

7 January 2021

Variation in the human TP53 gene affects old age survival and cancer mortality.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401910

7 January 2021

A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401910

7 January 2021

The role of P53 and MDM2 polymorphisms in the risk of esophageal squamous cell carcinoma.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401910

7 January 2021

Mice with reduced levels of p53 protein exhibit the testicular giant-cell degenerative syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401910

7 January 2021

A subset of p53-deficient embryos exhibit exencephaly

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401910

7 January 2021

High-frequency developmental abnormalities in p53-deficient mice.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401910

7 January 2021

Modifying effects of ethinylestradiol but not methoxychlor on N-ethyl-N-nitrosourea-induced uterine carcinogenesis in heterozygous p53-deficient CBA mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401910

7 January 2021

General keynote: hereditary cancer: lessons from Li-Fraumeni syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401910

7 January 2021

Estrogen receptor-dependent proteasomal degradation of the glucocorticoid receptor is coupled to an increase in mdm2 protein expression

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401910

7 January 2021

Negative control of p53 by Sir2alpha promotes cell survival under stress

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401910

7 January 2021

Mammalian SIRT1 represses forkhead transcription factors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401910

7 January 2021

The plasticity of aging: insights from long-lived mutants

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401910

7 January 2021

Calorie restriction--the SIR2 connection

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401910

7 January 2021

Nitric oxide-induced cellular stress and p53 activation in chronic inflammation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401910

7 January 2021

High levels of endogenous nitric oxide produced after burn injury in rats arrest activated T lymphocytes in the first G1 phase of the cell cycle and then induce their apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401910

7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4401910

1 reference

14 August 2017

1 reference

PubMed ID

16557269