Abnormalities of IGF-I signaling in the pathogenesis of diseases of the bone, brain, and fetoplacental unit in humans (Q37247491)

19 August 2017

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title

Abnormalities of IGF-I signaling in the pathogenesis of diseases of the bone, brain, and fetoplacental unit in humans (English)

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19 August 2017

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Sebastio Perrini

3

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Francesco Giorgino

object named as

Francesco Giorgino

series ordinal

4

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Luigi Laviola

series ordinal

1

object named as

Luigi Laviola

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19 August 2017

2

Annalisa Natalicchio

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19 August 2017

19 August 2008

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American Journal of Physiology - Endocrinology and Metabolism

19 August 2017

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19 August 2017

295

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19 August 2017

E991-9

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19 August 2017

5

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Insulin receptor substrate-2 maintains predominance of anabolic function over catabolic function of osteoblasts

19 August 2017

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

A potentially deleterious role of IGFBP-2 on bone density in aging men and women

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

High serum IGFBP-2 is predictive of increased bone turnover in aging men and women

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Insulin-like growth factor-1-dependent maintenance of neuronal metabolism through the phosphatidylinositol 3-kinase-Akt pathway is inhibited by C2-ceramide in CAD cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

p125Fak focal adhesion kinase is a substrate for the insulin and insulin-like growth factor-I tyrosine kinase receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Insulin-like growth factor (IGF)-binding proteins: interactions with IGFs and intrinsic bioactivities

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Igf1 gene disruption results in reduced brain size, CNS hypomyelination, and loss of hippocampal granule and striatal parvalbumin-containing neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Insulin-like growth factor-I stimulates tyrosine phosphorylation of endogenous c-Crk

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Insulin-like growth factor-1 promotes neuronal glucose utilization during brain development and repair processes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Methylmercury antagonizes the survival-promoting activity of insulin-like growth factor on developing cerebellar granule neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Neurodegeneration is associated to changes in serum insulin-like growth factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Insulin-like growth factor-I receptor signal transduction: at the interface between physiology and cell biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Insulin-like growth factors and osteoporosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Insulin-like growth factor I and Alzheimer's disease: therapeutic prospects?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Serum insulin-like growth factor I regulates brain amyloid-beta levels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Brain repair and neuroprotection by serum insulin-like growth factor I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Insulin-like growth factor I stimulates tyrosine phosphorylation of p130(Cas), focal adhesion kinase, and paxillin. Role of phosphatidylinositol 3'-kinase and formation of a p130(Cas).Crk complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Long-term depression of glutamate-induced gamma-aminobutyric acid release in cerebellum by insulin-like growth factor I

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Endogenous IGF1 enhances cell survival in the postnatal dentate gyrus

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Insulin-like growth factor 1 regulates developing brain glucose metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Subcutaneous administration of insulin-like growth factor (IGF)-II/IGF binding protein-2 complex stimulates bone formation and prevents loss of bone mineral density in a rat model of disuse osteoporosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Glycogen synthase kinase-3 beta activity is critical for neuronal death caused by inhibiting phosphatidylinositol 3-kinase or Akt but not for death caused by nerve growth factor withdrawal.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Insulin-like growth factors I and II. Peptide, messenger ribonucleic acid and gene structures, serum, and tissue concentrations

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

A growth-deficiency phenotype in heterozygous mice carrying an insulin-like growth factor II gene disrupted by targeting.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Structural and functional characteristics of the Val44Met insulin-like growth factor I missense mutation: correlation with effects on growth and development

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Rediscovering an old friend, IGF-I: potential use in the treatment of neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

The adapter protein GRB10 is an endogenous negative regulator of insulin-like growth factor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Characterization and function of the receptor for IGF-I in human preosteoclastic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Cellular actions of the insulin-like growth factor binding proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

The insulin-like growth factors and feto-placental growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Glutamate excitotoxicity attenuates insulin-like growth factor-I prosurvival signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Cross-talk between IGF-I and estradiol in the brain: focus on neuroprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Does insulin dysfunction play a role in Alzheimer's disease?

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Parallel phosphatidylinositol-3 kinase and p42/44 mitogen-activated protein kinase signaling pathways subserve the mitogenic and antiapoptotic actions of insulin-like growth factor I in osteoblastic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Interaction of Janus kinases JAK-1 and JAK-2 with the insulin receptor and the insulin-like growth factor-1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Inhibition of Insulin-Like Growth Factor-I Signaling by Ethanol in Neuronal Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Interaction between the Grb10 SH2 domain and the insulin receptor carboxyl terminus

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology [...]

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

IGF-I is critical for normal vascularization of the human retina

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Osteoblasts mediate insulin-like growth factor-I and -II stimulation of osteoclast formation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Growth hormone stimulates proliferation and differentiation of normal human osteoblast-like cells in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Insulin-like growth factor (IGF)-I stimulates cell proliferation and induces IGF binding protein (IGFBP)-3 and IGFBP-5 gene expression in cultured growth plate chondrocytes via distinct signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

The essential role of IGF-I: lessons from the long-term study and treatment of children and adults with Laron syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Mutations in the GIGYF2 (TNRC15) gene at the PARK11 locus in familial Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Intrauterine growth restriction in humans is associated with abnormalities in placental insulin-like growth factor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Cyclic AMP promotes neuronal survival by phosphorylation of glycogen synthase kinase 3beta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

The p66shc adaptor protein controls oxidative stress response and life span in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Specific inhibition by hGRB10zeta of insulin-induced glycogen synthase activation: evidence for a novel signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Essential role for p38alpha mitogen-activated protein kinase in placental angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Role of the p66Shc isoform in insulin-like growth factor I receptor signaling through MEK/Erk and regulation of actin cytoskeleton in rat myoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Insulin-like growth factor I modifies electrophysiological properties of rat brain stem neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Insulin receptor substrate-1 in osteoblast is indispensable for maintaining bone turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Up-regulation of functionally impaired insulin-like growth factor-1 receptor in scrapie-infected neuroblastoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

IGF-1 protects oligodendrocyte progenitors against TNFalpha-induced damage by activation of PI3K/Akt and interruption of the mitochondrial apoptotic pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Abnormalities of insulin-like growth factor-I signaling and impaired cell proliferation in osteoblasts from subjects with osteoporosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Variation among cell types in the signaling pathways by which IGF-I stimulates specific cellular responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

IGF-I is required for normal embryonic growth in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Placental expression of insulin-like growth factor receptor-1 and insulin receptor in the growth-restricted fetal rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

In vivo mechanical loading modulates insulin-like growth factor binding protein-2 gene expression in rat osteocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Insulin-like growth factor I and bone mineral density: experience from animal models and human observational studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

JunB is essential for mammalian placentation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

The BPS domain of Grb10 inhibits the catalytic activity of the insulin and IGF1 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

The role of glycogen synthase kinase 3beta in insulin-stimulated glucose metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Activation of glycogen synthase kinase 3 beta (GSK-3beta) by platelet activating factor mediates migration and cell death in cerebellar granule neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

RETRACTED: A new mechanism of neurodegeneration: a proinflammatory cytokine inhibits receptor signaling by a survival peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

The p66Shc longevity gene is silenced through epigenetic modifications of an alternative promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Homozygous and heterozygous expression of a novel insulin-like growth factor-I mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Grb10, a positive, stimulatory signaling adapter in platelet-derived growth factor BB-, insulin-like growth factor I-, and insulin-mediated mitogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Insulin-like growth factor-I is essential for embryonic bone development

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Irs-2 coordinates Igf-1 receptor-mediated beta-cell development and peripheral insulin signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Intrauterine growth retardation and postnatal growth failure associated with deletion of the insulin-like growth factor I gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Inflammation in neurodegenerative disease--a double-edged sword

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Imprinting of human GRB10 and its mutations in two patients with Russell-Silver syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Mechanism of STAT3 activation by insulin-like growth factor I receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

Stat3 plays an important role in oncogenic Ros- and insulin-like growth factor I receptor-induced anchorage-independent growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

cDNA Cloning of the Rat IGF I Receptor: Structural Analysis of Rat and Human IGF I and Insulin Receptors Reveals Differences in Alternative Splicing and Receptor-Specific Domain Conservation

21 January 2018

1 reference

https://api.crossref.org/works/10.1152%2FAJPENDO.90452.2008

10.1152/AJPENDO.90452.2008

21 January 2018

Identifiers

DOI

1 reference

19 August 2017

1 reference

PubMed ID

18713961