NF-kappaB pathways in the immune system: control of the germinal center reaction (Q37231783)

19 August 2017

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title

NF-kappaB pathways in the immune system: control of the germinal center reaction (English)

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19 August 2017

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Christine A Goetz

1

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PubMed ID

18670738

19 August 2017

Albert S Baldwin

series ordinal

2

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PubMed ID

18670738

19 August 2017

language of work or name

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1 January 2008

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19 August 2017

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19 August 2017

41

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19 August 2017

3

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19 August 2017

233-247

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https://scigraph.springernature.com/pub.10.1007/s12026-008-8033-1

19 August 2017

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cites work

The BCL6 proto-oncogene: a leading role during germinal center development and lymphomagenesis

1 reference

https://api.crossref.org/works/10.1007%2FS12026-008-8033-1

Cutting edge: germinal centers formed in the absence of B cell-activating factor belonging to the TNF family exhibit impaired maturation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-008-8033-1

ICOS, CD40, and lymphotoxin beta receptors signal sequentially and interdependently to initiate a germinal center reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-008-8033-1

I kappa B kinase 2 deficiency in T cells leads to defects in priming, B cell help, germinal center reactions, and homeostatic expansion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-008-8033-1

BCL-6 negatively regulates expression of the NF-kappaB1 p105/p50 subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS12026-008-8033-1

The germinal center response

21 January 2018

1 reference

12 December 2020

Immunological adjuvants promote activated T cell survival via induction of Bcl-3.

1 reference

12 December 2020

Constitutive nuclear factor kappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells

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12 December 2020

c-Rel is required for the protection of B cells from antigen receptor-mediated, but not Fas-mediated, apoptosis

1 reference

12 December 2020

Genetic dissection of antigen receptor induced-NF-kappaB activation

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12 December 2020

The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells

1 reference

12 December 2020

Critical roles for the Bcl-3 oncoprotein in T cell-mediated immunity, splenic microarchitecture, and germinal center reactions

1 reference

12 December 2020

Lymphocytes lacking I kappa B-alpha develop normally, but have selective defects in proliferation and function

1 reference

12 December 2020

Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR.

1 reference

12 December 2020

NF-kappa B RelA-deficient lymphocytes: normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responses

1 reference

12 December 2020

BCL6 represses CHEK1 and suppresses DNA damage pathways in normal and malignant B-cells

1 reference

12 December 2020

Severe liver degeneration in mice lacking the IkappaB kinase 2 gene

1 reference

12 December 2020

The putative oncoprotein Bcl-3 induces cyclin D1 to stimulate G(1) transition

1 reference

12 December 2020

Abnormal organogenesis of Peyer's patches in mice deficient for NF-kappaB1, NF-kappaB2, and Bcl-3.

1 reference

12 December 2020

The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation

1 reference

12 December 2020

Aberrant rel/nfkb genes and activity in human cancer

1 reference

12 December 2020

The primary germinal center response in mice.

1 reference

12 December 2020

The endless complexity of lymphocyte differentiation and lymphomagenesis: IRF-4 downregulates BCL6 expression

1 reference

12 December 2020

Visualization of the endogenous NF-kappa B p50 subunit in the nucleus of follicular dendritic cells in germinal centers.

1 reference

12 December 2020

Distinct activities of p52/NF-kappa B required for proper secondary lymphoid organ microarchitecture: functions enhanced by Bcl-3

1 reference

12 December 2020

Mouse bcl-3: cDNA structure, mapping and stage-dependent expression in B lymphocytes

1 reference

12 December 2020

Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune re

1 reference

12 December 2020

BCL6 is regulated by p53 through a response element frequently disrupted in B-cell non-Hodgkin lymphoma.

1 reference

12 December 2020

A role for the IkappaB family member Bcl-3 in the control of central immunologic tolerance

1 reference

12 December 2020

Essential role of RelB in germinal center and marginal zone formation and proper expression of homing chemokines

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12 December 2020

JunD/AP-1 and STAT3 are the major enhancer molecules for high Bcl6 expression in germinal center B cells.

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12 December 2020

A signaling pathway mediating downregulation of BCL6 in germinal center B cells is blocked by BCL6 gene alterations in B cell lymphoma.

1 reference

12 December 2020

Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunit

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12 December 2020

Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells.

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12 December 2020

IkappaB kinase alpha is essential for mature B cell development and function

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12 December 2020

A short domain within Bcl-3 is responsible for its lymphocyte survival activity

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12 December 2020

Lymphadenopathy, splenomegaly, and altered immunoglobulin production in BCL3 transgenic mice.

1 reference

12 December 2020

The molecular mechanisms of classic Hodgkin's lymphoma

1 reference

12 December 2020

Signatures of the immune response

1 reference

12 December 2020

B cells from p50/NF-kappa B knockout mice have selective defects in proliferation, differentiation, germ-line CH transcription, and Ig class switching

1 reference

12 December 2020

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B

1 reference

12 December 2020

Role of lymphotoxin and the type I TNF receptor in the formation of germinal centers

1 reference

12 December 2020

Viral induction of AID is independent of the interferon and the Toll-like receptor signaling pathways but requires NF-kappaB.

1 reference

12 December 2020

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression

1 reference

12 December 2020

B cells lacking RelB are defective in proliferative responses, but undergo normal B cell maturation to Ig secretion and Ig class switching

1 reference

12 December 2020

Mice deficient in nuclear factor (NF)-kappa B/p52 present with defects in humoral responses, germinal center reactions, and splenic microarchitecture

1 reference

12 December 2020

Limb and skin abnormalities in mice lacking IKKalpha

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12 December 2020

Immunological defects in mice with a targeted disruption in Bcl-3

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12 December 2020

Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice

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12 December 2020

Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses

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12 December 2020

Bcl-3 expression promotes cell survival following interleukin-4 deprivation and is controlled by AP1 and AP1-like transcription factors

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12 December 2020

MALT1 directs B cell receptor–induced canonical nuclear factor-κB signaling selectively to the c-Rel subunit

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12 December 2020

Antigen-specific memory B cell development

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12 December 2020

Regulation of Developing B Cell Survival by RelA-Containing NF-κB Complexes

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12 December 2020

Failure of lymphopoiesis after adoptive transfer of NF-kappaB-deficient fetal liver cells

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12 December 2020

Control of lymphocyte development by nuclear factor-kappaB.

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12 December 2020

IKK1-deficient mice exhibit abnormal development of skin and skeleton

1 reference

12 December 2020

Nuclear factor-kappaB and inhibitor of kappaB kinase pathways in oncogenic initiation and progression

1 reference

12 December 2020

Canonical NF-κB Activity, Dispensable for B Cell Development, Replaces BAFF-Receptor Signals and Promotes B Cell Proliferation upon Activation

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12 December 2020

Expression of the Bcl-3 proto-oncogene suppresses p53 activation

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12 December 2020

Control of B lymphocyte apoptosis by the transcription factor NF-kappaB.

1 reference

12 December 2020

Mouse models in tumor suppression

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12 December 2020

FDC-specific functions of p55TNFR and IKK2 in the development of FDC networks and of antibody responses.

1 reference

12 December 2020

BCL6 represses NFκB activity in diffuse large B-cell lymphomas

1 reference

12 December 2020

Regulation of secondary lymphoid organ development by the nuclear factor-kappaB signal transduction pathway

1 reference

12 December 2020

Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation

1 reference

12 December 2020

The t(14;19)(q32;q13)-positive small B-cell leukaemia: a clinicopathologic and cytogenetic study of seven cases

1 reference

12 December 2020

BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells

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12 December 2020

BCL-6 expression during B-cell activation.

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12 December 2020

Requirement for NF-kappaB in osteoclast and B-cell development

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12 December 2020

Nuclear factor-kappaB: a friend or a foe in cancer?

1 reference

12 December 2020

Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase

1 reference

12 December 2020

BCL-6 protein is expressed in germinal-center B cells

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12 December 2020

Accumulation of marginal zone B cells and accelerated loss of follicular dendritic cells in NF-kappaB p50-deficient mice.

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12 December 2020

Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme

1 reference

12 December 2020

Regulation of late B cell differentiation by intrinsic IKKalpha-dependent signals

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12 December 2020

Cutting edge: Bcl-3 up-regulation by signal 3 cytokine (IL-12) prolongs survival of antigen-activated CD8 T cells

1 reference

12 December 2020

An intact NF-kappa B signaling pathway is required for maintenance of mature B cell subsets

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12 December 2020

IkappaB kinase beta inhibition induces cell death in Imatinib-resistant and T315I Dasatinib-resistant BCR-ABL+ cells

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12 December 2020

Cooperative signaling through the signal transducer and activator of transcription 3 and nuclear factor-{kappa}B pathways in subtypes of diffuse large B-cell lymphoma

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12 December 2020

IkappaB kinases: key regulators of the NF-kappaB pathway

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12 December 2020

p53 represses cyclin D1 transcription through down regulation of Bcl-3 and inducing increased association of the p52 NF-kappaB subunit with histone deacetylase 1.

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12 December 2020

B lymphocytes differentially use the Rel and nuclear factor kappaB1 (NF-kappaB1) transcription factors to regulate cell cycle progression and apoptosis in quiescent and mitogen-activated cells

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12 December 2020

IkappaB kinase signaling is essential for maintenance of mature B cells

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12 December 2020

Regulation of 3' IgH enhancers by a common set of factors, including kappa B-binding proteins.

1 reference

12 December 2020

Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice

1 reference

12 December 2020

Signaling to NF-kappaB

1 reference

12 December 2020

A loss-of-function RNA interference screen for molecular targets in cancer

1 reference

12 December 2020

Stronger Correlation of bcl-3 than bcl-2, bcl-xL, Costimulation, or Antioxidants with Adjuvant-Induced T Cell Survival

1 reference

12 December 2020

Nuclear factor (NF)-kappa B2 (p100/p52) is required for normal splenic microarchitecture and B cell-mediated immune responses

1 reference

12 December 2020

10.1007/S12026-008-8033-1

Identifiers

DOI

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19 August 2017

1 reference

PubMed ID

18670738