Mass spectrometry-based targeted proteomics as a tool to elucidate the expression and function of intestinal drug transporters (Q37207759)

18 August 2017

Mass spectrometry-based targeted proteomics as a tool to elucidate the expression and function of intestinal drug transporters (English)

1 reference

18 August 2017

Marek Drozdzik

3

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author name string

Stefan Oswald

series ordinal

1

1 reference

18 August 2017

Christian Gröer

series ordinal

2

1 reference

18 August 2017

Werner Siegmund

series ordinal

4

1 reference

18 August 2017

language of work or name

English

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publication date

28 August 2013

1 reference

18 August 2017

1 reference

18 August 2017

15

1 reference

18 August 2017

4

1 reference

18 August 2017

1128-1140

1 reference

https://scigraph.springernature.com/pub.10.1208/s12248-013-9521-3

18 August 2017

0 references

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6 September 2017

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Fruit juice inhibition of uptake transport: a new type of food-drug interaction

6 September 2017

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Membrane transporters in drug development

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Methodological considerations for improving Western blot analysis

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6 September 2017

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6 September 2017

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6 September 2017

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Closing the gaps: a full scan of the intestinal expression of p-glycoprotein, breast cancer resistance protein, and multidrug resistance-associated protein 2 in male and female rats

6 September 2017

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The role of the intestine in drug metabolism and pharmacokinetics: an industry perspective

6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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Tissue-specific mRNA expression profiles of human ATP-binding cassette and solute carrier transporter superfamilies

6 September 2017

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6 September 2017

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6 September 2017

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Cytochromes P450 and MDR1 mRNA expression along the human gastrointestinal tract

6 September 2017

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CYP2D6 genotype and induction of intestinal drug transporters by rifampin predict presystemic clearance of carvedilol in healthy subjects.

6 September 2017

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The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteinsIntroduction

6 September 2017

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The gut as a barrier to drug absorption: combined role of cytochrome P450 3A and P-glycoprotein

6 September 2017

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The effect of rifampin administration on the disposition of fexofenadine

6 September 2017

1 reference

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Correlation between protein and mRNA abundance in yeast

6 September 2017

1 reference

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Real-time detection of the surface delivery of newly synthesized membrane proteins

6 September 2017

1 reference

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Absolute quantification and differential expression of drug transporters, cytochrome P450 enzymes, and UDP-glucuronosyltransferases in cultured primary human hepatocytes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787215

Development of a highly sensitive method using liquid chromatography-multiple reaction monitoring to quantify membrane P-glycoprotein in biological matrices and relationship to transport function

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787215

Protein quantification by chemiluminescent Western blotting: elimination of the antibody factor by dilution series and calibration curve

14 September 2017

1 reference

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Absolute quantification of multidrug resistance-associated protein 2 (MRP2/ABCC2) using liquid chromatography tandem mass spectrometry

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787215

Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787215

Expression of thirty-six drug transporter genes in human intestine, liver, kidney, and organotypic cell lines.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787215

Intestinal drug transporter expression and the impact of grapefruit juice in humans

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787215

Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787215

Correlation of gene expression of ten drug efflux proteins of the ATP-binding cassette transporter family in normal human jejunum and in human intestinal epithelial Caco-2 cell monolayers.

28 September 2017

1 reference

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The role of intestinal P-glycoprotein in the interaction of digoxin and rifampin

28 September 2017

1 reference

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Effect of coadministration of single and multiple doses of rifampicin on the pharmacokinetics of fexofenadine enantiomers in healthy subjects

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787215

Contribution of increased oral bioavailability and reduced nonglomerular renal clearance of digoxin to the digoxin-clarithromycin interaction

26 June 2018

1 reference

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LC-MS/MS-based quantification of clinically relevant intestinal uptake and efflux transporter proteins.

26 June 2018

1 reference

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Quantitative expression of human drug transporter proteins in lung tissues: analysis of regional, gender, and interindividual differences by liquid chromatography-tandem mass spectrometry.

3 September 2018

1 reference

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Absolute measurement of species differences in sodium taurocholate cotransporting polypeptide (NTCP/Ntcp) and its modulation in cultured hepatocytes.

3 September 2018

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Major active components in grapefruit, orange, and apple juices responsible for OATP2B1-mediated drug interactions

3 September 2018

1 reference

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Comprehensive study on regional human intestinal permeability and prediction of fraction absorbed of drugs using the Ussing chamber technique

3 September 2018

1 reference

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Expression profiles of metabolic enzymes and drug transporters in the liver and along the intestine of beagle dogs.

3 September 2018

1 reference

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Simultaneous absolute protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases as a novel approach for the characterization of individual human liver: comparison with mRNA levels and activities.

3 September 2018

1 reference

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Effect of variations in the amounts of P-glycoprotein (ABCB1), BCRP (ABCG2) and CYP3A4 along the human small intestine on PBPK models for predicting intestinal first pass.

3 September 2018

1 reference

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Simultaneous absolute quantification of 11 cytochrome P450 isoforms in human liver microsomes by liquid chromatography tandem mass spectrometry with in silico target peptide selection.

3 September 2018

1 reference

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Changes in mRNA expression levels of solute carrier transporters in inflammatory bowel disease patients.

3 September 2018

1 reference

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Human platelets express organic anion-transporting peptide 2B1, an uptake transporter for atorvastatin

3 September 2018

1 reference

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LC-MS/MS mediated absolute quantification and comparison of bile salt export pump and breast cancer resistance protein in livers and hepatocytes across species.

3 September 2018

1 reference

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Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories.

3 September 2018

1 reference

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Influence of genetic polymorphisms on intestinal expression and rifampicin-type induction of ABCC2 and on bioavailability of talinolol

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787215

Gene and protein expression of P-glycoprotein, MRP1, MRP2, and CYP3A4 in the small and large human intestine.

3 September 2018

1 reference

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Efflux transporters in ulcerative colitis: decreased expression of BCRP (ABCG2) and Pgp (ABCB1).

3 September 2018

1 reference

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Tissue-specific mRNA expression profiles of human phase I metabolizing enzymes except for cytochrome P450 and phase II metabolizing enzymes.

3 September 2018

1 reference

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Variability in mRNA expression of ABC- and SLC-transporters in human intestinal cells: comparison between human segments and Caco-2 cells.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787215

Intestinal expression of P-glycoprotein (ABCB1), multidrug resistance associated protein 2 (ABCC2), and uridine diphosphate-glucuronosyltransferase 1A1 predicts the disposition and modulates the effects of the cholesterol absorption inhibitor ezetim

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787215

Distribution of breast cancer resistance protein (BCRP/ABCG2) mRNA expression along the human GI tract

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787215

The talinolol double-peak phenomenon is likely caused by presystemic processing after uptake from gut lumen

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787215

Grapefruit juice ingestion significantly reduces talinolol bioavailability

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787215

Mapping of multidrug resistance gene 1 and multidrug resistance-associated protein isoform 1 to 5 mRNA expression along the human intestinal tract

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787215

Carbamazepine regulates intestinal P-glycoprotein and multidrug resistance protein MRP2 and influences disposition of talinolol in humans.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787215

Absolute quantification of the model biomarker prostate-specific antigen in serum by LC-Ms/MS using protein cleavage and isotope dilution mass spectrometry

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787215

Cytochrome P450 3A4 and P-glycoprotein expression in human small intestinal enterocytes and hepatocytes: a comparative analysis in paired tissue specimens

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787215

Tissue distribution of mRNA expression of human cytochrome P450 isoforms assessed by high-sensitivity real-time reverse transcription PCR.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787215

Real-time quantitative polymerase chain reaction for MDR1, MRP1, MRP2, and CYP3A-mRNA levels in Caco-2 cell lines, human duodenal enterocytes, normal colorectal tissues, and colorectal adenocarcinomas.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787215

Site-differential gastrointestinal absorption of benazepril hydrochloride in healthy volunteers

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787215

Differential absorption of amoxicillin from the human small and large intestine

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787215

Interindividual Variability in the Hepatic Expression of the Human Breast Cancer Resistance Protein (BCRP/ABCG2): Effect of Age, Sex, and Genotype

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3787215

Absolute immunoquantification of the expression of ABC transporters P-glycoprotein, breast cancer resistance protein and multidrug resistance-associated protein 2 in human liver and duodenum

4 December 2018

1 reference

12 December 2020

Absolute quantification of the G protein-coupled receptor rhodopsin by LC/MS/MS using proteolysis product peptides and synthetic peptide standards

1 reference

12 December 2020

P-glycoprotein increases from proximal to distal regions of human small intestine

1 reference

12 December 2020

Mass spectrometric quantification of endogenous beta-endorphin

1 reference

12 December 2020

Regional levels of drug transporters along the human intestinal tract: co-expression of ABC and SLC transporters and comparison with Caco-2 cells

1 reference

12 December 2020

Disposition and sterol-lowering effect of ezetimibe are influenced by single-dose coadministration of rifampin, an inhibitor of multidrug transport proteins

1 reference

12 December 2020

Regional distribution of solute carrier mRNA expression along the human intestinal tract

1 reference

12 December 2020

Direct demonstration of small intestinal secretion and site-dependent absorption of the beta-blocker talinolol in humans

1 reference

12 December 2020

Isotope dilution--mass spectrometric quantification of specific proteins: model application with apolipoprotein A-I

1 reference

12 December 2020

Expression profiles of various transporters for oligopeptides, amino acids and organic ions along the human digestive tract

1 reference

12 December 2020

P-glycoprotein inhibitor erythromycin increases oral bioavailability of talinolol in humans

1 reference

12 December 2020

Induction of P-glycoprotein by rifampin increases intestinal secretion of talinolol in human beings: a new type of drug/drug interaction

1 reference

12 December 2020

Quantitative atlas of membrane transporter proteins: development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria

1 reference

12 December 2020

Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors

1 reference

12 December 2020

Reliability and robustness of simultaneous absolute quantification of drug transporters, cytochrome P450 enzymes, and Udp-glucuronosyltransferases in human liver tissue by multiplexed MRM/selected reaction monitoring mode tandem mass spectrometry wi

1 reference

12 December 2020

10.1208/S12248-013-9521-3

Identifiers

DOI

1 reference

Dimensions Publication ID

18 August 2017

0 references

1 reference

18 August 2017

1 reference