Efflux transporters in ulcerative colitis: decreased expression of BCRP (ABCG2) and Pgp (ABCB1). (Q52576052)

3 May 2018

title

Efflux transporters in ulcerative colitis: decreased expression of BCRP (ABCG2) and Pgp (ABCB1). (English)

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Gunilla Englund

1

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Annica Jacobson

2

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Fredrik Rorsman

3

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Per Artursson

4

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Andreas Kindmark

5

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Anders Rönnblom

6

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publication date

1 March 2007

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3 May 2018

Inflammatory Bowel Diseases

published in

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volume

13

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page(s)

291-297

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issue

3

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ABC of oral bioavailability: transporters as gatekeepers in the gut.

cites work

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Role of transport proteins in drug absorption, distribution and excretion

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Downregulation of mdr1a expression in the brain and liver during CNS inflammation alters the in vivo disposition of digoxin.

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Regulation of the hepatic multidrug resistance gene expression by endotoxin and inflammatory cytokines in mice.

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Decreased expression and activity of P-glycoprotein in rat liver during acute inflammation.

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Suppression of drug-metabolizing enzymes and efflux transporters in the intestine of endotoxin-treated rats

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Association between the C3435T MDR1 gene polymorphism and susceptibility for ulcerative colitis.

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Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense

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Human breast cancer resistance protein: interactions with steroid drugs, hormones, the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine, and transport of cimetidine.

21 January 2018

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Identification of BCRP as transporter of benzo[a]pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists

21 January 2018

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The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk.

21 January 2018

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Breast cancer resistance protein (Bcrp1/Abcg2) reduces systemic exposure of the dietary carcinogens aflatoxin B1, IQ and Trp-P-1 but also mediates their secretion into breast milk

21 January 2018

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Mechanism of the pharmacokinetic interaction between methotrexate and benzimidazoles: potential role for breast cancer resistance protein in clinical drug-drug interactions

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The breast cancer resistance protein (BCRP/ABCG2) affects pharmacokinetics, hepatobiliary excretion, and milk secretion of the antibiotic nitrofurantoin.

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Breast cancer resistance protein (Bcrp/abcg2) is a major determinant of sulfasalazine absorption and elimination in the mouse

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Oxidative stress induces internalization of the bile salt export pump, Bsep, and bile salt secretory failure in isolated rat hepatocyte couplets: a role for protein kinase C and prevention by protein kinase A

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From symptom to diagnosis: clinical distinctions among various forms of intestinal inflammation

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Carboxylesterase-mediated sensitization of human tumor cells to CPT-11 cannot override ABCG2-mediated drug resistance

21 January 2018

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Multidrug resistance activity in human lymphocytes

21 January 2018

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Expression of the drug transporters MDR1/ABCB1, MRP1/ABCC1, MRP2/ABCC2, BCRP/ABCG2, and PXR in peripheral blood mononuclear cells and their relationship with the expression in intestine and liver

21 January 2018

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Pharmacokinetic considerations in the treatment of inflammatory bowel disease

21 January 2018

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Development of sulfasalazine resistance in human T cells induces expression of the multidrug resistance transporter ABCG2 (BCRP) and augmented production of TNFalpha

21 January 2018

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Cyclosporin A is a broad-spectrum multidrug resistance modulator

21 January 2018

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Identification of budesonide and prednisone as substrates of the intestinal drug efflux pump P-glycoprotein

21 January 2018

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ABCG2 transports sulfated conjugates of steroids and xenobiotics

21 January 2018

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Chemoprevention of colorectal cancer in ulcerative colitis

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/IBD.20030

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3 May 2018

PubMed ID

17206689

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3 May 2018