The role of SERCA2a/PLN complex, Ca(2+) homeostasis, and anti-apoptotic proteins in determining cell fate (Q37139450)

18 August 2017

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title

The role of SERCA2a/PLN complex, Ca(2+) homeostasis, and anti-apoptotic proteins in determining cell fate (English)

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18 August 2017

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Vasiliki Papalouka

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Elisabeth Vafiadaki

object named as

Elizabeth Vafiadaki

1

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Dimitrios A. Arvanitis

object named as

Demetrios A Arvanitis

3

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Despina Sanoudou

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Despina Sanoudou

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author name string

Evangelia G Kranias

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PubMed ID

18415121

18 August 2017

language of work or name

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16 April 2008

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18 August 2017

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18 August 2017

457

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18 August 2017

3

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18 August 2017

687-700

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https://scigraph.springernature.com/pub.10.1007/s00424-008-0506-5

18 August 2017

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cites work

Apoptosis and heart failure: A critical review of the literature

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https://api.crossref.org/works/10.1007%2FS00424-008-0506-5

Targeted overexpression of the sarcoplasmic reticulum Ca2+-ATPase increases cardiac contractility in transgenic mouse hearts

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00424-008-0506-5

Sarcoplasmic reticulum gene expression in cardiac hypertrophy and heart failure.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00424-008-0506-5

Ca2+ handling and sarcoplasmic reticulum Ca2+ content in isolated failing and nonfailing human myocardium.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-008-0506-5

Targeted ablation of the phospholamban gene is associated with markedly enhanced myocardial contractility and loss of beta-agonist stimulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-008-0506-5

Phospholamban gene dosage effects in the mammalian heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-008-0506-5

Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-008-0506-5

Epstein-Barr virus (EBV) nuclear antigen leader protein (EBNA-LP) forms complexes with a cellular anti-apoptosis protein Bcl-2 or its EBV counterpart BHRF1 through HS1-associated protein X-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-008-0506-5

Epstein-Barr virus nuclear antigen 5 interacts with HAX-1, a possible component of the B-cell receptor signalling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-008-0506-5

ER-mitochondria communication. How privileged?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00424-008-0506-5

Phospholamban phosphorylation in intact ventricles. Phosphorylation of serine 16 and threonine 17 in response to beta-adrenergic stimulation

21 January 2018

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12 December 2020

The presence of Lys27 instead of Asn27 in human phospholamban promotes sarcoplasmic reticulum Ca2+-ATPase superinhibition and cardiac remodeling

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12 December 2020

Phospholamban interacts with HAX-1, a mitochondrial protein with anti-apoptotic function

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12 December 2020

Cell biology. Apoptosis--the calcium connection.

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12 December 2020

Nature and site of phospholamban regulation of the Ca2+ pump of sarcoplasmic reticulum

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12 December 2020

Bax-mediated Ca2+ mobilization promotes cytochrome c release during apoptosis

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12 December 2020

Intracellular IL-1alpha-binding proteins contribute to biological functions of endogenous IL-1alpha in systemic sclerosis fibroblasts

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12 December 2020

A human phospholamban promoter polymorphism in dilated cardiomyopathy alters transcriptional regulation by glucocorticoids

1 reference

12 December 2020

Impaired cardiac performance in heterozygous mice with a null mutation in the sarco(endo)plasmic reticulum Ca2+-ATPase isoform 2 (SERCA2) gene

1 reference

12 December 2020

The protein product of the oncogene bcl-2 is a component of the nuclear envelope, the endoplasmic reticulum, and the outer mitochondrial membrane.

1 reference

12 December 2020

HAX-1, identified by differential display reverse transcription polymerase chain reaction, is overexpressed in lesional psoriasis

1 reference

12 December 2020

Abnormalities of calcium cycling in the hypertrophied and failing heart

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12 December 2020

Superinhibition of sarcoplasmic reticulum function by phospholamban induces cardiac contractile failure

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12 December 2020

Galpha13 stimulates cell migration through cortactin-interacting protein Hax-1.

1 reference

12 December 2020

The 3' untranslated region of human vimentin mRNA interacts with protein complexes containing eEF-1gamma and HAX-1

1 reference

12 December 2020

The mechanism of Ca2+ transport by sarco(endo)plasmic reticulum Ca2+-ATPases

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12 December 2020

Severe developmental delay and epilepsy in a Japanese patient with severe congenital neutropenia due to HAX1 deficiency.

1 reference

12 December 2020

Alterations of calcium-regulatory proteins in heart failure.

1 reference

12 December 2020

The endoplasmic reticulum gateway to apoptosis by Bcl-X(L) modulation of the InsP3R

1 reference

12 December 2020

BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis

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12 December 2020

Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, I: experimental studies

1 reference

12 December 2020

Multiple subcellular localization of bcl-2: detection in nuclear outer membrane, endoplasmic reticulum membrane, and mitochondrial membranes

1 reference

12 December 2020

Molecular cloning of the mammalian smooth muscle sarco(endo)plasmic reticulum Ca2+-ATPase

1 reference

12 December 2020

Phospholamban: a protein coming of age.

1 reference

12 December 2020

Sarcolipin and phospholamban as regulators of cardiac sarcoplasmic reticulum Ca2+ ATPase

1 reference

12 December 2020

Transgenic overexpression of the sarcoplasmic reticulum Ca2+ATPase improves reticular Ca2+ handling in normal and diabetic rat hearts.

1 reference

12 December 2020

Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis

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12 December 2020

Polymorphic SERCA2a variants do not account for inter-individual differences in phospholamban-SERCA2a interactions in human heart failure

1 reference

12 December 2020

Relation between myocardial function and expression of sarcoplasmic reticulum Ca(2+)-ATPase in failing and nonfailing human myocardium

1 reference

12 December 2020

Calcium cycling in congestive heart failure

1 reference

12 December 2020

Transgenic approaches to define the functional role of dual site phospholamban phosphorylation

1 reference

12 December 2020

A mutation in the human phospholamban gene, deleting arginine 14, results in lethal, hereditary cardiomyopathy.

1 reference

12 December 2020

Regulatory effects of phospholamban on cardiac function in intact mice

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12 December 2020

Threonine-17 phosphorylation of phospholamban: a key determinant of frequency-dependent increase of cardiac contractility

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12 December 2020

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

1 reference

12 December 2020

The nature of the modulation of Ca2+ transport as studied by reconstitution of cardiac sarcoplasmic reticulum

1 reference

12 December 2020

Apoptosis and cardiomyopathy

1 reference

12 December 2020

Apoptosis regulation by Bcl-x(L) modulation of mammalian inositol 1,4,5-trisphosphate receptor channel isoform gating.

1 reference

12 December 2020

Reduced loading of intracellular Ca(2+) stores and downregulation of capacitative Ca(2+) influx in Bcl-2-overexpressing cells.

1 reference

12 December 2020

HS1-Associated Protein X-1 Regulates Carcinoma Cell Migration and Invasion via Clathrin-Mediated Endocytosis of Integrin αvβ6

1 reference

12 December 2020

Bcl-2-mediated alterations in endoplasmic reticulum Ca2+ analyzed with an improved genetically encoded fluorescent sensor

1 reference

12 December 2020

Overexpression of calreticulin sensitizes SERCA2a to oxidative stress.

1 reference

12 December 2020

Alterations in sarcoplasmic reticulum gene expression in human heart failure. A possible mechanism for alterations in systolic and diastolic properties of the failing myocardium

1 reference

12 December 2020

Overexpression of HAX-1 protects cardiac myocytes from apoptosis through caspase-9 inhibition

1 reference

12 December 2020

There is more to life and death than mitochondria: Bcl-2 proteins at the endoplasmic reticulum

1 reference

12 December 2020

An anti-apoptotic protein, Hax-1, inhibits the HIV-1 rev function by altering its sub-cellular localization

1 reference

12 December 2020

Alterations of sarcoplasmic reticulum proteins in failing human dilated cardiomyopathy

1 reference

12 December 2020

Cardiac excitation-contraction coupling

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12 December 2020

A synopsis of research in cardiac apoptosis and its application to congestive heart failure

1 reference

12 December 2020

Human immunodeficiency virus type 1 Vpr interacts with antiapoptotic mitochondrial protein HAX-1

1 reference

12 December 2020

Mitochondrial functions and estrogen receptor-dependent nuclear translocation of pleiotropic human prohibitin 2

1 reference

12 December 2020

Role of leucine 31 of phospholamban in structural and functional interactions with the Ca2+ pump of cardiac sarcoplasmic reticulum

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12 December 2020

Accelerated onset of heart failure in mice during pressure overload with chronically decreased SERCA2 calcium pump activity

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12 December 2020

Bax and Bak promote apoptosis by modulating endoplasmic reticular and mitochondrial Ca2+ stores

1 reference

12 December 2020

Severe congenital neutropenia: new genes explain an old disease

1 reference

12 December 2020

Decreased expression of cardiac sarcoplasmic reticulum Ca(2+)-pump ATPase in congestive heart failure due to myocardial infarction

1 reference

12 December 2020

Complete complementary DNA-derived amino acid sequence of canine cardiac phospholamban

1 reference

12 December 2020

Gender influences on sarcoplasmic reticulum Ca2+-handling in failing human myocardium

1 reference

12 December 2020

Bcl-2-dependent modulation of Ca(2+) homeostasis and store-operated channels in prostate cancer cells

1 reference

12 December 2020

Phospholamban: protein structure, mechanism of action, and role in cardiac function

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12 December 2020

Mutation of the phospholamban promoter associated with hypertrophic cardiomyopathy

1 reference

12 December 2020

Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes

1 reference

12 December 2020

Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types

1 reference

12 December 2020

Evidence that HAX-1 is an interleukin-1 alpha N-terminal binding protein

1 reference

12 December 2020

Maintenance of calcium homeostasis in the endoplasmic reticulum by Bcl-2

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12 December 2020

Calcium and cardiac rhythms: physiological and pathophysiological

1 reference

12 December 2020

Comparative studies of cardiac and skeletal sarcoplasmic reticulum ATPases. Effect of a phospholamban antibody on enzyme activation by Ca2+.

1 reference

12 December 2020

Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate.

1 reference

12 December 2020

The Ca2+ concentration of the endoplasmic reticulum is a key determinant of ceramide-induced apoptosis: significance for the molecular mechanism of Bcl-2 action

1 reference

12 December 2020

Disruption of a single copy of the SERCA2 gene results in altered Ca2+ homeostasis and cardiomyocyte function.

1 reference

12 December 2020

Nucleotide sequences of avian cardiac and brain SR/ER Ca(2+)-ATPases and functional comparisons with fast twitch Ca(2+)-ATPase. Calcium affinities and inhibitor effects.

1 reference

12 December 2020

The polycystic kidney disease protein PKD2 interacts with Hax-1, a protein associated with the actin cytoskeleton

1 reference

12 December 2020

ATP2A2 mutations in Darier's disease: variant cutaneous phenotypes are associated with missense mutations, but neuropsychiatric features are independent of mutation class.

1 reference

12 December 2020

Modulation of endoplasmic reticulum calcium pump by Bcl-2.

1 reference

12 December 2020

Ca2+ -dependent interaction of S100A1 with the sarcoplasmic reticulum Ca2+ -ATPase2a and phospholamban in the human heart

1 reference

12 December 2020

Apoptotic crosstalk between the endoplasmic reticulum and mitochondria controlled by Bcl-2

1 reference

12 December 2020

Bcl-X(L) affects Ca(2+) homeostasis by altering expression of inositol 1,4,5-trisphosphate receptors

1 reference

12 December 2020

Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

1 reference

12 December 2020

The transgenic expression of highly inhibitory monomeric forms of phospholamban in mouse heart impairs cardiac contractility

1 reference

12 December 2020

Regulation of HAX-1 anti-apoptotic protein by Omi/HtrA2 protease during cell death

1 reference

12 December 2020

Excitation-contraction coupling in heart cells. Roles of the sodium-calcium exchange, the calcium current, and the sarcoplasmic reticulum

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12 December 2020

Bcl-2 family members and apoptosis, taken to heart

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12 December 2020

Displacement of SERCA from SR lipid caveolae-related domains by Bcl-2: a possible mechanism for SERCA inactivation

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12 December 2020

Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier disease

1 reference

12 December 2020

The Clinical, Immunohematological, and Molecular Study of Iranian Patients with Severe Congenital Neutropenia

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12 December 2020

Calcium and Cardiac Excitation-Contraction Coupling

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12 December 2020

Identification of HAX-1 as a protein that binds bile salt export protein and regulates its abundance in the apical membrane of Madin-Darby canine kidney cells

1 reference

12 December 2020

K15 protein of Kaposi's sarcoma-associated herpesvirus is latently expressed and binds to HAX-1, a protein with antiapoptotic function

1 reference

12 December 2020

Structural and functional implications of the phospholamban hinge domain: impaired SR Ca2+ uptake as a primary cause of heart failure

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12 December 2020

Phosphorylation of the Sarcoplasmic Reticulum and Sarcolemma

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12 December 2020

Endoplasmic reticulum localized Bcl-2 prevents apoptosis when redistribution of cytochrome c is a late event

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12 December 2020

Participation of endoplasmic reticulum and mitochondrial calcium handling in apoptosis: more than just neighborhood?

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12 December 2020

Characterization of rabbit cardiac sarco(endo)plasmic reticulum Ca2(+)-ATPase gene

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12 December 2020

The Bcl2 family: regulators of the cellular life-or-death switch

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12 December 2020

Phospholamban domain Ib mutations influence functional interactions with the Ca2+-ATPase isoform of cardiac sarcoplasmic reticulum

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12 December 2020

The Enhanced Contractility of the Phospholamban-deficient Mouse Heart Persists with Aging

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12 December 2020

Cardiac-specific overexpression of a superinhibitory pentameric phospholamban mutant enhances inhibition of cardiac function in vivo

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12 December 2020

Anti-apoptotic protein Bcl-2 interacts with and destabilizes the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA).

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12 December 2020

Wild-type, mitochondrial and ER-restricted Bcl-2 inhibit DNA damage-induced apoptosis but do not affect death receptor-induced apoptosis.

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12 December 2020

Histidine-rich Ca-binding protein interacts with sarcoplasmic reticulum Ca-ATPase

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12 December 2020

Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses

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12 December 2020

Mechanisms of disease: apoptosis in heart failure--seeing hope in death

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12 December 2020

Bcl-2 decreases the free Ca2+ concentration within the endoplasmic reticulum

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12 December 2020

Phospholamban: a crucial regulator of cardiac contractility

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12 December 2020

Amino acids Glu2 to Ile18 in the cytoplasmic domain of phospholamban are essential for functional association with the Ca(2+)-ATPase of sarcoplasmic reticulum

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12 December 2020

Mutational screening of phospholamban gene in hypertrophic and idiopathic dilated cardiomyopathy and functional study of the PLN -42 C>G mutation.

1 reference

12 December 2020

Bcl-2 protein family members: versatile regulators of calcium signaling in cell survival and apoptosis

1 reference

12 December 2020

Regulation of Sarco(endo)plasmic Reticulum Ca2+ Adenosine Triphosphatase by Phospholamban and Sarcolipin Implication for Cardiac Hypertrophy and Failure

1 reference

12 December 2020

Phospholamban regulation of cardiac sarcoplasmic reticulum (Ca(2+)-Mg2+)-ATPase. Mechanism of regulation and site of monoclonal antibody interaction

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12 December 2020

Regulation of myocardial Ca2+-ATPase and phospholamban mRNA expression in response to pressure overload and thyroid hormone

1 reference

12 December 2020

A single site (Ser16) phosphorylation in phospholamban is sufficient in mediating its maximal cardiac responses to beta -agonists

1 reference

12 December 2020

HAX-1, a novel intracellular protein, localized on mitochondria, directly associates with HS1, a substrate of Src family tyrosine kinases

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12 December 2020

Acylphosphatase interferes with SERCA2a-PLN association.

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12 December 2020

Cytoplasmic interactions between phospholamban residues 1-20 and the calcium-activated ATPase of the sarcoplasmic reticulum

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12 December 2020

Hairpin structure within the 3'UTR of DNA polymerase beta mRNA acts as a post-transcriptional regulatory element and interacts with Hax-1

1 reference

12 December 2020

Characterization of KIAA0513, a novel signaling molecule that interacts with modulators of neuroplasticity, apoptosis, and the cytoskeleton.

1 reference

12 December 2020

HAX1 deficiency causes autosomal recessive severe congenital neutropenia (Kostmann disease)

1 reference

12 December 2020

Ser16 prevails over Thr17 phospholamban phosphorylation in the beta-adrenergic regulation of cardiac relaxation.

1 reference

12 December 2020

Interaction of Epstein-Barr virus nuclear antigen leader protein (EBNA-LP) with HS1-associated protein X-1: implication of cytoplasmic function of EBNA-LP.

1 reference

12 December 2020

Phospholamban inhibitory function is activated by depolymerization

1 reference

12 December 2020

Comprehensive analysis of expression and function of 51 sarco(endo)plasmic reticulum Ca2+-ATPase mutants associated with Darier disease.

1 reference

12 December 2020

Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban

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12 December 2020

Losing heart: the role of apoptosis in heart disease--a novel therapeutic target?

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12 December 2020

Mitochondria-endoplasmic reticulum choreography: structure and signaling dynamics.

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12 December 2020

Amino acids Lys-Asp-Asp-Lys-Pro-Val402 in the Ca(2+)-ATPase of cardiac sarcoplasmic reticulum are critical for functional association with phospholamban.

1 reference

12 December 2020

Overexpression of the rat sarcoplasmic reticulum Ca2+ ATPase gene in the heart of transgenic mice accelerates calcium transients and cardiac relaxation

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12 December 2020

beta-Adrenergic regulation of cAMP and protein phosphorylation in phospholamban-knockout mouse hearts

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12 December 2020

The BCL-2 protein family: opposing activities that mediate cell death

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12 December 2020

10.1007/S00424-008-0506-5

Identifiers

DOI

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18 August 2017

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PubMed ID

18415121