The Endosome-associated Deubiquitinating Enzyme USP8 Regulates BACE1 Enzyme Ubiquitination and Degradation (Q37117319)

18 August 2017

The Endosome-associated Deubiquitinating Enzyme USP8 Regulates BACE1 Enzyme Ubiquitination and Degradation (English)

1 reference

Ubiquitin specific peptidase 8

18 August 2017

1 reference

GOA release 2020-03-11

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GOA release 2020-03-11

protein ubiquitination

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inferred from title

author name string

Eniola Funmilayo Aduke Yeates

series ordinal

1

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18 August 2017

Giuseppina Tesco

series ordinal

2

1 reference

18 August 2017

language of work or name

English

0 references

publication date

14 June 2016

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Journal of Biological Chemistry

18 August 2017

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18 August 2017

291

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18 August 2017

30

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18 August 2017

15753-15766

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describes a project that uses

18 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4957057/fullTextXML

inferred from PubMed Central ID database lookup

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BACE1 protein endocytosis and trafficking are differentially regulated by ubiquitination at lysine 501 and the Di-leucine motif in the carboxyl terminus

14 September 2017

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Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions

14 September 2017

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14 September 2017

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Ubiquitin regulates GGA3-mediated degradation of BACE1

14 September 2017

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14 September 2017

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Endosomal deubiquitinating enzymes control ubiquitination and down-regulation of protease-activated receptor 2.

14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity

14 September 2017

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14 September 2017

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14 September 2017

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A deubiquitinating enzyme UBPY regulates the level of protein ubiquitination on endosomes

14 September 2017

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The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation

14 September 2017

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14 September 2017

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Regulation of epidermal growth factor receptor down-regulation by UBPY-mediated deubiquitination at endosomes

14 September 2017

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Structural mechanism for ubiquitinated-cargo recognition by the Golgi-localized, gamma-ear-containing, ADP-ribosylation-factor-binding proteins

14 September 2017

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The GAT domains of clathrin-associated GGA proteins have two ubiquitin binding motifs

14 September 2017

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Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8

14 September 2017

1 reference

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Beta-secretase inhibition for the treatment of Alzheimer's disease--promise and challenge

14 September 2017

1 reference

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Interactions of GGA3 with the ubiquitin sorting machinery

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4957057

Take five--BACE and the gamma-secretase quartet conduct Alzheimer's amyloid beta-peptide generation.

14 September 2017

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Two isoforms of otubain 1 regulate T cell anergy via GRAIL

14 September 2017

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Signals for sorting of transmembrane proteins to endosomes and lysosomes

14 September 2017

1 reference

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STAM and Hrs are subunits of a multivalent ubiquitin-binding complex on early endosomes

14 September 2017

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The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility

14 September 2017

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Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

14 September 2017

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The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner

14 September 2017

1 reference

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Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

14 September 2017

1 reference

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A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP

14 September 2017

1 reference

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Purification and cloning of amyloid precursor protein beta-secretase from human brain

14 September 2017

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Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

14 September 2017

1 reference

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4957057

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4957057

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4957057

VEGFR2 Trafficking, Signaling and Proteolysis is Regulated by the Ubiquitin Isopeptidase USP8.

14 September 2017

1 reference

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Alkalizing drugs induce accumulation of amyloid precursor protein by-products in luminal vesicles of multivesicular bodies

14 September 2017

1 reference

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Essential role of ubiquitin-specific protease 8 for receptor tyrosine kinase stability and endocytic trafficking in vivo

14 September 2017

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Intracellular pH regulates amyloid precursor protein intracellular domain accumulation.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4957057

BACE is degraded via the lysosomal pathway

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4957057

The deubiquitinating enzyme UBPy/USP8 interacts with TrkA and inhibits neuronal differentiation in PC12 cells.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4957057

Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4957057

Molecular mechanism of ubiquitin recognition by GGA3 GAT domain

27 June 2018

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Regulation of neuronal survival and morphology by the E3 ubiquitin ligase RNF157.

27 June 2018

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UBPY-mediated epidermal growth factor receptor (EGFR) de-ubiquitination promotes EGFR degradation

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4957057

Processing of beta-secretase by furin and other members of the proprotein convertase family

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4957057

Alzheimer's disease. Closing in on gamma-secretase.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4957057

Mutations in the transmembrane domain of APP altering gamma-secretase specificity

3 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27302062

12 December 2020

inferred from PubMed ID database lookup

Expression of the deubiquitinating enzyme mUBPy in the mouse brain

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27302062

12 December 2020

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Identifiers

DOI

10.1074/JBC.M116.718023

1 reference

18 August 2017

1 reference

18 August 2017

1 reference