A systems biology approach to drug discovery (Q37115945)

18 August 2017

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title

A systems biology approach to drug discovery (English)

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18 August 2017

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3

Eric E Schadt

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18 August 2017

Jun Zhu

1

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PubMed ID

18358334

18 August 2017

Bin Zhang

series ordinal

2

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18 August 2017

1 January 2008

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18 August 2017

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18 August 2017

60

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18 August 2017

603-635

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The genome sequence of Drosophila melanogaster

18 August 2017

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Error and attack tolerance of complex networks

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Whole-Genome Shotgun Assembly and Analysis of the Genome of Fugu rubripes

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Systems biology. When proteomes collide.

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Emergence of Scaling in Random Networks

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Network biology: understanding the cell's functional organization

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Compact, universal DNA microarrays to comprehensively determine transcription-factor binding site specificities

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Genetic dissection of transcriptional regulation in budding yeast

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics'.

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Genome sequence of the nematode C. elegans: a platform for investigating biology

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Gene connectivity, function, and sequence conservation: predictions from modular yeast co-expression networks

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Gene co-expression network topology provides a framework for molecular characterization of cellular state

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Integrating QTL and high-density SNP analyses in mice to identify Insig2 as a susceptibility gene for plasma cholesterol levels

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

An effective structure learning method for constructing gene networks.

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Variations in DNA elucidate molecular networks that cause disease

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Regulatory gene networks and the properties of the developmental process

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Predicting transcription factor binding sites using local over-representation and comparative genomics

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Applying dynamic Bayesian networks to perturbed gene expression data

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Cis-acting expression quantitative trait loci in mice

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

The complete sequence of the mitochondrial genome of Saccharomyces cerevisiae

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Analysis of the human protein interactome and comparison with yeast, worm and fly interaction datasets

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Inferring genetic networks and identifying compound mode of action via expression profiling

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Identification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipids

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

A probabilistic methodology for integrating knowledge and experiments on biological networks.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Integrating genetic and network analysis to characterize genes related to mouse weight

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Linear and nonlinear causality between signals: methods, examples and neurophysiological applications

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Investigating Causal Relations by Econometric Models and Cross-spectral Methods

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Glucose induces de novo lipogenesis in rat muscle satellite cells through a sterol-regulatory-element-binding-protein-1c-dependent pathway

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

MPact: the MIPS protein interaction resource on yeast

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Evidence for dynamically organized modularity in the yeast protein-protein interaction network

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

From molecular to modular cell biology

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Growing genetic regulatory networks from seed genes.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

A common genetic variant is associated with adult and childhood obesity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Functional discovery via a compendium of expression profiles

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Sensitivity and specificity of inferring genetic regulatory interactions from microarray experiments with dynamic Bayesian networks

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

A new approach to decoding life: systems biology

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Integrated genomic and proteomic analyses of a systematically perturbed metabolic network

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Finishing the euchromatic sequence of the human genome

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Genetical genomics: the added value from segregation.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

A Bayesian Networks Approach for Predicting Protein-Protein Interactions from Genomic Data

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

From genomics to chemical genomics: new developments in KEGG

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Causal inference of regulator-target pairs by gene mapping of expression phenotypes

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

A probabilistic functional network of yeast genes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Identifying regulatory mechanisms using individual variation reveals key role for chromatin modification

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Structural model analysis of multiple quantitative traits

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Elucidating the murine brain transcriptional network in a segregating mouse population to identify core functional modules for obesity and diabetes.

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Genomic analysis of regulatory network dynamics reveals large topological changes

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

An improved map of conserved regulatory sites for Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Genetic inheritance of gene expression in human cell lines

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Genetic analysis of genome-wide variation in human gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Initial sequencing and comparative analysis of the mouse genome

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Causality and pathway search in microarray time series experiment.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

A mouse phenome project

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Uncovering the overlapping community structure of complex networks in nature and society

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

A DNA integrity network in the yeast Saccharomyces cerevisiae

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Inferring subnetworks from perturbed expression profiles.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Novel polymorphism in the A4 region of the amyloid precursor protein gene in a patient without Alzheimer's disease.

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Growing Bayesian network models of gene networks from seed genes.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Heritability and tissue specificity of expression quantitative trait loci

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Integrated gene expression profiling and linkage analysis in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Rapid rewiring of arcuate nucleus feeding circuits by leptin.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Transforming growth factor-beta-regulated expression of genes in macrophages implicated in the control of cholesterol homoeostasis.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Hierarchical organization of modularity in metabolic networks

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Comment on "A common genetic variant is associated with adult and childhood obesity"

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Towards a proteome-scale map of the human protein–protein interaction network

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Exploiting naturally occurring DNA variation and molecular profiling data to dissect disease and drug response traits

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Thematic review series: systems biology approaches to metabolic and cardiovascular disorders. Reverse engineering gene networks to identify key drivers of complex disease phenotypes

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Genetics of gene expression surveyed in maize, mouse and man

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

An integrative genomics approach to infer causal associations between gene expression and disease

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Embracing complexity, inching closer to reality

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Coordinated binding of NF-kappaB family members in the response of human cells to lipopolysaccharide.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Estimating the Dimension of a Model

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Probabilistic Boolean Networks: a rule-based uncertainty model for gene regulatory networks.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Gene expression profiling predicts clinical outcome of breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

The Sequence of the Human Genome

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Genetic and genomic analysis of a fat mass trait with complex inheritance reveals marked sex specificity

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Peeling the yeast protein network

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Physical network models.

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https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Medicine. The NIH Roadmap

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

A general framework for weighted gene co-expression network analysis

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

An integrative genomics approach to the reconstruction of gene networks in segregating populations.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

Increasing the power to detect causal associations by combining genotypic and expression data in segregating populations

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

A new dynamic Bayesian network (DBN) approach for identifying gene regulatory networks from time course microarray data

1 reference

https://api.crossref.org/works/10.1016%2FS0065-2660%2807%2900421-X

7 January 2021

10.1016/S0065-2660(07)00421-X

Identifiers

DOI

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18 August 2017

1 reference

PubMed ID

18358334