Relaxin treatment reverses insulin resistance in mice fed a high-fat diet (Q37110579)

18 August 2017

Relaxin treatment reverses insulin resistance in mice fed a high-fat diet (English)

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18 August 2017

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Jeffrey S Bonner

1

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18 August 2017

Louise Lantier

2

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18 August 2017

Kyle M Hocking

3

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18 August 2017

Li Kang

4

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18 August 2017

Mark Owolabi

5

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18 August 2017

Freyja D James

6

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18 August 2017

Deanna P Bracy

7

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18 August 2017

Colleen M Brophy

8

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18 August 2017

David H Wasserman

9

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18 August 2017

language of work or name

English

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publication date

25 June 2013

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18 August 2017

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18 August 2017

62

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18 August 2017

9

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18 August 2017

3251-3260

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Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

18 August 2017

start time

30 August 2021

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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describes a project that uses

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3749347/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Muscle-specific vascular endothelial growth factor deletion induces muscle capillary rarefaction creating muscle insulin resistance

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Relaxin increases human endothelial progenitor cell NO and migration and vasculogenesis in mice

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Losartan modulates muscular capillary density and reverses thiazide diuretic-exacerbated insulin resistance in fructose-fed rats.

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Expression of LDL-A module of relaxin receptor in prostate cancer cells inhibits tumorigenesis

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Relaxin ameliorates hypertension and increases nitric oxide metabolite excretion in angiotensin II but not N(ω)-nitro-L-arginine methyl ester hypertensive rats

14 September 2017

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Relaxin induces rapid dilation of rodent small renal and human subcutaneous arteries via PI3 kinase and nitric oxide

14 September 2017

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Angiogenic growth factors are new and essential players in the sustained relaxin vasodilatory pathway in rodents and humans

14 September 2017

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14 September 2017

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Diet-induced muscle insulin resistance is associated with extracellular matrix remodeling and interaction with integrin alpha2beta1 in mice

14 September 2017

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Emerging role of relaxin in the maternal adaptations to normal pregnancy: implications for preeclampsia

14 September 2017

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Skeletal muscle AMP-activated protein kinase is essential for the metabolic response to exercise in vivo

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14 September 2017

Four grams of glucose

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Glucose metabolism in vivo in four commonly used inbred mouse strains

14 September 2017

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Relaxin family peptide receptors--former orphans reunite with their parent ligands to activate multiple signalling pathways

14 September 2017

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Salutary effects of attenuation of angiotensin II on coronary perivascular fibrosis associated with insulin resistance and obesity

14 September 2017

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Microvascular recruitment is an early insulin effect that regulates skeletal muscle glucose uptake in vivo

14 September 2017

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Inhibiting NOS blocks microvascular recruitment and blunts muscle glucose uptake in response to insulin

14 September 2017

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Relaxin induces an extracellular matrix-degrading phenotype in human lung fibroblasts in vitro and inhibits lung fibrosis in a murine model in vivo

14 September 2017

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Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance

14 September 2017

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Collagen remodelling in myocardia of patients with diabetes

14 September 2017

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Skeletal muscle capillary density and fiber type are possible determinants of in vivo insulin resistance in man.

14 September 2017

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Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance

14 September 2017

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Relaxin promotes prostate cancer progression

14 September 2017

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The antifibrotic effects of relaxin in human renal fibroblasts are mediated in part by inhibition of the Smad2 pathway

29 September 2017

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Relaxin induces vascular endothelial growth factor expression and angiogenesis selectively at wound sites

29 September 2017

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29 September 2017

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29 September 2017

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Vascular inflammation, insulin resistance, and reduced nitric oxide production precede the onset of peripheral insulin resistance.

27 June 2018

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Control of muscle glucose uptake: test of the rate-limiting step paradigm in conscious, unrestrained mice

27 June 2018

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Role of blood flow in the regulation of muscle glucose uptake

27 June 2018

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Perivascular fat-mediated vascular dysfunction and remodeling through the AMPK/mTOR pathway in high-fat diet-induced obese rats

27 June 2018

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Chronic treatment with sildenafil improves energy balance and insulin action in high fat-fed conscious mice.

3 September 2018

1 reference

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Considerations in the design of hyperinsulinemic-euglycemic clamps in the conscious mouse

3 September 2018

1 reference

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Increased collagen content in insulin-resistant skeletal muscle

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3749347

Relaxin increases cardiac output and reduces systemic arterial load in hypertensive rats.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3749347

Relaxin reverses cardiac and renal fibrosis in spontaneously hypertensive rats

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3749347

Metabolic syndrome and the risk for chronic kidney disease among nondiabetic adults

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3749347

Diabetes induces endothelial dysfunction but does not increase neointimal formation in high-fat diet fed C57BL/6J mice.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3749347

Experimental hindlimb ischemia leads to neutrophil-mediated increases in gastrocnemius MMP-2 and -9 activity: a potential mechanism for ischemia induced MMP activation

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3749347

Knockout of the alpha2 but not alpha1 5'-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3749347

Measurement of size and turnover rate of body glucose pool by the isotope dilution method

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3749347

Insulin resistance in non-diabetic subjects is associated with increased incidence of myocardial infarction and death

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3749347

High glucose and hyperinsulinemia stimulate connective tissue growth factor expression: a potential mechanism involved in progression to fibrosis in nonalcoholic steatohepatitis

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3749347

Lipid peroxidation in hepatic steatosis in humans is associated with hepatic fibrosis and occurs predominately in acinar zone 3.

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3749347

Mechanism of insulin resistance in insulin-dependent diabetes mellitus: a major role for reduced skeletal muscle blood flow

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3749347

Relaxin ameliorates salt-sensitive hypertension and renal fibrosis

3 September 2018

1 reference

12 December 2020

Interaction between insulin sensitivity and muscle perfusion on glucose uptake in human skeletal muscle: evidence for capillary recruitment

1 reference

12 December 2020

Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic States: a possible explanation for impaired collateral formation in cardiac tissue

1 reference

12 December 2020

Skeletal muscle blood flow independently modulates insulin-mediated glucose uptake

1 reference

12 December 2020

Muscle fiber composition and capillary density in women and men with NIDDM

1 reference

12 December 2020

Lower capillary density but no difference in VEGF expression in obese vs. lean young skeletal muscle in humans

1 reference

12 December 2020

Vascular matrix metalloproteinase-9 mediates the inhibition of myogenic reactivity in small arteries isolated from rats after short-term administration of relaxin

1 reference

12 December 2020

Relaxin ameliorates fibrosis in experimental diabetic cardiomyopathy

1 reference

12 December 2020

1 reference

12 December 2020

Antifibrotic properties of relaxin: in vivo mechanism of action in experimental renal tubulointerstitial fibrosis

1 reference

12 December 2020

Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle

1 reference

12 December 2020

Identifiers

DOI

10.2337/DB13-0033

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18 August 2017

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18 August 2017

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