T-cell-targeted signaling inhibitors (Q37094686)

18 August 2017

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title

T-cell-targeted signaling inhibitors (English)

1 reference

18 August 2017

Jonghwa Won

1

1 reference

PubMed ID

18300054

18 August 2017

Ge Hyeong Lee

series ordinal

2

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18 August 2017

1 January 2008

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International Reviews of Immunology

18 August 2017

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18 August 2017

27

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18 August 2017

1-2

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18 August 2017

19-41

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The role of CD4 T cells in the pathogenesis of multiple sclerosis

18 August 2017

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

T cell-directed therapies: lessons learned and future prospects

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

The influence of the src-family kinases, Lck and Fyn, on T cell differentiation, survival and activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Lck regulates the tyrosine phosphorylation of the T cell receptor subunits and ZAP-70 in murine thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Leukocyte protein tyrosine kinases: potential targets for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Profound block in thymocyte development in mice lacking p56lck

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Suppression of CD4+ T cell activation by a novel inhibitor of Src family kinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Signal transduction: clamping down on Src activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

SH2 domain function is essential for the role of the Lck tyrosine kinase in T cell receptor signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Role of the Lck Src homology 2 and 3 domains in protein tyrosine phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Inhibitors of JAKs/STATs and the kinases: a possible new cluster of drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

A-420983: a potent, orally active inhibitor of lck with efficacy in a model of transplant rejection

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

A-770041, a novel and selective small-molecule inhibitor of Lck, prevents heart allograft rejection

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

A420983, a novel, small molecule inhibitor of LCK prevents allograft rejection

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Discovery and initial SAR of imidazoquinoxalines as inhibitors of the Src-family kinase p56(Lck).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

The Src homology-2 domains (SH2 domains) of the protein tyrosine kinase p56lck: structure, mechanism and drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Carboxymethyl-phenylalanine as a replacement for phosphotyrosine in SH2 domain binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Nonpeptidic, monocharged, cell permeable ligands for the p56lck SH2 domain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Rosmarinic acid inhibits TCR-induced T cell activation and proliferation in an Lck-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Rosmarinic acid inhibits Ca2+-dependent pathways of T-cell antigen receptor-mediated signaling by inhibiting the PLC-gamma 1 and Itk activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Identification of non-phosphate-containing small molecular weight inhibitors of the tyrosine kinase p56 Lck SH2 domain via in silico screening against the pY + 3 binding site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Tec kinases: a family with multiple roles in immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Altered T cell receptor signaling and disrupted T cell development in mice lacking Itk.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Requirement for Tec kinases Rlk and Itk in T cell receptor signaling and immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Impaired NFATc translocation and failure of Th2 development in Itk-deficient CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Attenuation of Immunological Symptoms of Allergic Asthma in Mice Lacking the Tyrosine Kinase ITK

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Selective Itk inhibitors block T-cell activation and murine lung inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Discovery and SAR of 2-amino-5-[(thiomethyl)aryl]thiazoles as potent and selective Itk inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Hit-to-lead studies on benzimidazole inhibitors of ITK: discovery of a novel class of kinase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

The role of PI3K in immune cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Phosphoinositide 3-kinase: diverse roles in immune cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Phosphoinositide 3-kinase gamma is an essential amplifier of mast cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Essential role for the p110delta phosphoinositide 3-kinase in the allergic response

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Cutting edge: T cell development requires the combined activities of the p110gamma and p110delta catalytic isoforms of phosphatidylinositol 3-kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Inactivation of PI3Kgamma and PI3Kdelta distorts T-cell development and causes multiple organ inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Therapeutic potential of phosphoinositide 3-kinase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

NFAT proteins: key regulators of T-cell development and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Transcriptional regulation by calcium, calcineurin, and NFAT

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Manipulating immune responses with immunosuppressive agents that target NFAT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

ISA(TX)247: a novel calcineurin inhibitor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Compared with cyclosporine, ISATX247 significantly prolongs renal-allograft survival in a nonhuman primate model

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

A randomized, multicenter, double-blind, placebo-controlled phase 2 trial of ISA247 in patients with chronic plaque psoriasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Potent immunosuppressive C32-O-arylethyl ether derivatives of ascomycin with reduced toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

A new cell-permeable peptide allows successful allogeneic islet transplantation in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Chemical genetics to identify NFAT inhibitors: potential of targeting calcium mobilization in immunosuppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Jaks and STATs: biological implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Is JAK3 a new drug target for immunomodulation-based therapies?

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Jak3 and the pathogenesis of severe combined immunodeficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Peripheral expression of Jak3 is required to maintain T lymphocyte function

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Prevention of Organ Allograft Rejection by a Specific Janus Kinase 3 Inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Effects of JAK3 inhibition with CP-690,550 on immune cell populations and their functions in nonhuman primate recipients of kidney allografts

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Immunosuppression by the JAK3 inhibitor CP-690,550 delays rejection and significantly prolongs kidney allograft survival in nonhuman primates

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

The JAK3 inhibitor CP-690550 selectively reduces NK and CD8+ cell numbers in cynomolgus monkey blood following chronic oral dosing

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Selective inhibitor of Janus tyrosine kinase 3, PNU156804, prolongs allograft survival and acts synergistically with cyclosporine but additively with rapamycin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Treatment of post-bone marrow transplant acute graft-versus-host disease with a rationally designed JAK3 inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Role of a JAK3-dependent biochemical signaling pathway in platelet activation and aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Targeting Janus kinase 3 in mast cells prevents immediate hypersensitivity reactions and anaphylaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Mapping the kinase domain of Janus Kinase 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

FTY720: altered lymphocyte traffic results in allograft protection

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

Potent inhibition of NFAT activation and T cell cytokine production by novel low molecular weight pyrazole compounds

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F08830180701798976

10.1080/08830180701798976

21 January 2018

Identifiers

DOI

1 reference

18 August 2017

1 reference

PubMed ID

18300054