Drug insight: selective agonists and antagonists of the glucocorticoid receptor (Q37062932)

18 August 2017

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title

Drug insight: selective agonists and antagonists of the glucocorticoid receptor (English)

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18 August 2017

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David W Ray

2

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author name string

Andrew McMaster

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1

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18 August 2017

1 February 2008

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Nature Clinical Practice Endocrinology and Metabolism

18 August 2017

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18 August 2017

4

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18 August 2017

2

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18 August 2017

91-101

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Effects of cortisone acetate and pituitary ACTH on rheumatoid arthritis, rheumatic fever and certain other conditions

18 August 2017

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A comparison of the acute inflammatory response in adrenalectomised and sham-operated rats

21 January 2018

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Beclomethasone dipropionate aerosol in treatment of perennial and seasonal rhinitis: a review of five years' experience

21 January 2018

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Perinatal corticosteroids: A review of research. Part I: Antenatal administration

21 January 2018

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Dexamethasone does not inhibit the release of mediators from human mast cells residing in airway, intestine, or skin

21 January 2018

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Interactions between GH, IGF-I, glucocorticoids, and thyroid hormones during skeletal growth

21 January 2018

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Taking glucocorticoids by prescription is associated with subsequent cardiovascular disease

21 January 2018

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Genetic manipulation of 11beta-hydroxysteroid dehydrogenases in mice

21 January 2018

1 reference

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Therapeutic benefit of a dissociated glucocorticoid and the relevance of in vitro separation of transrepression from transactivation activity

21 January 2018

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Receptor-mediated effects of glucocorticoids on inflammation: enhancement of the inflammatory response with a glucocorticoid antagonist

21 January 2018

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7 January 2021

Oral glucocorticoids and their complications. A review

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7 January 2021

A review of the pharmacology and pharmacokinetics of inhaled fluticasone propionate and mometasone furoate

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7 January 2021

Review article: medical treatment of moderate to severe Crohn's disease

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7 January 2021

New Glucocorticosteroids with an improved therapeutic ratio?

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7 January 2021

Effects of in vitro corticosteroids on B cell activation, proliferation, and differentiation

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7 January 2021

Molecular physiology of the regulation of hepatic gluconeogenesis and glycolysis

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7 January 2021

Glucocorticoids as counterregulatory hormones of leptin: toward an understanding of leptin resistance

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7 January 2021

Folic acid prevents and partially reverses glucocorticoid-induced hypertension in the rat

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7 January 2021

Correlational relationship between shock intensity and corticosterone secretion on the establishment and subsequent expression of contextual fear conditioning.

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7 January 2021

A role for brain glucocorticoid receptors in contextual fear conditioning: dependence upon training intensity.

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7 January 2021

Increased evening activation of the hypothalamic-pituitary-adrenal axis in depressed patients

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7 January 2021

Glucocorticoid-induced osteoporosis: pathophysiology and therapy

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7 January 2021

Patterns of cardiovascular risk in rheumatoid arthritis

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https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

The origin and functions of multiple human glucocorticoid receptor isoforms

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https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

Translational regulatory mechanisms generate N-terminal glucocorticoid receptor isoforms with unique transcriptional target genes.

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https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

Novel glucocorticoid receptor complex with DNA element of the hormone-repressed POMC gene.

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https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

Glucocorticoid-dependent transcriptional repression of the osteocalcin gene by competitive binding at the TATA box.

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https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

Hormone-mediated repression: a negative glucocorticoid response element from the bovine prolactin gene

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https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

Alternate surfaces of transcriptional coregulator GRIP1 function in different glucocorticoid receptor activation and repression contexts

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https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

Target-specific utilization of transcriptional regulatory surfaces by the glucocorticoid receptor

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https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

Chromatin immunoprecipitation (ChIP) scanning identifies primary glucocorticoid receptor target genes.

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https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids.

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https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase

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https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

Cytoplasmic catalytic subunit of protein kinase A mediates cross-repression by NF-kappa B and the glucocorticoid receptor.

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https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

Different glucocorticoids vary in their genomic and non-genomic mechanism of action in A549 cells

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https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

Rapid glucocorticoid receptor exchange at a promoter is coupled to transcription and regulated by chaperones and proteasomes

1 reference

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7 January 2021

Ligand-dependent regulation of vascular endothelial growth factor and erythropoietin expression by a plasmid-based autoinducible GeneSwitch system

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7 January 2021

Steroid receptor coactivator (SRC)-1 and SRC-3 differentially modulate tissue-specific activation functions of the progesterone receptor

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes.

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https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

Urban renewal in the nucleus: is protein turnover by proteasomes absolutely required for nuclear receptor-regulated transcription?

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https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

A life-long search for the molecular pathways of steroid hormone action

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https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

Transcriptional regulation by steroid receptor coactivator phosphorylation

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https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

Hierarchical affinities and a bipartite interaction model for estrogen receptor isoforms and full-length steroid receptor coactivator (SRC/p160) family members

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

Selective estrogen receptor modulators 4-hydroxytamoxifen and raloxifene impact the stability and function of SRC-1 and SRC-3 coactivator proteins

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https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

Dissociation of steroid receptor coactivator 1 and nuclear receptor corepressor recruitment to the human glucocorticoid receptor by modification of the ligand-receptor interface: the role of tyrosine 735

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https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

Dynamic cell type specificity of SRC-1 coactivator in modulating uterine progesterone receptor function in mice

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https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

Mice lacking the amplified in breast cancer 1/steroid receptor coactivator-3 are resistant to chemical carcinogen-induced mammary tumorigenesis

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https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

Dual functions of the steroid hormone receptor coactivator 3 in modulating resistance to thyroid hormone

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

Nuclear hormone receptor coregulator GRIP1 suppresses, whereas SRC1A and p/CIP coactivate, by domain-specific binding of MyoD.

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

Molecular determinants for the tissue specificity of SERMs

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https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription

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https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

Nuclear receptor coactivators: multiple enzymes, multiple complexes, multiple functions.

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https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

Results of a search for the mechanisms of steroid receptor regulation of gene expression

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https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition

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https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

The three-dimensional structures of antagonistic and agonistic forms of the glucocorticoid receptor ligand-binding domain: RU-486 induces a transconformation that leads to active antagonism

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

11beta-hydroxysteroid dehydrogenases: changing glucocorticoid action

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https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

Adipocyte-specific glucocorticoid inactivation protects against diet-induced obesity

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https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

Tissue-specific Cushing's syndrome, 11beta-hydroxysteroid dehydrogenases and the redefinition of corticosteroid hormone action

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https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

11beta-Hydroxysteroid dehydrogenase type 2 protects the neonatal cerebellum from deleterious effects of glucocorticoids

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

11Beta-hydroxysteroid dehydrogenases: a novel control of glucocorticoid action in the brain

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

Steric course of reactions of steroids

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https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

Is 11beta-hydroxysteroid dehydrogenase type 1 a good therapeutic target for blockade of glucocorticoid actions?

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https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

The search for safer glucocorticoid receptor ligands

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https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

Glucocorticoid Ligands Specify Different Interactions with NF-κB by Allosteric Effects on the Glucocorticoid Receptor DNA Binding Domain

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https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

Cell type-dependent divergence of transactivation by glucocorticoid receptor ligand

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https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

Effects of dissociated glucocorticoids on OPG and RANKL in osteoblastic cells

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https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

I kappaB alpha-independent downregulation of NF-kappaB activity by glucocorticoid receptor.

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https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor

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https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

DNA binding of the glucocorticoid receptor is not essential for survival

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https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis

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https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

Deflazacort. A review of its pharmacological properties and therapeutic efficacy

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https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

A novel antiinflammatory maintains glucocorticoid efficacy with reduced side effects

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https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

A fully dissociated compound of plant origin for inflammatory gene repression

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https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

Novel arylpyrazole compounds selectively modulate glucocorticoid receptor regulatory activity

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https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

Dissociated nonsteroidal glucocorticoid receptor modulators; discovery of the agonist trigger in a tetrahydronaphthalene-benzoxazine series

1 reference

https://api.crossref.org/works/10.1038%2FNCPENDMET0745

7 January 2021

Identifiers

DOI

10.1038/NCPENDMET0745

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18 August 2017

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PubMed ID

18212811