A physiologically based pharmacokinetic model for butadiene and its metabolite butadiene monoxide in rat and mouse and its significance for risk extrapolation. (Q42622460)

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scientific article published on January 1993

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English	A physiologically based pharmacokinetic model for butadiene and its metabolite butadiene monoxide in rat and mouse and its significance for risk extrapolation.	scientific article published on January 1993

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scholarly article

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13 October 2019

A physiologically based pharmacokinetic model for butadiene and its metabolite butadiene monoxide in rat and mouse and its significance for risk extrapolation (English)

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13 October 2019

pharmacokinetics

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Gunnar Johanson

1

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13 October 2019

author name string

J G Filser

2

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13 October 2019

publication date

1 January 1993

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13 October 2019

Archives of Toxicology

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13 October 2019

67

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13 October 2019

3

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13 October 2019

151-163

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13 October 2019

https://scigraph.springernature.com/pub.10.1007/bf01973302

0 references

Inhalation toxicity studies with 1,3-butadiene. 3. Two year toxicity/carcinogenicity study in rats

1 reference

https://api.crossref.org/works/10.1007%2FBF01973302

21 January 2018

Species differences in butadiene metabolism between mice and rats evaluated by inhalation pharmacokinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

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Detection of diepoxybutane-induced DNA-DNA crosslinks by cesium trifluoracetate (CsTFA) density-gradient centrifugation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

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Alkylation of nuclear proteins and DNA after exposure of rats and mice to [1,4-14C]1,3-butadiene

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

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Diurnal variation of hepatic glutathione concentration and its correlation with 1,1-dichloroethylene inhalation toxicity in rats

1 reference

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12 December 2020

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The effects of age and glutathione depletion on hepatic glutathione turnover in vivo determined by acetaminophen probe analysis

1 reference

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12 December 2020

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Activation of K-ras by codon 13 mutations in C57BL/6 X C3H F1 mouse tumors induced by exposure to 1,3-butadiene

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

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Multiple organ carcinogenicity of 1,3-butadiene in B6C3F1 mice after 60 weeks of inhalation exposure.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

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Spreadsheet programming — a new approach in physiologically based modeling of solvent toxicokinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of Hepatic Glutathione Turnover in Rats In Vivo and Evidence for Kinetic Homogeneity of the Hepatic Glutathione Pool

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic glutathione homeostasis in the rat: efflux accounts for glutathione turnover.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Testicular toxicity and alterations of glutathione metabolism resulting from chronic inhalation of ethylene oxide in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutathione depletion by methyl chloride and association with lipid peroxidation in mice and rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The closed chamber technique--uptake, endogenous production, excretion, steady-state kinetics and rates of metabolism of gases and vapors

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

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Mammalian Epoxide Hydrases: Inducible Enzymes Catalysing the Inactivation of Carcinogenic and Cytotoxic Metabolites Derived from Aromatic and Olefinic Compounds

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of some carbonyl compounds on rat liver glutathione levels

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhalation pharmacokinetics based on gas uptake studies. V. Comparative pharmacokinetics of ethylene and 1,3-butadiene in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of chronic ethanol feeding on glutathione turnover in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel physiological role of liver glutathione as a reservoir of L-cysteine

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Concentration-dependent depletion of non-protein sulfhydryl (NPSH) content in lung, heart and liver tissue of rats and mice after acute inhalation exposure to butadiene

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carcinogenicity of 1,3-butadiene in C57BL/6 x C3H F1 mice at low exposure concentrations

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Different responses of cytosolic and mitochondrial glutathione in rat livers after ethylene oxide exposure

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Susceptibility to 1,3-butadiene-induced leukemogenesis correlates with endogenous ecotropic retroviral background in the mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

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Effect of Styrene on Hepatic Mixed Function Oxidases, Glutathione Content and Glutathione-S-Transferase Activity in Rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Species differences in DNA damage by butadiene: role of diepoxybutane

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detoxification of styrene oxide by human liver glutathione transferase

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The isoenzymes of glutathione transferase

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diurnal fluctuation and pharmacological alteration of mouse organ glutathione content

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1,3-Butadiene: induction of micronucleated erythrocytes in the peripheral blood of B6C3F1 mice exposed by inhalation for 13 weeks

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of hemoglobin adduct formation in mice and rats after administration of [14C]butadiene or [14C]isoprene.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Species differences in the metabolism and disposition of inhaled 1,3-butadiene and isoprene.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Experimental data from closed chamber gas uptake studies in rodents suggest lower uptake rate of chemical than calculated from literature values on alveolar ventilation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Depletion of hepatic non-protein sulfhydryl content during exposure of rats and mice to butadiene

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of the biotransformation of 1,3-butadiene and its metabolite, butadiene monoepoxide, by hepatic and pulmonary tissues from humans, rats and mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cancer risk assessment for the inhalation of 1,3-butadiene using physiologically based pharmacokinetic modeling

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hemoglobin adducts and urinary mercapturic acids in rats as biological indicators of butadiene exposure

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo sister chromatid exchange and micronucleus induction studies with 1,3-butadiene in B6C3F1 mice and Sprague-Dawley rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Species differences in the disposition of inhaled butadiene

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Species differences in the formation of butadiene monoxide from 1,3-butadiene

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enzyme specific kinetics of 1,2-epoxybutene-3 in microsomes and cytosol from livers of mouse, rat, and man

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A physiologically based pharmacokinetic and pharmacodynamic model to describe the oral dosing of rats with ethyl acrylate and its implications for risk assessment

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutagenicity and chemical reactivity of epoxidic intermediates of the isoprene metabolism and other structurally related compounds.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of short-term inhalation exposure to 1,3-butadiene on murine immune functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhalation pharmacokinetics based on gas uptake studies. VI. Comparative evaluation of ethylene oxide and butadiene monoxide as exhaled reactive metabolites of ethylene and 1,3-butadiene in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Circadian variations in hepatic glutathione content, gamma-glutamylcysteine synthetase and gamma-glutamyl transferase activities in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and partial characterization of the glutathione S-transferase of rat erythrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic microsomal metabolism of 1,3-butadiene

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism of 1,3-butadiene by lung and liver microsomes of rats and mice repeatedly exposed by inhalation to 1,3-butadiene.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The regulation of hepatic glutathione

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiological model for tissue glutathione depletion and increased resynthesis after ethylene dichloride exposure

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of protooncogenes in spontaneously occurring non-liver tumors from C57BL/6 x C3H F1 mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhalation pharmacokinetics of 1,2-epoxybutene-3 reveal species differences between rats and mice sensitive to butadiene-induced carcinogenesis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Circadian periodicity of tissue glutathione and its relationship with lipid peroxidation in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased hepatic efflux of glutathione after chronic ethanol feeding.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The glutathione status in the liver and cardiac muscle of rats after starvation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8494494

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/BF01973302

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8494494%20AND%20SRC:MED&resulttype=core&format=json

13 October 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8494494%20AND%20SRC:MED&resulttype=core&format=json

13 October 2019

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